Chemical compositions and methods of use

ABSTRACT

The present invention is directed to methods for detecting a melanoma, methods for determining whether a melanoma is stable or progressive, methods for evaluating the extent of surgery resection in a subject having a melanoma, and methods for determining a response by a subject having a melanoma to a therapy.

CROSS-REFERENCE TO RELATED APPLICATIONS

This application is a Continuation of U.S. patent application Ser. No.15/984,935, filed on May 21, 2018, which claims the benefit of andpriority to U.S. Provisional Application No. 62/511,058, filed on May25, 2017. The contents of each of the aforementioned patent applicationare hereby incorporated by reference in their entireties for allpurposes.

INCORPORATION BY REFERENCE OF SEQUENCE LISTING

The instant application contains a Sequence Listing which has beensubmitted in ASCII format via EFS-Web and is hereby incorporated byreference in its entirety. Said ASCII copy, created on Sep. 28, 2021, isnamed “LBIO-001_C01US_SeqList.txt” and is about 272,331 bytes in size.

FIELD OF THE INVENTION

The present invention relates to melanoma detection.

BACKGROUND OF THE INVENTION

Melanoma is a common (˜24-35/100,000 incidence—US), highly aggressive,skin cancer with an incidence that continues to rise. The most common,cutaneous melanomas, are associated with UV exposure and immunedysregulation. As a group, melanoma is known to carry the highestmutational burden (>10 mutations/Mb). Major mutations include BRAF(˜50%), N-Ras (˜20%) and NF-1 (˜5%), which together, comprise 75% of allmutations. Melanomas are addicted to MAPK pathway activation, regardlessof whether tumors exhibit mutations in genes coding for proteins in thispathway. This provides the rationale for targeted therapy e.g., BRAFv600E agents, in this tumor. Other gain-of-function and loss-of-functionmutations e.g., in RASopathy genes and amplification of cyclin D1/cdk4and/or mutation/loss of the tumor suppressor PTEN, also characterize thetumor. This makes melanoma one of the most aggressive andtherapy-resistant cancers.

Five-year survival rates range from 95-100% for stage I, 65-93% forstage II, to 41-71% and 9-28% for stage III and IV, respectively.Surgery, immunotherapy and targeted therapies provide the basis formanagement, with chemotherapy and radiation as adjuncts. Surgery,however, has a critical role in melanoma care (diagnosis, cure andpalliation). Sentinel lymph node biopsy has become widespread, as itprovides prognostic information. Melanoma, however, lacks a clinicallyuseful non-invasive e.g., blood-based biomarker of disease activity tohelp guide patient management by providing predictive or prognosticinformation.

Blood-based factors include lactate dehydrogenase (LDH), detectingmutations in circulating tumor (ct) DNA, measurements of circulatingtumor cells (CTCs) and circulating mRNA. LDH is typically used toidentify aggressive tumor behavior and predict recurrence but itsmetrics are very low e.g., 30-50% accurate. It is also non-specific formelanoma. Mutations in target genes, like BRAF, can be detected in theblood in ctDNA but its utility as an indicator of therapeutic efficacyis limited e.g., 45-70% accurate. CTCs do not appear to be an accuratemarker in melanomas and there is no consensus as to their clinicalutility. Circulating microNAs (miRNA) have been detected but there is noevidence yet for clinical usefulness.

For melanomas, there are no multi-mRNA circulating biomarkers thatfunction as a diagnostic or as a prognostic for disease recurrence. Abiomarker that can be used to monitor the efficacy of surgery or drugtherapy in melanomas is currently lacking.

SUMMARY OF THE INVENTION

Among other things, disclosed herein is a 28-gene expression tool formelanoma. It has high sensitivity and specificity (>95%) for thedetection of melanoma and can differentiate aggressive untreated diseasefrom stable, treated disease.

One aspect of the present disclosure relates to a method for detecting amelanoma in a subject in need thereof, comprising: (1) determining theexpression level of at least 29 biomarkers from a test sample from thesubject by contacting the test sample with a plurality of agentsspecific to detect the expression of the at least 29 biomarkers, whereinthe at least 29 biomarkers comprise ATL1, ATP6VOD, C1ORF21, CFLAR,CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA,HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR,PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, YY2, and at leastone housekeeping gene; (2) normalizing the expression level of each ofATL1, ATP6VOD, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9,ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1,LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L,TDRD7, TXK, and YY2 to the expression level of the at least onehousekeeping gene, thereby obtaining a normalized expression level ofeach of ATL1, ATP6VOD, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD,DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A,IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5,SPATS2L, TDRD7, TXK, and YY2; (3) inputting each normalized expressionlevel into an algorithm to generate a score; (4) comparing the scorewith a first predetermined cutoff value; and (5) producing a report,wherein the report identifies the presence of a melanoma in the subjectwhen the score is equal to or greater than the first predeterminedcutoff value or identifies the absence of a melanoma in the subject whenthe score is below the first predetermined cutoff value, wherein thefirst predetermined cutoff value is 20 on a scale of 0 to 100.

In some embodiments, the method further comprises treating the subjectidentified as having a melanoma with surgery or drug therapy.

Another aspect of the present disclosure relates to a method fordetermining whether a melanoma in a subject is stable or progressive,comprising: (1) determining the expression level of at least 29biomarkers from a test sample from the subject by contacting the testsample with a plurality of agents specific to detect the expression ofthe at least 29 biomarkers, wherein the at least 29 biomarkers compriseATL1, ATP6VOD, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9,ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1,LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L,TDRD7, TXK, YY2, and at least one housekeeping gene; (2) normalizing theexpression level of each of ATL1, ATP6VOD, C1ORF21, CFLAR, CFLAR-AS1,CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA,HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5,SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, and YY2 to the expression levelof the at least one housekeeping gene, thereby obtaining a normalizedexpression level of each of ATL1, ATP6VOD, C1ORF21, CFLAR, CFLAR-AS1,CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA,HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5,SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, and YY2; (3) inputting eachnormalized expression level into an algorithm to generate a score; (4)comparing the score with a second predetermined cutoff value; and (5)producing a report, wherein the report identifies that the melanoma isprogressive when the normalized expression level is equal to or greaterthan the second predetermined cutoff value or identifies that themelanoma is stable when the normalized expression level is below thesecond predetermined cutoff value, wherein the second predeterminedcutoff value is 50 on a scale of 0 to 100.

Another aspect of the present disclosure relates to a method forevaluating the extent of surgical resection in a subject having amelanoma, comprising: (1) determining the expression level of at least29 biomarkers from a test sample from the subject after the surgicalresection by contacting the test sample with a plurality of agentsspecific to detect the expression of the at least 29 biomarkers, whereinthe at least 29 biomarkers comprise ATL1, ATP6VOD, C1ORF21, CFLAR,CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA,HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR,PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, YY2, and at leastone housekeeping gene; (2) normalizing the expression level of each ofATL1, ATP6VOD, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9,ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1,LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L,TDRD7, TXK, and YY2 to the expression level of the at least onehousekeeping gene, thereby obtaining a normalized expression level ofeach of ATL1, ATP6VOD, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD,DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A,IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5,SPATS2L, TDRD7, TXK, and YY2; (3) inputting each normalized expressionlevel into an algorithm to generate a score; (4) comparing the scorewith a third predetermined cutoff value; and (5) producing a report,wherein the report identifies that the surgical resection does notremove the entire melanoma when the normalized expression level is equalto or greater than the third predetermined cutoff value or identifiesthat the surgical resection removes the entire melanoma when thenormalized expression level is below the third predetermined cutoffvalue, wherein the third predetermined cutoff value is 20 on a scale of0 to 100.

In some embodiments, the report further identifies that the risk ofmelanoma recurrence is high when the normalized expression level isequal to or greater than the third predetermined cutoff value oridentifies that the risk of melanoma recurrence is low when thenormalized expression level is below the third predetermined cutoffvalue.

Yet another aspect of the present disclosure relates to a method fordetermining a response by a subject having a melanoma to a therapy,comprising: (1) determining a first expression level of at least 28biomarkers from a first test sample from the subject at a first timepoint by contacting the first test sample with a plurality of agentsspecific to detect the expression of the at least 28 biomarkers, whereinthe 28 biomarkers comprise ATL1, ATP6VOD, C1ORF21, CFLAR, CFLAR-AS1,CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA,HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5,SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, and YY2; (2) determining a secondexpression level of the at least 28 biomarkers from a second test samplefrom the subject at a second time point by contacting the second testsample with a plurality of agents specific to detect the expression ofthe at least 28 biomarkers, wherein the second time point is after thefirst time point and after the administration of the therapy to thesubject; (3) comparing the first expression level with the secondexpression level; and (4) producing a report, wherein the reportidentifies that the subject is responsive to the therapy when the secondexpression level is significantly decreased as compared to the firstexpression level.

In some embodiments, the first time point is prior to the administrationof the therapy to the subject. In some embodiments, the first time pointis after the administration of the therapy to the subject. In someembodiments, the therapy comprises an immunotherapy or a targetedtherapy (e.g., a BRAF inhibitor).

In some embodiments, the at least one housekeeping gene is selected fromthe group consisting of ALG9, SEPN, YWHAQ, VPS37A, PRRC2B, DOPEY2,NDUFB11, ND4, MRPL19, PSMC4, SF3A1, PUM1, ACTB, GAPD, GUSB, RPLP0, TFRC,MORF4L1, 18S, PPIA, PGK1, RPL13A, B2M, YWHAZ, SDHA, HPRT1, TOX4, andTPT1.

In some embodiments, the at least one housekeeping gene comprises TOX4and TPT1.

In some embodiments, the normalized expression level is obtained by: (1)normalizing the expression level of each of ATL1, ATP6VOD, C1ORF21,CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP,HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471,LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, and YY2 tothe expression level of TOX4, thereby obtaining a first normalizedexpression level of each of ATL1, ATP6VOD, C1ORF21, CFLAR, CFLAR-AS1,CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA,HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5,SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, and YY2; (2) normalizing theexpression level of each of ATL1, ATP6VOD, C1ORF21, CFLAR, CFLAR-AS1,CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA,HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5,SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, and YY2 to the expression levelof TPT1, thereby obtaining a second normalized expression level of eachof ATL1, ATP6VOD, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9,ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1,LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L,TDRD7, TXK, and YY2; and (3) averaging the first normalized expressionlevel and the second normalized expression level to obtain thenormalized expression level.

In some embodiments, the method can have a specificity, sensitivity,and/or accuracy of at least 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%,96%, 97%, 98%, or 99%. In some embodiments, the method has a sensitivityof greater than 90%. In some embodiments, the method has a specificityof greater than 90%.

In some embodiments, the biomarker is RNA, cDNA, or protein. When thebiomarker is RNA, the RNA can be reverse transcribed to produce cDNA,and the produced cDNA expression level is detected. In some embodiments,the expression level of the biomarker is detected by forming a complexbetween the biomarker and a labeled probe or primer. When the biomarkeris RNA or cDNA, the RNA or cDNA can be detected by forming a complexbetween the RNA or cDNA and a labeled nucleic acid probe or primer. Whenthe biomarker is protein, the protein can be detected by forming acomplex between the protein and a labeled antibody. In some embodiments,the label is a fluorescent label.

In some embodiments, the test sample is blood, serum, plasma, orneoplastic tissue.

In some embodiments, the first predetermined cutoff value can be derivedfrom a plurality of reference samples obtained from subjects free of aneoplastic disease. The second predetermined cutoff value can be derivedfrom a plurality of reference samples obtained from subjects whosemelanomas are being adequately controlled by therapies like immunetherapy. The third predetermined cutoff value can be derived from aplurality of reference samples obtained from subjects whose melanomashave been completely removed by surgery and they are considered “diseasefree.” In some embodiments, each reference sample can be blood, serum,plasma, or non-neoplastic tissue.

In some embodiments, the subject in need thereof is a subject diagnosedwith a melanoma, a subject having at least one melanoma symptom, or asubject having a predisposition or familial history for developing amelanoma. In some embodiments, the subject is a human.

In some embodiments, the algorithm is XGB, RF, glmnet, cforest, CART,treebag, knn, nnet, SVM-radial, SVM-linear, NB, NNET, or mlp.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 is a graph showing visualization of the melanoma score as asystem of three contributors to the clinical picture—Control, Response,and Progression. Samples towards each of the corner represent purerepresentations of each clinical group. Samples in the middle are in thearea of both algorithmic and clinical uncertainty.

FIG. 2 is a graph showing the metrics for the test in the test setranged from 87-100%.

FIGS. 3A-3C are a set of graphs showing the evaluation of thecirculating melanoma gene test (Melanomx) in test set 2. Values weresignificantly higher in melanoma samples than in controls (FIG. 3A).Patients who were responding to therapy had values similar to controls.Receiver operator curve analysis of test set 2 identifying the AUC fordifferentiating melanoma from controls was >0.95 (FIG. 3B). The metricsfor the test ranged from 78-92% (FIG. 3C).

FIGS. 4A-4B are a set of graphs showing the effect of surgery on theMelanomx. Levels were significantly decreased by surgery (p<0.0001)(FIG. 4A). Values in the NED (no evidence of disease after surgery)group were significantly lower than in those with residual disease aftersurgery (p=0.0007) (FIG. 4B).

FIG. 5 is a graph showing the effect of therapy on the Melanomx score.Levels were significantly decreased by immunotherapy (ipilimumab) or aBRAF inhibitor (Vemurafenib).

FIGS. 6A-6B are a set of graphs showing Melanomx score in 3 differentmelanoma cell lines. FIG. 6A identifies the cell lines demonstrateelevated expression—Melanomx score ranging from 40 (A375) to 95 (Hs294).FIG. 6B identifies that spiking these cells into blood from a subjectthat does not have a melanoma, resulted in detectable gene expressionand scores. A minimum of 1 cell/ml of blood could be consistentlyidentified.

FIGS. 7A-7B are a set of graphs showing expression in tumor tissue andits correlation with blood samples collected at the same time. In FIG.7A, the Melanomx score ranged 40-97 in melanoma tumor tissue. Incontrast, normal epithelium exhibited values <20. In FIG. 7B, geneexpression in tumor tissue is compared to matched blood samples. This ishighly concordant (correlation ˜0.80).

DETAILED DESCRIPTION OF THE INVENTION

The details of the invention are set forth in the accompanyingdescription below. Although methods and materials similar or equivalentto those described herein can be used in the practice or testing of thepresent invention, illustrative methods and materials are now described.Other features, objects, and advantages of the invention will beapparent from the description and from the claims. In the specificationand the appended claims, the singular forms also include the pluralunless the context clearly dictates otherwise. Unless defined otherwise,all technical and scientific terms used herein have the same meaning ascommonly understood by one of ordinary skill in the art to which thisinvention belongs. All patents and publications cited in thisspecification are incorporated herein by reference in their entireties.

Early signs of melanoma include changes to the shape or color ofexisting moles or, in the case of nodular melanoma, the appearance of anew lump anywhere on the skin. At later stages, the mole may itch,ulcerate or bleed. Visual inspection is the most common diagnostictechnique. Melanoma can be divided into the following types: lentigomaligna, lentigo maligna melanoma, superficial spreading melanoma, acrallentiginous melanoma, mucosal melanoma, nodular melanoma, polypoidmelanoma, and desmoplastic melanoma.

Measurements of circulating melanoma transcripts—the Melanomx-identifymelanomas and decreases in the Melanomx score correlate with theefficacy of therapeutic interventions such as immunotherapy and targetedtherapy. Targeted gene expression profile of RNA can be isolated fromthe peripheral blood of patients with melanoma. This expression profileis evaluated in an algorithm and converted to an output (prediction). Itcan identify active disease, provide an assessment of treatmentresponses, or predict risk of relapse, in conjunction with standardclinical assessment and imaging.

In one aspect, the present disclosure provides a method for detecting amelanoma in a subject in need thereof, including: (1) determining theexpression level of at least 29 biomarkers from a test sample from thesubject by contacting the test sample with a plurality of agentsspecific to detect the expression of the at least 29 biomarkers, whereinthe at least 29 biomarkers comprise ATL1, ATP6VOD, C1ORF21, CFLAR,CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA,HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR,PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, YY2, and at leastone housekeeping gene; (2) normalizing the expression level of each ofATL1, ATP6VOD, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9,ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1,LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L,TDRD7, TXK, and YY2 to the expression level of the at least onehousekeeping gene, thereby obtaining a normalized expression level ofeach of ATL1, ATP6VOD, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD,DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A,IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5,SPATS2L, TDRD7, TXK, and YY2; (3) inputting each normalized expressionlevel into an algorithm to generate a score; (4) comparing the scorewith a first predetermined cutoff value; and (5) producing a report,wherein the report identifies the presence of a melanoma in the subjectwhen the score is equal to or greater than the first predeterminedcutoff value or identifies the absence of a melanoma in the subject whenthe score is below the first predetermined cutoff value, wherein thefirst predetermined cutoff value is 20 on a scale of 0 to 100.

In some embodiments, the at least one housekeeping gene is selected fromthe group consisting of ALG9, SEPN, YWHAQ, VPS37A, PRRC2B, DOPEY2,NDUFB11, ND4, MRPL19, PSMC4, SF3A1, PUM1, ACTB, GAPD, GUSB, RPLP0, TFRC,MORF4L1, 18S, PPIA, PGK1, RPL13A, B2M, YWHAZ, SDHA, HPRT1, TOX4, andTPT1.

In some embodiments, the at least one housekeeping gene comprises TOX4and TPT1. In some embodiments, the normalized expression level isobtained by: (1) normalizing the expression level of each of ATL1,ATP6VOD, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1,FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127,LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK,and YY2 to the expression level of TOX4, thereby obtaining a firstnormalized expression level of each of ATL1, ATP6VOD, C1ORF21, CFLAR,CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA,HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR,PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, and YY2; (2)normalizing the expression level of each of ATL1, ATP6VOD, C1ORF21,CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP,HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471,LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, and YY2 tothe expression level of TPT1, thereby obtaining a second normalizedexpression level of each of ATL1, ATP6VOD, C1ORF21, CFLAR, CFLAR-AS1,CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA,HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5,SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, and YY2; and (3) averaging thefirst normalized expression level and the second normalized expressionlevel to obtain the normalized expression level.

Among the provided methods are those that are able to classify or detecta melanoma. In some embodiments, the provided methods can identify orclassify a melanoma in a human blood sample. In some examples, themethods can provide such information with a specificity, sensitivity,and/or accuracy of at least 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%,96%, 97%, 98%, or 99%.

The agents can be any agents for detection of the biomarkers, andtypically are isolated polynucleotides or isolated polypeptides orproteins, such as antibodies, for example, those that specificallyhybridize to or bind to the at least 29 biomarkers.

The biomarker can be RNA, cDNA, or protein. When the biomarker is RNA,the RNA can be reverse transcribed to produce cDNA (such as by RT-PCR),and the produced cDNA expression level is detected. The expression levelof the biomarker can be detected by forming a complex between thebiomarker and a labeled probe or primer. When the biomarker is RNA orcDNA, the RNA or cDNA detected by forming a complex between the RNA orcDNA and a labeled nucleic acid probe or primer. The complex between theRNA or cDNA and the labeled nucleic acid probe or primer can be ahybridization complex.

When the biomarker is protein, the protein can be detected by forming acomplex between the protein and a labeled antibody. The label can be anylabel, for example a fluorescent label, chemiluminescence label,radioactive label, etc. The protein level can be measured by methodsincluding, but not limited to, immunoprecipitation, ELISA, Western blotanalysis, or immunohistochemistry using an agent, e.g., an antibody,that specifically detects the protein encoded by the gene.

In some embodiments, the methods are performed by contacting the testsample with one of the provided agents, more typically with a pluralityof the provided agents, for example, a set of polynucleotides thatspecifically bind to the at least 29 biomarkers. In some embodiments,the set of polynucleotides includes DNA, RNA, cDNA, PNA, genomic DNA, orsynthetic oligonucleotides. In some embodiments, the methods include thestep of isolating RNA from the test sample prior to detection, such asby RT-PCR, e.g., QPCR. Thus, in some embodiments, detection of themelanoma biomarkers, such as expression levels thereof, includesdetecting the presence, absence, or amount of RNA. In one example, theRNA is detected by PCR or by hybridization.

In some embodiments, the polynucleotides include sense and antisenseprimers, such as a pair of primers that is specific to each of the atleast 29 biomarkers. In one aspect of this embodiment, the detection ofthe at least 29 biomarkers is carried out by PCR, typically quantitativeor real-time PCR. For example, in one aspect, detection is carried outby producing cDNA from the test sample by reverse transcription; thenamplifying the cDNA using the pairs of sense and antisense primers thatspecifically hybridize to the panel of at least 28 biomarkers, anddetecting products of the amplification.

The test sample can be any biological fluid obtained from the subject.Preferably, the test sample is blood, serum, plasma or neoplastictissue.

The first predetermined cutoff value can be derived from a plurality ofreference samples obtained from subjects free of a neoplastic disease.Each reference sample can be any biological fluid obtained from asubject not having, showing symptoms of or diagnosed with a neoplasticdisease. In some embodiments, the reference sample is blood, serum,plasma, or non-neoplastic tissue.

The subject in need thereof can be a subject diagnosed with a melanoma,a subject having at least one melanoma symptom or a subject having apredisposition or familial history for developing a melanoma. Thesubject can be any mammal. Preferably, the subject is human. The terms“subject” and “patient” are used interchangeably herein.

The score is the Melanomx score, which has a scale of 0 to 100. TheMelanomx score is the product of a classifier built from predictiveclassification algorithms, e.g., XGB, RF, glmnet, cforest, CART,treebag, knn, nnet, SVM-radial, SVM-linear, NB, NNET, or mlp. Thealgorithm analyzes the data (i.e., expression levels) and then assigns ascore.

The method can further include treating the subject identified as havinga melanoma with surgery, drug therapy, radiation therapy, or acombination thereof. The drug therapy can be an immunotherapy, atargeted therapy, a chemotherapy, or a combination thereof. In someembodiments, the drug therapy includes an immunotherapy. Examples ofimmunotherapies for treating a melanoma include, but are not limited to,Imlygic (T-VEC), Yervoy in combination with Opdivo, Opdivo (nivolumab),Keytruda (pembrolizumab), Yervoy (ipilimumab), Interleukin-2 (IL-2), andInterferon alpha 2-b. In some embodiments, the drug therapy includes atargeted therapy such as a BRAF inhibitor. Examples of targetedtherapies for treating a melanoma include, but are not limited to,Zelboraf in combination with Cotellic (cobimetinib), Tafinlar incombination with Mekinist, Tafinlar (dabrafenib), Mekinist (trametinib),and Zelboraf (vemurafenib). In some embodiments, the drug therapyincludes a chemotherapy. In some embodiments, the chemotherapy includesdacarbazine.

The present disclosure also provides a method for determining whether amelanoma in a subject is stable or progressive, including: (1)determining the expression level of at least 29 biomarkers from a testsample from the subject by contacting the test sample with a pluralityof agents specific to detect the expression of the at least 29biomarkers, wherein the at least 29 biomarkers comprise ATL1, ATP6VOD,C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL,HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471,LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, YY2, andat least one housekeeping gene; (2) normalizing the expression level ofeach of ATL1, ATP6VOD, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD,DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A,IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5,SPATS2L, TDRD7, TXK, and YY2 to the expression level of the at least onehousekeeping gene, thereby obtaining a normalized expression level ofeach of ATL1, ATP6VOD, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD,DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A,IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5,SPATS2L, TDRD7, TXK, and YY2; (3) inputting each normalized expressionlevel into an algorithm to generate a score; (4) comparing the scorewith a second predetermined cutoff value; and (5) producing a report,wherein the report identifies that the melanoma is progressive when thenormalized expression level is equal to or greater than the secondpredetermined cutoff value or identifies that the melanoma is stablewhen the normalized expression level is below the second predeterminedcutoff value, wherein the second predetermined cutoff value is 50 on ascale of 0 to 100.

The second predetermined cutoff value can be derived from a plurality ofreference samples obtained from subjects whose melanomas are beingadequately controlled by therapies like immune therapy.

Surgical resection is a procedure that removes melanoma tissues from thesubject in need thereof. The present disclosure also provides a methodfor evaluating the extent of surgical resection in a subject having amelanoma, including: (1) determining the expression level of at least 29biomarkers from a test sample from the subject after the surgicalresection by contacting the test sample with a plurality of agentsspecific to detect the expression of the at least 29 biomarkers, whereinthe at least 29 biomarkers comprise ATL1, ATP6VOD, C1ORF21, CFLAR,CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA,HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR,PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, YY2, and at leastone housekeeping gene; (2) normalizing the expression level of each ofATL1, ATP6VOD, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9,ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1,LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L,TDRD7, TXK, and YY2 to the expression level of the at least onehousekeeping gene, thereby obtaining a normalized expression level ofeach of ATL1, ATP6VOD, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD,DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A,IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5,SPATS2L, TDRD7, TXK, and YY2; (3) inputting each normalized expressionlevel into an algorithm to generate a score; (4) comparing the scorewith a third predetermined cutoff value; and (5) producing a report,wherein the report identifies that the surgical resection does notremove the entire melanoma when the normalized expression level is equalto or greater than the third predetermined cutoff value or identifiesthat the surgical resection removes the entire melanoma when thenormalized expression level is below the third predetermined cutoffvalue, wherein the third predetermined cutoff value is 20 on a scale of0 to 100.

The third predetermined cutoff value can be derived from a plurality ofreference samples obtained from subjects whose melanoma disease has beencompletely removed by surgery and they are considered “disease free.”

When it is determined that the surgical resection does not remove theentire melanoma, the subject is at risk of melanoma recurrence.Accordingly, in some embodiments, the report further identifies that therisk of melanoma recurrence is high when the normalized expression levelis equal to or greater than the third predetermined cutoff value oridentifies that the risk of melanoma recurrence is low when thenormalized expression level is below the third predetermined cutoffvalue.

The present disclosure also provides a method for determining a responseby a subject having a melanoma to a therapy, comprising: (1) determininga first expression level of at least 28 biomarkers from a first testsample from the subject at a first time point by contacting the firsttest sample with a plurality of agents specific to detect the expressionof the at least 28 biomarkers, wherein the 28 biomarkers comprise ATL1,ATP6VOD, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1,FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127,LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK,and YY2; (2) determining a second expression level of the at least 28biomarkers from a second test sample from the subject at a second timepoint by contacting the second test sample with a plurality of agentsspecific to detect the expression of the at least 28 biomarkers, whereinthe second time point is after the first time point and after theadministration of the therapy to the subject; (3) comparing the firstexpression level with the second expression level; and (4) determiningthat the subject is responsive to the therapy when the second expressionlevel is significantly decreased as compared to the first expressionlevel.

In some embodiments, the methods can predict treatment responsivenessto, or determine whether a patient has become clinically stablefollowing, or is responsive or non-responsive to, a melanoma treatment,such as a surgical intervention or drug therapy (for example, animmunotherapy or targeted therapy). In some cases, the methods can do sowith a specificity, sensitivity, and/or accuracy of at least 75%, 80%,85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99%. In some cases,it can differentiate between treated and untreated melanoma with aspecificity, sensitivity, and/or accuracy of at least 75%, 80%, 85%,90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99%.

In some embodiments, the first and second test samples can be of thesame type. In some embodiments, the first and second test samples can beof different types.

In some embodiments, the therapy can be a drug therapy. The drug therapycan be an immunotherapy, a targeted therapy, a chemotherapy, or acombination thereof. In some embodiments, the therapy can be a radiationtherapy.

In some embodiments, the first time point is prior to the administrationof the therapy to the subject. In some embodiments, the first time pointis after the administration of the therapy to the subject. The secondtime point can be a few days, a few weeks, or a few months after thefirst time point. For example, the second time point can be at least 1day, at least 7 days, at least 14 days, at least 30 days, at least 60days, or at least 90 days after the first time point.

In some embodiments, the second expression level is significantlydecreased as compared to the first expression level when the secondexpression level is at least 10% less than the first expression level.In some embodiments, the second expression level is significantlydecreased as compared to the first expression level when the secondexpression level is at least 20% less than the first expression level.In some embodiments, the second expression level is significantlydecreased as compared to the first expression level when the secondexpression level is at least 30% less than the first expression level.In some embodiments, the second expression level is significantlydecreased as compared to the first expression level when the secondexpression level is at least 40% less than the first expression level.In some embodiments, the second expression level is significantlydecreased as compared to the first expression level when the secondexpression level is at least 50% less than the first expression level.In some embodiments, the second expression level is significantlydecreased as compared to the first expression level when the secondexpression level is at least 60% less than the first expression level.In some embodiments, the second expression level is significantlydecreased as compared to the first expression level when the secondexpression level is at least 70% less than the first expression level.In some embodiments, the second expression level is significantlydecreased as compared to the first expression level when the secondexpression level is at least 80% less than the first expression level.In some embodiments, the second expression level is significantlydecreased as compared to the first expression level when the secondexpression level is at least 90% less than the first expression level.

In some embodiments, the method further comprises determining a thirdexpression level of the at least 28 biomarkers from a third test samplefrom the subject at a third time point by contacting the third testsample with a plurality of agents specific to detect the expression ofthe at least 28 biomarkers, wherein the third time point is after thesecond time point. The method can further comprise creating a plotshowing the trend of the expression level change.

The present disclosure also provides an assay comprising: (1)determining the expression level of biomarkers consisting essentially ofthe following 30 biomarkers from a test sample from a patient diagnosedof a melanoma or a subject suspected of having a melanoma: ATL1,ATP6VOD, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1,FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127,LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK,YY2, TOX4, and TPT1, wherein the expression level is measured bycontacting the test sample with a plurality of agents specific to detectthe expression of the 30 biomarkers; (2) normalizing the expressionlevel of each of ATL1, ATP6VOD, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55,DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A,IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5,SPATS2L, TDRD7, TXK, and YY2 to the expression level of TOX4, therebyobtaining a first normalized expression level of each of ATL1, ATP6VOD,C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL,HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471,LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, and YY2;(3) normalizing the expression level of each of ATL1, ATP6VOD, C1ORF21,CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP,HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471,LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, and YY2 tothe expression level of TPT1, thereby obtaining a second normalizedexpression level of each of ATL1, ATP6VOD, C1ORF21, CFLAR, CFLAR-AS1,CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA,HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5,SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, and YY2; (4) averaging the firstnormalized expression level and the second normalized expression levelto obtain a normalized expression level for each biomarker; (5)inputting each normalized expression level into an algorithm to generatea score; and (6) comparing the score with a first predetermined cutoffvalue.

The present disclosure also provides an assay comprising: (1)determining the expression level of biomarkers consisting of thefollowing 30 biomarkers from a test sample from a patient diagnosed of amelanoma or a subject suspected of having a melanoma: ATL1, ATP6VOD,C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL,HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471,LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, YY2, TOX4,and TPT1, wherein the expression level is measured by contacting thetest sample with a plurality of agents specific to detect the expressionof the 30 biomarkers; (2) normalizing the expression level of each ofATL1, ATP6VOD, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9,ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1,LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L,TDRD7, TXK, and YY2 to the expression level of TOX4, thereby obtaining afirst normalized expression level of each of ATL1, ATP6VOD, C1ORF21,CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP,HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471,LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, and YY2;(3) normalizing the expression level of each of ATL1, ATP6VOD, C1ORF21,CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP,HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471,LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, and YY2 tothe expression level of TPT1, thereby obtaining a second normalizedexpression level of each of ATL1, ATP6VOD, C1ORF21, CFLAR, CFLAR-AS1,CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA,HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5,SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, and YY2; (4) averaging the firstnormalized expression level and the second normalized expression levelto obtain a normalized expression level for each biomarker; (5)inputting each normalized expression level into an algorithm to generatea score; and (6) comparing the score with a first predetermined cutoffvalue.

The sequence information of the melanoma biomarkers and housekeepers isshown in Table 1.

TABLE 1 Melanoma Biomarker/Housekeeper Sequence Information SEQ GeneRefSeq ID Name Accession Sequence NO: ATL1 NM_001127713.1AGTTTGAGGC TGCACTGCAC ACCTGCACAA CCTGCCTTCT 1ACTTAGTTCT TCTGAGACAT TTCTGAAAGT CTGAATTCCTAGGACTGCTC AATGACCTTT GTCCCTGTTG GGCACACGCAGTGTCTCATC GCTGGTATTG CACCTTTAAT GAGACCAGGAGTTCCGCAAA AGTAAAACAA AGGGGTCACA GACTGGTTCTGGTTCTACCA CTTCCTCAGT ATGTGCTCTG GGACAAAACAGCATATTTGG CAACATCTCG GTGTCCTTAT CTGCAGCTTGAAGAGGCGCC ACAGCAACAT CCTCAGAGTC TGAGCGAACTGCGCCCAGCG CGGGCACGGA GCCTCCCACC GCCAGCAACCTGCGGCCCCG GAGAAGGCAG CGAGCGCAGT GACAGCGCCTCACCGCCACC AGCTCCTGGA CCACCATGGC CAAGAACCGCAGGGACAGAA ACAGTTGGGG TGGATTTTCG GAAAAGACATATGAATGGAG CTCAGAAGAG GAGGAGCCAG TGAAAAAGGCAGGACCAGTC CAAGTCCTCA TTGTCAAAGA TGACCATTCCTTTGAGTTAG ATGAAACTGC ATTAAATCGG ATCCTTCTCTCGGAGGCTGT CAGAGACAAG GAGGTTGTTG CTGTATCTGTTGCTGGAGCA TTTAGAAAAG GAAAATCATT CCTGATGGACTTCATGTTGA GATACATGTA CAACCAGGAA TCAGTTGATTGGGTTGGAGA CTACAATGAA CCATTGACTG GTTTTTCATGGAGAGGTGGA TCTGAGCGAG AGACCACAGG AATTCAGATATGGAGTGAAA TCTTCCTTAT CAATAAACCT GATGGTAAAAAGGTTGCAGT GTTATTGATG GATACTCAGG GAACCTTTGATAGTCAGTCA ACTTTGAGAG ATTCAGCCAC AGTATTTGCCCTTAGCACAA TGATCAGCTC AATACAGGTA TATAACTTATCCCAAAATGT CCAGGAGGAT GATCTTCAGC ACCTCCAGCTTTTCACTGAG TATGGCAGAC TGGCAATGGA GGAAACATTCCTGAAGCCAT TTCAGAGTCT GATATTTCTT GTTCGAGACTGGAGTTTCCC ATACGAATTT TCATATGGAG CCGATGGTGGTGCCAAATTC TTGGAAAAAC GCCTCAAGGT CTCAGGGAACCAGCATGAAG AACTACAGAA CGTCAGAAAA CACATCCATTCCTGTTTCAC CAACATTTCC TGTTTTCTGC TACCTCATCCTGGCTTAAAA GTAGCTACCA ATCCAAACTT TGATGGAAAATTGAAAGAAA TAGATGATGA ATTCATCAAA AACTTGAAAATACTGATTCC TTGGCTACTT AGTCCCGAGA GCCTAGATATTAAAGAGATC AATGGGAATA AAATCACCTG CCGGGGTCTGGTGGAGTACT TCAAGGCTTA TATAAAGATC TATCAAGGTGAAGAATTACC ACATCCCAAA TCCATGTTAC AGGCCACAGCAGAAGCTAAC AATTTAGCAG CCGTGGCAAC TGCCAAGGACACATACAACA AAAAAATGGA AGAGATTTGT GGTGGTGACAAACCATTTCT GGCCCCAAAT GACTTGCAGA CCAAACACCTGCAACTTAAG GAAGAATCTG TGAAGCTATT CCGAGGGGTGAAGAAGATGG GTGGGGAAGA ATTTAGCCGG CGTTACCTGCAGCAGTTGGA GAGTGAAATA GATGAACTTT ACATCCAATATATCAAGCAC AATGATAGCA AAAATATCTT CCATGCAGCTCGTACCCCAG CCACACTGTT TGTAGTCATC TTTATCACATATGTGATTGC TGGTGTGACT GGATTCATTG GTTTGGACATCATAGCTAGC CTATGCAATA TGATAATGGG ACTGACCCTTATCACCCTGT GCACTTGGGC ATATATCCGG TACTCTGGAGAATACCGAGA GCTGGGAGCT GTAATAGACC AGGTGGCTGCAGCTCTGTGG GACCAGGCTT TGTACAAGCT TTACAGTGCAGCAGCAACCC ACAGACATCT GTATCATCAA GCTTTCCCTACACCAAAGTC GGAATCTACT GAACAATCAG AAAAGAAAAAAATGTAATGC AAATTTTAAG AAATACAGGT GCATGACCAATTGTCAATTA AATATTCAGT TTTATGTCTC CATGCAAACATTCAAAGTGC TTCCATCAGA ACGGAGTAAA ATACTAAACACCTCTGAAGA CTGCAAACTG GATTAGTTCT TTTACTTCAGTGTTTAATAA GCAGATGTAT GTATGCATGG TTATACTATTTTGTTAACAT GTACAATTTC CTGATTTTTC TTCAAAAATGCTGTTATAAA GTATTTGTCT ATTTATGATA ACAGTACACGTGTTCTGCTT GAATTTACTA AATTCTACTA CTGGGTTATAATTAAATCAT GTGATATTCC ACGTTTGGAT ATGCTCATTTAATTTCTACA GAAAAAATTT TAAATTATTT CACATTAGCCATTTGTTAAA ACACAGCATC ATAACTCAGC AGGCTGGATTTAATCTGTAT CATCTTATAT ATATCACAAT CTTATTTTTAAGCACATTTT AGAGTTCCTT AGTTGCTTTA TCAAAAACCAGATATTGCTT TTACATGGTT TAATAGAATA TAAACCTCTTGATAAAAAAT GCACAAAAAA TCACTTTGTA TATGTGAGTTTCACTGCATT GTATATTTTT TCATTTGGTA CACAAAGAATGTATTCTTCA TAGGTTTATT CTTTTAATAT GTGAACTATTATTAAAGTTT ACTCTGGTTC CTAAGATTAA AAACAAATGC TTACTGAATT TGAAAAAAAA AATP6V0D NM_004691.4 ACTTGACAGC CCGCTGAGGA CGCAGCGTCA GCTGACCTGG 2GGAGTCGCGA TTCGTGCCGG CCGGTCCTGG TTCTCCGGTCCCGCCGCTCC CGCAGCAGCC ATGTCGTTCT TCCCGGAGCTTTACTTTAAC GTGGACAATG GCTACTTGGA GGGACTGGTGCGCGGCCTGA AGGCCGGGGT GCTCAGCCAG GCCGACTACCTCAACCTGGT GCAGTGCGAG ACGCTAGAGG ACTTGAAACTGCATCTGCAG AGCACTGATT ATGGTAACTT CCTGGCCAACGAGGCATCAC CTCTGACGGT GTCAGTCATC GATGACCGGCTCAAGGAGAA GATGGTGGTG GAGTTCCGCC ACATGAGGAACCATGCCTAT GAGCCACTCG CCAGCTTCCT AGACTTCATTACTTACAGTT ACATGATCGA CAACGTGATC CTGCTCATCACAGGCACGCT GCACCAGCGC TCCATCGCTG AGCTCGTGCCCAAGTGCCAC CCACTAGGCA GCTTCGAGCA GATGGAGGCCGTGAACATTG CTCAGACACC TGCTGAGCTC TACAATGCCATTCTGGTGGA CACGCCTCTT GCGGCTTTTT TCCAGGACTGCATTTCAGAG CAGGACCTTG ACGAGATGAA CATCGAGATCATCCGCAACA CCCTCTACAA GGCCTACCTG GAGTCCTTCTACAAGTTCTG CACCCTACTG GGCGGGACTA CGGCTGATGCCATGTGCCCC ATCCTGGAGT TTGAAGCAGA CCGCCGCGCCTTCATCATCA CCATCAATTC TTTCGGCACA GAGCTGTCCAAAGAGGACCG TGCCAAGCTC TTTCCACACT GTGGGCGGCTCTACCCTGAG GGCCTGGCGC AGCTGGCTCG GGCTGACGACTATGAACAGG TCAAGAACGT GGCCGATTAC TACCCGGAGTACAAGCTGCT CTTCGAGGGT GCAGGTAGCA ACCCTGGAGACAAGACGCTG GAGGACCGAT TCTTTGAGCA CGAGGTAAAGCTGAACAAGT TGGCCTTCCT GAACCAGTTC CACTTTGGTGTCTTCTATGC CTTCGTGAAG CTCAAGGAGC AGGAGTGTCGCAACATCGTG TGGATCGCTG AATGTATCGC CCAGCGCCACCGCGCCAAAA TCGACAACTA CATCCCTATC TTCTAGCGTCCTGGCCCAAG GCTCTCAATT GCACTCTTTG TGTGTGTGTGTGTGTGTGTG CGCGTGTGTG TGCGTGTGTG TGTATGTGGTCTGTGACAAG CCTGTGGCTC ACCTGCCTGT CCGGGGTGTAGTACGCTGTC CTAGCGGCTG CCCAGTTCTC CTGACCCTCTTAGAGACTGT TCTTAGGCCT GAAAAGGGGC TGGGCACCCCCCCCCACCAA GGATGGACGA AGACCCCCTC CAGAGCAAGGAGGCCCCCTC AGCCCTGTGG TTACAGCCGC TGATGTATCTAAGAAGCATG TCACTTTCAT GTTCCTCCCT AACTCCCTGACCTGAGAACC CTGGGGCCTG GGGGCAGTTT GAGCCTCCTCTCCCTTCTGT GGGTCGCTCC CAGAGCCATG GCCCATGGGAAGGACAGAGT GTGTGTGTCC TTGGGGCCTG GGGGGATGTTGCTCCTCAGC TCCCTCCCTC AGCCCTGCCC CTCTGAGACAATAAAACTGC CCTCTCTAAG GCCAACTGTC AAAAAAAAAA AAAAAAAA C1ORF21 NM_030806.3CCCTCCCTCG CTCGCTCCTC GCAAGCTCCC GCTCGCTCCC 3TGCCCACTCC CGGGGGGACG TTCCGTGCCG CGGCCGCCGCGGCCGCTGCT TCTTTCACAC TTTAGTTGGG AGCTGCGCGCCGCGCTCAGT TACTGGAGAG CTGGCCGCGC GCCGCCGCCTCCCGCACGCT TGCACGCGGG CCCGGCTTCG GGGTTTTGGGTTCTTACTCC AAGCGGCGGG GAGGAGGGGG AGCCCCGGACACACTGTGGG GAGGAGGAGG AAGAAGAGGA GGAGGGAGGAAGAAAAAAGA CGAGGAGGAC AGGGGCGGGG GGCGGGAGGCTTGCCACCTT CAGCCCCCCC GCGAACGCCC AAGGTGCACACATCTTGACC AACTCAGCAG CAAGGTGGAT TTTCTTTGTGTTTAAAGAAA AAAAATGTCC CTGTGTCTGT AGAGATGATTTGCAGTTCAG CCCGGCTGAA GCTGACCGAA TGAGACTATGGGCTGTGCCT CCGCCAAGCA TGTTGCCACT GTTCAAAATGAAGAGGAAGC CCAGAAAGGG AAAAACTACC AGAACGGAGATGTGTTTGGC GATGAGTATA GGATCAAACC AGTGGAAGAGGTCAAATACA TGAAAAATGG GGCAGAAGAA GAGCAGAAAATAGCAGCCAG GAACCAAGAA AACTTGGAAA AAAGTGCCAGCTCAAATGTA AGACTTAAAA CTAATAAAGA GGTTCCGGGATTAGTTCATC AACCCAGAGC AAACATGCAC ATCTCTGAAAGCCAACAAGA ATTCTTCAGA ATGCTGGATG AAAAAATTGAAAAGGGTCGG GATTACTGTT CGGAAGAAGA GGATATCACATAGCACCAAT TTTACCACTC AAACCAGGAG CTACTACTGTGTAAATAGGT TACACCCCAG TTGAAATCTT TGCAAAGGTCGGTTCTATTC AGCGAACAGC ACTATAGCAA AAGAAGATCGTTCCATATTG TACGCCCCAT TAAATTACAG TGTTTCTTAATGAACTTGCA AAGGAATATT GCTAAAAACA AACAAAAAAAACTGTTATCG AACTTTCTTT GTTGCTGCTA GTTAAAACTTGTTGCAACTT TTCACTTCTC TTGTGTCCAG GTATGCAGCAAAATTCTGCA ATTTCACCTT AAAGATACTG TTGGTTTTACAGATGCTCTC CAACCTATTT TCTATAAGAT GAGGTAGTGGTGAACTCAGA TAACAAACTT CTCTTCTAAA CTGGTTCTGCTTCTAAGACA AGCATCTCCT GCCCTCTCTC CTTCCTCCCCATCTCTCGCA CGCAGTCTAG AGATGGACTG AGCCTTGCTTCTCACTGGCA GTGTTGAGCT TTGGAGATGG GATGGTTGCTATGCCAAGCC TTGTTTCTCT GCTCAGAAGA AGTAGAGAAGCTATTATCAA TTAAAAGCAT GCTGTGATGT GACTCCTGGAAGTGACGTAG GAGTGAGTGG CAGGTTGTTT GATTTAATAGGTATCTTAAT CAAGAATTAA GCTTGCAACA TTGGCTTTGCTCAGATGCAG ATGGAAGTGT GATCACAATC ATTTTGAATCCCTCTTCCTC ACTTTTTTTT CTAAGAAAAT AAACATTTTACTGTTTTTAT GGATCCTTGT CTTCTCCCAT TCATCCAGCTCAGTGTTTTA AGATGATCCT GGGTGCAGAA GTTGAGCCCTCCTTTGCATT GACACTGATA ATTAGCCTAT AGGGCTCCCTACCCTTCCAT TAAGAATCTA CCAAGCATTA GCAAGGCTGAAAGTGGTCTA AGAGGTGAGG GGACATCCTA TGACTTTTTAGGAAGGCCTG AAACCACCTT GTTACCTTTC ATTTTGTTAGCAAATAAACC ATCCTATTTT GTAACTCTCC CCCTTCAAAATGCTACATGA GCCTTGCCAC TTCCTTTTTC TCTTACTTCCAGCACACTAG ACATAGCAAA AGTGTTTGCC TACTCAAAAACATAATACTT TTATGCTGAT GATGGTATTT GGAGATGTGAAAGCCAAAAG CCCCTGGCAG TGGTGGGGAA TGTTGACTGAGTGTTCAGCA GAGTTTATTT TTCCATACTA TATGAAGAGAATGATCTCTT CTCAAAGACA GAAGTGATAT TTTTAACAAATATTGTCACA AGTAAATAGC AATCAAAAGG AGAAAATAACTTTTGTATTT TTTTAATGTG TTTGATAGCT TTGACGAGGGTTCTCTTTGT TACTTTCAGG GGAGGGCATC CTATTAAATGCCACGCCAGC AGTCCGGGTC TGGGTTTGTC CCACAAAATCACAGGAGCAC TGTATGTTCC TCTCTTTTGG AGTTGTGACTTTGAAGGGCC TCAATATTAG CCACACTGCC GCCTGCAGAAGGTGGAGAGT TAAGATGTTC TATGTCAATT TGCTCTTGCCGAAAAGATGA GCCTCGATTT TAAAATCTAT CCACATCCAACTGATGGCAC CATTGATGTG CAAATAATGA GATTCCCTATCTCCTTTTAG ACCTGGGACG GCAAAAGGGA AGGGAAGGAAACTTAGCAGA GTGCTATTGA CTATAGATTC ACATATTAGCAACAAAATCC CGTAATTCTT TTGGCCAACA GCAGCTATTTTGGGGAGCAG CTGTGGCTGT TACATAAATA GAGATGCAGCCAAAATTTTA GGCCTTTTAT CCTGCTTCTA GCAGAAAAATGCAGGGAGAG TCAAGTAGTC TAGGGTTTCA GGTTGCCTCCCCTCATATGG TTTTTGGCCA AGTGACTAAA ACAGTTTTCCACAACTGTAA ACAAACTGCT AAGCCCCACC TCAAACTTGTTCACTGGGGA CTTTGCTTAC CGTTCTGTGG GTGACCTTTTCCGGGATTTC TTGTTCTTAT CAAGCAAGAA TTAAGCACATGCTAAACGTC TTCCATTTGA CTTCTCTACT CGGTGTCTCAGACAGTGTCT TCCCAGAAAA CCACCACCCT CTACCCAAAGATGAAACATG CTCATGTCAT TTTTCTCATG GTCACATTTAACAGTTTTGA CATGTTATAC TTGCGCATAG ATCCAAGCGTTTCTTGGGAA CCTGACTTTT GAGTGTTTAA TAAAGCCGGAAGTGGTGTTG CCCTGAACCA GCAGATTTTC ACCTGGGTTCTGGCTCCGGT GTTTAACACT GGATACATCT TTGATGTGCGAAAGTGAGTT CATCTTCAGA CACATTTGGT ACATCCAGAAATAGATCCAA GAAATGGGGT GGTTGAGTGG GTCCGCACGAAATGCTTGAT TATGTCAGCA ACACCCAACA CTGTCTGTTTTCCATTTGTT GGTTTTAATC ATAAAATTGT CAAGTGATTCGTGTTTGTAC TTTATTTTTT TGTGCCTTCT GAAAGGATCTAAAACAAAAA TATTTTGCCT TTTTTTCCCC ACGTGTATCTGAACATTAAG CAGATTGGCT CAGACACAAT GAAAAGGATAATCCAATGTA CGTGCTGGTG CACTCTGCTA GTTGTTATCTCTGTAGGGCT CAGGAAGCTG GAAGGAGGAA GGGAGGGTAAGTGGCCTGGT GAGTGGAGGT AGAAAAATGA TGAGAAATGAACTGAGAGCA TTAAGCAGAG AGGGTTGATA GGCTGGCCGTGTCCGGGGTG AAATTGGAAA TCCAGCTGCC TAGTGGCCAGTGGGTGGGGC AAGACTGTCA ACGAGATTTA CAGCTGGCTTACACATGCCT TATGTCCTCT GAGTTGTAGA GTTGTAAAAGTTCAGCAGTG TGTGCACAGC TTTCTTTTGG TTGGCAGAGATTCAGGATCA TGGAGTACTG CTCTCATAAT TGAAGACGTGTTTGTTATTG GCAGAGAACC TTAAAAAAGG CCTTTACCTCAGCGATGCTT CCTAGCCCCA GGCTTGCAGA GAACACAGAGTGGTGTTGTG GTCTATTTAG GGACAAAGAA GGTATAAAGTCCAGAGATGA GAAAACTGGG TCAGCCCTCA GAAACTGCAGCAGCCACGCA CACAGAAGCC TGCTGGAAGA CAGGTCTCTCTCCGTCCACA GTGCCCATCA TCTGAGCCTG GGCTGGGATGACTCAACTTA GCAAAGACGG ACCCAGGAGG AGTGCTGGTTCTTCAGTCTT TGTACTGGCC CCATCCTCTC CTCACTGTAATGTGAGGAAG CACCTCTGTG TCAGGGCTCA CCTGGGCATCCAAAGCGGCC ACGCCCACAA TCCGACAGCC CCCAGGAGCAGGTCCAGGGA TGATGCAGCC CCCTTCTTGG TCCCATGTGATGTCATCCTG CTTTGTTATC TTCTTATAAC TTTATCCTGCTATAACTTTA TCCTCTTCCC AGCCTCATCC CTGTTTTTCTGTTAGGGCAA GACTCTTCCA TAAGCCTGCT AAAAAACAGAGATGATACCT CTTACAAACT TTACCTCATA GCCTGTGAAGCAGGTTGGCA TGTGGATTAC AAGTCCTGCT TTGACACTGGGCAAGAATTT AAGATTGTTC TATCTCTACT AGTCATAGAAAAGAAACATT GTTAAACATG TTGAGTTTTA AAGGAAGAAATATTTTCAAA TTCTTAATCC AAGAAAATAC TGAGTTGGAATCTTAGACTT CGGGACTCTG ACACGTTCTT TATGAAAGGCAAAATAATTG GTATCTAAAG TTCTCTCCTT CCTGCCTCCCCTAAAGAAAA AGGATATTAG ATTGCACACT ATAATTTTACATAAGATCTG CCTTCCACAC TTCCCTGCTG GAAGGCATTCTCAGAGCTTT ATGTCTTCGT ACCTCTCAGA GATTGGACTTTTTCTTGTTT AAAACCCCAA CCAAAAAAAA TAATAAGGCATGATTGGTGG GGAGGGAATG TGTATTTAGG GGCATAATAAAAAGGTGGCT CGAAGCAGGA ACTTTGGCCT CATGGTGTCATGGGTGGATG CCTGGACTCC AGTGTGCCTG TGAGGGGCTGGGTTAGGCAG TCGGCTGTCA CACTCACATG TGCCTGCAATAAACCTTTTG GAATTTCATG AACGAGGTCT ATGAATTGCCTTTTGCCAAT GAATGGATGT ATTTTTCCAA GGGGGGAATAGTATCCTTGA CTTTGGCAGT CACCTTTTTG TATGTCTCTAGAAAGGGGTC AAAAAACTAT GGTAAAGATG AGGCTTATGAGTGAATACCT CTGGGACAAA CCTTAGGACT CACAAGCTATGCCATGTTTT TCAGGAGACT CTTGTACCTT ATCTGGAATCTAATCTTGGG AGAAGAGGAA AAAGGAGCTA ATATTTGTCATTTATACTCA CTCTGTGCCA GATACTGTGC TAGGCATTTTATAATTGTTT TGTGTCATCC TCATGATAAT CCTGTGAAGTAGATCTATTA CCCCCGTGTT CTAAATAATA GATCTTAAGTGTGGAATGCA TCTATCCAAC ATAAATGCCC ATGTTGAAAGAAGGAAAGAT GTCATTCAAG TATTTTTCAA ATTCTTTTTATTATGACTAT GCCCTTCGCA ACACTGTGAA AACAACCCCTGGGGGCATCT GCCTTCCAGA ATCTCTCTCT GGCTTCTCACCAGCTTGGTT TCCTCATGGG GAGTGTTTTA TTTGGCCTCCCCTATCTGAG CTGCACACAC ACCAGGGGAG GCCACTGGCTAACAGTAGGA CTTCAGTGCC CTGAGGAAAA GGCTTTGGGAATTTAGGCAC ACGTTTCTCT CCTTGGAATC CTTCTAGCATCTGGAAAAGG AACCTGGTAT TTCTGCAGTT AGATACCAGATGCAACCAGA ACAGGCTTTC GAGTGCTGTG ATTTCTTTCCTGGGTTCCCA AGTCTTGTTG TTTCATCACA AACTGTATCTTTTTAAGGTT AAAAGTCTTG ACCTTCATGG GGGTCTGGGACAATCCGATC TCCAAGCATG GAGGAAAGGC AATGCCTGGACCACTGACTT GCATTGAAAT CCTTTCTTGT GGGCTAGGGTTTGATGTCTC TTTTTCATCT TTGGACTGGG GATCTGCATCTTCCAGGTCC ATTTAAGCAC TGAAACTAGA TGCAAATCTCTTTCGAGACC TTACATGTTT TAGATAGTCA TGTAATGACTTGGATAGACA TTTAAATAAC TTGTTCCAAG GTCGGAAGAGCCCAAGAACT CCTCAGAGTT CCTCTTCTTG CTTCTTGAATCACATCCTCT AAAGATGACT CATGTCTCCA TAGCAACTGTTAAAGGTGCT GCCTAGACGG GACCCGCTCC CACCTTTACTTACTTTGCTC GAAGGAACCA AAACAATGTC CTTGTGTAAAGGGGCTGTCA TATCCAGTTT TCCTTTGAAA TCTGGCCCCCAAGATCCTGC TTCTTTCTAA CCTGGCAGCT GTCATGTCCCTTCAAGATGA TGTGGGAAAT GGCCCTTACA ACTTGGGAACCACAGAAATT GCTGTATTTC GGGAAGATTC ACCTCTAAACTGAAGGCTTC ATTCTGATAG TGTCTGCCCT CTCTACCCTGATTTCGCCCT TCTTTGCTTC CATTTTTAGC CCAAGGCTTTGAATTTGATT GAGTAAGACT TAGAGGCAGT ATAAAGAACACCATAAACTT AGGCAGAGGT CCCTTAGGGT CTCTAGAGTTGAAAATAATT CTACAGCCTT AGGGGGACCT CTTGGCATTGACTCTAAAGG GAGAGAATAG CCCCTGTGTC CTGGCATTTCAGTCTAGACC TTCAAGGACT GTTCTCTCTT GACAGGCAAGCAAGCAAAGA AAGTTTTGCA ATAGATTTCA AGCCAGTTTTTCCATTCAAA CCAAGATGCA AATTCATAAA ATTACTCTTTTCCTGGAATA GATCCAGGCA GCTGCCTTAT TAGAACTTTAGATTCGGATC TATTTTCTTA ACACACATAC ACATACACGCGCATACATAC ATATACAGAG AGATACGTGG AGAAAGGAAATTTACTCTAT CATTGCAATA CTTCAAGAAA GAGCTGTATTTTGCCTTTCT GTAATCTCCA AGATAGTGTC TAGGAAAGTAATAGTATAAC TATAGGGATA CCGAAACAGG AAAAACCAGCCATCACTCTT GAGAAAGTTT GAGTTCGACT CACATGGGAGAATCGAGGTC TGCTACTCGT CTTGCTTTGT GCCCCATCTGTGCCTGGATG CCCTACTACA TCTGCTTGAC TCGTCTGGGCTGCTAGCCGG GGTGTTGTGG CTGACATCCT TTCCTGGCCTTACACACATA ATAGACACAT CCCTAACGGC GTGTGCCTGGTCCAGCCACA TACAGCCACC ACATGTGTCA CACACTGTCCCCCTCATCCA TGTGGACTTG ACTGGCATTT CAGCAGCTCCACTGGGATGC TCTAACCCCA GTGTGTGGAG TTGGGGTCCCTTCATCTAGG TTGACCCAGG TATAGCATTT TTAGCATTGCCTTTCCAGTC TTGATGATTC ATTCATTGAA CTCATTTATTTCTGGAGCCC CTGGTACACT CCAGGCACTG CGCTAATTGCCAGCAAAGCA CAACTGAACT AAATCCACCT TCAAGGAACCTAGCCATAAC GAGGGAGGCA GCATGGAAGT ACCCTACAGGGGAAAGTCCT GAGTGCTGTG GGAGCATCTC ACCGTGGCAGCCAGCCCAGT TTTGGCAATC AGGGGCTTCC TGAAAGAGGTGACATCAAAG CCCGGATGTG TCAGAGGACT GAGGGAGAGTGTTACTAAAG GACTTTCAGG CTGAGAGGAT AGCACAGGACTCAGCCCAAA GGAGGGCCAG TGTGGACTGT CCAGGGCCAGCCTGCAGTAC AGAGGCTGGA GCTTGGACTT GTAGAGGGAGAGAGAAGAGC AAGGGACGTG GACGGGGCAG TGAGCCAGGCTAGCCACAGA GGGTTCCCGG GGCTTTGCTG GGGATTCAGGGAGCATAAAT AAGAGCTTTA GGTGGTGCTG TGTCCTCTGCAGCCCACTGC TGAGGTCCTC CAGACAGGTA AGGTGTGGTCACAATCAGGG CCGGGGTTTC CCTGCTCACT GCGGCAGTGCAGGGGTGCTT GCTGAGATGA TTCATCCCAG GGTGTCCTCTGTCCCTTACC CAGCCCCAAC TCCTCTTCCT CTGCCAAAAGCTATTTGAAT TCAAGGACTT TAACCTGGGC CGGATCTGGTTTGGAGACAA AGGGGACAGC TCTGGGTCAG CATGACCTTCTTTAGAGCCA CTAAGGCGAA AAATACCGTT TGGGACCAGGCTGGCCTAGA CCCAGGGATG AGAATGCACC CTAAAATAAATATACGGGAA GCAGCAGAGG GCTTCCCTGT CTAGTGTGTGATCCTAACTA AAGGCAGCTC TCTTGGACAG CCTTCCCCTGGATTAGGTCA CATACACCTG GTGGCCAAGC CTCTGCTGGGTCCCAAATAC ACACCCGAGT CCTGCCAAAG AAAGGAGATTTTTAAAAAGC ACAGACAAAT TGTATGCAAG TGGAAAATACCCATAGGCCT AGACAGCTGT GGAGGGAAGA CCTCGTGGGTACCTGGAGGC TGCCAGAGCT GGGAGCTCTG CAGGTATGAGTCAGGGAAGG CTCAGAGACA AGCAGAATCT CTCTATGGAGACAACTTGCA GTGCCTTTTA GGTTTTCCAA ATAACCTCGGAGTTCAGAGC ATTGGGTTTT TTTCTCCCCT CCCCACCCCCAGAAAAATAA TTAGAAAAAT GTTTAGGAGA AAGGAAAAGAATTAGATGCA TCAGAATACC AGCTATAAGC CAACACTGTTTCCAGAAACT CAAGAAAAAG CTCAAACAGA AGACAGTTCCCCTGAGAGGC TGGAGGCGTT GGTGCTGAAG GCAATTTTCCTAGCTAAGGG GCACTGGGCC TTGCTGCACC TTGGGGCTGACCTTTTTTGC AAAACACCCA CCCCTGCCCT CCTGGCATACTCAACAGCAA CGCCAGCTTT CTGGACCCTT GGAAAGATGTTAGCTCAAAC ACCCACTTTT TCCAGATCTT CCTCTTGCTCTTCACTGAGG AATTTGTAAT TCTGAGGCTA GCGATGCCCACTCGGATATT CCGCAGGCCC AGGTGTTTAG ATTAGAATTTGTCCAGCGGT AATCCTGATG CTGGAAACCA ACAAACATTTGGCCTCATAT TCACCCATTT AAAAACTAGA GCCCCTGGCAGGTCCCCTTA GGGCCATGTG TTCATGGAAT ATAAGCCAAGTTTGCCTTAG GCTTGTTCAT GGAATATAAG CCAAGTTTACCTCTCCCCAT TTTCTGCCCT GGCCCACTTC CCACTCACCTCCACCTCATT GCCAGGAAGG GATCAAAATG CCTCCATGCCAGTTGTTAAT GGCTACATAT TTGCCCTTCC CAAGGGTATTTGCATTTTAT TTAGGAACAT GGCCTTATAT TCAAGGAAAATCTAGCATCA AGATTACGAG GCATCACCTC TCAATCAGGTCTGGGAGGTA TCTTGGGGCA TTGCTCTTCT GAACACCTGCAGAGGCTTCC TCAGGTGAGT GTGGGAGCCC GGAAGGGTGGCCTCCCTAAC CACTCTGCCT GCACATGAAT TCTCCAAAGCAGTGGGCCCC CATCTGTTTC AATTACACAT GCCTGTCAGCAAAAACTTCG TGAGATGCAC TCTCTCTGTG TGTTTATTAATTTATTTAAA GCATATATCC CTTTACTTTT GTACTACTATATTAGGCACA TTATAAAAAG TATACAGCAT AGAAACTTTAAATGAATAAG ACACAAAATA TTATAAACAG AGGTTCTGGCATTTTCTCTC TGAACTCCTG AGGGGGACCT TGGGCACCTCCTGGTATGTG CACACCCCAC TTTGAACACC CTTGCTTTAGTGCAAATCAG CACGCCTAAA TAGCATCCCA AACCACTGTGCGACATTTGG CCTGCAGAAT AAGAAAGTCC TAAGGCAGAATCCCCAGGAA CTTCAAATCT GGGAGATGAG GAAAGAAAACTCACTCACAA ACAACATAAA TGTAAATAAT TCAAAACCCTAAAGGAGAGC TGTCCCTAGA CAGTAGTGGC TACAGGTGCTAAGCAAAAGT CAGGTACACT GGACAGAGCC ATGCGATTGATTGTTCATCT TCCCTCTCTG GGTCTCCAGA AAAGGACACTGGCAATATCC CCAGCTCTCT CCTGATTGGA ATTCTTTGAACCCTCGAAGT GCTCCAGCAG TACTACCCCC CACGTAGCAGTGGGCCCATG TCGCTTGAAT ATTATTTTTG ATTTGACCACCAAGATGTAA TGATGATTCT ATTCCATTTT GAAAAGGGTCTGAGAAAGTG TACAGGTCTA ATTATATATA CATATTTATACATGTGTATT TTTGTTTATT GTTACATTTT GACATTGGACTTTCTATTAA ATAATTTTTA AGAGTTGG CFLAR NM_001127183.2GACCACGCAT GGAGAATTTT ACCACCCAGA GACACGCGAG 4TGGCCCTGTG CAAGTTTCAA CTGCGCGGGG GGCGGGGAATTCCGCAGACA GGATTCTAGA ATTTATGTCT TGTGTGGTAACATTTCAGCC GGTGGGTGGC GGGGATTAGG CGTGAAGCGGTTCAGCAGGC AGAGGTTCTC GGACGCCCTC CGGCGAAGCCACCTGTTGAT GCTTTTGACT TTCTGTCCTT GTTCCTCGTCCCATCTGGAG CATTTCCAAT TCTGGTTTTG CGGAGCAGCAGGTCTGAGCT TGTCCGGCGA GGGTGGGAGT TGGTCCCGGCGGAGATCCAG TGGGAAGAGC CGGCGGCTGC CCGGGCAACTCCCCCACTGG AAAGGATTCT GAAAGAAATG AAGTCAGCCCTCAGAAATGA AGTTGACTGC CTGCTGGCTT TCTGTTGACTGGCCCGGAGC TGTACTGCAA GACCCTTGTG AGCTTCCCTAGTCTAAGAGT AGGATGTCTG CTGAAGTCAT CCATCAGGTTGAAGAAGCAC TTGATACAGA TGAGAAGGAG ATGCTGCTCTTTTTGTGCCG GGATGTTGCT ATAGATGTGG TTCCACCTAATGTCAGGGAC CTTCTGGATA TTTTACGGGA AAGAGGTAAGCTGTCTGTCG GGGACTTGGC TGAACTGCTC TACAGAGTGAGGCGATTTGA CCTGCTCAAA CGTATCTTGA AGATGGACAGAAAAGCTGTG GAGACCCACC TGCTCAGGAA CCCTCACCTTGTTTCGGACT ATAGAGTGCT GATGGCAGAG ATTGGTGAGGATTTGGATAA ATCTGATGTG TCCTCATTAA TTTTCCTCATGAAGGATTAC ATGGGCCGAG GCAAGATAAG CAAGGAGAAGAGTTTCTTGG ACCTTGTGGT TGAGTTGGAG AAACTAAATCTGGTTGCCCC AGATCAACTG GATTTATTAG AAAAATGCCTAAAGAACATC CACAGAATAG ACCTGAAGAC AAAAATCCAGAAGTACAAGC AGTCTGTTCA AGGAGCAGGG ACAAGTTACAGGAATGTTCT CCAAGCAGCA ATCCAAAAGA GTCTCAAGGATCCTTCAAAT AACTTCAGGC TCCATAATGG GAGAAGTAAAGAACAAAGAC TTAAGGAACA GCTTGGCGCT CAACAAGAACCAGTGAAGAA ATCCATTCAG GAATCAGAAG CTTTTTTGCCTCAGAGCATA CCTGAAGAGA GATACAAGAT GAAGAGCAAGCCCCTAGGAA TCTGCCTGAT AATCGATTGC ATTGGCAATGAGACAGAGCT TCTTCGAGAC ACCTTCACTT CCCTGGGCTATGAAGTCCAG AAATTCTTGC ATCTCAGTAT GCATGGTATATCCCAGATTC TTGGCCAATT TGCCTGTATG CCCGAGCACCGAGACTACGA CAGCTTTGTG TGTGTCCTGG TGAGCCGAGGAGGCTCCCAG AGTGTGTATG GTGTGGATCA GACTCACTCAGGGCTCCCCC TGCATCACAT CAGGAGGATG TTCATGGGAGATTCATGCCC TTATCTAGCA GGGAAGCCAA AGATGTTTTTTATTCAGAAC TATGTGGTGT CAGAGGGCCA GCTGGAGGACAGCAGCCTCT TGGAGGTGGA TGGGCCAGCG ATGAAGAATGTGGAATTCAA GGCTCAGAAG CGAGGGCTGT GCACAGTTCACCGAGAAGCT GACTTCTTCT GGAGCCTGTG TACTGCGGACATGTCCCTGC TGGAGCAGTC TCACAGCTCA CCATCCCTGTACCTGCAGTG CCTCTCCCAG AAACTGAGAC AAGAAAGAAAACGCCCACTC CTGGATCTTC ACATTGAACT CAATGGCTACATGTATGATT GGAACAGCAG AGTTTCTGCC AAGGAGAAATATTATGTCTG GCTGCAGCAC ACTCTGAGAA AGAAACTTATCCTCTCCTAC ACATAAGAAA CCAAAAGGCT GGGCGTAGTGGCTCACACCT GTAATCCCAG CACTTTGGGA GGCCAAGGAGGGCAGATCAC TTCAGGTCAG GAGTTCGAGA CCAGCCTGGCCAACATGGTA AACGCTGTCC CTAGTAAAAA TACAAAAATTAGCTGGGTGT GGGTGTGGGT ACCTGTATTC CCAGTTACTTGGGAGGCTGA GGTGGGAGGA TCTTTTGAAC CCAGGAGTTCAGGGTCATAG CATGCTGTGA TTGTGCCTAC GAATAGCCACTGCATACCAA CCTGGGCAAT ATAGCAAGAT CCCATCTCTTTAAAAAAAAA AAAAAAGGAC AGGAACTATC TTACTCAATGTATTAGTCAT GTTTCTCTAG AGGGACAGAA CTAATAGGATACATGTATAT AAAAAGGGGA GTTTATTAAG GAGTATTGACTCACATGATC ACAGGGTTAG GTCCCACAAT AGGTCATCTGCAAGCAAGGA AGCCAATTCA AGTCCCAAAG CTGAAGAACTTGGAGTCCAA TGTTTGAGGG CAGGAAGCAT TCAGCATGAGAGAAAGATGG AGGCCAGAAG ACTACACCAG TCTAGTCTTTCCATGTTTTG CCTGCTTTTA TTCTGGCAGT GCTGGCAGCTGATTAGATGG TGCCCACCCA GATTGAGGAT GGTCTGCCTTTCCCAGTCCA CTGACTCAAA TGTTAAATCT CCTTTGGCAGCACCCTCACA GATGTACCCG GGAACACTTT GCATCCTTCTATTCAATCAA GTTGATACTC AGTATTAACC ATCACAGTCCATTTGGGCAA CTATACCAAA TTACCATAGA CCAGGTGACTTAAACAGCAG TTATTTCTCA CAGTTCCGGA GGCTGGGAAATCCAACATCT AAGTGGTAGC ATATCTGGTG TCTGGTAAGGCATGCTTCCA GATCTTACCA GATGTCAGTC TTTTGATGTTCTCACATGGC AGAAAAAGAG GATGCAAACT CTCAAGTATATCTTTAAGGG CACAAATTCC ATTCATGAGG GCTCTACCCTCATCACCTAA TTACCTCCCA AAGGCCCCAC CTTCTGATACTGTCACTTTG GGGATACTGT CTCCCCTTTG AATTCTGGGGGGAATACAAA CATTCAGTTT GTAACAATAG CCTTATGATTTAGAGGTTAC TTGTTCATTC ACCTAGACCT CAAATTGCATTTTACAGCTA GTCAAGTATA TCTTTCTCTG ATTTGATAGTGTGACCTAAA AGGGGACCAT TGTTTGAAAT ATCATTAGAGTTGCTTATTA TTATTATTAT TATTATTATT ATTATTATTATTATTATTAT TGAGACAGAG TTTCATTCTG CTGCCCAGGCTGGAGTGCAG TGGCATCATC TTGGCTCATT GCAACCTCTGCCTTCTGGGT TCAAGCGATT CTCCTGCCTC AGCCTCCCGAGTAGCTGGGA TTACAGGCTC CTGCCACCAC ACCCGGCTAATTTTTGTATT TTTAGTGGAG ACAGGGTTTC CACCATGTTGGCCAGCGTGG TCTTGAACTC CTGACCTCAG GTGATTCACCAGCCTCGGCC TCCCAAAGTG CTGGGATTAC AGGTGTGAGCCACTGCACCT GGCCTATTAT TATTTTTAAA TTTTTTTTTTTTAATTGATC ATTCTTGGGT GTTTCTCACA GAGGGTGATTTGGCAGGGTC ACAGGACAAT AGTGGAGGGA AGGTCAGCAGATAAACAAGT GAACAAAGGT CTCTGGTTTT CCTAGGCAGAGGACCCTGCG GCCTTCCGCA GTGTTTGTGT CCCTGGGTACTTGAGATTAG GGAGTGGTGA TGACTCTTAA GGAGCATGCTGCCTTCAAGC ATCTGTTTAA CAAAGCACAT CTTGCACTGCCCTTAATCCA TTTAACCCTG AGTGGACACA GCACATGTTTCAGAGAGCAC AGGGTTGGGG GTAAGGTCAT AGATCAACAGCATCCTAAGG CAGAAGAATT TTTCTTAGTA CAGAACAAAATGAAGTCTCC CATGTCTACT TCTTTCTACA CAGACACAGCAACAATCTGA TTTCTCTATC TTTTCCCCAC CTTTCCCCCTTTTCTATTCC ACAAAACCGC CATCGTCATC ATGGCCTGTTCTCAATGAGC TGTTGGGTAC ACCTCCCAGA CGGGGTGGCGGCTGGGCAGA GGGGCTCCTC ACTTCCCAGA TGGGGCGGCCAGGCGGACGC GCCCCCCACC TCCCTCCCGG ACGGGATAGCTGGCCGGGCG GGGGCTGACC CCCCACCTCC CTCCCCGACGGGGCGGCTGG CCGGGCGGGG GCTGACCCCC ACGCCTCCCTCCCGGACGGG GCGGCTGCCA GGCGGAGGGG CTCCTCACTTCTCAGACGGG GTGGCTGCTG GGCGGAGACG CTCCTCACTTCCCAGACAGG GTGGCTGTCG GGCGGAGGGG CTCCTCACTTCTCAGACGGG GCAGCTGCGG GCGGAGGGGC TCCTCACTTCTCAGACGGGG TGGCCGGGCA GAGAAGCTCC TCACATCCCAGACGGGGGGG CGGGGCAGAG GCGCTCCCCA CATCTCAGACGATGGGCGGC CGGGCAGAGA CGCTCCTCAC TTCATCCCAGACGGGGTGGC GGCCGGGCAG AAGCTGTAAT CTCGGCACCCTGGGGGGCCA AGGCAGGCGG CTGGGAGGCG GAGGCCGTAGCCAGCTGAGA TCACACCACT GCACTCCAGC CTGGGCAACATTGAGCACTG AGTGGACGAG ACTCTGCCCG CAATCCCGGCACCTCGGGAG GCCGAGGCTG GCAGATCACT CGCAGTCAGGAGCTGGAGAC CAGCCCGGCC AACACAGTGA AACCCTGTCTCCACCAAAAA AATACGAAAA CCAGTCAGGC GTGGCGGCGCCCGCAATGGC AGGCACGCGG CAGGCCGAGG CGGGAGAATCAGGCAGGGAG GCTGCAGTGA GCCGAGATGG CAGCAGTACAGTCCAGCTTC GGCTCGGCAT CAGAGGGAGA CCGTGGGGAGAGGGAGAAGA GAGGGAGGGG GAGAGGGCTA TTTTTAAAATTTTTTAAAAT TGCTGAACAG GGGTACCTCT GGGCAGTGTGTCAGAATACC ACTTTTTAAA TATTTTATGA TTTATTTATTTTTCTATTTC TTGAGGTTTT AACTGATGTG TATCTGTATGTCTATTTGTG TATATTTTGT CATGATCATG TAACAGAGTCTGAAAAGTGT CGAAGAGACA GTTTTCAGGA ACAACAAGCAATTATTCCTA CTTTCCAAGT TATTTTGATG CCATGGTGGCTCATACCTAT AATCTGAGTA CTTTGGGAGG CTGAGGTGGACTGATCACTT GAGCCCAGGA GTTTGAGACC AGCCTGGGCAACATAGCAAG ACTCCATCTC TACAAAAAAA GACAAAATTTAGCTGAGCGT GGTGGCGTGT TCCTGTAGTC CCAGCTACTTGGGAGGCTGA AGTGAGTGGA TCCCCTGAGC CCAGAGAGGTCAAGGTTGTG ATGAGCTGTG ATCACACCAC TGCACTTCAGCATGGGAGAC AGAGTGAGAC CCTGTTTCAG AAAAAATAAATAAATAAAAC CACCAGCACC ACAAACAACA ACAAAAAGTTATTTTGTACT TGTTTTGAGC ACAGGACTCC TGAGGGTATCTTTGCATTTA ATATTACATA GGGGTGCCAG TGGGAAGTAATGTGTATGCT TGGCCTCATG AGCTAAAACC CTGTGTTAATTATGACAGAA GGAAAGTGTG TGAGAGAGAT CTTAACTACCTAGCAGCTCT AGCTGCCATC TTGAACCATG AAGATACGGGCCACACGTAG GGGTAGCTGG GTAGTGAGCA GCAAGAAGCCTTGTTGGATG AGGGCACGAA GGAGCAGAAT CACTGGAATCACTGTGTCAG CCCTAATTAC CTACCTCTGG ACTTTTATGTGAGGGGAAAA AAAATTGACA GTTTATATTT ATCTCAACCTAGTTAACCCA AGTGATGCAT TGTTATGAGA TTAAAATGTTTGGAGGCCGG GTGCGGTGGC TCACGCCTAT AATCCCAGCCCTTTGGGAGG CCAAGGCGGG CGGATCACGA GGTCAGGAGATCAAGACCAT CCTGGCTAAC ATGTAAAACC CCGTCTCTACTAAAAATACA AAAAATTAGC CAGGCGTTGT GGCGGTCGCCTGTAGTCCCT GCTATTTGGG AGGCCGAGGC AAGAGAACGGCATGAACCTG GGAGGTGGAG CTTGCAGCGA GCTGAGATCTTGCCACTGCA CTCCAGCCTG GGCGACAGTG CGAGACTCTGTCTCAAAAAT AAATAAATAA ATAAATAATA AATAAAATGTTTGGAATGTT GGCTTCATCC CTGGGATGCA AGGCTGGTTCAACATACGCA AATCAAGAAA CATAATTCAT CACATAAACAGAACTAAAGA CAAAAACCAC ATGATTATCT CAATAGATACAGAAAAGGCC TTCAATAAAA TTCAACGTTG CTTCATGTTAAAAACTCTCA ATAAACTAGG TATTGATGGA AAATATCTCAAAATAATAAC CATTTATGAC AAACCCACAG CCATTATCATACTGAATGGG CAAAAGCTGG AAGCATTCCC CTTGAAAACTGGCACAAGAC AGGGATGCCG TCTCACCACT CCTATTTAACATAGTATTGG AAGTTCTGGC CAAGAAAATC AGGCAAGAGAAACAAATAAG GGGTATTCAA ATAGGAAAAG AGGAAGTAAAACTGTGTTTG CAGATGACAT GATACTATAT CTAGAAAACCCCATTATCTC CACCCAAAAG TTCCTTAAGC TGATAAGCAACTTCAGCAAA GTCTCAGGAT ACAAAATCAA TGTGCAGAAATCACAAGCAT TCTATACACC AACAATACAC AAGCAGAGAGCCAAATCATG AATGAACTCC CATTCACAGT TGCTAGAAAGAGAATAAAAT ACCTAGGAAT ACAGCTAATA AGATGTGAAGGATCTCTTCA AGGAGAACTA CAAACCACTG CTCAAGGAAATAAGAGAGGA CACAAATGAA AAAACATTCC ATTCTCGTGGATAGGAAGAA TCAATATCAT GAAAATGGCC ATACTACCCAAAGTAATTTA TAGGTTCATT GCTATTCCCA TTAAACTACTATTGACATTC TTCACAGAAT TAGAAAAAAA CTACTTTAAAATTCAAATGG AACCAAAAAA GAGCCCGTAT AACCAAGACAACAATAAGCA AAAAGAACAA AGCTGGAAGC ATCACACTACCCAACTTCAA AGTATACTGC AAGGCTACAG TAGCCAAAATGGCATGGTAC TGGTACAAAA ACAGACACAT AGACCAATGGAACAGAATAG AGACCAGAGA AAGAAGACCA CACATCTACAGCCATCTGAT CATCGACAAA CCTGACAAAA ACAAGCAATGGGGAAAAGAT TCCCTATTTA ATAAATGGTG CTGGGAAAACTGGCTAGCCA TATGCAGAAA ATTGAAACTG ACCCCTTCCTTACACCTTAT ACAAAAATTA ACTCAAGATT AAAGACTTAATGTAAAACCT AAAACTATAA AAACCCTAGA AGAAAATCTATTTAATACCA TTCAAGACAT AGGCACAAGC AAAGGTTTCATGACAAAAAC ATCAAAAGCA ATTGCAACAA AAGCAAAAATTACAAATGGG ATCTAATTAA ACTAAAGAGC TCCTGCACAGCAAAAGAAAC TATCATTAGA GTGAACAGGC AACCTACAGAATGGGAGAAC ATTTTTGCAA TCTATCCATC TGACAAAGGTCTAATATCCA GAACCTACAA GGAACTTAAA ACAAATTTACAAGGAAAAAA ACAACCCCAT CAAAAAGTGG ACAAAGGACATGAACAGACA CTTCTCAAAA GAAGACATTT ATGTGGCCAACAAACATATA AAAAAAAGCT CAACCTTACT GATCATTAGAGAAATGCAAA GGAGAACCAC AATGAGATAC CATCTCATGCCGGTCAGAAT GGTGATTATT AAAAAGTCAA AAAACAACAGATGCTGGCGA GGCTGTGGAG AAGTAGGAAC ACTTTTACATTGTTGGTGGG AATGTAAATT AGTTCAACCG TTGTGGAAGTGTGTGTGGCT ATTCCTCAAA GATCTAGAAC TAGAAATACTATTTGTCCCA GCAATCCCAT TACTGGGTAT ATACCCAAAGGAATATAAAC CATTTTATTA TAAAGATACA TGCACATTTTTGTTCATTGC AGCACTCTTC ACAATAGCAA AGACACAATAGCAAATGCCC ATCAAAGATA GACTGGATAA AGAAAATGTGGTACATATAC ACCATGGAAT ACTGTGCAGT GCAGCCATTACAGCTTTTGG TGATACAGTG AATCAGATTT TTCATTAATTCTTTTAATTG GTTATTACTG AACGTGAAAA AGTAATGTTTGTATTGAAAT CTTGAGTCTG GCCATGTTTC TATTTTAAATTCATAAAGAA TTCTAACAAG AGGAATTCCA AGAATGTCATAAATGGATGT TTCTCCATGG ATGAAGGAAC TGTTTTATTCACTTGCTGAT AATTCAGCCT AATCCAGTTT GACATCATATAGATAAGTAG TTGAATTATG GATTTAAAAT ACATATCATTTTCTAACTCC AAAGGTAATA CTTATTTAAA TGGTTTTGAAAATATAGAAA GGCACAATTT CTTTTTAAAT CTGTTATTCTCCACCACCAC TCAATCTGTC TATCATCTAT CTCTCCATTCATTCTTCCAT TTGTTTATAT CTGTTAATCT TTGTATGTGTTCATGTATAG CTTTTACATG ATTGGAATCA TAATGCATATTCCATTTTGA AGTCTGCTTT TTTTTACACA AAAATATGTTGTGAATATTT TCCTATATTA TGAAATATCA TTAGCTGAGCTTTTAGAATT GACTGCATGT TTTGGTACCA TTTAGATATAGTTTAAGATA CTTAGAAGTT ATGTGGCTTT GCCACTATGGATGAATCTTA TTTACTCAAT ATTAATTACT TACAAATAACCTCACCTAAA CACTACTCAG CCATAAAAAG GAATGAATTAATGACATTCA CAGCAACCTG GAGACTATTA CTCTAAAGGAAGTAACTGAG GAATGGAAAA CCAAACATTG TATGTTCTCACTCATAAGTG GGAGATAAGC TATGAGGATG CAAAGGCATAAGAAGGATAC AATGGACTTT GGGGACTTAG GGGAAAGGGTGGGAGGGGGG TGAAGGATAA AAGAATACAA ATTGGGTTCAGTGTATACTG CTCAGGTGAT GGGTGCACCA GAATCTCACAAGTAACCACT TAATTACTTA CGCATGTAAC CAGATACCACCTGTTCCCCA AACACCTATG GAAATAATTT TGTTTTTTTTTTTAAAAAAG GAATGAGATC ATGTCCTTTG CAGGGACATGGATGAAGCTG GAAGCCATTA TCCTCAGCAA ACTAACAGAGGAGCAGGAAA CCAAACACCA CATGTTCTCA CTTGTAAGCGGAAGCTGAAC AATGAGAACA CACGGACACA GGGATGAGATCAACACACAC TGGGGCCTGA TGCAGGGGCC GTAGCGGGGAGAGCATCAGG ATAACTAGCT AATGCATGTG GGGCTTAATACCTAGGTGAT AGGTTGATAG GTGCAGCAAA CCACCATGGGACACGTTTAC CTATGTAACA AACCCGCACA TCCTGCACTTGTATCCAGAA CTTAAAATAT TTTAAAAATC TTTAGAGAATACAAAAAAAA AAAAAAAGAT TCTTCAATGC ATACACAATAAAATTGCAGT TCAGTCAAAC ATTGGAAGTC TTTCTCTGACTGTCTAGTTG GTATCTTCAT TTTCAGCTTC TTCAAGATCCCACTCCAAAC ACTGTTAGCT CAGCCAAATT GAACAGCTCATATCTCCTAC CTCTGGATCT TTGGTTCTGG TGATTGTATATTTCTGGACC ATCTGGAACC CCAGCATATC ACCCTACCCCACATCTCCAC ATCCCCAAAA TATAACCATA CTTCAAGGGCAGTTCAAATA CCATCTCCTT CTATCCTCCA TGAAGTCAGTTATCTCTTCC ATTGGAATTA TCGCCCCCTC TCCTGAACAGTACTATTTCG TGTGAATCTC CTCCAAGCCT TCTTTTCATTTTATATCTCA TGCTGTAATT CTTGGAAAGT ATGCTGTAGCTCAAGTGCAG AATTCTCATC AGTTTTATCT TTATATCTCTCCTAAACACT TTACCTGATG AAGAGCCTGG CATACACATAAATATATATT GAATGAATCA GTGATGGATT GAAAAGAGAAATGATGGATC TCCTAAATTT TAACTTTTAT AAAATATTTTGATACATTCA TGACCTTACT TTAGCAAGCA ATGAACGTGATGTAAACTAT TGTTGATATA GTTTTTATAT TGGAAGTGTAAGTAGTTTGT GGCATGGGAT TGTGACATAT CCTAGGTTTCCTCATCTTCT TTTTATTGAA ATGTAATTCA CAAGCCATAAAATTTGCCCC TTTAAAGTAA ATGATGCAGT GGATTTTAGTATATTTACAG AGTTGTGCAA TCATCACCAC TATCTAATTCCAGAACATTT CCATCTACCT AGAAACTCCA TACCAGTGAGCTGCCACTCT AATCCTCCTC TTCCCCCAGC CTCTAGAAACAATAATCCAT TTTCTGTCTC TATGATTTGC CTGTTCTAGATATTTTATAA AAATAAACAT GTGGCCTTTC GTGTCTGACTTCCTTCACTT AAAAAAAAAA AAAAAAAA CFLAR- NR_040030.1CATGCATACA GCCCAGTCTA ACGTACAGGA TCAAAAAGAG 5 AS1ACCTTATTTC GGCTGGCAAT TACCTTACCC GCTTGTTCATTATCTGACTC CTGCACTCCT CCCAAGTGTT CAATGTTAACCAGATGGCAA AGTTAACCAG ACAGAGGAAA TCCACATAATTACTCTAGAT GAAGCCCCCT AACTGCGGAT TAGAAGGAAAAGAGATGAAG GGTGCTGCAC TAATAATAAC AACCATTTTCAACCAAGGCA GGATTCTGGG CCTAGAATCT TCAGTGACAAATTACCAGGA GAGGAGGAGG GAAATGAAGA GCTGGAGGCCTAGGGAGATG GTGTGAGGAG AGGAGACTGT GCCTTTCCACTTCTTAATAA TTAATGTTCT CCTGCTGCTC TGAGTCTGCATCACCAGTGA TTCAGTTTGA GTCAGACATC CAACAACAACTGAGCAAAAG AATCATCTCA GATCCAAGCA ATGGTGACGCGCAGATAGAA GAGACTGAGG CCAACGACCA AAGCAAAGGACAGCAGAACT GACTGACACA GCTCAGAAAA TATCCAAAGCTCTGTATGCT CTGGAAAGGA AGACAAGAAA TGCTAAAGACTCTGGATATT GCTCTGTTTC TATAAGGTCC CACCCATATACCATCTCTTC TTTTGGATTT CCTTTGGCAG GGTTCCCTTGTATGGAAGTT CTCAGGAGAA CAACACTCTC AGAGTCCCACTGTCTCAAAG AATTCTTAAT GGACAGCTAT ACTTGGCCCCAAGGTTTCAA CCTCACACTG AAGAAAGTGA CATAAGAAAACACAAGTCCC AGTGCTATCA GGGGCTATCT GGAAAAGCTGCTTAAACAGC AAGTGAAAGA AGGCTCTCCC CTACCCCGTTCTAGACTCAC CCTGAAGTTA TTTGAAGGAT CCTTGAGACTCTTTTGGATT GCTGCTTGGA GAACATTCCT GTAACTTGTCCCTGCTCCTT GAACTATAAA AGCAGAAGGG AGGTACTGAGTTAAAACTTA CAAATTATTA TCAAATAAAT CTTCAATAGT G CHP1 NM_007236.4ACCACCCCTG GGTTCCCTCC CGGGTCCGCA GTGGAAACAC 6TGCCCTCTCC CTTCTTGACC CCTAGCCCTT CCTTCCCTCCCTCCTTCCCT CCTGTCGCCG TCTCTTCTGG CGCCGCTGCTCCCGGAGGAG CTCCCGGCAC GGCGATGGGT TCTCGGGCCTCCACGTTACT GCGGGACGAA GAGCTCGAGG AGATCAAGAAGGAGACCGGC TTTTCCCACA GTCAAATCAC TCGCCTCTACAGCCGGTTCA CCAGCCTGGA CAAAGGAGAG AATGGGACTCTCAGCCGGGA AGATTTCCAG AGGATTCCAG AACTTGCCATCAACCCACTG GGGGACCGGA TCATCAATGC CTTCTTTCCAGAGGGAGAGG ACCAGGTAAA CTTCCGTGGA TTCATGCGAACTTTGGCTCA TTTCCGCCCC ATTGAGGATA ATGAAAAGAGCAAAGATGTG AATGGACCCG AACCACTCAA CAGCCGAAGCAACAAACTGC ACTTTGCTTT TCGACTATAT GATTTGGATAAAGATGAAAA GATCTCCCGT GATGAGCTGT TACAGGTGCTACGCATGATG GTCGGAGTAA ATATCTCAGA TGAGCAGCTGGGCAGCATCG CAGACAGGAC CATTCAGGAG GCTGATCAGGATGGGGACAG TGCCATATCT TTCACAGAAT TTGTTAAGGTTTTGGAGAAG GTGGATGTAG AACAGAAAAT GAGCATCCGATTTCTTCACT AAAGGAGACC AAACTGTTCC TTGCGGTCTAGTATTTAAGA ACTGGAACTT GAAAGTCCTC CTTCTACCAACTCCACCTCC ACCCCCTCAT TCCCCTTCTC CCAAAGTACTACTGCTGTTG CATGACAACC CCAAATATGT TCTGTCAACACAAACCTGCC TTTGGTGTAT AAACAGGGCA TTACAGAATGGTACACCCTA TATATTTCTG TTCAGTATCC ATTCACTAGTTCTTCATTTA TAAATATCAT CTTCCCCATT CTGCTGCTGAATGCCACACA TCCATCCAGT CTGAGAAAGT GAGAGAGGCAATCATGCCAA GAACAAGCCA GCAAAGCTCT TTCACCAGATGTAGACTGTA GCCCTGCTGC CTTCCCTCCA GCGAGTCTGCCAGCATGCTT CTTCATCCTT TTTATATGTT CTTTGCTTCCTACTTCCCTG TCTTCCAACA TACTGTTCAC TTACTCTGGCAGTCTTTCTG CTTTTCATTA AGCCTCAAAA TCTCCTCTGTTCTACTTGGC ACCACAAGCT ATGTCCTATA TATGTATTTCTGACTTGGCA GGATAGTTCA GGGGTCTGGC AGTTTTTATTTACCTTCATT ATTAAATGGG CCTCTGGGAT GTTGCCTCTTCAGGAGCTTT TTGGTAATCA ATACTTCTCT CAGAAGTATGAGACCATCCT CTGCACTCTG CTCTGTCATC AAAGGCTGCTGGGTGGAGAT ACCCTTTTTG AAAGGTGGCC TTGGTGAGAGGTATGGAGCC AAGTCTTCTA GGTTGCTTGC CCACATCACTCTATCTCTGG CCTCTGATTC TCAACTTTGT ACCTGTGTGGCTCCTCTTGT TAGTGCAATG TTGACTGTTG AAAAAGCAGCAGTATGCTTA CAGGTTTGCT TAGTTTGGGG ACACCGTTACCACCAGAATG GCTGCTCTGA CAATATGCCT AGGGACTTTCTCATGGCTTT TATTTAATAA GGAGGCTGGG CACCCTATAAAGCCTCATGC ATTCACACCT TTGCAGCATG GTTTATGCCTCAGTGTTATG TGCACTGGAA TGTTTTCCAC TTCACATTTCCAAGTAGAAA TATTAGTGTT ACGGAAGTGC CTAATATCCCAGTCCAAATT TTTTTTTTTT TTTTTTTTTT TTTTTGAGACAGAGTCTTGC TCTGTCACCC AGGCTGGAGT GCAGTGGTGCGATCGCTCAC TGCAACCTCA GCCTCCTGGA TTTAAGTGATTCTCCTGCCT CAGCCTCCCA AGTAGCTGGG ATTACAGGTGTGCACCACCA TGCCCGGCTA ATTTTTTGTA TTTTTAGTGGAGACAGGGTT TCACCATGTT GGCCAGGCTG GTCTCGAACTCCTGACCTCG TGATCCGCCT GCCTCAGCCT CCCAAAGTGCTGGGATTACA GGTGTGAGCC ACCACGCCTG GCCCCAGTCCAAAATATTTA AAGATTGTTT CCTTAGTGTC TTGAAGTTTTGCACAAAATT CTTTTTTTTG AGATGGAGTC TCACTCTGTCACCCAGGCTG GAGTGCAGTG GCGTGATCTT GGCTCACTGCAACCTCTGCC TCCTGGGTTC AAGCAATTCT CCCACCTCAGCCTCCCAAGT AGCTGGGATT ACAGACGTGT GCCACCATACCTGGGTAATT TTTGCATTTT TAGTGGAGAG GGAGTTTCACCATGTTGGCC AGGTTGGTCT TGAACTCCTG ACCTCAGGTGATCCTCCTGC CTCGGCCTCC CAAAGTGCTG GGATTACAGGCATGAGCCAC CGTGCTCAGC CGCAAAATTC TTTATGAATTTTACACTTGG CAAATGTTAA TGACGGAAGC CATAGTCTGCTCCTAATACA TGTCCAAAGC ATTGACTGTT GTGTCATTAGCTGCCTGGTT ACATTAGCTC CCTGGCTTCT TGTTTAGACCACTGCTAATC CCTTAAAAAC AAGAGGTCTG GCACTAGTAGCACAACCTAA GGTGGCATTA CAGATCTTTG AGCGAGCCACAGCAACTTTT CTGCCAAGTC AGCTTAGTTT AGACTTCAGTGAATCAGGCT ATTGCTATCC TAATGTATGT CTCTATGAGTGTATTTAGCC ACACATCTGC CCTTGGTTGA CTTTCTGACTCATTGCTTGC TTGCTTGTTT CCTTGCTTTG GAAAACTATTGAAGATTGCT AAAAAATACC ACTGCAAAGT GATGGAAAAGGGTGGAGAAC AGGGGAGTAG CCAGGCTGGA TGGCTCAAATATAAATGAAT GAGGAATTCT TTATGAAGTA TCAGTCAGATTTTATGATTA AGTGATGTAA TATAGGAATT ATGTAAAAGGGAAGAATGTC TGATACTGAT CTATTAGAGA GGTACTTTAGAGGCTTCTTG ATTGGCATAA AGTTCCTAAG GTTATAGATTTTCCCCCCTT TTGGCTGTAT AGCAAAGTGT TTTAATCCACGGTTGTGCCT TATTGTTCCA TTAAAATTGT ATCTTCGATCCATCAATAAA TACTTGTGGT TGAAACAAAA DDX55 NM_020936.2AGCGGAAGTG CTCGTTGGGG GTGCACAAGG CGCGTTCGAG 7CAGCGGCGAC CGACGCGGCG AAGGAGCGCG CCATGGAGCATGTGACAGAG GGCTCCTGGG AGTCGCTGCC TGTGCCGCTGCACCCGCAGG TGCTGGGCGC GCTGCGGGAG CTGGGCTTCCCGTACATGAC GCCGGTGCAG TCCGCAACCA TCCCTCTGTTCATGCGAAAC AAAGATGTCG CTGCAGAAGC GGTCACAGGTAGTGGCAAAA CACTCGCTTT TGTCATCCCC ATCCTGGAAATTCTTCTGAG AAGAGAAGAG AAGTTAAAAA AGAGTCAGGTTGGAGCCATA ATCATCACCC CCACTCGAGA GCTGGCCATTCAAATAGACG AGGTCCTGTC GCATTTCACG AAGCACTTCCCCGAGTTCAG CCAGATTCTT TGGATCGGAG GCAGGAATCCTGGAGAAGAT GTTGAGAGGT TTAAGCAACA AGGTGGGAACATCATTGTGG CCACTCCAGG CCGCTTGGAG GACATGTTCCGGAGGAAGGC CGAAGGCTTG GATCTGGCCA GCTGTGTGCGATCCCTGGAT GTCCTGGTGT TGGATGAGGC AGACAGACTTCTGGACATGG GGTTTGAGGC AAGCATCAAC ACCATTCTGGAGTTTTTGCC AAAGCAGAGG AGAACAGGCC TTTTCTCTGCCACTCAGACG CAGGAAGTGG AGAACCTGGT GAGAGCGGGCCTCCGGAACC CTGTCCGGGT CTCAGTGAAG GAGAAGGGCGTGGCAGCCAG CAGTGCCCAG AAGACCCCCT CCCGCCTGGAAAACTACTAC ATGGTATGCA AGGCAGATGA GAAATTTAATCAGCTGGTCC ATTTTCTTCG CAATCATAAG CAGGAGAAACACCTGGTCTT CTTCAGCACC TGTGCCTGTG TGGAATACTATGGGAAGGCT CTGGAAGTGC TGGTGAAGGG CGTGAAGATTATGTGCATTC ACGGAAAGAT GAAATATAAA CGCAATAAGATCTTCATGGA GTTCCGCAAA TTGCAAAGTG GGATTTTAGTGTGCACTGAT GTGATGGCCC GGGGAATTGA TATTCCTGAAGTCAACTGGG TTTTGCAGTA TGACCCTCCC AGCAATGCAAGTGCCTTCGT GCATCGCTGC GGTCGCACAG CTCGCATTGGCCACGGGGGC AGCGCTCTGG TGTTCCTCCT GCCCATGGAAGAGTCATACA TCAATTTCCT TGCAATTAAC CAAAAATGCCCCCTGCAGGA GATGAAGCCC CAGAGAAACA CAGCGGACCTTCTGCCAAAA CTCAAGTCCA TGGCCCTGGC TGACAGAGCTGTGTTTGAAA AGGGCATGAA AGCTTTTGTG TCATATGTCCAAGCTTATGC AAAGCATGAA TGCAACCTGA TTTTCAGATTAAAGGATCTT GATTTTGCCA GCCTTGCTCG AGGTTTTGCCCTGCTGAGGA TGCCCAAGAT GCCAGAATTG AGAGGAAAGCAGTTTCCAGA TTTTGTGCCC GTGGACGTTA ATACCGACACGATTCCATTT AAAGATAAAA TCAGAGAAAA GCAGAGGCAGAAACTCCTGG AGCAACAAAG AAGAGAGAAA ACAGAAAATGAAGGGAGAAG AAAATTCATA AAAAATAAAG CTTGGTCAAAGCAGAAGGCC AAAAAAGAAA AGAAGAAAAA AATGAATGAGAAAAGGAAAA GGGAAGAGGG TTCTGATATT GAAGATGAGGACATGGAAGA ACTTCTTAAT GACACAAGAC TCTTGAAAAAACTTAAGAAA GGCAAAATAA CTGAAGAAGA ATTTGAGAAGGGCTTGTTGA CAACTGGCAA AAGAACAATC AAGACAGTGGATTTAGGGAT CTCAGATTTG GAAGATGACT GCTGATTCCAGTGCCACAGA TGAACCCACA AGGACATAGC TGTTCCCTAACTTGGTGGAT GGCTCCAGTT TGCTTTTAAC GAAAATCACAACTTCAGGAG ACATCTGAAA AGAATGATGT CTCTGAAAGCTGTCCTTTCA GATGAGGGAG AAATGAAGGA TTTCACACTTCAGAATATTT TACTAAAAAC ATTCCAGTCT TGGCCGGGTGCGGTGGCTCC TGCCTATAAT CCCAGCACTT TGGGAGGCTGAGGCAGGAGG ATCACTTGAG CCCAGGAGTT CAAGACCAGCCTGGGAACAC AGCGAGACCC TCTCATTAAA AACAACAAAACAAAACAATT CCAGTCTTGG AGTAGTCTAA CAGAAGAAAATGTAAAATTA TTTGAGTGTA AATAATAGAT GTCAGTATTTATCATGATGG GTCACATATA GACATATGTA CATATTATATATATATATAT ATATATATAT ATATATATAT ATATATATATATAAGCTCTT TTTTCTGAGG CTATTTTATA GTTATTTTTAAACATAAAGA TACAGAAGTC TTCTTGACTT CTGATTTTCAAAACCATTCC TCAGTATCTT CAGGCATTTG ACCTCCTGAATGTGCTTGGC CCTGGGCTTC AGTTATCCTT TGATGTCCTGCAGGGGTGGC TAATGTGCTG GGGTTTTTCT GTGTTAATAGTCACAGTATT GTTTTATTGG TGAATAGCTG AAAAACAGAGGGATTAAGTC ATATTCCGGG AAAGAGAATT ATAGTTTTTATGCCTCCTGT TGAATAAATG GTGTCCTGAT TGCCTGGG DMD NM_000109.3CGTTAAATGC AAACGCTGCT CTGGCTCATG TGTTTGCTCC 8GAGGTATAGG TTTTGTTCGA CTGACGTATC AGATAGTCAGAGTGGTTACC ACACCGACGT TGTAGCAGCT GCATAATAAATGACTGAAAG AATCATGTTA GGCATGCCCA CCTAACCTAACTTGAATCAT GCGAAAGGGG AGCTGTTGGA ATTCAAATAGACTTTCTGGT TCCCAGCAGT CGGCAGTAAT AGAATGCTTTCAGGAAGATG ACAGAATCAG GAGAAAGATG CTGTTTTGCACTATCTTGAT TTGTTACAGC AGCCAACTTA TTGGCATGATGGAGTGACAG GAAAAACAGC TGGCATGGAA GATGAAAGAGAAGATGTTCA AAAGAAAACA TTCACAAAAT GGGTAAATGCACAATTTTCT AAGTTTGGGA AGCAGCATAT TGAGAACCTCTTCAGTGACC TACAGGATGG GAGGCGCCTC CTAGACCTCCTCGAAGGCCT GACAGGGCAA AAACTGCCAA AAGAAAAAGGATCCACAAGA GTTCATGCCC TGAACAATGT CAACAAGGCACTGCGGGTTT TGCAGAACAA TAATGTTGAT TTAGTGAATATTGGAAGTAC TGACATCGTA GATGGAAATC ATAAACTGACTCTTGGTTTG ATTTGGAATA TAATCCTCCA CTGGCAGGTCAAAAATGTAA TGAAAAATAT CATGGCTGGA TTGCAACAAACCAACAGTGA AAAGATTCTC CTGAGCTGGG TCCGACAATCAACTCGTAAT TATCCACAGG TTAATGTAAT CAACTTCACCACCAGCTGGT CTGATGGCCT GGCTTTGAAT GCTCTCATCCATAGTCATAG GCCAGACCTA TTTGACTGGA ATAGTGTGGTTTGCCAGCAG TCAGCCACAC AACGACTGGA ACATGCATTCAACATCGCCA GATATCAATT AGGCATAGAG AAACTACTCGATCCTGAAGA TGTTGATACC ACCTATCCAG ATAAGAAGTCCATCTTAATG TACATCACAT CACTCTTCCA AGTTTTGCCTCAACAAGTGA GCATTGAAGC CATCCAGGAA GTGGAAATGTTGCCAAGGCC ACCTAAAGTG ACTAAAGAAG AACATTTTCAGTTACATCAT CAAATGCACT ATTCTCAACA GATCACGGTCAGTCTAGCAC AGGGATATGA GAGAACTTCT TCCCCTAAGCCTCGATTCAA GAGCTATGCC TACACACAGG CTGCTTATGTCACCACCTCT GACCCTACAC GGAGCCCATT TCCTTCACAGCATTTGGAAG CTCCTGAAGA CAAGTCATTT GGCAGTTCATTGATGGAGAG TGAAGTAAAC CTGGACCGTT ATCAAACAGCTTTAGAAGAA GTATTATCGT GGCTTCTTTC TGCTGAGGACACATTGCAAG CACAAGGAGA GATTTCTAAT GATGTGGAAGTGGTGAAAGA CCAGTTTCAT ACTCATGAGG GGTACATGATGGATTTGACA GCCCATCAGG GCCGGGTTGG TAATATTCTACAATTGGGAA GTAAGCTGAT TGGAACAGGA AAATTATCAGAAGATGAAGA AACTGAAGTA CAAGAGCAGA TGAATCTCCTAAATTCAAGA TGGGAATGCC TCAGGGTAGC TAGCATGGAAAAACAAAGCA ATTTACATAG AGTTTTAATG GATCTCCAGAATCAGAAACT GAAAGAGTTG AATGACTGGC TAACAAAAACAGAAGAAAGA ACAAGGAAAA TGGAGGAAGA GCCTCTTGGACCTGATCTTG AAGACCTAAA ACGCCAAGTA CAACAACATAAGGTGCTTCA AGAAGATCTA GAACAAGAAC AAGTCAGGGTCAATTCTCTC ACTCACATGG TGGTGGTAGT TGATGAATCTAGTGGAGATC ACGCAACTGC TGCTTTGGAA GAACAACTTAAGGTATTGGG AGATCGATGG GCAAACATCT GTAGATGGACAGAAGACCGC TGGGTTCTTT TACAAGACAT CCTTCTCAAATGGCAACGTC TTACTGAAGA ACAGTGCCTT TTTAGTGCATGGCTTTCAGA AAAAGAAGAT GCAGTGAACA AGATTCACACAACTGGCTTT AAAGATCAAA ATGAAATGTT ATCAAGTCTTCAAAAACTGG CCGTTTTAAA AGCGGATCTA GAAAAGAAAAAGCAATCCAT GGGCAAACTG TATTCACTCA AACAAGATCTTCTTTCAACA CTGAAGAATA AGTCAGTGAC CCAGAAGACGGAAGCATGGC TGGATAACTT TGCCCGGTGT TGGGATAATTTAGTCCAAAA ACTTGAAAAG AGTACAGCAC AGATTTCACAGGCTGTCACC ACCACTCAGC CATCACTAAC ACAGACAACTGTAATGGAAA CAGTAACTAC GGTGACCACA AGGGAACAGATCCTGGTAAA GCATGCTCAA GAGGAACTTC CACCACCACCTCCCCAAAAG AAGAGGCAGA TTACTGTGGA TTCTGAAATTAGGAAAAGGT TGGATGTTGA TATAACTGAA CTTCACAGCTGGATTACTCG CTCAGAAGCT GTGTTGCAGA GTCCTGAATTTGCAATCTTT CGGAAGGAAG GCAACTTCTC AGACTTAAAAGAAAAAGTCA ATGCCATAGA GCGAGAAAAA GCTGAGAAGTTCAGAAAACT GCAAGATGCC AGCAGATCAG CTCAGGCCCTGGTGGAACAG ATGGTGAATG AGGGTGTTAA TGCAGATAGCATCAAACAAG CCTCAGAACA ACTGAACAGC CGGTGGATCGAATTCTGCCA GTTGCTAAGT GAGAGACTTA ACTGGCTGGAGTATCAGAAC AACATCATCG CTTTCTATAA TCAGCTACAACAATTGGAGC AGATGACAAC TACTGCTGAA AACTGGTTGAAAATCCAACC CACCACCCCA TCAGAGCCAA CAGCAATTAAAAGTCAGTTA AAAATTTGTA AGGATGAAGT CAACCGGCTATCAGGTCTTC AACCTCAAAT TGAACGATTA AAAATTCAAAGCATAGCCCT GAAAGAGAAA GGACAAGGAC CCATGTTCCTGGATGCAGAC TTTGTGGCCT TTACAAATCA TTTTAAGCAAGTCTTTTCTG ATGTGCAGGC CAGAGAGAAA GAGCTACAGACAATTTTTGA CACTTTGCCA CCAATGCGCT ATCAGGAGACCATGAGTGCC ATCAGGACAT GGGTCCAGCA GTCAGAAACCAAACTCTCCA TACCTCAACT TAGTGTCACC GACTATGAAATCATGGAGCA GAGACTCGGG GAATTGCAGG CTTTACAAAGTTCTCTGCAA GAGCAACAAA GTGGCCTATA CTATCTCAGCACCACTGTGA AAGAGATGTC GAAGAAAGCG CCCTCTGAAATTAGCCGGAA ATATCAATCA GAATTTGAAG AAATTGAGGGACGCTGGAAG AAGCTCTCCT CCCAGCTGGT TGAGCATTGTCAAAAGCTAG AGGAGCAAAT GAATAAACTC CGAAAAATTCAGAATCACAT ACAAACCCTG AAGAAATGGA TGGCTGAAGTTGATGTTTTT CTGAAGGAGG AATGGCCTGC CCTTGGGGATTCAGAAATTC TAAAAAAGCA GCTGAAACAG TGCAGACTTTTAGTCAGTGA TATTCAGACA ATTCAGCCCA GTCTAAACAGTGTCAATGAA GGTGGGCAGA AGATAAAGAA TGAAGCAGAGCCAGAGTTTG CTTCGAGACT TGAGACAGAA CTCAAAGAACTTAACACTCA GTGGGATCAC ATGTGCCAAC AGGTCTATGCCAGAAAGGAG GCCTTGAAGG GAGGTTTGGA GAAAACTGTAAGCCTCCAGA AAGATCTATC AGAGATGCAC GAATGGATGACACAAGCTGA AGAAGAGTAT CTTGAGAGAG ATTTTGAATATAAAACTCCA GATGAATTAC AGAAAGCAGT TGAAGAGATGAAGAGAGCTA AAGAAGAGGC CCAACAAAAA GAAGCGAAAGTGAAACTCCT TACTGAGTCT GTAAATAGTG TCATAGCTCAAGCTCCACCT GTAGCACAAG AGGCCTTAAA AAAGGAACTTGAAACTCTAA CCACCAACTA CCAGTGGCTC TGCACTAGGCTGAATGGGAA ATGCAAGACT TTGGAAGAAG TTTGGGCATGTTGGCATGAG TTATTGTCAT ACTTGGAGAA AGCAAACAAGTGGCTAAATG AAGTAGAATT TAAACTTAAA ACCACTGAAAACATTCCTGG CGGAGCTGAG GAAATCTCTG AGGTGCTAGATTCACTTGAA AATTTGATGC GACATTCAGA GGATAACCCAAATCAGATTC GCATATTGGC ACAGACCCTA ACAGATGGCGGAGTCATGGA TGAGCTAATC AATGAGGAAC TTGAGACATTTAATTCTCGT TGGAGGGAAC TACATGAAGA GGCTGTAAGGAGGCAAAAGT TGCTTGAACA GAGCATCCAG TCTGCCCAGGAGACTGAAAA ATCCTTACAC TTAATCCAGG AGTCCCTCACATTCATTGAC AAGCAGTTGG CAGCTTATAT TGCAGACAAGGTGGACGCAG CTCAAATGCC TCAGGAAGCC CAGAAAATCCAATCTGATTT GACAAGTCAT GAGATCAGTT TAGAAGAAATGAAGAAACAT AATCAGGGGA AGGAGGCTGC CCAAAGAGTCCTGTCTCAGA TTGATGTTGC ACAGAAAAAA TTACAAGATGTCTCCATGAA GTTTCGATTA TTCCAGAAAC CAGCCAATTTTGAGCAGCGT CTACAAGAAA GTAAGATGAT TTTAGATGAAGTGAAGATGC ACTTGCCTGC ATTGGAAACA AAGAGTGTGGAACAGGAAGT AGTACAGTCA CAGCTAAATC ATTGTGTGAACTTGTATAAA AGTCTGAGTG AAGTGAAGTC TGAAGTGGAAATGGTGATAA AGACTGGACG TCAGATTGTA CAGAAAAAGCAGACGGAAAA TCCCAAAGAA CTTGATGAAA GAGTAACAGCTTTGAAATTG CATTATAATG AGCTGGGAGC AAAGGTAACAGAAAGAAAGC AACAGTTGGA GAAATGCTTG AAATTGTCCCGTAAGATGCG AAAGGAAATG AATGTCTTGA CAGAATGGCTGGCAGCTACA GATATGGAAT TGACAAAGAG ATCAGCAGTTGAAGGAATGC CTAGTAATTT GGATTCTGAA GTTGCCTGGGGAAAGGCTAC TCAAAAAGAG ATTGAGAAAC AGAAGGTGCACCTGAAGAGT ATCACAGAGG TAGGAGAGGC CTTGAAAACAGTTTTGGGCA AGAAGGAGAC GTTGGTGGAA GATAAACTCAGTCTTCTGAA TAGTAACTGG ATAGCTGTCA CCTCCCGAGCAGAAGAGTGG TTAAATCTTT TGTTGGAATA CCAGAAACACATGGAAACTT TTGACCAGAA TGTGGACCAC ATCACAAAGTGGATCATTCA GGCTGACACA CTTTTGGATG AATCAGAGAAAAAGAAACCC CAGCAAAAAG AAGACGTGCT TAAGCGTTTAAAGGCAGAAC TGAATGACAT ACGCCCAAAG GTGGACTCTACACGTGACCA AGCAGCAAAC TTGATGGCAA ACCGCGGTGACCACTGCAGG AAATTAGTAG AGCCCCAAAT CTCAGAGCTCAACCATCGAT TTGCAGCCAT TTCACACAGA ATTAAGACTGGAAAGGCCTC CATTCCTTTG AAGGAATTGG AGCAGTTTAACTCAGATATA CAAAAATTGC TTGAACCACT GGAGGCTGAAATTCAGCAGG GGGTGAATCT GAAAGAGGAA GACTTCAATAAAGATATGAA TGAAGACAAT GAGGGTACTG TAAAAGAATTGTTGCAAAGA GGAGACAACT TACAACAAAG AATCACAGATGAGAGAAAGC GAGAGGAAAT AAAGATAAAA CAGCAGCTGTTACAGACAAA ACATAATGCT CTCAAGGATT TGAGGTCTCAAAGAAGAAAA AAGGCTCTAG AAATTTCTCA TCAGTGGTATCAGTACAAGA GGCAGGCTGA TGATCTCCTG AAATGCTTGGATGACATTGA AAAAAAATTA GCCAGCCTAC CTGAGCCCAGAGATGAAAGG AAAATAAAGG AAATTGATCG GGAATTGCAGAAGAAGAAAG AGGAGCTGAA TGCAGTGCGT AGGCAAGCTGAGGGCTTGTC TGAGGATGGG GCCGCAATGG CAGTGGAGCCAACTCAGATC CAGCTCAGCA AGCGCTGGCG GGAAATTGAGAGCAAATTTG CTCAGTTTCG AAGACTCAAC TTTGCACAAATTCACACTGT CCGTGAAGAA ACGATGATGG TGATGACTGAAGACATGCCT TTGGAAATTT CTTATGTGCC TTCTACTTATTTGACTGAAA TCACTCATGT CTCACAAGCC CTATTAGAAGTGGAACAACT TCTCAATGCT CCTGACCTCT GTGCTAAGGACTTTGAAGAT CTCTTTAAGC AAGAGGAGTC TCTGAAGAATATAAAAGATA GTCTACAACA AAGCTCAGGT CGGATTGACATTATTCATAG CAAGAAGACA GCAGCATTGC AAAGTGCAACGCCTGTGGAA AGGGTGAAGC TACAGGAAGC TCTCTCCCAGCTTGATTTCC AATGGGAAAA AGTTAACAAA ATGTACAAGGACCGACAAGG GCGATTTGAC AGATCTGTTG AGAAATGGCGGCGTTTTCAT TATGATATAA AGATATTTAA TCAGTGGCTAACAGAAGCTG AACAGTTTCT CAGAAAGACA CAAATTCCTGAGAATTGGGA ACATGCTAAA TACAAATGGT ATCTTAAGGAACTCCAGGAT GGCATTGGGC AGCGGCAAAC TGTTGTCAGAACATTGAATG CAACTGGGGA AGAAATAATT CAGCAATCCTCAAAAACAGA TGCCAGTATT CTACAGGAAA AATTGGGAAGCCTGAATCTG CGGTGGCAGG AGGTCTGCAA ACAGCTGTCAGACAGAAAAA AGAGGCTAGA AGAACAAAAG AATATCTTGTCAGAATTTCA AAGAGATTTA AATGAATTTG TTTTATGGTTGGAGGAAGCA GATAACATTG CTAGTATCCC ACTTGAACCTGGAAAAGAGC AGCAACTAAA AGAAAAGCTT GAGCAAGTCAAGTTACTGGT GGAAGAGTTG CCCCTGCGCC AGGGAATTCTCAAACAATTA AATGAAACTG GAGGACCCGT GCTTGTAAGTGCTCCCATAA GCCCAGAAGA GCAAGATAAA CTTGAAAATAAGCTCAAGCA GACAAATCTC CAGTGGATAA AGGTTTCCAGAGCTTTACCT GAGAAACAAG GAGAAATTGA AGCTCAAATAAAAGACCTTG GGCAGCTTGA AAAAAAGCTT GAAGACCTTGAAGAGCAGTT AAATCATCTG CTGCTGTGGT TATCTCCTATTAGGAATCAG TTGGAAATTT ATAACCAACC AAACCAAGAAGGACCATTTG ACGTTCAGGA AACTGAAATA GCAGTTCAAGCTAAACAACC GGATGTGGAA GAGATTTTGT CTAAAGGGCAGCATTTGTAC AAGGAAAAAC CAGCCACTCA GCCAGTGAAGAGGAAGTTAG AAGATCTGAG CTCTGAGTGG AAGGCGGTAAACCGTTTACT TCAAGAGCTG AGGGCAAAGC AGCCTGACCTAGCTCCTGGA CTGACCACTA TTGGAGCCTC TCCTACTCAGACTGTTACTC TGGTGACACA ACCTGTGGTT ACTAAGGAAACTGCCATCTC CAAACTAGAA ATGCCATCTT CCTTGATGTTGGAGGTACCT GCTCTGGCAG ATTTCAACCG GGCTTGGACAGAACTTACCG ACTGGCTTTC TCTGCTTGAT CAAGTTATAAAATCACAGAG GGTGATGGTG GGTGACCTTG AGGATATCAACGAGATGATC ATCAAGCAGA AGGCAACAAT GCAGGATTTGGAACAGAGGC GTCCCCAGTT GGAAGAACTC ATTACCGCTGCCCAAAATTT GAAAAACAAG ACCAGCAATC AAGAGGCTAGAACAATCATT ACGGATCGAA TTGAAAGAAT TCAGAATCAGTGGGATGAAG TACAAGAACA CCTTCAGAAC CGGAGGCAACAGTTGAATGA AATGTTAAAG GATTCAACAC AATGGCTGGAAGCTAAGGAA GAAGCTGAGC AGGTCTTAGG ACAGGCCAGAGCCAAGCTTG AGTCATGGAA GGAGGGTCCC TATACAGTAGATGCAATCCA AAAGAAAATC ACAGAAACCA AGCAGTTGGCCAAAGACCTC CGCCAGTGGC AGACAAATGT AGATGTGGCAAATGACTTGG CCCTGAAACT TCTCCGGGAT TATTCTGCAGATGATACCAG AAAAGTCCAC ATGATAACAG AGAATATCAATGCCTCTTGG AGAAGCATTC ATAAAAGGGT GAGTGAGCGAGAGGCTGCTT TGGAAGAAAC TCATAGATTA CTGCAACAGTTCCCCCTGGA CCTGGAAAAG TTTCTTGCCT GGCTTACAGAAGCTGAAACA ACTGCCAATG TCCTACAGGA TGCTACCCGTAAGGAAAGGC TCCTAGAAGA CTCCAAGGGA GTAAAAGAGCTGATGAAACA ATGGCAAGAC CTCCAAGGTG AAATTGAAGCTCACACAGAT GTTTATCACA ACCTGGATGA AAACAGCCAAAAAATCCTGA GATCCCTGGA AGGTTCCGAT GATGCAGTCCTGTTACAAAG ACGTTTGGAT AACATGAACT TCAAGTGGAGTGAACTTCGG AAAAAGTCTC TCAACATTAG GTCCCATTTGGAAGCCAGTT CTGACCAGTG GAAGCGTCTG CACCTTTCTCTGCAGGAACT TCTGGTGTGG CTACAGCTGA AAGATGATGAATTAAGCCGG CAGGCACCTA TTGGAGGCGA CTTTCCAGCAGTTCAGAAGC AGAACGATGT ACATAGGGCC TTCAAGAGGGAATTGAAAAC TAAAGAACCT GTAATCATGA GTACTCTTGAGACTGTACGA ATATTTCTGA CAGAGCAGCC TTTGGAAGGACTAGAGAAAC TCTACCAGGA GCCCAGAGAG CTGCCTCCTGAGGAGAGAGC CCAGAATGTC ACTCGGCTTC TACGAAAGCAGGCTGAGGAG GTCAATACTG AGTGGGAAAA ATTGAACCTGCACTCCGCTG ACTGGCAGAG AAAAATAGAT GAGACCCTTGAAAGACTCCA GGAACTTCAA GAGGCCACGG ATGAGCTGGACCTCAAGCTG CGCCAAGCTG AGGTGATCAA GGGATCCTGGCAGCCCGTGG GCGATCTCCT CATTGACTCT CTCCAAGATCACCTCGAGAA AGTCAAGGCA CTTCGAGGAG AAATTGCGCCTCTGAAAGAG AACGTGAGCC ACGTCAATGA CCTTGCTCGCCAGCTTACCA CTTTGGGCAT TCAGCTCTCA CCGTATAACCTCAGCACTCT GGAAGACCTG AACACCAGAT GGAAGCTTCTGCAGGTGGCC GTCGAGGACC GAGTCAGGCA GCTGCATGAAGCCCACAGGG ACTTTGGTCC AGCATCTCAG CACTTTCTTTCCACGTCTGT CCAGGGTCCC TGGGAGAGAG CCATCTCGCCAAACAAAGTG CCCTACTATA TCAACCACGA GACTCAAACAACTTGCTGGG ACCATCCCAA AATGACAGAG CTCTACCAGTCTTTAGCTGA CCTGAATAAT GTCAGATTCT CAGCTTATAGGACTGCCATG AAACTCCGAA GACTGCAGAA GGCCCTTTGCTTGGATCTCT TGAGCCTGTC AGCTGCATGT GATGCCTTGGACCAGCACAA CCTCAAGCAA AATGACCAGC CCATGGATATCCTGCAGATT ATTAATTGTT TGACCACTAT TTATGACCGCCTGGAGCAAG AGCACAACAA TTTGGTCAAC GTCCCTCTCTGCGTGGATAT GTGTCTGAAC TGGCTGCTGA ATGTTTATGATACGGGACGA ACAGGGAGGA TCCGTGTCCT GTCTTTTAAAACTGGCATCA TTTCCCTGTG TAAAGCACAT TTGGAAGACAAGTACAGATA CCTTTTCAAG CAAGTGGCAA GTTCAACAGGATTTTGTGAC CAGCGCAGGC TGGGCCTCCT TCTGCATGATTCTATCCAAA TTCCAAGACA GTTGGGTGAA GTTGCATCCTTTGGGGGCAG TAACATTGAG CCAAGTGTCC GGAGCTGCTTCCAATTTGCT AATAATAAGC CAGAGATCGA AGCGGCCCTCTTCCTAGACT GGATGAGACT GGAACCCCAG TCCATGGTGTGGCTGCCCGT CCTGCACAGA GTGGCTGCTG CAGAAACTGCCAAGCATCAG GCCAAATGTA ACATCTGCAA AGAGTGTCCAATCATTGGAT TCAGGTACAG GAGTCTAAAG CACTTTAATTATGACATCTG CCAAAGCTGC TTTTTTTCTG GTCGAGTTGCAAAAGGCCAT AAAATGCACT ATCCCATGGT GGAATATTGCACTCCGACTA CATCAGGAGA AGATGTTCGA GACTTTGCCAAGGTACTAAA AAACAAATTT CGAACCAAAA GGTATTTTGCGAAGCATCCC CGAATGGGCT ACCTGCCAGT GCAGACTGTCTTAGAGGGGG ACAACATGGA AACTCCCGTT ACTCTGATCAACTTCTGGCC AGTAGATTCT GCGCCTGCCT CGTCCCCTCAGCTTTCACAC GATGATACTC ATTCACGCAT TGAACATTATGCTAGCAGGC TAGCAGAAAT GGAAAACAGC AATGGATCTTATCTAAATGA TAGCATCTCT CCTAATGAGA GCATAGATGATGAACATTTG TTAATCCAGC ATTACTGCCA AAGTTTGAACCAGGACTCCC CCCTGAGCCA GCCTCGTAGT CCTGCCCAGATCTTGATTTC CTTAGAGAGT GAGGAAAGAG GGGAGCTAGAGAGAATCCTA GCAGATCTTG AGGAAGAAAA CAGGAATCTGCAAGCAGAAT ATGACCGTCT AAAGCAGCAG CACGAACATAAAGGCCTGTC CCCACTGCCG TCCCCTCCTG AAATGATGCCCACCTCTCCC CAGAGTCCCC GGGATGCTGA GCTCATTGCTGAGGCCAAGC TACTGCGTCA ACACAAAGGC CGCCTGGAAGCCAGGATGCA AATCCTGGAA GACCACAATA AACAGCTGGAGTCACAGTTA CACAGGCTAA GGCAGCTGCT GGAGCAACCCCAGGCAGAGG CCAAAGTGAA TGGCACAACG GTGTCCTCTCCTTCTACCTC TCTACAGAGG TCCGACAGCA GTCAGCCTATGCTGCTCCGA GTGGTTGGCA GTCAAACTTC GGACTCCATGGGTGAGGAAG ATCTTCTCAG TCCTCCCCAG GACACAAGCACAGGGTTAGA GGAGGTGATG GAGCAACTCA ACAACTCCTTCCCTAGTTCA AGAGGAAGAA ATACCCCTGG AAAGCCAATGAGAGAGGACA CAATGTAGGA AGTCTTTTCC ACATGGCAGATGATTTGGGC AGAGCGATGG AGTCCTTAGT ATCAGTCATGACAGATGAAG AAGGAGCAGA ATAAATGTTT TACAACTCCTGATTCCCGCA TGGTTTTTAT AATATTCATA CAACAAAGAGGATTAGACAG TAAGAGTTTA CAAGAAATAA ATCTATATTTTTGTGAAGGG TAGTGGTATT ATACTGTAGA TTTCAGTAGTTTCTAAGTCT GTTATTGTTT TGTTAACAAT GGCAGGTTTTACACGTCTAT GCAATTGTAC AAAAAAGTTA TAAGAAAACTACATGTAAAA TCTTGATAGC TAAATAACTT GCCATTTCTTTATATGGAAC GCATTTTGGG TTGTTTAAAA ATTTATAACAGTTATAAAGA AAGATTGTAA ACTAAAGTGT GCTTTATAAAAAAAAGTTGT TTATAAAAAC CCCTAAAAAC AAAACAAACACACACACACA CACATACACA CACACACACA AAACTTTGAGGCAGCGCATT GTTTTGCATC CTTTTGGCGT GATATCCATATGAAATTCAT GGCTTTTTCT TTTTTTGCAT ATTAAAGATAAGACTTCCTC TACCACCACA CCAAATGACT ACTACACACTGCTCATTTGA GAACTGTCAG CTGAGTGGGG CAGGCTTGAGTTTTCATTTC ATATATCTAT ATGTCTATAA GTATATAAATACTATAGTTA TATAGATAAA GAGATACGAA TTTCTATAGACTGACTTTTT CCATTTTTTA AATGTTCATG TCACATCCTAATAGAAAGAA ATTACTTCTA GTCAGTCATC CAGGCTTACCTGCTTGGTCT AGAATGGATT TTTCCCGGAG CCGGAAGCCAGGAGGAAACT ACACCACACT AAAACATTGT CTACAGCTCCAGATGTTTCT CATTTTAAAC AACTTTCCAC TGACAACGAAAGTAAAGTAA AGTATTGGAT TTTTTTAAAG GGAACATGTGAATGAATACA CAGGACTTAT TATATCAGAG TGAGTAATCGGTTGGTTGGT TGATTGATTG ATTGATTGAT ACATTCAGCTTCCTGCTGCT AGCAATGCCA CGATTTAGAT TTAATGATGCTTCAGTGGAA ATCAATCAGA AGGTATTCTG ACCTTGTGAACATCAGAAGG TATTTTTTAA CTCCCAAGCA GTAGCAGGACGATGATAGGG CTGGAGGGCT ATGGATTCCC AGCCCATCCCTGTGAAGGAG TAGGCCACTC TTTAAGTGAA GGATTGGATGATTGTTCATA ATACATAAAG TTCTCTGTAA TTACAACTAAATTATTATGC CCTCTTCTCA CAGTCAAAAG GAACTGGGTGGTTTGGTTTT TGTTGCTTTT TTAGATTTAT TGTCCCATGTGGGATGAGTT TTTAAATGCC ACAAGACATA ATTTAAAATAAATAAACTTT GGGAAAAGGT GTAAAACAGT AGCCCCATCACATTTGTGAT ACTGACAGGT ATCAACCCAG AAGCCCATGAACTGTGTTTC CATCCTTTGC ATTTCTCTGC GAGTAGTTCCACACAGGTTT GTAAGTAAGT AAGAAAGAAG GCAAATTGATTCAAATGTTA CAAAAAAACC CTTCTTGGTG GATTAGACAGGTTAAATATA TAAACAAACA AACAAAAATT GCTCAAAAAAGAGGAGAAAA GCTCAAGAGG AAAAGCTAAG GACTGGTAGGAAAAAGCTTT ACTCTTTCAT GCCATTTTAT TTCTTTTTGATTTTTAAATC ATTCATTCAA TAGATACCAC CGTGTGACCTATAATTTTGC AAATCTGTTA CCTCTGACAT CAAGTGTAATTAGCTTTTGG AGAGTGGGCT GACATCAAGT GTAATTAGCTTTTGGAGAGT GGGTTTTGTC CATTATTAAT AATTAATTAATTAACATCAA ACACGGCTTC TCATGCTATT TCTACCTCACTTTGGTTTTG GGGTGTTCCT GATAATTGTG CACACCTGAGTTCACAGCTT CACCACTTGT CCATTGCGTT ATTTTCTTTTTCCTTTATAA TTCTTTCTTT TTCCTTCATA ATTTTCAAAAGAAAACCCAA AGCTCTAAGG TAACAAATTA CCAAATTACATGAAGATTTG GTTTTTGTCT TGCATTTTTT TCCTTTATGTGACGCTGGAC CTTTTCTTTA CCCAAGGATT TTTAAAACTCAGATTTAAAA CAAGGGGTTA CTTTACATCC TACTAAGAAGTTTAAGTAAG TAAGTTTCAT TCTAAAATCA GAGGTAAATAGAGTGCATAA ATAATTTTGT TTTAATCTTT TTGTTTTTCTTTTAGACACA TTAGCTCTGG AGTGAGTCTG TCATAATATTTGAACAAAAA TTGAGAGCTT TATTGCTGCA TTTTAAGCATAATTAATTTG GACATTATTT CGTGTTGTGT TCTTTATAACCACCAAGTAT TAAACTGTAA ATCATAATGT AACTGAAGCATAAACATCAC ATGGCATGTT TTGTCATTGT TTTCAGGTACTGAGTTCTTA CTTGAGTATC ATAATATATT GTGTTTTAACACCAACACTG TAACATTTAC GAATTATTTT TTTAAACTTCAGTTTTACTG CATTTTCACA ACATATCAGA CTTCACCAAATATATGCCTT ACTATTGTAT TATAGTACTG CTTTACTGTGTATCTCAATA AAGCACGCAG TTATGTTAC DNAJC9 NM_015190.4GGATGCGCGG CGTGGCCACG CCCCTTCAGT GCTTGTGACG 9CAGGCGCCCT GGGCTTTTTG GGCGCGAAAA AGAAGCAGTCCTGGGTTGTA CCCGGCGCAG CTGGGAGCGG CTGCTTCCTCCGGGGTCGTA TCTCCGCCCG GCATGGGGCT GCTGGACCTTTGCGAGGAAG TGTTCGGCAC CGCCGACCTT TACCGGGTGCTGGGCGTGCG ACGCGAGGCC TCCGACGGCG AGGTCCGACGAGGCTACCAC AAGGTGTCCC TGCAGGTACA CCCGGACCGGGTGGGTGAGG GCGACAAGGA GGACGCCACC CGCCGCTTCCAGATCCTGGG AAAAGTCTAT TCCGTTCTCA GTGACAGAGAACAGAGAGCA GTGTACGATG AGCAGGGAAC AGTGGACGAGGACTCTCCTG TGCTCACCCA AGACCGAGAC TGGGAGGCGTATTGGCGGCT ACTCTTTAAA AAGATATCTT TAGAGGACATTCAAGCTTTT GAAAAGACAT ACAAAGGTTC GGAAGAAGAGCTGGCTGATA TTAAGCAGGC CTATCTGGAC TTCAAGGGTGACATGGATCA GATCATGGAG TCTGTGCTTT GCGTGCAGTACACAGAGGAA CCCAGGATAA GGAATATCAT TCAGCAAGCTATTGACGCCG GAGAGGTCCC ATCCTATAAT GCCTTTGTCAAAGAATCGAA ACAAAAGATG AATGCAAGGA AAAGGAGGGCTCAGGAAGAG GCCAAAGAAG CAGAAATGAG CAGAAAGGAGTTGGGGCTTG ATGAAGGCGT GGATAGCCTG AAGGCAGCCATTCAGAGCAG ACAAAAGGAT CGGCAAAAGG AAATGGACAATTTTCTGGCT CAGATGGAAG CAAAGTACTG CAAATCTTCCAAAGGAGGAG GGAAAAAATC TGCTCTCAAG AAAGAAAAGAAATAATGGAA TTTTTCTCTT CAAAGGTCCT TAGGTGTAAATTGATGCCAT CGTAGGCAAG GTGCAGGCAG GATTTGAAGGCAAAAGTCAA TTCAGCTCTT GAGAAAAGGT GTCTTTCCAGCCTGAATTTT TCAGATTGAC TAGACCAAGC AGAATCTCTCAACCTGATCT TAGTATTTCC TAGAAAGCAC TTGACATTGTGTGAGGTCTC ACCTGAAGGA ACTTGGTGGT GACATTTGGGAGGGTGGAGG GAGGCAGTGT CCTTCCTGAC AGCACTTGCCTCCATGGATC TTCTGTACAC AGAACTCTTA TCTAGGATGTGGTTCTGTTC ATGCTGCTTT CTGCGATGTG CGTGTCTGTTAGAATAGGCT CTCTACCCAG CTAGAACACC TTCCAGACACTTGCTGGACA GCTATCTTCC ACATACTTCC CAGTTTACATTTGGTCTTAA TGATCTTGAA TAGATCCTCT CTTCATTTTACTCAGCCAGG TTTTGTACTG ATGTACAGGT GTTAAATTACTTCAAGCATT TTTGTAAGAG GTGTATATAA TTCAATAAAAAAGGTAAAAC ATGATGATTA AGTTCTGGGG GCTTTGTAAATGATCCCACT AAAATGTGAC CTAGGAAAAA TATGAATGGTGTTTAGGATG AGAGAAAAGG GGAAAACAAT AGCCCTGGTCAGCTTTATAA TAGAGAGCCT GGTTTCCCTA GCATGAAGAGATGTATGTTG TAGTCCTGCC ACTGATTACT GAAGTCCTGCCATTAATTGC TGAATGTCTT CAGTTGGGCC ACTGAGCTTGTCTGAATCTG TTCCCTTTTA TAAAAGAGTT ACTACATCAAAACAAAGAGT GAAATCCAAA TTTGTCAAAC TGTATGTATTAAACATGTCC AGTTTTTTGG TTAAAAAAAA ATTGCACTGGCTTTGAGGGA AAACACACAG GGTGAGGGAA TTGGGCTAAATGACTTCTTA CAGGCCCCTT TCTGATTCTT TAACTTTGAAAGGCAAGCCA TATTGATCCA GTTGTTATAG TGAACTCATGGTAATGGTTT GTGAGAACAA TAGAGATTTT CATTTCTATGTAGATGAGTT GGTATGAGAA TATATGGAAT TTTTAAGGGACTGTTTAAAT CTTTGATTTG TAGACTATTA AATATACCGTATGCATAAAG TAAGCCTTTA GCTCTAAGGT AAAGACGACACGTTTTCGGT TTGTGACTAC AAATAGGTTA AAAATAGATTTTAATTTTAT TAAAAATATA ATTTAATGCA GGTTGTTTGAAGCATCTGTC TTCATATGAT GGCATTAGAA CACCTTGGTATAATAAAAAG TTACCGTAAT TTATGATTAT TTGAATTTATCCATTCTGAA AATTAATAAG ATCTAAAACT GGCATGACAATCAAGATTTG TATTTAGTGA AATTTAAAAT AAATGTAAGC CATAGTTAAA AAAAAAAAAA AAAAAENOSF1 NM_001126123.3 CGCCCTCCCG CCGCGCGCTC GGGATCCCGA CCAGTCCTGA 10CCGCACGGGG GCCGCGGCCA CGGGGCGCAG GGGCCATGGTGCGCGGCAGG ATCTCCCGGC TCTCGGTCCG GGACGTGCGCTTCCCCACGT CGCTTGGGGG CCACGGCGCG GACGCCATGCACACGGACCC TGACTACTCG GCTGCCTATG TCGTCATAGAAACTGATGCA GAAGATGGAA TCAAGGGGTG TGGAATTACCTTCACTCTGG GAAAAGGCAC TGAAGTTGAT TGGTCCAGAAAAGGGCGTGG TGCACCTGGC GACAGCGGCC GTCCTAAACGCGGTGTGGGA CTTGTGGGCC AAGCAGGAGG GAAAGCCTGTCTGGAAGTTA CTTGTGGACA TGGATCCCAG GATGCTGGTATCCTGCATAG ATTTCAGGTA CATCACTGAT GTCCTGACTGAGGAGGATGC CCTAGAAATA CTGCAGAAAG GTCAAATTGGTAAAAAAGAA AGAGAGAAGC AAATGCTGGC ACAAGGATACCCTGCTTACA CGACATCGTG CGCCTGGCTG GGGTACTCAGATGACACGTT GAAGCAGCTC TGTGCCCAGG CGCTGAAGGATGGCTGGACC AGGTTTAAAG TAAAGGTGGG TGCTGATCTCCAGGATGACA TGCGAAGATG CCAAATCATC CGAGACATGATTGGACCGGA AAAGACTTTG ATGATGGATG CCAACCAGCGCTGGGATGTG CCTGAGGCGG TGGAGTGGAT GTCCAAGCTGGCCAAGTTCA AGCCATTGTG GATTGAGGAG CCAACCTCCCCTGATGACAT TCTGGGGCAC GCCACCATTT CCAAGGCACTGGTCCCATTA GGAATTGGCA TTGCCACAGG AGAACAGTGCCACAATAGAG TGATATTTAA GCAACTCCTA CAGGCGAAGGCCCTGCAGTT CCTCCAGATT GACAGTTGCA GACTGGGCAGTGTCAATGAG AACCTCTCAG TATTGCTGAT GGCCAAAAAGTTTGAAATTC CTGTTTGCCC CCATGCTGGT GGAGTTGGCCTCTGTGAACT GGTGCAGCAC CTGATTATAT TTGACTACATATCAGTTTCT GCAAGCCTTG AAAATAGGGT GTGTGAGTATGTTGACCACC TGCATGAGCA TTTCAAGTAT CCCGTGATGATCCAGCGGGC TTCCTACATG CCTCCCAAGG ATCCCGGCTACTCAACAGAA ATGAAGGAGG AATCTGTAAA GAAACACCAGTATCCAGATG GTGAAGTTTG GAAGAAACTC CTTCCTGCTCAAGAAAATTA AGTGCTCAGC CCCAACAACT TTTTTCTTTCTGAAGTGAAA GGGCTTAAAA TTTCTTGGAA ATAGTTTTACAAAAATGGAT TTAAAAAATC CTACCGATCA AGATGAGTTCAGCTAGAAGT CATACCACCC TCAGGAATCA GCTAAAGCAAAAAGAACTTT TACCTCGGCA TCCAGCCCAA CCCCTAAAGACTGACAATAT CCTTCGAGCT CCTTTGAAAG CACCCTAAACAGCCATTTCC ATTTTAATAG TTGGATGCGG ATTGTACCCTTCAATCTGAA AGTCTTCAGC TTTGAAGTCA TCAATTTTCTCAACTTTTCG AAGAATCCTG AGCTTTGGGA AAGGTCTGGGTTCTCGCTGA AGCTAAAAAC AAAATAAGGC CATTATTTTGCCATAATTGT ACGACCTGTT GTAATTGCTC CTCATGTCCGTGAAACAAGT ACACAGGATG TGATCAACAA AGTTCTATTTTACAGGAGTA TGATCCTGTC GATACCTTGC CGTAGGTTATGTAACATGAT TGGAGCGCAA CCAGCTGTTC TCTTGCACAGATCGAGAGTG AGGGGTATTT TGTGACATTA CACAGCATCAGGAGCCTGGT GCCTCATCAG GTGTAAGTTC TTATAACCACTCTTGGCAAA TTTATTAAAG ACAGGAACAC AGTCAATCTGTAACTCATAG TAGCTCTACG TTTACTTGAA TTCCACAATCCCTAACCCAT CTGTCCCTGG CAGAAAGAAG GAAAGATGACATGCATGGAC AGTGAACAGA AAGGGATGAA AGCCAGGATTCCTGGGATGA ACAGACAGTG GCAATTAGGA TGTGAAGACAGGTCACAACC TATTACTATG TCTAAAAACG ACCAGAGCAGAGAGCCAGAG AGAATAAGCC TGAAGTCACC TCCACTCAAAAGCAGCCAAA CTCCCTCAAA GGAGTAACTT TTAAAACCTGGATCTAACCT GGAAGGGGCT AAAAAGTGTC TGGTTCTGAGTTTTTTTCCT TAAGGCTCAT GAAGCAGATG AACTTACATTTTTATTGCCA TTTCATATCA ATTGTTGGCT GCTATAACTTAGGGATTTCA ACAGACTTTT GAAGTTTGGA CCTAAATATTGTACTTAATG TAAAATTAAC AAAAAATATT TATGGCCAGGGTGGTGGCTT ATGCCTGTAA TTCCAGAATT TTCGGAGGCTGAGGCAGGTG GATCACTTGA AGTCAGGAGT TTGAGACTAGCCTGGCCAAC ATGATGAAAC CCCATCTCTA CTAATAATACAAAAATTAGC TGGGTGTGGT GGCATGTGCC TGTAATCCCAGCTACCTGGG AGGCTGAGGC AGAAGAATTG CTTGAACCCGGGAGGTGGAG GTTGCAGTGA GCTGAGATCG CACCACGGCACACTCCAGCC TGGCCGACAG AGAAAGACTC CATCTCAAAAAAAAAAGAAA AGGAAAAACA TTTGCACTTC AATTCTCCTTCAAGTTAAAA TGAGTTAAAA TGCCCCCTTT TGGACAATCCCCTGGCTTGA ATGTGGCTCT TCCCTCTCTG GTACTGGTGCTTAGTACCTC ACAGCACCTG ACATGTTAAG TGCCCATGGTTGCTGAGGCA GATGCCTGCC TTGTCCTGCC CACCTGCCCACCACTTCTCC CTAAACTGAA GCCCCACATT TGGAGCAGTCATCTTTATCT TGGACACAGC ATTGAGCAGA TGCCTGTTCCACAGTCAACC TTTTATCAAG AGAAGGTACC AAACCCAAAAGTATAACATC TAATTCTTAC CTGAATTTTC AGTGGCTCGATGTGATTCAG GTAAATATGT GCATCTCCCA AAGTGTGTATAAAGTCACCT GGCTATAAAC CCGGGGGAGA AAGCAGAACAGTATGTTAGT TTCAATTCTT TAAAACATCA TTTAAAAACATTAGAATATG CAGACACCGC AAGGCTTTTT TTAAAAAAATAATTTAGTGT AGCTTTTCCA TTTTTTTGTA GCAACAGCATCTTGTTATGT TGCCCAGGCT GGTATTGAAC TCCAGACCTCAAGCAATTGC TCCTGTCTCA GTCTCCCAAA GTGCTGGGATTACAGGCATG AGCCACCATA CCCAACCTCA GCATAGCTTTTGAGAAAATC CATAGAAGCT GTATCACAAA CAACCTGTATAGATCTGTTA GTGCGTATAC CACAGGGCCA GAAAACCTTCCAGAAGAGGA AGGTTTCAAA GTAAAAGCTG GTTCATTTCTTACTTACACA TATCAAATTT AAAAGCTAAT CAGAGACTAAACTCTGCAAT TTGTTTTCCC ATATTAAAGA ACTGAAGAGCTCAGTGTGGT AGGCTGGCAA GTCACCCTTC CCGAGACAGCCCACCTTCAG GCCCGTGATG TGCGCAATCA TGTACGTGAGCAGGGCGTAG CTGGCGATGT TGAAAGGCAC ACCGAGGCCCATGTCTCCCG ATCTCTGGTA CAGCTGGCAG GACAGCTCACTGTTCACCAC ATAGAACTGG CAGAGGGCAT GGCATGGAGGCAGCGCCATC AGAGGAAGAT CTGAGGAACC AGCAGAGGAAGATAAGGAGG GATGGTGGTT TGAAAGACCA CAGCTAAAGGCAAAGTAAAA CAGGAGAGAA ACAGAAGCCA ACTCATATGGTGGAGACCAG GAGAGAGAGC CACTGGGCTG CAGTGATGTCCATAACAGCC TCTGCAGCGA TGGCACGGAG CTGAGGGAGACTATCCATCG GTGCAAGGTT TCTGCAGGTG TCCATTTACGGCTGAAGCAA TGCTCTTCCA TCAGAGCTGA AGGGATCTGGGCTACCTCGT GGCACCAGAT TACAAATACA GCAGGAATAATTCTGTTTGC CACAGGAAAC TGGTGCTTCT GGTACACCCTCCTATATTAA AAGTCTCTAT TACATGGCAA AAAAAAAAAA AAAAAA FANCL NM_001114636.1AGCGGACTGC GCATGTGCAG GACCCAGCAG GTCTAGAGCT 11TTTCTGTGTT TCTCCGGACT TCGAGCCATG GCGGTGACGGAAGCGAGCCT GTTGCGCCAG TGCCCCCTGC TTCTGCCCCAGAACCGGTCG AAAACCGTGT ATGAGGGATT CATCTCGGCTCAGGGAAGAG ACTTCCACCT TAGGATAGTG TTGCCTGAAGATTTACAACT GAAGAATGCA AGATTATTAT GTAGTTGGCAGCTGAGAACA ATACTTAGTG GATACCATCG AATAGTACAACAGAGAATGC AGCACTCTCC TGATCTAATG AGCTTTATGATGGAGTTGAA GATGCTTTTG GAAGTTGCCT TAAAGAATAGACAAGAGCTG TATGCACTAC CTCCTCCTCC CCAGTTCTACTCAAGCCTTA TTGAAGAGAT AGGAACTCTT GGTTGGGATAAACTTGTGTA TGCGGATACC TGCTTCAGTA CCATCAAGTTAAAAGCAGAA GATGCTTCTG GTAGAGAGCA TTTAATCACTCTCAAGTTGA AGGCAAAGTA TCCTGCAGAA TCACCAGATTATTTTGTGGA TTTTCCTGTT CCATTTTGTG CCTCCTGGACACCTCAGGTA AATTCTCCTC AGAGCTCCTT AATAAGCATTTATAGTCAGT TTTTGGCAGC AATAGAATCA CTAAAGGCATTCTGGGATGT TATGGATGAA ATCGATGAGA AGACCTGGGTACTTGAGCCA GAAAAACCTC CACGGAGTGC AACAGCACGCAGAATTGCAT TAGGTAATAA TGTTTCCATA AATATAGAGGTAGACCCCAG GCATCCTACT ATGCTTCCTG AGTGCTTCTTTCTTGGAGCT GACCATGTGG TAAAACCCCT GGGAATTAAGCTGAGCAGGA ACATACATTT GTGGGATCCA GAAAATAGTGTGTTACAAAA TTTGAAAGAT GTTTTAGAAA TTGATTTTCCAGCTCGTGCT ATCCTGGAAA AATCTGATTT TACTATGGATTGTGGAATTT GTTATGCTTA TCAACTTGAC GGTACCATTCCTGATCAAGT GTGTGATAAT TCTCAGTGTG GACAACCTTTCCATCAAATA TGCTTATATG AGTGGCTGAG AGGACTACTAACTAGTAGAC AGAGTTTTAA CATCATATTT GGTGAATGTCCATATTGTAG TAAGCCAATT ACCTTAAAAA TGTCTGGAAGGAAACACTGA AATAAGAATA CAACATTTCG GTGAAGAGCTGGAAACTTAA AAAATTATCA AAAGGAATTT TGGTATCATCTTCAGAGAAA AAATAAAGCA AGAAATACTA ACATCAAAAGGACAGGTATG ATGATGCGAT AATAATAAAC ATCTGCGTTTGTCTCTTCAC TAAGAGTAAA CTGGGAAATT GTAGGCCAAAGTCCAGTTGA ACTTTCTAAG TCTGTGATCC CCGTGCTGACTGTGGAAGTG TATTTATACC AAGATGGAGA TCTTGACTTCTTGAATATAT CTGGACTGGT AAAATCTTGA TGAGGCTCATAAAATGAGTT TGGGAATTGT GTATAGCTGA TTTTTTGTGGGAAACTGTTT ACTTCATTCA AAGGTTCTTG AGACTCTTGATATTTCTGTC TTCTCCTTGT GCTTTCCTAT GGAAAAAATACATATATAGT TTAGTTTGTT AGACGTGAGT TATCCAAGTATTTATTTTGT GTAGTGTGTA AGAATGCTAA ATAAAATGTTATACAAGATC AAAAAAAAAA AAAAAAAAAA AAA HJURP NM_018410.4CTATTTGAGT TTGTGGCGCG CGAGGCCCTG CAGTCCGGGT 12TGGCGCTTGG GTACTGGCTG GGTCCGATGC TGGGTACGCTGCGCGCCATG GAGGGCGAGG ACGTGGAAGA CGACCAGCTGCTGCAGAAGC TCAGGGCCAG TCGCCGCCGC TTCCAGAGGCGCATGCAGCG GCTGATAGAG AAGTACAACC AGCCCTTCGAGGACACCCCG GTGGTGCAAA TGGCCACGCT GACCTACGAGACGCCACAGG GATTGAGAAT TTGGGGTGGA AGACTAATAAAGGAAAGAAA CGAAGGAGAG ATCCAGGACT CCTCCATGAAGCCCGCGGAC AGGACAGATG GCTCCGTGCA AGCTGCAGCCTGGGGTCCTG AGCTTCCCTC GCACCGCACA GTCCTGGGAGCCGATTCAAA AAGCGGTGAG GTCGATGCCA CGTCAGACCAGGAAGAGTCA GTTGCTTGGG CCTTAGCACC TGCAGTGCCTCAAAGCCCTT TGAAAAATGA ATTAAGAAGG AAATACTTGACCCAAGTGGA TATACTGCTA CAAGGTGCAG AGTATTTTGAGTGTGCAGGT AACAGAGCTG GAAGGGATGT ACGTGTGACTCCGCTGCCTT CACTGGCCTC ACCTGCCGTG CCTGCCCCCGGATACTGCAG TCGTATCTCC AGAAAGAGTC CTGGTGACCCAGCGAAACCA GCTTCATCTC CCAGAGAATG GGATCCTTTGCATCCTTCCT CCACAGACAT GGCCTTAGTA CCTAGAAATGACAGCCTCTC CCTACAAGAG ACCAGTAGCA GCAGCTTCTTAAGCAGCCAG CCCTTTGAAG ATGATGACAT TTGCAATGTGACCATCAGTG ACCTGTACGC AGGGATGCTG CACTCCATGAGCCGGCTGTT GAGCACAAAG CCATCAAGCA TCATCTCCACCAAAACGTTC ATCATGCAAA ACTGGAACTC CAGGAGGAGGCACAGATATA AGAGCAGGAT GAACAAAACA TATTGCAAAGGAGCCAGACG TTCTCAGAGG AGCTCCAAGG AGAACTTCATACCCTGCTCT GAGCCTGTGA AAGGGACAGG GGCATTAAGAGATTGCAAGA ACGTATTAGA TGTTTCTTGC CGTAAGACAGGTTTAAAATT GGAAAAAGCT TTTCTTGAAG TCAACAGACCCCAAATCCAT AAGTTAGATC CAAGTTGGAA GGAGCGCAAAGTGACACCCT CGAAGTATTC TTCCTTGATT TACTTCGACTCCAGTGCAAC ATATAATCTT GATGAGGAAA ATAGATTTAGGACATTAAAA TGGTTAATTT CTCCTGTAAA AATAGTTTCCAGACCAACAA TACGACAGGG CCATGGAGAG AACCGTCAGAGGGAGATTGA AATCCGATTT GATCAGCTTC ATCGGGAATATTGCCTGAGT CCCAGGAACC AGCCTCGCCG GATGTGCCTCCCGGACTCCT GGGCCATGAA CATGTACAGA GGGGGTCCTGCGAGTCCTGG TGGCCTTCAG GGCTTAGAAA CCCGCAGGCTGAGTTTACCT TCCAGCAAAG CAAAAGCAAA AAGTTTAAGTGAGGCTTTTG AAAACCTAGG CAAAAGATCT CTGGAAGCAGGTAGGTGCCT GCCCAAGAGC GATTCATCTT CATCACTTCCAAAGACCAAC CCCACACACA GCGCAACTCG CCCGCAGCAGACATCTGACC TTCACGTTCA GGGAAATAGT TCTGGAATATTTAGAAAGTC AGTGTCACCC AGCAAAACTC TTTCAGTCCCAGATAAAGAA GTGCCAGGCC ACGGAAGGAA TCGTTACGATGAAATTAAAG AAGAATTTGA CAAGCTTCAT CAAAAGTATTGCCTCAAATC TCCTGGGCAG ATGACAGTGC CTTTATGTATTGGAGTGTCT ACAGATAAAG CAAGTATGGA AGTTCGATATCAAACAGAAG GCTTCTTAGG AAAATTAAAT CCAGACCCTCACTTCCAGGG TTTCCAGAAG TTGCCATCAT CACCCCTGGGGTGCAGAAAA AGTCTACTGG GCTCAACTGC AATTGAGGCTCCTTCATCTA CATGTGTTGC TCGTGCCATC ACGAGGGATGGCACGAGGGA CCATCAGTTC CCTGCAAAAA GACCCAGGCTATCAGAACCC CAGGGCTCCG GACGCCAGGG CAATTCCCTGGGTGCCTCAG ATGGGGTGGA CAACACCGTC AGACCGGGAGACCAGGGCAG CTCTTCACAG CCCAACTCAG AAGAGAGAGGAGAGAACACG TCTTACAGGA TGGAAGAGAA AAGTGATTTCATGCTAGAAA AATTGGAAAC TAAAAGTGTG TAGCTAGGTTATTTCGGAGT GTTATTTATC TTCCCACTTG CTCTCTGTTTGTATTTTTGT TTTGTTTTTG ATTCTTGAGA CTGTGAGGACTTGGTTGACT TCTCTGCCCT TAAAGTAAAT ATTAGTGAAATTGGTTCCAT CAGAGATAAC CTCGAGTTCT TGGTGTAGAAATTATGTGAA TAAAGTTGCT CAATTAGAAT TTTTAGGGTTCTCTTTGATA GGCCTGTTTT TCTGATGTGT GTGTTTTTTTTGGGGGGGGG TTATTTGTTT GTTTGTTTGT TTGTTTGTTTGTTTTTGAGA CAGTCTCTCT CTATCGCCCA GGCTGGAGTGCGGTGGCACA ATCTTGGCTC ACTGCAACTT CCGCCTCCCGGGTTCAAGCG ATTCTTCTGC CTCAGCCTCC CGAGTAGCTGGGATTACAGG CGCGCGCCAC CACGCCTGGC TAATTTTTGTAGTTTTAGTA GAGACGGGGT TTCACCATAT TGACCAGGCTGGTCTCGAGC TCCTGGCCTC GTGATCCATC TGCCTCGGCCTCCCAAAGTG CTGGGATTAT AGGCGTGAGC CACTGCTCCCAGCCGTGTGT TCTTTTTTAA ATTTAGATAT GTCCAGAGAATCCTCTCTCC TGTTTCCCAT TTCATTCGAG AATATTGTTTGCTTGTGAGA CGTAAGTTCG AGCCCTGCAT GCAATGACCCTTGAAGGAAA ATAAACAGTC CTGGTGGTCC CAGACGCTCCTGCAGCCACA GCGCCTGTGA CTCCTCATGA TTCTTACTGAAGCTGTTGAT GACAGGATAT CATGGTGACG TTTTTGTAATGAAATATTTC ACATATTCAG AATACATTGG TGAAACTCATGCTGGAGTAA ATAGTTAATA TATGGCCAT HLA- NM_002119.3CTTCTTCTTT ACCTCCGCCT TGTTCCTGTC CTCACCACAC 13 DOAGGACTGAGAC TGATTTGATT AAAGCACCAG AGTGTAATGGCCCTCAGAGC AGGGCTGGTC CTGGGGTTCC ACACCCTGATGACCCTCCTG AGCCCGCAGG AGGCAGGGGC CACCAAGGCTGACCACATGG GCTCCTACGG ACCCGCCTTC TACCAGTCTTACGGCGCCTC GGGCCAGTTC ACCCATGAAT TTGATGAGGAACAGCTGTTC TCTGTGGACC TGAAGAAAAG CGAGGCCGTGTGGCGTCTGC CTGAGTTTGG TGACTTTGCC CGCTTTGACCCGCAGGGCGG GCTGGCCGGC ATCGCCGCAA TCAAAGCCCATCTGGACATC CTGGTGGAGC GCTCCAACCG CAGCAGAGCCATCAACGTGC CTCCACGGGT GACCGTGCTC CCCAAGTCTCGGGTGGAGCT GGGCCAGCCC AACATCCTCA TCTGCATCGTGGACAACATC TTCCCCCCTG TGATCAATAT CACCTGGCTGCGCAACGGCC AAACTGTCAC TGAGGGAGTG GCCCAGACCAGCTTCTATTC CCAGCCTGAC CATTTGTTCC GCAAGTTCCACTACCTGCCC TTCGTGCCCT CAGCCGAGGA CGTCTATGACTGCCAGGTGG AGCACTGGGG CCTGGATGCG CCACTCCTCAGGCATTGGGA GCTCCAGGTG CCTATTCCAC CACCAGATGCCATGGAGACC CTGGTCTGTG CCCTGGGCCT GGCCATCGGCCTGGTGGGCT TCCTCGTGGG CACCGTCCTC ATCATCATGGGCACATATGT GTCCAGTGTC CCCAGGTAAT GATCCTTCTGAGAGAAATGA CTTGTGGGAG ACACCCTGCA GATCCTCATGGGTTTGTGAC AGCCCCTGCG TGCTCAGTGC CCTTTAAGTGCATCCCGCTG TGCTGACTTT GAGTGGGATC AACATCTGTCCTACGGGTCC CCTCTTTTTT GGCCCCAGTA TTCATGGCAGGGTTTGTTGG ACACCTACTA GCTTCCCTTC CCATTCAACACACACACACA TTCTTGCTCT ACCCAAAGCT CTGGCTGGCAGCACTAAATG CTTTGGTGGT GTTTGCACTG TGTCCTTTCCAGGCCTTGGC CAGTTCTTCC AGGGGTGAGG CATGTGGTGCTGGGGATTGG CAGCCATCCT GGGGCCCACA CAGGTGTGTCTTGCTCCATT TGGCCCATTG TGTGTTACTT TGTGAATGAGCCATTTCACA TGGACTTCAT GAAATTTGCC TCCTGAGTTCAGGTTTACCC TGAAAGGGAT GCAGATTATC CTGTTCCTCACGACCCCCTC AGCTAACAAC AGTTCTGAAG GGTGCTGGGACAGGACAGGC TCATGGGGAC TCCACTCCTG CCTGGGTTTACTCTGTATGA AGAGGCCACT GGTATCCTGC CATGATGTTATCTCCTTTTT CTACTTTTCC CTAGAGTCCC ATGCATGATAAAGAGAGGCC CAAGGCTTGG ATAAGGTGGC CACTTCCCTCAGTGGAGTCA GTCATGTTAG GTAGGAGGTG GTAGAGTCGGTCTGCGAGGT ATCTCGTAAG AGGGGAGGTC CACCTAGACACACTCTAAAT ATGTGGCCTA GAAGATTTTG GTCTACTTTTCTGTGAACAG AATTTAAAAC ATACAAAGAG ATAAATCACCATACCACATA GTTTATGTCA GGACCAAAAT GAGCAATACAGATTACGGTT TTCAAACCAG AATGCACATA AGAACTGCTTGGGATCCTTT TAAAAGTACA GGCATTGGCC TGGTGCAGTGGCTCATTCCT GTAATCCCAG CACTTTGGGA GGCCAAGGGGACAGGACTGC TTGAGGCCAA GAGGTGGAAA CCATCTTGGGCTACATAGAG AGACCCCATC TCTACAAAGA AAGATTTAAAAATTAACCAG GCATGGTGGC TCGCACCTGT ATTCCCAGCCACTGGGGAGG CTGAGGCCGG AGGAGTGCTT GAGCCCAGGAGTTCAAGGCT GCAGTGAGCC AAGATTGCGC CACTGCACTCCAGCCTAGGT GACAGAGTGA GACCCTGTCT CTAAATAAATAAATAAATAA AATATAAAAA TAACAGTCAT CACCCAGACCTACTGAATTA GAATCTCGGG AGTGCAGGGG GCAGCAACAGGGAGGCTGTC TTTTCTGAGA TGGGGTCTCA CTCTGTCACCAGGCTGGAGT GCCATGGCAT GATCTCAGCT CACTGCAACCTCCACCTCCT GAGTTCAAGC CATTCTCCTG CCTCAGCCTCCTGAGTAGCT GGGACTACAG GTGTGCGCCA CTACACTCAGCTAATTTTTG TATTTTAAGT AGAGACGGGG TTTCATCATGTTGGCCAGGA TGGCCTCCAT CTCTTGACCT CGTGATCCACCCACCTTCCC TCCCAAAGTA CTGGAATTAC AGGCATTAGCCACTGTGCCC AGCCGAGGCT GTCATTTTTA ACCGGCTCTGGATGACTCTG ATGCAGCCAT CCTGGACCTT GGCTGTGGTCTGGTAACTGG AACCCAGTGA CGTAATCAGG TGCCATCGGGGGTCATGGGA AAGGGGGATC CCCAAGGTCT GAGGTGGACTAGGAAGGCTT TCTGAAGAAC CTGGGTCTGT TAGGGCATCAGCCAATCAAG GTACAAGTAA ATAGAGGCAA AATGAGGGTTTGAACTGTGA GCAGTTGGTC CTGGAAAAGA AAGAAACCAAGAGATTATGG GGACTCAATG GGCTTCTTAA GAGAGAATAAGTTGAAATCA ATGACCAGAA GACCCTGATG GAAGTGGAGGAGAATCATCT CAGGCAAACT TTTTGTGTGC CAGTAACAGAAACCCTCTTT GTGTGATCAC ATGCAAAGTA TAGGATATTTGCAATATAGC CATGGGGAGG AGTGCAGGGC CCAAGGGTAGATTTTAGCCA GGCCTCCCAG GAACAGAACT CGGATCCGAAAAGCCCAGAG AAGCTAGAGC TGCCCCTCCA ACACTCTCGGATCCACATGG TCTGTGTTCT CTAGACCCCC CTGCATGTTAGCGGTGTTCT CTCTCTGTGG ACTGACTGTC CTTCTCAGTGAACATGTCCA CCCGACAGCT CCTGAGTTTA TATCATCTCAACCCTCACAA CCCACAGAGG CTGTGTCTCC TAGTCACAGCTTTAAATTAC TGGAAAAATA AATGACTGGC CAAACTTGGAGCAGGTGTCC ATCCCAGCCC TGTGTAGTTA GAGCAGGAATCAAGATCTCA ACACAAATGT GGCTGCCAAG CACTCAGCCCCGGGGCGAGG GGTCAAGTTC TTCTCAGAGA AAGAGGAATAAGTTGGTTCT CAGAAGACAT CACAAGATAC GTGTGTACCCAACAATCTCT GATCTCTGCT GATCTTTTGC TTAGACGTTAACTTGATGCA TCATTGGAAA GGTGTTTCTC TCATCTCTGTCCTAAGGCTT GATAAAGTCA TTAAAATTGT GTTCTTTTGA CTAAA HLA- NM_019111.4TTTTAATGGT CAGACTCTAT TACACCCCAC ATTCTCTTTT 14 DRACTTTTATTCT TGTCTGTTCT GCCTCACTCC CGAGCTCTACTGACTCCCAA CAGAGCGCCC AAGAAGAAAA TGGCCATAAGTGGAGTCCCT GTGCTAGGAT TTTTCATCAT AGCTGTGCTGATGAGCGCTC AGGAATCATG GGCTATCAAA GAAGAACATGTGATCATCCA GGCCGAGTTC TATCTGAATC CTGACCAATCAGGCGAGTTT ATGTTTGACT TTGATGGTGA TGAGATTTTCCATGTGGATA TGGCAAAGAA GGAGACGGTC TGGCGGCTTGAAGAATTTGG ACGATTTGCC AGCTTTGAGG CTCAAGGTGCATTGGCCAAC ATAGCTGTGG ACAAAGCCAA CCTGGAAATCATGACAAAGC GCTCCAACTA TACTCCGATC ACCAATGTACCTCCAGAGGT AACTGTGCTC ACAAACAGCC CTGTGGAACTGAGAGAGCCC AACGTCCTCA TCTGTTTCAT AGACAAGTTCACCCCACCAG TGGTCAATGT CACGTGGCTT CGAAATGGAAAACCTGTCAC CACAGGAGTG TCAGAGACAG TCTTCCTGCCCAGGGAAGAC CACCTTTTCC GCAAGTTCCA CTATCTCCCCTTCCTGCCCT CAACTGAGGA CGTTTACGAC TGCAGGGTGGAGCACTGGGG CTTGGATGAG CCTCTTCTCA AGCACTGGGAGTTTGATGCT CCAAGCCCTC TCCCAGAGAC TACAGAGAACGTGGTGTGTG CCCTGGGCCT GACTGTGGGT CTGGTGGGCATCATTATTGG GACCATCTTC ATCATCAAGG GATTGCGCAAAAGCAATGCA GCAGAACGCA GGGGGCCTCT GTAAGGCACATGGAGGTGAT GGTGTTTCTT AGAGAGAAGA TCACTGAAGAAACTTCTGCT TTAATGGCTT TACAAAGCTG GCAATATTACAATCCTTGAC CTCAGTGAAA GCAGTCATCT TCAGCATTTTCCAGCCCTAT AGCCACCCCA AGTGTGGATA TGCCTCTTCGATTGCTCCGT ACTCTAACAT CTAGCTGGCT TCCCTGTCTATTGCCTTTTC CTGTATCTAT TTTCCTCTAT TTCCTATCATTTTATTATCA CCATGCAATG CCTCTGGAAT AAAACATACAGGAGTCTGTC TCTGCTATGG AATGCCCCAT GGGGCATCTCTTGTGTACTT ATTGTTTAAG GTTTCCTCAA ACTGTGATTTTTCTGAACAC AATAAACTAT TTTGATGATC TTGGGTGGAAAAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AA HNRNPA3P1 NR_002726.2CGAGTTGGAA GAGGTGAGTC CTGTCTCAAA ATGGAGGTAA 15AACCGCCGCC TGGTTGCCCC CAGCCCGACT CCGGCAGTCGCCGTCGCCAC TGGGGGGAGG AGGGCCATGA TCCAAAGGAACCAGAGCAGC TGAGAAAACT GTTTATTGGT GGTCTGAGCTTTGAAACTAC AGATGATAGT TTAAGAGAAC ATTTTGAGAAATGGGGCACA CTCACAGATT GTCTGGTAAT GAGAGACCCCCAAACAAAAC GTTCCAGGGG CTTTGGTTTT GTGACTTATTCTTGTGTTAC AGAGGTGGAT GCAGCAATGC GTGCTCGACCATTCAAGGTT GATGGGCGTG TAGTGGAACC AAAGAGAGCTGTTTCTAGAG AGGATTCTGT GAAGCCTGGT GCCCATCTAACAGTGAAGAA AATTTTTGTT GGCAGTATTA AAGAAGATACAGAAGAATAT AATTTGAGAG ACTACTTTGA AAAGTACGGCAAGATTGAAA CCATAGAAGT TATGGAAGAC AGGCAGAGTGGAAAAAAGAG AGGATTTGCT TCTGTAACTT TTGATGATCATGATACAGTT GATAAAATTG TTGTTCAGAA ATACCACACTATTAATGGGC ATAACTGTGA AGTGAAAAAG GCCCTTGCTAAACAAGTGAT GCAGCCGGCT GGATCACAGA GGGGTCGTGGAGGTGGATCT GGCAATTGTA TGGGTCACAG AGGAAACTTTGGAGGTGGTG GAGGTAATTT TGGCCGTGAT GGAAACTTTGGTGGAAGAGG AGGCTATGGT GGTGGAGGTG GTGGCAGCAGAGGTAGTTAT GGAGGAGGTG ATGTGGATAT AATGGATTAGGAGGTGATGG TGGCAACTAT GGCAGTGGTC CTGGTTATAGTAGTAGAGGC GGGTATGGTG GTGGTGGACC AGGATATGGAAACCAAGGTG GTGGATATGG TGGCGGTGTT GGAGGATATGATGGTTACAA TGAAGGAGGA AATTTTGACG GTAGTAACTATGGTGGTGGT GGGAACTATA ATGATTTTGG AAATTACAGTGGACAACAGC AATCAAATTA TGGACACATG AAAGGGGGCAGTTTTGGTGG AAGAAGCTCG GGCAGTCCCT ATGGTGGTGGTTATGGATCT GGTGGTGGAA GTGGTGGATA TGGTAGCAGAAGGTTCTAAA AACAGCAGGA AAGGGCTACA GTTCTTAGCAGGAGAGAGAG TGAGGAGTTG TCAGGAAAGC TACAGGTTACTTTGAGACAG TCGTCCCAAG TGCATTAGAG GAACTGTAAAAATCTGTCAC AGAAGGAACG ATGATCCATA ATCAGAAAAGTTACTGCAGC TTAAACAGGA AACCCTTCTT GTTCAGGACTGTCATAGCCA CAGTTTGCAG GAAGTGCAGC TATCGATTAATGCAATGTAG CGTCAATTAG ATGTACATTC CTCAGGTCTTTTATCTGTTG TAGCTTTGTC TTATTCTTTT TCTTTTCATTACATCAGGTA TATTGCCCTG TAAATTGTGG TAGTGGTACCAGGAATAAAA AATTAAGGAA TTTTTAACTT TTCAATATCTGTGTAGTTCA GTTTTTCTAC ATTTTAGTAC AGAAACTTTAACAAAATGCA GTTTTGAAGG TGTTTCCTTG TGAGTTAACAAGTAAAGAAG ATCAATTGTT AATTACTATT TTGTATAAATTTTGCTAAAG TTAACTGTAA AGAAACACCT GCTGACTTGCAGTTTAAGGG GAATCTATTC TCCCCATTTC CAAACCATGATATGAATGGA CGCCGACATG TGGAGAGAAC AGATAATTTGTGTGTTTGCA ATGTGTGTTT TAGGTAAATA GGATTGGGTATTTAAATTAG CATTTGTGAA TTTAATAGCA TTAAGATTACCTTCAAATAA AAAAGTCTCA AAATTTCTTT TTGGTTTTTGTGCACTTTCT TTTAAAATGT AATCACATGA TTTTAGTGTGTTAGACTTGC TGAGTCCTAG CTGTGTTTAG AACATCTCCATTCTACATTT ACCTTGGTCA AATTTGAACT GCTGCCATAGGTTTTGGGTG TAAAGAATGT TTACTGCCCT CCATTTAAATTCTGAAAAGG TATAGTGGAT GTTTTCCCTC TCCTACATTAGAAACCATTC TTAAAAACTT TTCAAAATAT AGAACCATTAAGCCTGCTAT ATCTGAGCAA ATTAGTGGGT ACCTTTTTTCCTTTTTTAAA GCACAAGAGG CCCATAAATC TTGAGTTATTTGCATTAGTT TACATTTTTT GATACAACTT TTCAGACCAAGAGAATAAAA ATCATGCGTT ATTAAACCCC TAGCTGGCTGGCATGCTTTC CTGTTTGTAC TGTATACATT TTGCTGGATGAAACCAAGGA TAGTTTAGGT ATAATTGTCC AAAATAACCTAACTGCAGCA GAAATGTAGG ACAGTTGCTT AGTACAGGCTTCTCACTTCC TACAGACCTG AATTCAAATT TGGATAGTCTGAGTTATTAA ATTCCCAAAG ACAAAGAACA CACTCTTATTTCTTGTGTAT ATTTCAACAT AAATCATGTT GTTACCAATTTGTTGGGAAG GCCCTGGTTG AGAAGAGTTT TAGATAATAAGGCTGTATAT ATATAGATAT ATATAGATAT ATACCAATGTCTATATATAG AGATATTTTA TATATATATA TACAGGTATATATATGTGTG TGTATATATA TAGGTATATA CATATATACATATATATATA TATATATATG GATATATACC CATGTCTACTGTTTTGCTTC AGCTAGTGCT TACAATTTCA TTCAAGTCCTGAGTATGTGT CCTGCTGTTA CTCCTTCTTT GGTAGTTGAACGTTGAATTC AAGTCTTTCC TTCTGTTTTA AGAAGTACTAAGCAAACAAG CAATAAAAAG GGGAATGGCG CATGCTAGTGTTTGAATATG CTCTCTTGTT GCTCTAATTC TGTGCCTCCGTGCATTAATA TTTGGATGCA TGCAATGCCA GCATGGAAAT TGGCCT IL23A NM_016584.2AAAACAACAG GAAGCAGCTT ACAAACTCGG TGAACAACTG 16AGGGAACCAA ACCAGAGACG CGCTGAACAG AGAGAATCAGGCTCAAAGCA AGTGGAAGTG GGCAGAGATT CCACCAGGACTGGTGCAAGG CGCAGAGCCA GCCAGATTTG AGAAGAAGGCAAAAAGATGC TGGGGAGCAG AGCTGTAATG CTGCTGTTGCTGCTGCCCTG GACAGCTCAG GGCAGAGCTG TGCCTGGGGGCAGCAGCCCT GCCTGGACTC AGTGCCAGCA GCTTTCACAGAAGCTCTGCA CACTGGCCTG GAGTGCACAT CCACTAGTGGGACACATGGA TCTAAGAGAA GAGGGAGATG AAGAGACTACAAATGATGTT CCCCATATCC AGTGTGGAGA TGGCTGTGACCCCCAAGGAC TCAGGGACAA CAGTCAGTTC TGCTTGCAAAGGATCCACCA GGGTCTGATT TTTTATGAGA AGCTGCTAGGATCGGATATT TTCACAGGGG AGCCTTCTCT GCTCCCTGATAGCCCTGTGG GCCAGCTTCA TGCCTCCCTA CTGGGCCTCAGCCAACTCCT GCAGCCTGAG GGTCACCACT GGGAGACTCAGCAGATTCCA AGCCTCAGTC CCAGCCAGCC ATGGCAGCGTCTCCTTCTCC GCTTCAAAAT CCTTCGCAGC CTCCAGGCCTTTGTGGCTGT AGCCGCCCGG GTCTTTGCCC ATGGAGCAGCAACCCTGAGT CCCTAAAGGC AGCAGCTCAA GGATGGCACTCAGATCTCCA TGGCCCAGCA AGGCCAAGAT AAATCTACCACCCCAGGCAC CTGTGAGCCA ACAGGTTAAT TAGTCCATTAATTTTAGTGG GACCTGCATA TGTTGAAAAT TACCAATACTGACTGACATG TGATGCTGAC CTATGATAAG GTTGAGTATTTATTAGATGG GAAGGGAAAT TTGGGGATTA TTTATCCTCCTGGGGACAGT TTGGGGAGGA TTATTTATTG TATTTATATTGAATTATGTA CTTTTTTCAA TAAAGTCTTA TTTTTGTGGC TAAAAAAAA IQGAP1 NM_003870.3GGACCCCGGC AAGCCCGCGC ACTTGGCAGG AGCTGTAGCT 17ACCGCCGTCC GCGCCTCCAA GGTTTCACGG CTTCCTCAGCAGAGACTCGG GCTCGTCCGC CATGTCCGCC GCAGACGAGGTTGACGGGCT GGGCGTGGCC CGGCCGCACT ATGGCTCTGTCCTGGATAAT GAAAGACTTA CTGCAGAGGA GATGGATGAAAGGAGACGTC AGAACGTGGC TTATGAGTAC CTTTGTCATTTGGAAGAAGC GAAGAGGTGG ATGGAAGCAT GCCTAGGGGAAGATCTGCCT CCCACCACAG AACTGGAGGA GGGGCTTAGGAATGGGGTCT ACCTTGCCAA ACTGGGGAAC TTCTTCTCTCCCAAAGTAGT GTCCCTGAAA AAAATCTATG ATCGAGAACAGACCAGATAC AAGGCGACTG GCCTCCACTT TAGACACACTGATAATGTGA TTCAGTGGTT GAATGCCATG GATGAGATTGGATTGCCTAA GATTTTTTAC CCAGAAACTA CAGATATCTATGATCGAAAG AACATGCCAA GATGTATCTA CTGTATCCATGCACTCAGTT TGTACCTGTT CAAGCTAGGC CTGGCCCCTCAGATTCAAGA CCTATATGGA AAGGTTGACT TCACAGAAGAAGAAATCAAC AACATGAAGA CTGAGTTGGA GAAGTATGGCATCCAGATGC CTGCCTTTAG CAAGATTGGG GGCATCTTGGCTAATGAACT GTCAGTGGAT GAAGCCGCAT TACATGCTGCTGTTATTGCT ATTAATGAAG CTATTGACCG TAGAATTCCAGCCGACACAT TTGCAGCTTT GAAAAATCCG AATGCCATGCTTGTAAATCT TGAAGAGCCC TTGGCATCCA CTTACCAGGATATACTTTAC CAGGCTAAGC AGGACAAAAT GACAAATGCTAAAAACAGGA CAGAAAACTC AGAGAGAGAA AGAGATGTTTATGAGGAGCT GCTCACGCAA GCTGAAATTC AAGGCAATATAAACAAAGTC AATACATTTT CTGCATTAGC AAATATCGACCTGGCTTTAG AACAAGGAGA TGCACTGGCC TTGTTCAGGGCTCTGCAGTC ACCAGCCCTG GGGCTTCGAG GACTGCAGCAACAGAATAGC GACTGGTACT TGAAGCAGCT CCTGAGTGATAAACAGCAGA AGAGACAGAG TGGTCAGACT GACCCCCTGCAGAAGGAGGA GCTGCAGTCT GGAGTGGATG CTGCAAACAGTGCTGCCCAG CAATATCAGA GAAGATTGGC AGCAGTAGCACTGATTAATG CTGCAATCCA GAAGGGTGTT GCTGAGAAGACTGTTTTGGA ACTGATGAAT CCCGAAGCCC AGCTGCCCCAGGTGTATCCA TTTGCCGCCG ATCTCTATCA GAAGGAGCTGGCTACCCTGC AGCGACAAAG TCCTGAACAT AATCTCACCCACCCAGAGCT CTCTGTCGCA GTGGAGATGT TGTCATCGGTGGCCCTGATC AACAGGGCAT TGGAATCAGG AGATGTGAATACAGTGTGGA AGCAATTGAG CAGTTCAGTT ACTGGTCTTACCAATATTGA GGAAGAAAAC TGTCAGAGGT ATCTCGATGAGTTGATGAAA CTGAAGGCTC AGGCACATGC AGAGAATAATGAATTCATTA CATGGAATGA TATCCAAGCT TGCGTGGACCATGTGAACCT GGTGGTGCAA GAGGAACATG AGAGGATTTTAGCCATTGGT TTAATTAATG AAGCCCTGGA TGAAGGTGATGCCCAAAAGA CTCTGCAGGC CCTACAGATT CCTGCAGCTAAACTTGAGGG AGTCCTTGCA GAAGTGGCCC AGCATTACCAAGACACGCTG ATTAGAGCGA AGAGAGAGAA AGCCCAGGAAATCCAGGATG AGTCAGCTGT GTTATGGTTG GATGAAATTCAAGGTGGAAT CTGGCAGTCC AACAAAGACA CCCAAGAAGCACAGAAGTTT GCCTTAGGAA TCTTTGCCAT TAATGAGGCAGTAGAAAGTG GTGATGTTGG CAAAACACTG AGTGCCCTTCGCTCCCCTGA TGTTGGCTTG TATGGAGTCA TCCCTGAGTGTGGTGAAACT TACCACAGTG ATCTTGCTGA AGCCAAGAAGAAAAAACTGG CAGTAGGAGA TAATAACAGC AAGTGGGTGAAGCACTGGGT AAAAGGTGGA TATTATTATT ACCACAATCTGGAGACCCAG GAAGGAGGAT GGGATGAACC TCCAAATTTTGTGCAAAATT CTATGCAGCT TTCTCGGGAG GAGATCCAGAGTTCTATCTC TGGGGTGACT GCCGCATATA ACCGAGAACAGCTGTGGCTG GCCAATGAAG GCCTGATCAC CAGGCTGCAGGCTCGCTGCC GTGGATACTT AGTTCGACAG GAATTCCGATCCAGGATGAA TTTCCTGAAG AAACAAATCC CTGCCATCACCTGCATTCAG TCACAGTGGA GAGGATACAA GCAGAAGAAGGCATATCAAG ATCGGTTAGC TTACCTGCGC TCCCACAAAGATGAAGTTGT AAAGATTCAG TCCCTGGCAA GGATGCACCAAGCTCGAAAG CGCTATCGAG ATCGCCTGCA GTACTTCCGGGACCATATAA ATGACATTAT CAAAATCCAG GCTTTTATTCGGGCAAACAA AGCTCGGGAT GACTACAAGA CTCTCATCAATGCTGAGGAT CCTCCTATGG TTGTGGTCCG AAAATTTGTCCACCTGCTGG ACCAAAGTGA CCAGGATTTT CAGGAGGAGCTTGACCTTAT GAAGATGCGG GAAGAGGTTA TCACCCTCATTCGTTCTAAC CAGCAGCTGG AGAATGACCT CAATCTCATGGATATCAAAA TTGGACTGCT AGTGAAAAAT AAGATTACGTTGCAGGATGT GGTTTCCCAC AGTAAAAAAC TTACCAAAAAAAATAAGGAA CAGTTGTCTG ATATGATGAT GATAAATAAACAGAAGGGAG GTCTCAAGGC TTTGAGCAAG GAGAAGAGAGAGAAGTTGGA AGCTTACCAG CACCTGTTTT ATTTATTGCAAACCAATCCC ACCTATCTGG CCAAGCTCAT TTTTCAGATGCCCCAGAACA AGTCCACCAA GTTCATGGAC TCTGTAATCTTCACACTCTA CAACTACGCG TCCAACCAGC GAGAGGAGTACCTGCTCCTG CGGCTCTTTA AGACAGCACT CCAAGAGGAAATCAAGTCGA AGGTAGATCA GATTCAAGAG ATTGTGACAGGAAATCCTAC GGTTATTAAA ATGGTTGTAA GTTTCAACCGTGGTGCCCGT GGCCAGAATG CCCTGAGACA GATCTTGGCCCCAGTCGTGA AGGAAATTAT GGATGACAAA TCTCTCAACATCAAAACTGA CCCTGTGGAT ATTTACAAAT CTTGGGTTAATCAGATGGAG TCTCAGACAG GAGAGGCAAG CAAACTGCCCTATGATGTGA CCCCTGAGCA GGCGCTAGCT CATGAAGAAGTGAAGACACG GCTAGACAGC TCCATCAGGA ACATGCGGGCTGTGACAGAC AAGTTTCTCT CAGCCATTGT CAGCTCTGTGGACAAAATCC CTTATGGGAT GCGCTTCATT GCCAAAGTGCTGAAGGACTC GTTGCATGAG AAGTTCCCTG ATGCTGGTGAGGATGAGCTG CTGAAGATTA TTGGTAACTT GCTTTATTATCGATACATGA ATCCAGCCAT TGTTGCTCCT GATGCCTTTGACATCATTGA CCTGTCAGCA GGAGGCCAGC TTACCACAGACCAACGCCGA AATCTGGGCT CCATTGCAAA AATGCTTCAGCATGCTGCTT CCAATAAGAT GTTTCTGGGA GATAATGCCCACTTAAGCAT CATTAATGAA TATCTTTCCC AGTCCTACCAGAAATTCAGA CGGTTTTTCC AAACTGCTTG TGATGTCCCAGAGCTTCAGG ATAAATTTAA TGTGGATGAG TACTCTGATTTAGTAACCCT CACCAAACCA GTAATCTACA TTTCCATTGGTGAAATCATC AACACCCACA CTCTCCTGTT GGATCACCAGGATGCCATTG CTCCGGAGCA CAATGATCCA ATCCACGAACTGCTGGACGA CCTCGGCGAG GTGCCCACCA TCGAGTCCCTGATAGGGGAA AGCTCTGGCA ATTTAAATGA CCCAAATAAGGAGGCACTGG CTAAGACGGA AGTGTCTCTC ACCCTGACCAACAAGTTCGA CGTGCCTGGA GATGAGAATG CAGAAATGGATGCTCGAACC ATCTTACTGA ATACAAAACG TTTAATTGTGGATGTCATCC GGTTCCAGCC AGGAGAGACC TTGACTGAAATCCTAGAAAC ACCAGCCACC AGTGAACAGG AAGCAGAACATCAGAGAGCC ATGCAGAGAC GTGCTATCCG TGATGCCAAAACACCTGACA AGATGAAAAA GTCAAAATCT GTAAAGGAAGACAGCAACCT CACTCTTCAA GAGAAGAAAG AGAAGATCCAGACAGGTTTA AAGAAGCTAA CAGAGCTTGG AACCGTGGACCCAAAGAACA AATACCAGGA ACTGATCAAC GACATTGCCAGGGATATTCG GAATCAGCGG AGGTACCGAC AGAGGAGAAAGGCCGAACTA GTGAAACTGC AACAGACATA CGCTGCTCTGAACTCTAAGG CCACCTTTTA TGGGGAGCAG GTGGATTACTATAAAAGCTA TATCAAAACC TGCTTGGATA ACTTAGCCAGCAAGGGCAAA GTCTCCAAAA AGCCTAGGGA AATGAAAGGAAAGAAAAGCA AAAAGATTTC TCTGAAATAT ACAGCAGCAAGACTACATGA AAAAGGAGTT CTTCTGGAAA TTGAGGACCTGCAAGTGAAT CAGTTTAAAA ATGTTATATT TGAAATCAGTCCAACAGAAG AAGTTGGAGA CTTCGAAGTG AAAGCCAAATTCATGGGAGT TCAAATGGAG ACTTTTATGT TACATTATCAGGACCTGCTG CAGCTACAGT ATGAAGGAGT TGCAGTCATGAAATTATTTG ATAGAGCTAA AGTAAATGTC AACCTCCTGATCTTCCTTCT CAACAAAAAG TTCTACGGGA AGTAATTGATCGTTTGCTGC CAGCCCAGAA GGATGAAGGA AAGAAGCACCTCACAGCTCC TTTCTAGGTC CTTCTTTCCT CATTGGAAGCAAAGACCTAG CCAACAACAG CACCTCAATC TGATACACTCCCGATGCCAC ATTTTTAACT CCTCTCGCTC TGATGGGACATTTGTTACCC TTTTTTCATA GTGAAATTGT GTTTCAGGCTTAGTCTGACC TTTCTGGTTT CTTCATTTTC TTCCATTACTTAGGAAAGAG TGGAAACTCC ACTAAAATTT CTCTGTGTTGTTACAGTCTT AGAGGTTGCA GTACTATATT GTAAGCTTTGGTGTTTGTTT AATTAGCAAT AGGGATGGTA GGATTCAAATGTGTGTCATT TAGAAGTGGA AGCTATTAGC ACCAATGACATAAATACATA CAAGACACAC AACTAAAATG TCATGTTATTAACAGTTATT AGGTTGTCAT TTAAAAATAA AGTTCCTTTATATTTCTGTC CCATCAGGAA AACTGAAGGA TATGGGGAATCATTGGTTAT CTTCCATTGT GTTTTTCTTT ATGGACAGGAGCTAATGGAA GTGACAGTCA TGTTCAAAGG AAGCATTTCTAGAAAAAAGG AGATAATGTT TTTAAATTTC ATTATCAAACTTGGGCAATT CTGTTTGTGT AACTCCCCGA CTAGTGGATGGGAGAGTCCC ATTGCTAAAA TTCAGCTACT CAGATAAATTCAGAATGGGT CAAGGCACCT GCCTGTTTTT GTTGGTGCACAGAGATTGAC TTGATTCAGA GAGACAATTC ACTCCATCCCTATGGCAGAG GAATGGGTTA GCCCTAATGT AGAATGTCATTGTTTTTAAA ACTGTTTTAT ATCTTAAGAG TGCCTTATTAAAGTATAGAT GTATGTCTTA AAATGTGGGT GATAGGAATTTTAAAGATTT ATATAATGCA TCAAAAGCCT TAGAATAAGAAAAGCTTTTT TTAAATTGCT TTATCTGTAT ATCTGAACTCTTGAAACTTA TAGCTAAAAC ACTAGGATTT ATCTGCAGTGTTCAGGGAGA TAATTCTGCC TTTAATTGTC TAAAACAAAAACAAAACCAG CCAACCTATG TTACACGTGA GATTAAAACCAATTTTTTCC CCATTTTTTC TCCTTTTTTC TCTTGCTGCCCACATTGTGC CTTTATTTTA TGAGCCCCAG TTTTCTGGGCTTAGTTTAAA AAAAAAATCA AGTCTAAACA TTGCATTTAGAAAGCTTTTG TTCTTGGATA AAAAGTCATA CACTTTAAAAAAAAAAAAAA CTTTTTCCAG GAAAATATAT TGAAATCATGCTGCTGAGCC TCTATTTTCT TTCTTTGATG TTTTGATTCAGTATTCTTTT ATCATAAATT TTTAGCATTT AAAAATTCACTGATGTACAT TAAGCCAATA AACTGCTTTA ATGAATAACAAACTATGTAG TGTGTCCCTA TTATAAATGC ATTGGAGAAGTATTTTTATG AGACTCTTTA CTCAGGTGCA TGGTTACAGCCCACAGGGAG GCATGGAGTG CCATGGAAGG ATTCGCCACTACCCAGACCT TGTTTTTTGT TGTATTTTGG AAGACAGGTTTTTTAAAGAA ACATTTTCCT CAGATTAAAA GATGATGCTATTACAACTAG CATTGCCTCA AAAACTGGGA CCAACCAAAGTGTGTCAACC CTGTTTCCTT AAAAGAGGCT ATGAATCCCAAAGGCCACAT CCAAGACAGG CAATAATGAG CAGAGTTTACAGCTCCTTTA ATAAAATGTG TCAGTAATTT TAAGGTTTATAGTTCCCTCA ACACAATTGC TAATGCAGAA TAGTGTAAAATGCGCTTCAA GAATGTTGAT GATGATGATA TAGAATTGTGGCTTTAGTAG CACAGAGGAT GCCCCAACAA ACTCATGGCGTTGAAACCAC ACAGTTCTCA TTACTGTTAT TTATTAGCTGTAGCATTCTC TGTCTCCTCT CTCTCCTCCT TTGACCTTCTCCTCGACCAG CCATCATGAC ATTTACCATG AATTTACTTCCTCCCAAGAG TTTGGACTGC CCGTCAGATT GTTGCTGCACATAGTTGCCT TTGTATCTCT GTATGAAATA AAAGGTCATT TGTTCATGTT AAAAAAAAALOC494127 NR_036691.1 GCAGTGCCCG ACTCCGCAGG AGCGCCAGGG CGGCTCCTGC 18TCTTCCTGGA CTCCCTGAAG AGGCGTTTGT CGAAATGTCCACAGAAGGAG GATTTGGTGG TACTAGCCGC AGTGATGCCCAGCAAAGCCT AAAGTCCTTC TGGCTTCGGG TCATGGAAGAAATCTGGAAT TTAGCAGTGA AAGATTTCTG AATGCAGGAACTCCCACTGG CTCGTATTAA GAAGATTATG AAACTGGATGAAGATGTGAA GATGATCAGT GCAGAGGCCC CTGTGCTCTTTGCCAGGGCA GCCCAGATTT TTTATCACAG AGTTGACTCTTCGAGCCTGG ATTCACACAG AGGATAACAA CTGCCGGACTTATGTCGCCA TGGCAATTAC GAAATTTGAT CAATTGGATTTTCTCATCGA TATTGTTCTA AGAGATGAAC TGAAACCTCCAAAGTGTCAG GAGGAGGTGC TGCAGTCTGT AACTCCTGCTGAGCCAGTCC AATACTATTT CACGCTGGCT CAGCAGCCCACCGCCCGTCC AAGTCCAGGG ACAGCAGCAA GGCCAGACCACCGCCAGCTC CATGACCACC ATGCAGCCTG GGCAGATCATCATCGCACAG CTTCAGCAGG GCCAGACCAC GCCCGTGACGACGCAGGTTG GAGAAGGTCA GCAGGTGCAG ATTGTCCAGGCCCAGCCACA GGGTCAAGCC CAGTAGGCCC AGAGTGGTACTGGATGGACC GTGCAGGTGA TGTAGCAGAT CCTCACTAACACAGGAGAGA TCCAGCAGAT CCCGGTGCAG CTGAAGGCTGGCCAGCTGCA GTGTATCCGC TTAGCCCAGT CTGTATCAGGCACCCACGTT CTGCAGGGAC AGATCCAGAC ACTTGCCACCAGCGCTCAAC CGATTACACA GACAGAGGTC CAGCAAAGACAGCAGTAGTT CAGCCAGTTC ACAGATGGAC AGCAGCTCTACCAGATCCAG CAAGTATCCA TACCTGCGGG CCAGGACCTGCCCAGCCCAT GTTTTTCCAG TCAGTCAACC AGCCCTCTGATGGGCAGGCC CCCCGGGTGA CTGGCGGCTG AGGGCCGGAGCTGGCAAGGC CGAGGACACT CAACACAATT TTTGCCGTACAGCCCCAGGT CATGAACACA GCCTTCTTCC CCAGAGGACCCGGCCGACCT CAGCTCCTCC TGCAGGCTAG GACAATGGCGCACTAGGCCT CATGCCTGGG GGCCGAGATT CTCCAACAGAAAGATGCAAT ATTTTTTGTT TCCTTTTTTC TCCAAGGAATCAATATTTCA ATATGTTGAG CTGTGTGTCC AATGCTATGAAATTAAAATA TTAAATCACA AAAAAAAAAA AAAA LOC646471 NR_024498.1AATGAATCCA ACTACTGTCC TTGTCCTCTC CTCTCTAGGT 19TTGTGGAGAC TGAATTCCAC AAACCTAGGG ACAGGGCACTCTCTAGGGGC AAGTCAACTC TCAATTATAG TGAGGGCAGGTTCCCCAGTT GCCAGCCTAC ACCCTGGCCA GCCACCCAAGGGAATACCTG CTGCTGCTAA GGCAGTCAAT GTTGGGAGGGTCAGGGAAGG GGAGAGGAAG TAGCTGAGTG TAGAGATTATCCAGGCTTTC CTTCCCGTCC TCTGTACAGA AAGGCAGACATACACTGACT CCTGAAGTGC CCCAGGATCA TAGTTGGTTCTTCTTAGGGG GAGGGAGTGA AACGGTGGCC TTGCTCCAATTCCAGGCCTC TGGAGAAAGG AGTGCTCAAC TGGAGAGTCTCAGAACCTTT TACAGTACTT CAGCAGGCCC AGCACCCAACCTTCCCCACC ATACCCCTGC CCTGGGAATG CCCCTTACCACAGTGGCTTC CATTCCTGAC ATTTGAACCA GCTCCTGCACTTGAAGGACA AGGCAGCCAC TGGGCAGCTC CGGGAGGCGGGAGGCGTGAC TCCTTCATAT CAGGCCATCT GGAGGAGCACCAGATTTCCC TCTTGTGAAA CAACCCCCCA CAGTGGGGATTTAATGGTCA CCACACAAGC CCCAAAAAAC CAGGCCCTGCAGAGCCATGA CTTCACAGGG GAGAAAACCA GCCCAAGAGGCTGCCCTCAC CCAACACTTA GCTCTAAGTC CAGACTCTTAAAGGTTCTGT TAAAGATCTG CGGCCAGGCG CAGTGGCTCACATCTGTAAT CCCAGCACTT TGGGAGGCCG AGGTGGGCGGATCACGAGGT CAGGAGAGCG AGACCATCCT GGCTAACACAGTGAAGCCCT GTCTCTACTA AAAATACAAA AAATTAGCCAGGTGTGGTGG CGGGCACCTG TAGTACCAGC TACTTGGGAGGCTGAGGCAG GAGAATGGCG TGAACCCAGG AGGCAGAGCTTGCAGTGAGC CGAGATCACG CCACTGCACT CCAACCTGGGTGACAGAGCG AGACTCCGTC TCAAAAAAAA AAAAAAAAAAAAAAGATTTG CCTAGTGAGC TTGGCCAACC CAAGAGCCTTCCTGGGCTCT CAGGTTTCTT GAGGCAAAAC TTCTAAAGATGCAAATAGAA TCCTTGGTAG CTACAAAGCT CATCTAGCCAAATTATAAGT ACTATCCAAG CCCAGGATTC ATTCTTGAAGATGAGATGTA AAAGCACTGC TGGGCCCTTG CAAAGGGAGAGATCAGAGAA AATAGGAGAA CGAACACCAG CTCATGCCAATCTCAGTCTC ATGAGCTACA GAGAAAAAGA GCCAAAAAAGTTTATCCTGG CTCAGCCACC TTCTGGCTTT GTAGCTACAGGCAAGTTATT TAACTTTTCT GAATGTTGGT TTTTCCATCTGGAAAAAGGA GACAGGAAAA GCTGCCACTG GAGGCTACCTTAAGGGTCAA TGAGTGAAAT GGGGTTGAGT GCTTAATGAACTGTTAAAAC ATGACACAGA TGGGTGAGGT GACATCTGACTGCTCTTCAC AGCAGTCCTT GCATGGTGAG CAGATGCAATCAGTGTGCTC GTTCATTCAC TTGTTCATCA AACACCAACAGTACCCACTT GTGCCAGGCC TTGTGCTGGG CACCGTAGGGGCTATGGAAG GAGTAAGACA CAGTCATGCT CTCAAGGAACTCGCTGTCCA GCAGAGTGAT AGGACATGAA TACATACTTCTAGCAAAGGC TGAGTAGCAT TAGGCAGGTG GCCAGATGAGGTCAGAGCTC TGGCCCTAGT GCCCTGTAGT AAGTTGCGAGGGAGTAGGAA ATGAAGACAA AACAGCAAGA GCACAGGTCCAGCACAAGAA GGTGAAGGAC ATGGAAAGAG GAGCAGAGCATGATAAAGCT ACAAAAGTAG GGGGCAAGTC ATGAGGTCCGGGTCACTGGG GAGCCCTGGA CAGGCTCTGA ATGGGAGATAGACTAGACTG ACAAAGCAGC TCTTTCTGGA GACCTCCTGTGGAGGGTCCC CTCTTCTACC CTTGGGAGAC GAGGTGTCATTCACTTCACG ATACACATGG GGAAAGGAAG TTGGACAGGGGAAGGCACTT GTCTAAGGTC ACTCAGTGGT CATGCCAGTGCAAAGCACCC AAAGCCTGGT CCAGGTCCTG CCACCTCCTGCGTGGGCTCC ATCTTCTCGG CTCAGTTCAA GCCTTTATTATCAGAGTCCC TCTGTGTGCC AGGCTCTGTG CTGAATGTCCGTGTCGGCCA CAAATTGCAC TAACGGTGCT TACTGCCACTTCCTCTCCGA CCTTACCTCC AAAGACCCAG CCGGGCCTAACCCTCACACA CAGCCAGAGG AATCCTTCCC AAACACAGTTAATCACATCG CTCATCCGTT TAAAACTGGC TTACTAGAGCCAACACAGGA TAAAATCCAC AATCAGTCCC AAACCCATCTTTCTCTGCCG TCTCTAGACC ACATTCACTG AGCACCAAGGCCTGCACGCT TCGCAGCCAG CCCTCCTGCT CTCCCCCTTGCCCTCCAGCC ACACTGGCCC TCAACCCCCA ACACTGGGCCCACCTCTGAG CCCTGCATCA AACACCAGCA CCCCCTTCGCCGAGCTCATT CTTCATCATT CCTCAGAGCT CAGCTTAAGCATCACCTTCC TTCCCTGCGA CAGGGTCAGG TCCTTTCCTGTGCGCTCCGC AGCACCCTGC CTGTCCCTCG GAGTCCTCGCGAGAGGAACT AGATAACTGT GATCCCCGCG CACAGCACGGTGTCTGCCTA GGACACAGTG AGCGCTTCAA CGCGCTGAACTAAACGAATG AAGGGGAACA CCAACTCAGC TGTCACCCCCGCCCCCAAGT GTCACTGGCT AGAAGATCTT CCCCCGGTTCGCCGGCAGCA CCGGTGGGTC TTGTCACCTC TGCGCCCCGCAGCCCTCCGG AGGCTGCAGT TGCTGTCTGC TGACAGGCGTCCCCTCAGGA GAACGGGAGC TCCTCCAGCG CAGGGCCCTGCTCAGCACCC CTGGTCCCGG GGGCCCCCAC GGAGGCCGCCGCGCTCAGTG AAACTTTGCC GCGCGCAGCA GTGGCCGGAGACCCGCGCGG ACCCTCTCCC CGCGGGGACC CGCCAGGGCGAGTCGCCCCT CCCCCGCGGC AGACGACCCG ACCTGGGCCAAGGTCGGCCA AGTGCTCGCC GCCTGCCCAG CGGCCCTTGGACCCACAGGA CCCGGACCCG AGTGCGCGGA AGCCTCCGAGCCGCGGCCAG GTCTCAGAAT GCGCGGCGGG GCAGCCCGGCCCGTCAAGCA GCGAAGCCGA AACTAGAAGC CTGAGGTCTGGCTTGGTCAC TGTTTGCTGG GGAACTCCGA CGAGCAACTACCCTTCGGGG ACTCAGTTTC CCCCGGGCCA AGTGAGACGGACAGCTGCGG CTCCCGCGAG AACTCGCGCG GGAACAGGAGCTGCGGGCTC CGCACAGCGC CCGGCACGTA GACCCAGTCTACTAACGGGC TGGAAGGTCG CGCTCCCGCC TCCGCGCCTCCCTAGAACCT TTCTCACCTC AAGCTCGGGC TCCCGGACTCTCTCACCTCA CGGCCCCTCC TTCCACCTTG GGCCGCCCAG CCTCAACCGC CCT LOH12CRNR_024061.1 GGCTACGCAA GACCTTCAGT TCCGGATTAG GAGGCCCCGC 20CCCCCGGCCC GAGGGAGGGG CGGAGAGACC CGCTCCTGCGACTTAGGGCG ATGCCACCTT AAAGGGCTTG ACCTCCTCGAAGCCAGAACT GCGGAAGAGG ATGGAGAAAG AAACGCTAGATAGACCCAGG ATTCGAACCC ACAACAGCTT GGATGCAAAGCTCATTTTGA ATTCTGAAGA GCTGGGAGTT TAGCAGTGGACGACCAAACA AAAAAATACC AGAAGACGGT GAAAGCAGCAGCTGGAAATG AGAGAAAAAT TAAGAAATAG AAAATGCTGTTTCATGTATT AGGGAGTGCA CATCTTTAAA GAGAAGTGAAGAACCTTTTT GGCTAGGCGC TTTCTGGGGA CCTTGGCAGTTATCAACAAG TCACTCTGAA ACTAACAGAA GGTGAGGAGGGAGTAATCCA GAAAGGAAAC TGCCATTTTT GCTAGGGCAAGAAAGTAGAC CTAGCAATGC AATGCCATCA AGGAGTTAGCTGGCTCTAGC GTTCTCCGAA CTTTGCAACT CATTTTATATTACATTGTCT GCGTCAAGAA ATTTCAAGTA AATGCCTTGAGATTTTATAT GTATAAAATG TAGTCTCTGG CCAGGCGGGGTGGCTCACGC CTGTAATCCC AGCACTTTGG GAGGCTGAGGCGAGTAGATC ACGATGTCAG GAGATCAAGA CCATCCTGGCTAACATGGTG AAACCCCGTC TCTACTAAAA AATACAAAAAATTAGCCGGG CATGATGGTG GGCGCCTGTA GTCCCAGCTACTCGGGAGGC TGAGACAGGA GAATGGTGTG AACCCGGGAGGCAGAGCTTG CAGTGAGCCG AGATCGCGCC ACTGCACTCCAGCCTGGGCG ACAGAGCGAG ACTCCGTCTC AAAAAAAAAAAAAAAAAAAA AAGTCTCAGA AGAAGTGTCA AGTTGACTAAATGATTTTTA AGTCCCTTCC ACTCTACTAT ATCACAATAATTTCCCCTAT TTTACCTTAT TTAATTTTCA CAACAACCCTGCAGCCTGTA AGTAGGTGAC TCCTCCATGG TCAGCAGGTGGTCAGTGGTC GAACTATTTA GGACTATCTG ATGCTCTTTCCTCTGCTCAC CATTGCAATA CAATGAGAAA AATGCAAATGAATCTAAGTA CAGTGTTCTC TGGGAATATG AAGATAGAACTAAAAACTGC CTGAGAGATC AGGGCAGGCT TCTAGAAAGTTGTGTCTAAC TAGTCTTGAG GTTTACATAA ACCACACCAGGCTGATGGGA CTGGGAAGGG CCCACTAAGC AGTGAGACCATTCCCTTTTG GAGAGTCCTT GCATCCCCTC CCAGATTTCCTCTTTGAGGG GAAGGTGAGA GAGGAGGTAA AAGGGGTGAGGAATGGAGAA TAACTCATTC TGGTTCTTGT TTCCCCTTTTCCACATAAAA GTATATTTGT CTTGTGTTCC ATACACCAGTCCATACTGAT GTGATGGTGT TTTTTATGCT TCCTTTTGAA TAAACATTTC ATTCTTAA PBXIP1NM_020524.3 GGTCAGTTTC TGGTCACATG ATTTTCTTCT CGGGCTGCAA 21ACAAAGGGAA GCCTGCAACA AGTTAAGCTG AAGACCGAAGCAAGAGCTGG TTCAGGTGGC AGCCACAGCA GCCTCAGGGACCTCAGCAAC TATGGCCTCC TGCCCAGACT CTGATAATAGCTGGGTGCTT GCTGGCTCCG AGAGCCTGCC AGTGGAGACACTGGGCCCGG CATCCAGGAT GGACCCAGAA TCTGAGAGAGCCCTGCAGGC CCCTCACAGC CCCTCCAAGA CAGATGGGAAAGAATTAGCT GGGACCATGG ATGGAGAAGG GACGCTCTTCCAGACTGAAA GCCCTCAGTC TGGCAGCATT CTAACAGAGGAGACTGAGGT CAAGGGCACC CTGGAAGGTG ATGTTTGTGGTGTGGAGCCT CCTGGCCCAG GAGACACAGT AGTCCAGGGAGACCTGCAGG AGACCACCGT GGTGACAGGC CTGGGACCAGACACACAGGA CCTGGAAGGC CAGAGCCCTC CACAGAGCCTGCCTTCAACC CCCAAAGCAG CTTGGATCAG GGAGGAGGGCCGCTGCTCCA GCAGTGACGA TGACACCGAC GTGGACATGGAGGGTCTGCG GAGACGGCGG GGCCGGGAGG CCGGCCCACCTCAGCCCATG GTGCCCCTGG CTGTGGAGAA CCAGGCTGGGGGTGAGGGTG CAGGCGGGGA GCTGGGCATC TCCCTCAACATGTGCCTCCT TGGGGCCCTG GTTCTGCTTG GCCTGGGGGTCCTCCTCTTC TCAGGTGGCC TCTCAGAGTC TGAGACTGGGCCCATGGAGG AAGTGGAGCG GCAGGTCCTC CCAGACCCCGAGGTGCTGGA AGCTGTGGGG GACAGGCAGG ATGGGCTAAGGGAACAGCTG CAGGCCCCAG TGCCTCCTGA CAGTGTCCCCAGCCTGCAAA ACATGGGTCT TCTGCTGGAC AAGCTGGCCAAGGAGAACCA GGACATCCGG CTGCTGCAGG CCCAGCTGCAGGCCCAAAAG GAAGAGCTTC AGAGCCTGAT GCACCAGCCCAAAGGGCTAG AGGAGGAGAA TGCCCAGCTC CGGGGGGCTCTGCAGCAGGG CGAAGCCTTC CAGCGGGCTC TGGAGTCAGAGCTGCAGCAG CTGCGGGCCC GGCTCCAGGG GCTGGAGGCCGACTGTGTCC GGGGCCCAGA TGGGGTGTGC CTCAGTGGGGGTAGAGGCCC ACAGGGTGAC AAGGCCATCA GGGAGCAAGGCCCCAGGGAG CAGGAGCCAG AACTCAGCTT CCTGAAGCAGAAGGAACAGC TGGAGGCTGA GGCACAGGCA TTAAGGCAAGAGTTAGAGAG GCAGCGACGG CTGCTGGGGT CTGTACAGCAGGATCTGGAG AGGAGCTTGC AGGATGCCAG CCGCGGGGACCCAGCTCATG CTGGCTTGGC TGAGCTGGGC CACAGATTGGCCCAGAAACT GCAGGGCCTG GAGAACTGGG GCCAGGACCCTGGGGTCTCT GCCAATGCCT CAAAGGCCTG GCACCAGAAGTCCCACTTCC AGAATTCTAG GGAGTGGAGT GGAAAGGAAAAGTGGTGGGA TGGGCAGAGA GACCGGAAGG CTGAGCACTGGAAACATAAG AAGGAAGAAT CTGGCCGGGA AAGGAAGAAGAACTGGGGAG GTCAGGAGGA CAGGGAGCCA GCAGGAAGGTGGAAGGAGGG CAGGCCAAGG GTGGAGGAGT CGGGGAGCAAGAAGGAGGGC AAGCGACAGG GCCCGAAGGA ACCCCCAAGGAAAAGTGGTA GCTTCCACTC CTCTGGAGAA AAGCAGAAGCAACCTCGGTG GAGGGAAGGG ACTAAGGACA GCCATGACCCCCTGCCATCC TGGGCAGAGC TGTTGAGGCC CAAGTACCGGGCACCCCAGG GCTGCTCAGG TGTGGACGAG TGTGCCCGGCAGGAGGGCCT GACTTTCTTT GGCACAGAGC TAGCCCCAGTGCGGCAACAG GAGCTGGCCT CTCTGCTAAG AACATACTTGGCACGGCTGC CCTGGGCTGG GCAGCTGACC AAGGAGCTACCCCTCTCACC TGCTTTCTTT GGTGAGGATG GCATCTTCCGTCATGACCGC CTCCGCTTCC GGGATTTTGT GGATGCCCTGGAGGACAGCT TGGAGGAGGT GGCTGTGCAA CAGACAGGTGATGATGATGA AGTAGATGAC TTTGAGGACT TCATCTTCAGCCACTTCTTT GGAGACAAAG CACTGAAGAA GAGGTCAGGGAAGAAGGACA AGCACTCACA GAGCCCAAGA GCTGCGGGGCCCAGGGAGGG GCACAGCCAT AGCCACCACC ACCACCACCGGGGCTGACAC CCTGCCCCAC AGGGAATGGC CTTGGCCTGGCCCAGCCCAA GATCCCAGCG TTATCTAACT CCTGGAGGGTGGACTCTGTC CTGGCTTGTT TGGTGTCCTC AGATATCTTTCACACAGTAG AGCAAAATCA CCAGCCCTGC ACTGATGTCACTTTATGTAG AAAAAGGCCT TAGCTGGACC TGCGTTGCCGTCTATGCAAA TGCATGCAAA TACTCCAGGC CCTGGGATGTGGGCTTGTGT TTTGTCACTG TGAAGGGGGA GATGGGAGAGGAGCCTGTTT TGGGGTGGGG TCTGGGGAAG GCAATCTGATTCTGAAGCTA AAGAGCTTTC ATCCTCTTGA GTGTATGTCCCCATAGTGGG CCCCTTGACC CACATGCTGA CCGGTGCCTTGGGATTTGAC TAGAGTTGCT GGCTCGAGGC CCAGCACGAGGACTTACCCT GGGGTTTTGT TAGGTTTGGA AGCAGCTGTCCCTAGGGGGT GAAGTCCCCC CCCTTTTTTT TTTTACCCCTGCTTCTCCCA CGGCTTCACC TCCCTATGTG AACTGTAGACTCAGATCCCA ATAAAGTGCT GTTGCAGCTA TGATGCTAGGTGGTTTCTAA GCACAGGGGA CACCCCACAC CCCCTGCCTGAATGGATGGG TCCATCCCAG GCACTGGTAC TTGCCCCCTTGTTCTGTATC CCCCTTTGCC CTTGCCTTGC CCTTCCAACAAACCCTAGGC CCTTGAGAAG CTGATACTTC TCCTTTTGCTCACAGCTGCC TTGGCCCCAC CCCTGGGAGA TGTAGCAAATTGAGTGTGGG TTTTGGAGTC TGAGCCTCAG GCTCAAATCCAGGCCAAGTG ATCTTGGGCA AGTTAATCTC TGGGAACTTTGGGTTTCTTA TCCTCAAAAA AGGCGATGGA AGGGCTGGGGAAGTGATTAA ATAAAAGCAA CGCAAGAAAA AAAAAAAAAA AAAAA RNF5 NM_006913.3AATAGTGATT AGGAAACCTT GAAGCCTGCC CAACGATCGT 22GGGCAGGAGG TGGTTTCTGG TTTGTTGGGG CGTGTGTATGTGTATTTGGG GGGACTGAAG GGTACGTGGG GCGAAACAAAACCGGCCATG GCAGCAGCGG AGGAGGAGGA CGGGGGCCCCGAAGGGCCAA ATCGCGAGCG GGGCGGGGCG GGCGCGACCTTCGAATGTAA TATATGTTTG GAGACTGCTC GGGAAGCTGTGGTCAGTGTG TGTGGCCACC TGTACTGTTG GCCATGTCTTCATCAGTGGC TGGAGACACG GCCAGAACGG CAAGAGTGTCCAGTATGTAA AGCTGGGATC AGCAGAGAGA AGGTTGTCCCGCTTTATGGG CGAGGGAGCC AGAAGCCCCA GGATCCCAGATTAAAAACTC CACCCCGCCC CCAGGGCCAG AGACCAGCTCCGGAGAGCAG AGGGGGATTC CAGCCATTTG GTGATACCGGGGGCTTCCAC TTCTCATTTG GTGTTGGTGC TTTTCCCTTTGGCTTTTTCA CCACCGTCTT CAATGCCCAT GAGCCTTTCCGCCGGGGTAC AGGTGTGGAT CTGGGACAGG GTCACCCAGCCTCCAGCTGG CAGGATTCCC TCTTCCTGTT TCTCGCCATCTTCTTCTTTT TTTGGCTGCT CAGTATTTGA GCTATGTCTGCTTCCTGCCC ACCTCCAGCC AGAGAAGAAT CAGTATTGAGGGTCCCTGCT GACCCTTCCG TACTCCTGGA CCCCCTTGACCCCTCTATTT CTGTTGGCTA AGGCCAGCCC TGGACATTGTCCAGGAAGGC CTGGGGAGGA GGAGTGAAGT CTGTGCATAGATGGGAGAGC CTTCTGCTCA GAGGCTCACT CAGTAACGTTGTTTAATTCT CTGCCCTGGG GAAGGAGGAT GGATTGAGAGAATGTCTTTC TCCTCTCCTA AGTCTTTGCT TTCCCTGATTTCTTGATTTG ATCTTCAAAG GTGGGCAAAG TTCCCTCTGACTCTTCCCCC ACTCCCCATC TTACTGATTT AATTTAATTTTTCACTCCCC AGAGTCTAAT ATGGATTCTG ACTCTTAAGTGCTTCCGCCC CCTCACTACC TCCTTTAATA CAAATTCAATAAAAAAGGTG AAATATAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAA SERTAD2NM_014755.2 CTCCTGCACG GCGAGTGCTG GAGCACGACG TACCGCTCGC 23TCGGTCAGGG CGCCCCCTCC GCCCGCCTCC TGCTTCCTCCTCCGCTGCCT GCCGCCGCCG CCTCCACCAT TGTATAATGCTCGGGGCGCG CAGGCAGAGA ACGGCGGAGT CTTAGCTTCAGCCTCGCCTG CTGCCCGCTC CCCGGCGCCA CCCTCGGGCCCCTGGAGCGG GGCACTCCGC ATGGAGCGGG AGTAGCTGAGGAGTGGGCGG AAACCCCTCC TGATGCGTTA GTTCCCAGGTGGAGCTGCAT GTGATATATG TTGGGTAAAG GAGGAAAACGGAAGTTTGAT GAGCATGAAG ATGGGCTGGA AGGCAAAATCGTGTCTCCCT GTGACGGTCC ATCCAAGGTG TCTTACACCTTACAGCGCCA GACTATCTTC AACATTTCCC TTATGAAACTCTATAACCAC AGGCCCCTGA CAGAGCCCAG CTTGCAAAAGACCGTTTTAA TTAACAACAT GTTGAGGCGG ATCCAGGAGGAACTCAAACA GGAAGGCAGC CTGAGGCCCA TGTTCACCCCCTCCTCCCAG CCCACCACCG AGCCCAGCGA CAGCTACCGAGAGGCCCCGC CGGCCTTCAG CCACCTGGCG TCCCCGTCCTCCCACCCCTG CGACCTCGGA AGCACTACGC CCCTGGAGGCCTGCCTCACC CCGGCCTCAC TGCTCGAGGA CGACGATGACACGTTTTGCA CCTCCCAGGC CATGCAGCCC ACGGCTCCCACCAAACTGTC ACCTCCAGCC CTCTTGCCAG AAAAGGACAGTTTCTCCTCT GCCTTGGACG AGATCGAGGA GCTCTGTCCCACATCTACCT CCACAGAGGC GGCCACGGCT GCGACTGACAGTGTGAAAGG GACCTCCAGC GAGGCTGGCA CCCAGAAACTCGACGGTCCT CAAGAGAGCC GCGCAGATGA CTCAAAACTGATGGACTCTC TGCCTGGGAA TTTTGAAATA ACGACGTCCACGGGTTTCCT GACAGACTTG ACCCTGGATG ACATCCTGTTTGCTGACATT GATACGTCCA TGTATGATTT TGACCCCTGCACTTCCTCAT CAGGGACAGC CTCAAAAATG GCCCCTGTGTCTGCCGACGA CCTCCTCAAA ACTCTGGCTC CTTACAGCAGTCAGCCTGTC ACCCCAAGTC AGCCTTTCAA AATGGACCTCACAGAGCTGG ACCACATCAT GGAGGTGCTT GTTGGGTCCTAAGACCCAGG GACCCAGCGA CTATGCCCAC CCAGACCCCAGAGCGTTCCC ATAACCCTGA CAGTTCTCCA CACTGTGCATGCACCCTTGC TTGCCTTTTT CAGAGAAAAA GAAAATTTTACAACAGGATC ACACTAGTTT TTGCTTTGAG CAGAGTTGGAGTGCCTTCAT CCAAGTATGA CCACTTTTAA TACACTTTTTTGAGTGGTTC CTCAGAGACC TACTACCCTG GTATAGGAAAGAATCCATTT GAAGACAATG TTGCAATGTT GAATGACAAAAATAAACAGT TCAAGTGAAG CACAAGGATT AAGTTGGAAAAGCTGTAAAT TGCATGTGCA TATTTGTCTA TTTTTTCTATAAGTTTTATT GCAAGAGGTA AAGAAGAAAA CTATATATATATATCTTATT TAGATAATCT CAGTACCTTT TCTGGCATTTTTGCCCTGTA TAGGTTGACT TGGCAATTCG GCCTTTTTAGAGGCATTAAC TACTCCTCGT AAGTGTTGCA TTTACATGGCTGTTTAGAAA ACTGCTGCCC AAATTTATTT TATATTTTTGTACAGATTCT GCAGTTTATG ATATTGTTTT TCTAAAAACAAATGCTGTTT ATACATATGA GATAGCTATT TTGATAGGATTTGCTCACAT AGTTCCTGCA AACTTCAGAT GTACAAGTTGCACTTGTACT TTTATAGAGT TGTAATGTTT TATATGTGTATGGTGCAAGA GAAAATTGGA TCAAATCAAT CTGCAGTTGATGTCCCCAAA TGCAAACACA GGCACACACA TGCACACACCCATAAACACA CACACAGTGC TTTAAGAAAG GGCCAGGTGATATCACACCC AAATTTCACA AGCACTGACC CCCTGGCACCAACACCCGCC AGTACTGTGA CTTCCAAAGC CAGAGCCACATGTGCTCATC AAACTTGCAT TAAGCAGTTG GCGGGAGATGGCTGTGGAGC TGGGGGTTTA AGTGATGGTT CTCTTTTGCTCCCTCTTTTG AGGGTAAAGC TACTGTCTTT CTTAAGAGTGTATTTATGCC AAGTTTGCGC TTTTAATTGT TTTTATTTTGTTTTTTAATG AAAACCCAGA TCTTTCCTTT TTGGCATAATTTTTATGATG ACCTGAAATT TTACATCCGA ACAAAATTTTACATCCGAAA AGCAACCAAC TTCTTCATGG AACTCAGCCCTGTTGCAATG CTTAGGGCCC TTAAAGAAGA AAATCTCCCCAGAAGGCATC CATCATGTTG CTTAATTGTC TTCTGCAGCTTCCTTTCCCT AGAGCTTTCC CTGTGTTGCT AAGAGCTGAAAATGGCATCT TCGTGATCAC CACAGTGAGC TTGGCTCGCCTCGGCCGGCC CGGGATGCAC TCTTACAACA TGTGTGACTCTTGAACCTGG AGTTCATCAC ATTACGTCAC AGCTTCCCATCTGGTTGCTT TCCTGAGTCA GCTACTTCAC ACTTGTCAAGGCTGTTTTAC CCCAAAACTC AGACAGGACT TTCTATGCATGTTTTCCCTC CTCCCCCCAA TTCCCCCCCC CATCACCTTATCTCCCAGGA CACACTTGAG AAGTAGCTTT TTATTCCTAGTGGTGTACAT TTAATTTTAA AAAGGTTGCA ATGTATCATGCTTGTTGCCG AAACTGTTTA TGGCCTTCTT GTTTCAGTTTTTTCTTTTCT TCCAATGGTA CTTTAGCTGT TGAGTGCAGGTTACAACCTA TATTGTTATG CAGATGGCTT CTTTAGGAATAACTTTTATA TTTATTTAAA AATTTTTAAA TTATGGGATGTTTTGTTGTT GTTGTTGTCT TTGTTGTTGG TCATTTGTCAATATTCAGTC ACCAATTCTG CTCACTTCTT GCCATGGATAAAATTGGGTC TTTCTGGCTA ATTAAAAAAG ACAACTTTATAAAATGGCAC TTTAAGCAAG CCATAGTTAG TTTTATTTTTGTAATGCACA TGGCAAAGCA AAGACGTTTG TGATGAAGGAACTGCTCATC TAAGCAAAAG ATTTGAGTAT GATATGATAAAGGCTTTCTA CATTCTAATT TACTTTTTCC CCCCACTTGAATGTGTTTTA AAGGCTAATT ATCAGCTCAG TAGAGCAGTGAGAAACTGAT CAAATTGCAC TTGTTCTCCT ACAAGCAACCTCCACGCAGA CACCTCGTAC TGCTACAGGT GTGTCATTTCCTTTAATAGG ACCAGGGACC ATGTAACTGA GGTGAGGGTTGTAGTAGATG CTTCCAGTGT CAGTATGCCT GTTAATTTTAAGAGCTTCCC TTTCTTGCAG AGAACAAGTC TGCCCAGATTCCATGCTTTC TATAACTGGA GGACCTGGCA AACCTGCCGCATGCTGCACA CATCTACCTA CGTACACATA TACAATAGTATTGATGATTC TGAACAATAA CAGGGTAAAA CAGTTGGTTTGCCATTGTTA AAAACTGATT TACAGTAACT TACAACAACTGTACTTTTGT TGGATTAGCA AATCATGTGT TTAAACAAATCCCATATGTT GGGCAACAGT TCAAATAAGC ACGGAGAAGTGTTGCCCAAA CTTGGTTCTC TGACTCTTAT GTATTTGTAAGGCTGGGCTT CAAAATCAAA ACAAAAACCC CAAAAACAGCAGGCAAATGC TTTTTAACTC TGACACCGTT GCCATAAATCCCTGATACTC AAAGTCTAAC AAGAAAGACA TGGAAAATTAGCAGCCCATT TTCAGAAAGA TCAAAATGAT CTAGGGTTCTAATTGCTTTT GCATCCTATT CTTACAAAGT GATGTCCCAACAGGGAACAG TAGGAGCTGG AGTGGGATCT CCAAGTCCCAGTTTGAGTGT GGGATGTGCT TCCAGCAGTG CCTTCCCTTTATGAAAGACA TCACATGGCA TCCAGGGCCA GGCAGGCAGCTTGAGGTGCC TTTACGAGAA AACCGAGCTG GGGCTGGGAGAGGACAGTTA TTGACACTGA TGTGCAATGA AGTGACAAGATGAGAGCAGA ATCGTAAGAG CTTTGAATTT GAAGTGAGTTTTTTTCCCCC CATAAGTTAT TTATTCCTTT TTTCTGTGTAAATATATTTA TTTTACTGTG GAGCGCTAAC ATCTGGATCGTAACATGTGC AGAATGTATG GTAGGAATGT ATTCTCTTGTAGGAATGTAA ATCTGTATTA AAAGGGGGTC CAAGCCAGGCCCCCAGGTCT TCTCATTGTA TGCACAGTCC GCATTCATTTTTACTCTTCT CTAATATGGG TCTATTTGAA ATATGCAAAAGGTATGAGGA ATGTTTTAAT ACCTCCAAAT TTTTAAGAAAAGCATCAAAG GGTTGATATT TTTTAAAGTT TTTTTAGTAGCACTTTCTCT GGATGACAGA AGGAGCAACC ACATGGGCACCCTTGTTCAT ACCAAAGGGT GAGCAGTGGC CAGAGCCTCCTCTGCACCTC TCGAGTGTCT TTACCAATTG AGCTTTTTATCGCCATAGCC CCTTGGAGTG CCCCAGCTGC CCTGAGGTCAATCAAGGAAA ATTTCTTAAT GAAATAAGCT CCAAAGAGCCAAAGTATCAA CTTACAGATC GTTTTTAAAG CTTAAATTTATGAACCACCT TTGTGGTAAA CAATGAATTA TGAATACCGCAGGGCAGCCT TCTTAAATGA CAAATGTAAA AAAAAAAAAAAAAAAGACTC TACTTCGTGC AGCAATTGCT ACTCTATACGAATTGTCTTA ATTTGAAAAC CTTGCTGTTA CAAATTGGACCTTTATACAT TTTCTGAAAA CAATGAAAAG AGTATATTTAACCTTTTCTG GCTGTAAATG GTTACCTTCC TGTAACTGCCCCGCACCTGG AGGCATGGAG TTGTGTGCAT CCTGCTTATGTACAATTGTT TTCAGTGTTT CTAAGAATGA GTCTGAATGGTTCTTGAAAA TTAGCCAGGA TCAAATGCTA TTGCAGACAAAGCCAATAAA AAGTTGGACT TCTTTTGGGG ATAACAAGTTTTGGAAGAGA AATGCAGGCC ATATGTGCGC ATGACCGAGATTTTGAAAAA AGATGTACAT AGTGACATGT TTGGTGCATGGTTTTTGAGG AGGGCTTTTG TCAAAAAGGA GGTATAACCTTTCCCCCACA GACCTGAGAG CTGTGCCTTT TCTATGCAATATTACAGACG TTACATCGGA ACCCAGATGG CTGTATTCACATGTAGGTTT GGGCTGTAAT CTAAACAATT GGACAGATTAAATGTACATG GAAATGAGCA GTCTTACTTT TGTAGTTTTATATTATACAA TAAACAGTTA AAAGATGAAA AAAAAAAAAA AAAAA SLC35G5 NM_054028.1TACCACCTCA GGAGAGTTCC AGGGAAGAAC CCCACCCGCA 24CTCCAATGAG GTCACAATGG CTGGAGCTCT GAGGGGCCCAGGCTCCCTGA GCCAGGAGGA GAGGAGAAAG TCCAAGGAAAGATGGCTGGC AGTCACCCCT ACTTCAACCT GCCTGACTCCACACACCCAT CGCCGCCCTC CGCTCCACCC AGCCTCCGCTGGCACCAGCG CTGCCAGCCC TCTGGTGCCA CCAATGGCCTGCTGGTGGCC CTGCTGGGTG GGGGCCTGCC TGCTGGCTTCGTGGGCCCCC TTTCTCGTAT GGCTTACCAG GGTTCCAACCTGCCCTCGCT GGAGCTGCTC ATCTGTCGAT GCCTCTTCCACCTCCCTATT GCCCTGCTAC TTAAACTGCG TGGCGACCCCCTTCTGGGAC CTCCTGACAT CCGAGGCTGG GCCTGCTTCTGTGCCCTGCT CAACGTCCTC AGCATTGGAT GTGCCTACAGTGCAGTTCAG GTGGTGCCCG CTGGCAACGC TGCCACTGTTCGCAAAGGTT CTTCCACCGT ATGCTCCGCT GTCCTCACCCTCTGCCTTGA GAGCCAGGGT CTCGGTGGCT ACGAGTGGTGTGGACTGTTG GGCAGCATCC TAGGACTAAT CATCATTCTGGGACCTGGAC TCTGGACACT ACAGGAGGGG ACCACAGGTGTCTACACCAC CCTGGGCTAT GTGCAGGCTT TCCTGGGAGGCCTGGCGCTG TCCCTGGGGC TTCTGGTCTA TCGTTCTCTGCACTTTCCCT CCTGCCTCCC AACAGTGGCC TTCCTATCTGGCTTGGTGGG GCTGCTGGGC TGTGTGCCAG GCCTCTTTGTGCTGCAGACC CCCGTGTTGC CCAGTGACCT CCTGAGTTGGAGTTGTGTGG GGGCAGAGGG GATCCTCGCC TTGGTCTCCTTCACATGTGT GGGCTATGCG GTCACCAAGG CCCACCCTGCCCTGGTGTGC GCTGTCCTGC ATTCCGAGGT GGTTGTGGCCCTTATACTGC AGTATTATAT GCTCCATGAG ACTGTGGCACTTTCTGACAT CATGGGGGCA GGGGTTGTGC TGGGCAGCATTGCCATCATT ACAGCCCGGA ACCTCAGCTG TGAGAGGACAGGGAAGGTGG AGGAGTGAGA TAGAACTTGG GAGCCCGGGGGTTGGGAGGG ACAGGGATAA ATAAAGACAA AGACTGAAGA C SPATS2L NM_001100422.1AGTGCTGAGG GAGCAAAGTT CATTTTCTCG GGTAGGAGAA 25GATGATTCTC TTGCAACACG TGCGGATTGT GACAAAATCTTTCATTAACA AGGGGAGTTT CGGTGAAGTG GAGGTTTGGGGAAAGGCGAG GAAGTCGGTC TGGAGCAAGC AAGCAAAGTGCGGAAGCTGT ACTGGGATTC TTCTAGAAAG TGGGGTGGGAAAGGAGCTAG GGAGGGCGTG TGGAGGGACG AGATCTGTGTCAGAACGTGC GTGTGAGCGG ATACAAAACC CGAGAGAGGCGTGAGCAGCG CTGTGTTTGC GAGCGGGAGC GAGGGGCGCCGGCTGGGGTG TGTGCTCCTG AGCTCTTCAG AAACCAGGCTGCTTTCAGGA ACATTGCTGT GGATTCCCAG GGCCTATTCCACTAGAAGCA AGATGGCTGA ACTCAATACT CATGTGAATGTCAAGGAAAA GATCTATGCA GTTAGATCAG TTGTTCCCAACAAAAGCAAT AATGAAATAG TCCTGGTGCT CCAACAGTTTGATTTTAATG TGGATAAAGC CGTGCAAGCC TTTGTGGATGGCAGTGCAAT TCAAGTTCTA AAAGAATGGA ATATGACAGGAAAAAAGAAG AACAATAAAA GAAAAAGAAG CAAGTCCAAGCAGCATCAAG GCAACAAAGA TGCTAAAGAC AAGGTGGAGAGGCCTGAGGC AGGGCCCCTG CAGCCGCAGC CACCACAGATTCAAAACGGC CCCATGAATG GCTGCGAGAA GGACAGCTCGTCCACAGATT CTGCTAACGA AAAACCAGCC CTTATCCCTCGTGAGAAAAA GATCTCGATA CTTGAGGAAC CTTCAAAGGCACTTCGTGGG GTCACAGAAG GCAACAGACT ACTGCAACAGAAACTATCCT TAGATGGGAA CCCCAAACCT ATACATGGAACAACAGAGAG GTCAGATGGC CTACAGTGGT CAGCTGAGCAGCCTTGTAAC CCAAGCAAGC CTAAGGCAAA AACATCTCCTGTTAAGTCCA ATACCCCTGC AGCTCATCTT GAAATAAAGCCAGATGAGTT GGCAAAGAAA AGAGGCCCAA ATATTGAGAAATCAGTGAAG GATTTGCAAC GCTGCACCGT TTCTCTAACTAGATATCGCG TCATGATTAA GGAAGAAGTG GATAGTTCCGTGAAGAAGAT CAAAGCTGCC TTTGCTGAAT TACACAACTGCATCATTGAC AAAGAAGTTT CATTAATGGC AGAAATGGATAAAGTTAAAG AAGAAGCCAT GGAAATCCTG ACTGCTCGTCAGAAGAAAGC AGAAGAACTA AAGAGACTCA CTGACCTTGCCAGTCAGATG GCAGAGATGC AGCTGGCCGA ACTCAGGGCAGAAATTAAGC ACTTTGTCAG CGAGCGTAAA TATGACGAGGAGCTCGGGAA AGCTGCCCGG TTTTCCTGTG ACATCGAACAGCTGAAGGCC CAAATCATGC TCTGCGGAGA AATTACACATCCAAAGAACA ACTATTCCTC AAGAACTCCC TGCAGCTCCCTGCTGCCTCT GCTGAATGCG CACGCAGCAA CCTCTGGGAAACAGAGTAAC TTTTCCCGAA AATCATCCAC TCACAATAAGCCCTCTGAAG GCAAAGCGGC AAACCCCAAA ATGGTGAGCAGTCTCCCCAG CACCGCCGAC CCCTCTCACC AGACCATGCCGGCCAACAAG CAGAATGGAT CTTCTAACCA AAGACGGAGATTTAATCCAC AGTATCATAA CAACAGGCTA AATGGGCCTGCCAAGTCGCA GGGCAGTGGG AATGAAGCCG AGCCACTGGGAAAGGGCAAC AGCCGCCACG AACACAGAAG ACAGCCGCACAACGGCTTCC GGCCCAAAAA CAAAGGCGGT GCCAAAAATCAAGAGGCTTC CTTGGGGATG AAGACCCCCG AGGCCCCGGCCCATTCTGAA AAGCCCCGGC GAAGGCAGCA CGCTGCAGACACCTCGGAGG CCAGGCCCTT CCGGGGTAGT GTCGGTAGGGTTTCACAGTG CAATCTCTGC CCCACGAGAA TAGAAGTTTCCACAGATGCA GCAGTTCTCT CAGTCCCGGC TGTGACGTTGGTGGCCTGAG CTAGGAGGAA AAAGAGCAGT TTTCACTCAGTTTTGGTTCC CTGCCCGAGG TGCTGACCCA ATTCGCTGCCAAAAGAGTGT CAATCAGAAT ATACAAATCC CGTATGGTTGTGTCATCCTC TCTTAATCAT TTTTACTAAT TCTAATAATCAGCTCTAGCT TGCTTCATAA TTTTCATGGC TTTGCTTGATCTGTTGATGC TTTCTCTCAT CAAGACTTTG CAGCATTTTAGCCAGGCAGT ATTTACTCAT TATTAGGAAA ATCAAGATGTGGCTGAAGAT CAGAGGCTCA GTTAGCAACC TGTGTTGTAGCAGTGATGTC AGTCCATTGA TTGTCTTTAG AGAGTTAATGTTACAAAAAA GAATTCTTAA TAATCAGACA AACATGATCTGCTGAGGACA CATGCGCTTT TGTAGAATTT AACATCTGGTGTTTTTCTGA AAAAATATAT ATACATATAT TGCTTTATTTGAAACAAATT AAAATATGCT GCATTTGACA CCTGGCTAGTTTCTTTTATT GATACCCACC TAGTTATTGA ATGTACTGTTTAGTGCTTTC AAAAAAAACT TTAGAGACTA GAGGTTGTGGTGCAAAGCTG TGTACAATAA ATACTGTTTC TGTTGAGACAAGTACTCTTT CAGGAAAATA TATATATGCC CTTTCAATTAGATTACACAA ATAGATGGAT ATGCACCCTG ATCATCTTAGACACACCATG TGGCAGTTGG GCAGTTGGAA ACATTGGTTGCAAGTACTAC AAACCTCAGC TGAGCCTAGC TTCAACAATAAGAATTTATT GGTTCAGTGA GTGAAAAGTC CAGTTGGTCCAATTTGATCA GGATTTCAGC TCCCATCTCT TTTTTTTTTTTCTTTTTTCT TTTTCTTTTT TTGAGACAGT CTTGCTTTGTCACCCAGGTG GAGTGCAATG GCATGATCTC GGCTCACTGCAACCTCCGCC TCCTGGGTTC AAGCCATTCT CCTGCCCGGCCTTCCGAGTA GCTGGGATTA CAGGCATGTG CCACCACGCCCTGCTAATTT TTATATTATT AGTACAGACA GGATTTCACCATGTTGTCCA GGCTGGTCTC AAACCCCTGA CCTCAGGTGATCCACCTGCT TTGGCCTCCG AAACTGCCGG AATTACAGGCATGAGCCACC GTACCCGGCC AGCTCCCATC TCTTAATTATCTTAGCTCTC CTTTCCTCCT TGGGTTGACA TTGCATTCAGAATTGTGGCA AAGGGCCACC ATGCTCTTAA GACTCAAGTCTATTTTCCAC ACTGTCCAGA GGAGAGAAGT TATCCTAGTAGCTTCTACAC AGAGCAAGTG TCTTTCTCAG AAATCCCAGCAAAGGTCTTG CATACCATTG CTGGTAGGCC TGTCTCTTAAACCAATCATG AAAGGGGGGA GAGAAGTGAA TGGGATGAACTAATTTGCAT AGACTAATTA GAGCCCACCC CTGGAGCCTGGGTGTGGCCA TCTTCCCAGA GTTCCTGAGC TAGATGGAGAAGGGGTACTT CTCAGAAAGG GAAAATGGAT ACCCAATGGCCCAAACCCAA AATAGCCCCA GTTCCCCTAA CTTTGACTACAGGGCAGTCC AGTTTGGGTG CCGCTTCCGT TGCACTCACATGTCCTACAT ATCTGTTGAC TACTCACAAG TGCAAATGCTTATTCTCAAC TCAACATTAA CATTTTTTCT GGCAACCCAGGTTCACTGGT TCTCTTCCAC AGAGCGGCCC TGAGCAGCTGAGCCTGCAAG CCACGCAAGC ATCTGTTTCT TCTTTTGCCAAGTACAGGAG GATGTTTGCT CTCTCTGTAG AGAGCTTTCTGAGGTCTCTG GGTGTACCCA GAGATTTAAT AGAAATTCTTAACGTTAAGT CACATTCCAG GAAGGAAGGA AGAGTTGTTCGTTCAAATAA GAAAGATAAA TGTTCGGCAC TGTAGGCCCTGTTTACCCCA TCTGAGGCCC TGAATTCATA TATTACAAGACGGAAGGATT TTGCACAGTT TTTTATGTAG CAAGATTTTGCTCACCACTG AAAAATGTCA GTGTAAATGT GACCGCTTTAAAGATGAGTC AAGTAATTCT TGGAACAGGG AAAAAAATGAATTTGCCAGG TCAGGAGTTC ACCTGCCTTT GTCAGAGTTGAACCCAACCA CTCTTGACCT CGACTCACTC CCTTAGGGTTAAGAAAGCCC AAACACATTC CTGAGCACAG AGCAAACACTCCCATGTCAC TGAAAAGAAA CAAAAGAATG CTAAAAAGTGCTCAGACCTG ATCACATTTT TTCCAATATT TTTTCCTTTTTTTTTTTTTT TTTGAGACAG GGTCTTGCTC TATCACCTAGGCTGGAGTGC ATGTTTTTGA GACAGGGTCT TGCTCTATCACCTAGGCTGG AGTGCATGAT CATGGCTCAC TATAGCCTTGAACTCCTGGG CTCAAGCCAT CCTCAGCCTC CCAAGTTGCGAGGACTACAG GTGTGCACCA CAACGTCCCA GCTACTTTTTAAATTTTTAG TAGAAACGAG GTCTCACTAT GGTGCCCAGACTGGTCTCGA ACTCCGGAGC TCAAGTGATC TTCCTGCTTTGGCCTCCCAA AGTGTTAGAA TTACAGGCAT GAGCCACCTCGCCTGGCTGG TTTTTGCCTT TCTTATAGAC CCTGGGCATGTAAGCATTTA TTAGTTTGCA TTTTTGAAAC AGTAATTTCAATATTTTAGT GCCAATGTCA GGCCGCTTAA ACACTGTATTACATATCTTC ATCTGTCTGG TGGAACTATT GGTGTGATCCTAGAGAACTG AGTCCTATTC TGCCATTCAT TTAAAGTGTTTTAAACTCTA ATCTCTCTAC TTAATGCACA GTAGTCAGATTATTCTCTTA AACATTTGCC TAGTAGAGGT TAAAATAGTTTAATCCTTAT GAAGATGGAA TAACTTCAAA CTCACATTGTGGCACTTAGA TCTTCCACCA AGACTTCATC CGTGAAATCCACACCTCCCT GTTGGGTTCC CAATTACATT CCAAATTTACATTTCTTTTG AGAATCTCTG CATACTCCAG CTCTGTCCTGTTGATCCTAT TCTAGAAGTG CTTAATGCAG CAAGACACAGAAAGTTAAAC GCAAATTGCT GCAAAATTCA CCCTCAGTGGAGGACTAGAA ACACAACATG TCCAATTTAA AGCTCAGTTCACAAGCAGTT CAATTCTGCT GGCATCAGAA AAGGAGATTCTAATTAAACA TTCTTAGGGA AGGACATCAA ATGAGGTTAATGGGAAACGT TACCAGATTA AAAGCAGTTT TTTGACAAAGTAACAGATTT GGAAATTCTG ACTCTCTGAA AGCCTTGATTTGAACCTCAA ACTTGATTTC ACCATGAGAA GTGGGGATCAAGGGCCTGCG CAGTTCTTTT CCTAAATCGA TTCGGTGCTCCCCACCCCGA CGCAGGCACA GGTCCGCAAC CAGATAGGGAGATGCCTGAA TTTCAGGCTA CCTTTGACAA AGCTTTCTTCCTCCCTCCCT CCCTTTGCAC GCTGCATCCC ACGCTGCCTGCTTAAAGCGC CCTCATGTGT CTACAGATGG TAAAACGTTTATTTCTCAAC AGACATTCCA GTGATAGCAT CCAATGACCTATGTAACGGC ACCCTTTTTT GCTGTACGCG TTTTTTGAGATGGAGTCTCG CTCTGTCGCC CAGGCTGGAG TGCAGTGGCGCGGTCTCGGC TCACTGCAAG CTCCGCCTCC CGGGTTCACGCCATTCTCCT GCCTCAGCCT CCCGAGTAGC TGGGACTACAGGCACCCGCC ACCACACCTG GCTAATTTTT TGTATTTTTAGTAGATACAG GGTTTCACCG TGTTAGCCAG GATGGTTTTGATCTCCTGAC CTCGTGATCC ACCCCCCTCG GCCTCCCAAAGTGCTGGGAT TACAGGGGTG AGCCACTGCG CCCGGCCCCAGTCACTTGTT CTTAAGTTTC TTAAGCAAAC TATAAAATAGCAAAAGACCA AAAAAAAAGG AAAAAAAGCA GTTCGCCTAATACATTGTTC CAGCATTTCC TTGAAAGTAC TGAGCCATCTCAATTGCTCT GATTTTGTGA GAAAATTATG AAGAGTTGCAAAGTCCCAGT GATTCTCTTG TTACTTAGCT AAGAATTTGAAATGTAATTT AAATACTATT CTTTACAATC CATTATAAGGATTTTAAAAT CTTTTTGCTT CTTTAATAAA TTCTAACAAA GAAAAAAAAA AAAAA TDRD7NM_001302884.1 AGAGCCGAGG CCAGGCTGCC CTCGAAGCGG GGCGGGGCGA 26AGCGGGGCGG GGCCGAGCAG GGCGGGGCGG GGGCTTGAGGTGATTCCCAA GCCGCGGGGC GGCTCCGGTG GTGCGGGGAAACCGAAAGTG GGCGGCGGCC GCGGCGGGGC CCCTGGCGGAGACGGCGGCA GGAGCTGGGC CCAGAGACGC GGGGACGGGCCGTGGGCCCC CGGAACGAGA TTACCTGCTA TGCCATGGCCTGCACAGAAA CTGCAAGAAT TGCTCAGCTT GTGGCTCGTCAAAGGAGTTC TAAAAGGAAA ACCGGGCGTC AAGTTAATTGTCAGATGAGA GTGAAGAAAA CCATGCCATT TTTTCTAGAAGGAAAACCAA AAGCAACCCT CAGACAACCA GGATTTGCTTCAAATTTTTC TGTTGGCAAA AAACCTAATC CAGCACCGTTAAGAGACAAA GGAAACTCTG TTGGAGTTAA GCCTGATGCTGAAATGTCTC CTTATATGCT ACACACAACT CTTGGAAATGAAGCATTCAA AGACATTCCA GTGCAAAGGC ATGTGACCATGTCCACCAAC AACAGGTTTA GCCCAAAGGC GTCCCTTCAACCACCTTTGC AGATGCATCT CTCAAGAACC TCTACTAAGGAAATGAGTGA TAATTTAAAT CAGACTGTTG AAAAACCCAATGTCAAGCCT CCTGCCTCTT ACACTTATAA AATGGATGAGGTTCAAAATC GCATAAAGGA AATACTAAAC AAGCATAACAATGGCATTTG GATATCTAAG CTTCCACATT TTTACAAAGAGTTATATAAA GAAGACCTTA ATCAAGGAAT TTTACAACAGTTTGAACACT GGCCTCATAT TTGCACGGTG GAGAAACCTTGCAGTGGTGG CCAAGATTTA CTTCTTTATC CAGCTAAGAGAAAGCAGCTT TTGAGAAGTG AACTGGATAC TGAGAAAGTACCTCTATCCC CACTACCTGG TCCCAAACAA ACACCACCGTTGAAAGGGTG TCCAACAGTT ATGGCAGGAG ACTTTAAAGAAAAAGTGGCA GACCTGCTGG TGAAATACAC AAGTGGCCTTTGGGCCAGTG CACTTCCGAA AGCATTTGAG GAAATGTACAAAGTGAAATT CCCTGAGGAT GCCTTAAAAA ATCTTGCCTCACTTTCTGAT GTATGCAGCA TAGACTACAT TTCTGGAAATCCCCAGAAGG CCATTCTCTA TGCTAAACTT CCATTGCCCACTGACAAAAT CCAAAAGGAT GCAGGGCAAG CACATGGTGATAATGATATC AAGGCTATGG TTGAACAAGA GTATTTGCAGGTAGAAGAAA GCATTGCTGA AAGTGCTAAT ACCTTTATGGAGGACATAAC AGTTCCTCCT TTAATGATTC CAACTGAAGCATCACCATCT GTATTGGTGG TTGAACTGAG CAACACAAATGAAGTGGTTA TCAGGTATGT GGGCAAAGAC TATTCTGCTGCTCAGGAATT AATGGAAGAT GAGATGAAGG AATATTACAGTAAGAATCCT AAGATCACAC CAGTCCAGGC TGTGAATGTTGGGCAGTTGC TGGCCGTAAA TGCCGAGGAG GACGCCTGGTTACGGGCACA GGTCATCTCA ACAGAAGAGA ACAAAATAAAGGTATGCTAT GTTGACTATG GTTTTAGTGA AAATGTTGAAAAAAGCAAAG CATACAAATT AAACCCGAAG TTTTGTTCACTCTCATTTCA AGCTACAAAA TGTAAGCTTG CAGGCTTGGAAGTCCTAAGC GATGACCCTG ATCTAGTGAA GGTGGTTGAATCTTTAACTT GTGGAAAGAT CTTTGCAGTG GAAATACTTGACAAAGCTGA CATTCCACTT GTTGTTCTGT ACGATACCTCAGGAGAAGAT GATATCAATA TCAATGCCAC CTGCTTGAAGGCTATATGTG ACAAGTCACT AGAGGTTCAC CTGCAGGTTGACGCCATGTA CACAAATGTC AAAGTAACTA ATATTTGCTCTGATGGGACA CTCTACTGCC AGGTGCCTTG TAAGGGTCTGAACAAGCTCA GTGACCTTCT ACGTAAGATA GAGGACTACTTCCATTGCAA GCACATGACC TCTGAGTGCT TTGTTTCATTACCCTTCTGT GGGAAAATCT GCCTCTTCCA TTGCAAAGGAAAATGGTTAC GAGTAGAGAT CACAAATGTT CACAGCAGCCGGGCTCTTGA TGTTCAGTTC CTGGACTCTG GCACTGTGACATCTGTAAAA GTGTCAGAGC TCAGGGAAAT TCCACCTCGGTTTCTACAAG AAATGATTGC AATACCACCT CAGGCCATTAAGTGCTGTTT AGCAGATCTT CCACAATCTA TTGGCATGTGGACACCAGAT GCAGTGCTGT GGTTAAGAGA TTCTGTTTTGAATTGCTCGG ACTGTAGCAT TAAGGTTACA AAAGTGGATGAAACCAGAGG GATCGCACAT GTTTATTTAT TTACCCCTAAGAACTTCCCT GACCCTCATC GCAGTATTAA TCGCCAGATTACAAATGCAG ACTTGTGGAA GCATCAGAAG GATGTGTTTTTGAGTGCCAT ATCCAGTGGA GCTGACTCTC CCAACAGCAAAAATGGCAAC ATGCCCATGT CGGGCAACAC TGGAGAGAATTTCAGAAAGA ACCTCACAGA TGTCATCAAA AAGTCCATGGTGGACCATAC GAGCGCTTTC TCCACAGAGG AACTGCCACCTCCTGTCCAC TTATCAAAGC CAGGGGAACA CATGGATGTGTATGTGCCTG TGGCCTGTCA CCCAGGCTAC TTCGTCATCCAGCCTTGGCA GGAGATACAT AAGTTGGAAG TTCTGATGGAAGAGATGATT CTATATTACA GCGTGTCTGA AGAGCGCCACATAGCAGTGG AGAAAGACCA AGTGTATGCT GCAAAAGTGGAAAATAAGTG GCACAGGGTG CTTTTAAAAG GAATCCTGACCAATGGACTG GTATCTGTGT ATGAGCTGGA TTATGGCAAACACGAATTAG TCAACATAAG AAAAGTACAG CCCCTAGTGGACATGTTCCG AAAGCTGCCC TTCCAAGCAG TCACAGCTCAACTTGCAGGA GTGAAGTGCA ACCAGTGGTC TGAGGAGGCTTCTATGGTGT TTCGAAATCA TGTGGAGAAG AAACCTCTGGTGGCACTGGT GCAGACAGTC ATTGAAAATG CTAACCCTTGGGACCGGAAA GTAGTGGTCT ACTTAGTGGA CACATCGTTGCCAGACACCG ATACCTGGAT TCATGATTTT ATGTCAGAGTATCTGATAGA GCTTTCAAAA GTTAATTAAT GACTGCCTCTGAAACCTTGA CAACTAATTC AGATTTTTTA GCAATAACAAAATGTAGTAG GCTTAAAAAA AATCTTAACT CTGCTACATGGCTCTGACTG CTGTGGGGGA TTGAAAAGAA TATGCTTATGTTTGATGAAA GATATTTAAC AAGTTTTGTT TTAACAGAGTTGACTTTTCA AAGAAAATTG TACTTGAATT ATTACTATAATATTAGAATA AAAATGTTTA TCAATATAAA AAAAAAAAAA AAAAAAAAAA AA TOX4NM_001303523.1 AGCAGAGAGA ACACACGTCC TTGCGGAAGT GACGGCAGTT 27 (house-CCGAGTCCAG TGGGGGCGGT GGGAGCGATG AGGGTCTGAG keepingACGGTGGGAG CGGTTGTGTG AAGATGGAGA CATTCCATAC gene)ACCAAGCTTG GGTGATGAGG AATTTGAAAT CCCACCTATCTCCTTGGATT CTGATCCCTC ATTGGCTGTC TCAGATGTGGTTGGCCACTT TGATGACCTG GCAGACCCTT CCTCTTCACAGGATGGCAGT TTTTCAGCCC AGTATGGGGT CCAGACATTGGACATGCCTG TGGGCATGAC CCATGGCTTG ATGGAGCAGGGCGGGGGGCT CCTGAGTGGG GGCTTGACCA TGGACTTGGACCACTCTATA GGAACTCAGT ATAGTGCCAA CCCACCTGTTACAATTGATG TACCAATGAC AGACATGACA TCTGGCTTGATGGGGCATAG CCAGTTGACC ACCATTGATC AGTCAGAACTGAGTTCCCAG CTGGGTTTGA GCCTAGGGGG TGGCACCATCCTGCCACCTG CCCAGTCACC TGAAGATCGT CTTTCAACCACCCCTTCACC TACTAGTTCA CTTCACGAGG ATGGTGTTGAGGATTTCCGG AGGCAACTTC CCAGCCAGAA GACAGTCGTGGTGGAAGCAG GGAAAAAGCA GAAGGCCCCA AAGAAGAGAAAAAAGAAAGA TCCTAATGAA CCTCAGAAAC CAGTTTCAGCATATGCTTTA TTCTTTCGTG ATACACAGGC TGCCATCAAGGGACAGAATC CTAATGCCAC TTTTGGTGAG GTTTCAAAAATTGTGGCCTC CATGTGGGAT AGTCTTGGAG AGGAGCAAAAACAGGTATAT AAGAGGAAAA CTGAGGCTGC CAAGAAAGAGTATCTGAAGG CACTGGCTGC TTACAAAGAC AACCAGGAGTGTCAGGCCAC TGTGGAAACA GTGGAATTGG ATCCAGCACCACCATCACAA ACTCCTTCTC CACCTCCTAT GGCTACTGTTGACCCAGCAT CTCCAGCACC AGCTTCAATA GAGCCCCCTGCCCTGTCCCC ATCCATTGTT GTTAACTCCA CCCTTTCATCCTATGTGGCA AACCAGGCAT CTTCTGGAGC TGGGGGTCAGCCCAATATCA CCAAGTTGAT TATTACCAAA CAAATGTTGCCCTCTTCTAT TACTATGTCT CAAGGAGGGA TGGTTACTGTTATCCCAGCC ACAGTGGTGA CCTCCCGGGG GCTCCAACTAGGCCAAACCA GTACAGCTAC TATCCAGCCC AGTCAACAAGCCCAGATTGT CACTCGGTCA GTGTTGCAGG CAGCAGCAGCTGCTGCTGCT GCTGCTTCTA TGCAACTGCC TCCACCCCGACTACAGCCCC CTCCATTACA ACAGATGCCA CAGCCCCCGACTCAGCAGCA AGTTACCATT CTGCAGCAGC CTCCTCCACTCCAGGCCATG CAACAGCCTC CACCTCAGAA AGTTCGAATCAATTTACAGC AACAGCCTCC TCCTCTGCAG ATCAAGAGTGTGCCTCTACC CACTTTGAAA ATGCAGACTA CCTTAGTCCCACCAACTGTG GAAAGTAGTC CTGAGCGGCC TATGAACAACAGCCCTGAGG CCCATACAGT GGAGGCACCT TCTCCTGAGACTATCTGTGA GATGATCACA GATGTAGTTC CTGAGGTTGAGTCTCCTTCT CAGATGGATG TTGAATTGGT GAGTGGGTCTCCTGTGGCAC TCTCACCCCA GCCTCGATGT GTGAGGTCTGGTTGTGAGAA CCCTCCCATT GTGAGTAAGG ACTGGGACAATGAATACTGC AGCAATGAGT GTGTGGTGAA GCACTGCAGGGATGTATTCT TGGCCTGGGT AGCCTCTAGA AATTCAAACACAGTGGTGTT TGTGAAATAG TCCTTCCTGT TCTCCAAGCCAGTGAAGAGT TATCTGCTGG GAAAGTGTCC AAGAGCCTGTTTTTGAAACA CAAGCTGGGC TTCTGGTAGT GCCTCATCACAACCCATGAT GGCTGTTCAT GTTTCACCCC TTTTCTTCCTTCAGCAGAGG CCAGGCTATG GAGCAGGGCC ACTGAATTTGCTGTAATCTG GAGATGCTTT TTACTTTCAA CCATAAGCGGTAATAGCAGA GGAAAGGGTG AAGGGAGTCT GGGCAAGCAAAGCATAGAGA TGGTGGGGTG GTGGTGGGGT TGAAGAAACTTGTTGGTATA ATTGTCATAG GACTTGCCTA AAATATTATTAAAATTACGG GAGTGTACTC AGCTTTGAGC CTAGGAGAAAATGCCACTGT GTGCATCCAT TTTAAAGGGT TCCCTCATAAAAAAATGTTA TTCCCCATTA TCACATCAGT ACACTGCTTTGAAAACAAAA CTTTTCAACA TGGGCATACT GGGCTACATGGAAAATGACA TCACCCAGGA GTGATTTCTC TTTATATATATTATTTCTGC AGTTACCATC CTTATCTGAG TTATCACAGTTCATGAATCT AAGAGGCGGA ACTCTACATC ATTAGTAAGAGGTTCCACCA AAGTCTAAAG TTGTATTCAC TTGTGTTTGATGAACTATCT TTAAAAGACC ATAGGTCTAT CATTATTTCTTAGACATAAT CTAAAGAAAA ACAGACTAGA GAAGCCACCTGGTTGTAACA GAATAAGCAG AAGTTTACAG CATGATAGTCCAAGTGGTGA TAACTTTAAA TAAAACTCAA ATTTTTACTGTTTGTAGACA GGAATGCTGT CCTAGAGAAC CTCCTCCTCAACCAGCTACG TACATAGTTT TATCCTATGC ATTCCTGTTTTCTGTGTGTT TTTTGTTTTT TTTTTTTTTT TTTTTTTTTGAGACAGAGTC TCGCTCTGTC ACCCAGGCTG GAGTGCAGTGGTGCGACCTC AGCTCACTGA AACCTCTGCC TCCCGGGTTCAAGCGATTCT CCTGCATCAG CCTCCCGAGT AGCTAGGATTACAGGCGCCC GCCACTACGC CCAGCTAATT TGTGGTATTTTTAGTAGAGA CAGGGTTTCA CCATGTTGGC CAGGCTGGTCTCGAACTCCT GACCTCATGA TCCGCCCGCC TTGACCTCCCAAAGTGCTGG GATTACAGGC ATGAGCCACC GCACCCAGCCTGCATTCCTG TTTTTTTAAT GGTTTTGGAG GGTAGCAGTAGAGATGGGGT CTCACTATGT TGCCCAGTCT AGTCTTGAACTCCTGGGCTA CAGTTACCCT CCTACCTCGG CTTCCCAAAGTGCTCGGATT ACAGGTGTGA GCCACTGTGC CTAGCCTATAATGATCATTT TAATGTTTCC CATGCACTCA TTTAGTTTGAACCTTCACAG CAACCCAATG AGGTAATACT CCCATTTCACATATAATACT GAGAGATGAG TTGCACAAGA TTATACACTGTTAAGTAGCA GAGCCAGAAT GGACTTCAGA ATCCCAACTACAATACAAAT GTTTATTTAA ATAAAGAAGA AAGCTATTGTACAAATATCA CTCTTCAGGT TTAGCTTACA GAGCCATGGCTATGGATTCT TAGCTCTGTA AGGAAGTGCT TCTATAAATTCTTAGGTTTA GAGATGATAC CATCTGGGTA CCTTTGCTTGAACCGTGCAA CCACATCTGG GTCTAGTAGG TGGATCCCATCCAGTTGGTT TCCAAGGGTG ATCCTGAAAC AGTGTAAAAGGAGGGGCAAA CCAGAAATCC TGGAATTAGA GGGTTTAATATTGTTAAAAA ATGCATACCA AATGAAGACT GCCTATCATCATATCAAATA TGCCAATTCT AAAAAGAGCT TAACATTAGAATAGTATATG GTAGAATTAC TAGTTCAGAA TTGGCATAGATTCTGGTGTT AAAATAGACT GGATCTGTAT TATCTGAGGGTTAGTAACTA ATGCTTAGCC AGGCCTGCTT CACAGAGTTGCTACCAGGGA GTATTCTTTG GATAAGCAAA ATGCTAGCAGCATGTGTTTT AAGCTCTGTT AAGGGGTGAA AGATGTAATTATTGACAGAT TAAATAGATA ACTTCGTAAC CACCAGGGGGCAGATTCAAT ACATCACAGA ATGGCTGAGG AAGATCCTTGGGTTGTGAAG AGAGTAGAAA CCCTAGGGAG CAGTGCTTTTGGGTCCTAGA ACCTGTTGAG TTTCTAATGA ATATTTGTAGAATCTCATAA AACAGTTTAA ATACAAGCTT AAGTGGCTTATGAATCCTGT GAAGCTCATT TATGGACTAG TGTAAAACAATGTGAAGCTC TACTAAGTTC TGTCCTTAAT CATAAATAATAGCCCCTTGA GGACTAGCCT GTTCTCTGGT CACCTTACCAGTTGGGTTGC ACATTGTGTG GTCGTCCAAA TAACTCAATCTTGCGAGTGC CAGGAGATAG TCTTTCAATC ATGCCATAGATTTCATCTGG TTTATGACTG GTGGAACGAA CCTAGGAAATAAAAACTAGC TGCTTTTTAA GTTACACAAG AAAAAA TPT1 NM_001286272.1CTTCGTGCCA CGTCACCGCC TGCGTCGCTT CCGGAGGCGC 28 (house-AGCGGGCGAT GACGTAGAGG GACGTGCCCT CTATATGAGG keepingTTGGGGAGCG GCTGAGTCGG CCTTTTCCGC CCGCTCCCCC gene)CTCCCCCCGA GCGCCGCTCC GGCTGCACCG CGCTCGCTCCGAGTTTCAGG CTCGTGCTAA GCTAGCGCCG TCGTCGTCTCCCTTCAGTCG CCATCATGAT TATCTACCGG GACCTCATCAGCCACGATGA GATGTTCTCC GACATCTACA AGATCCGGGAGATCGCGGAC GGGTTGTGCC TGGAGGTGGA GGGGAAGATGGTCAGTAGGA CAGAAGGTAA CATTGATGAC TCGCTCATTGGTGGAAATGC CTCCGCTGAA GGCCCCGAGG GCGAAGGTACCGAAAGCACA GTAATCACTG GTGTCGATAT TGTCATGAACCATCACCTGC AGGAAACAAG TTTCACAAAA GAAGCCTACAAGAAGTACAT CAAAGATTAC ATGAAATCAA TCAAAGGGAAACTTGAAGAA CAGAGACCAG AAAGAGTAAA ACCTTTTATGACAGGGGCTG CAGAACAAAT CAAGCACATC CTTGCTAATTTCAAAAACTA CCAGTTCTTT ATTGGTGAAA ACATGAATCCAGATGGCATG GTTGCTCTAT TGGACTACCG TGAGGATGGTGTGACCCCAT ATATGATTTT CTTTAAGGAT GGTTTAGAAATGGAAAAATG TGATGCAAAA GAAAGAAATC CCTGCGCTTTCTGTCTGTCT TTGTGGCGGC CCAGATTGAA TTGGGGAATACATCTTTAGC CTGGAAATGT AGGCTGCATG TTAATGGTAATGTAACTTTT GCAGTGTAAT GTTTGAAAAA TATTAATGTAGTTTTTGCTT TTACAGTAAC AAATGTGGCA ATTATTTTGGATCTATCACC TGTCATCATA ACTGGCTTCT GCTTGTCATCCACACAACAC CAGGACTTAA GACAAATGGG ACTGATGTCATCTTGAGCTC TTCATTTATT TTGACTGTGA TTTATTTGGAGTGGAGGCAT TGTTTTTAAG AAAAACATGT CATGTAGGTTGTCTAAAAAT AAAATGCATT TAAACTCATT TGAGAGAATGCCTTTTAGTT TAATGCATAT TTAAACTAAA TTGATCCTGTAGTGTTCCTG GAGAAGCTAG AGCCTGATTG TAGGCTACTACTCATCAATT AACTTCTACA GTGGAGACTA CTTCTGGGACTGGAATATAA AAAAGAATCA AAGGTTCTGA TTTTGAGTTGCAATAAAGGG AAAGACCATG CTCATAGCAG TGCCAACATCTGAAGTGTGG AGCCTTACCC ATTTCATCAC CTACAACGGAAGTAGTTAAC TGGAAGAGAT TACCAAGAGA ATAAAAAGAGACTCATTCAG TGGAAGCAAC TTTGTCTCAG CTTATTTCACATAAAGAGAG CGAAGTCTTT TGGGATGAAT GTTAATTAAACTCCCTGGTA ACTAGAACAG GGACTGGCAA ACTAGCCTATCTGACCACCT GTTTTGTACA CTTTAAGGTG GTTGGTTGCCTTTTTAAATG GTTGAGGGGA AAAGAATACC TTGTGGGATATGGAATTTAA GTTCGAGTCC AGTTTTATTG GAACGTGGCTATGCTTATTC ATTTATGGAT TGACTGTGGC TGTTGTCAGTGCATGAGCAG AGTTGTGTCT AACAGACTAG AGCCTGCAAGTTTGCCAGCC CCTGATTTAA AAGATGAAGG TACACAGAATGTGGGCTGGC TGGTGGGCAA AGGGGTAAAA ATGTTCTCTATATTGTATCT GAAAAGATGG GGTGTCTGAA TAAGAAAATGCATCTATTTG ACAGACCTGG AGCAGTTGCT ATCTGCTGCTATGGTTTCCA CCACAGATGC AAGAAGAACA TGTCCTTGCGCTTTCCGTCT GTCTAATTGT GGCAGCTGAG ATTGAATAGAGGAATACAGG AGGAAAAAAA GCGGGAAGAG TTTTTGAGGCAGGTCGGTCA CCCAGGCTTG TAGTGCAGTG GCACAAGCAACTCACTGCAT TCTCTGCATC CTGTGCTCAA GCCATTTTCCCACCTCAGTC TCACTAGTTG CTGGGACTGC AGGCATGCACCCCTATGCCC AGCTAATTTT TGTAGAGACC GAGTATCGCTTAGTTGCCCA GGGTGGTCTC AACTCCTGGG CTCAAGGAGATCTGCCCACC TCAGCCTCCC AAAGTGCAGG CCTAGCCTGGGAGGGGAATT TTCAAAACGT GAGTTTTGGG AAATAGTCTATCAGCCTTAC CTGGTTGATT ACACTTGTAA AAGAAAGATTAAAAGCAGGC CAGTGACTCT GGTCTGCTTG AACATGTGAATGTAGTGGTT TGAGCAATCT GGAGTTTGCC CTAGTGTCAAATTCCAGACT GTCCATAGTG TCCAAAACCT GAGGCAGATACTAATGTTAA CCCCCAGCAC CCCGTGATTG GAAACAAACCTAAATACGTA TTGGGAACTT AATAGCAATT TTAAGCATTCTGATAGATTT TTTGTAGGGA TGGGGTCATG CCATGTGGCCCAGGCTGGTC TGAAAACTCT GGCCTCAAGT GATCTCAAGCTTTGGCCTTC TAAAGTGTTG GGATTACAGG TGTGAGGCATTGCACCTGGC TTAGCGTTCT GATTTGACAT TGTAATGAAAAGTGTGAGTC TCATCTACAG GGCCTTTTGT CCTCTGAAATGATAGCAGGA AGGGAATTTT CAGGCAGTGG TCAAAGCTGGGGAAACCAGG ATAGTGAAGA AGGCCTTGAG GTGAGAGATGGAAGCTAATT GGTGAACTAG CCTTGGAAGC CTGAAACAGACAAGTAGCAA TTCAGAGACT TTGTGGGCTC CACTGCTCCAACTTGTTTTG AAGATTTTCA GTTCTGCAGA AGAGGTATTTCCCCAGTTGT CCTTTCAGTG CTCTTAGCTG TTTTCCCAACATCCAGATCC AATCAAGGCT GGGACATAGC ATTTTATCATGTCTATTTAA GTCAGAAGTG ATGAACCCCA GCTGTTTACCTCATGGTAAA CCTTTGAAGA TTCCAGGTAG AATCTTCTCAGACTTTGAAG ACTGTCTCAT TTTATATCTT TTTCTCGTTATTCCTAGGGT CAAGACGTTT TGGGCAAGAA TAAGGATGTGAACATCAGAA AGCTCATAAC ATTTTGTTTT TGATGCTAAGTTTAACAAAG GCATGCTTTA GTAGCCTGTG GGCCCTAGGGTTTGTTAAAG TGTGGAGAAC AACTGAGTGG AGCAAGAGGACTTTTCTAGG AAGGTCCTTG TAATGTGACA TTTGAAAACAAATGAAGGTG TGGAAGTAGG CCATGTGGAT ATCAGGACAAACCATTCCAG GCCAAGACAA CAGCAGTTAG TCTGGAGTGTGATGTGTTCT GGGAAAAAAG TGGCCACTTT GCTAACCCAAGAAGACAGGA AGGGTTGTAA AGCAGTGGGA GTGTGCAAGGAAGGAAGACC AGACCTCAAG GAAACCACAG GCGCTCTGAGCAGAAGAGTT ACATGATATG ACTCAAATTT TTAAAGGATCACTTTGGCTG CCAGGTGGCA GGGTAAAAGC ATAGAATAATTGTGTATAAT GTGTTTTTAA GGCAAAGATA GTGGCTTAGTCTAGGGTAGT AGACTGAGGT GGTAGGAAAT GAAGATAGAGACAACAGGAT ATGCTGGTGG GTGAGGATGG ATTTAATGTTGATACAAGTA TTTTGGTCTG AGCGTTTGGA AGAAAGTTGGCACTGAGGTG GGAAGTCGAG TTTAGTTTTG TTAGTTTTGGATGTGTTAAG TTTGAGATGC TGATTCTTCA GAGAAGTCTAAGCTGGAGAA CTATATAGAG AGTGGAAAGA TAACAATAGACATTGAAAGC CATGATACAG GATAAGGTCA TTTGGAGAGAGGATAGACTG CATTCCAACA TGAGATTGGT TGACAAAGAGAAACCAACAA AGGTAATTAA GAGGTGCTCC CACTGCACTTGTACTCAGAA GGCTGAGGTA GGATTGTTAG AGGCCAGCCTGGGCACCACA GGGAGACCCC ATCTCTAAAA TTTAGCCAGGAACCATGGCT CATGCCTGTA GCCCCAGGAA TTTGGGAGGCTGAGTGGGGA GGATCGCTTG AGGTCAGGAG TTTGAGACCAGCCTGGGCAA CATAGGGAGA CCTAAAAAAA TTAATTGGGCATCTGTAGTC CCAGCTACTC AGGCGGCTGA GCTGAGAGGATGGCTTGAGT CCGAGAGATT GAGGGTGCAG TGAGCTGTGATCATACCACT GCACTCCAGC CTGGGCGGCA GTGAGACACTATCTGAAAAA AGTTTAAAAA TTTTAAAAAA GAAGGAACTGCCCCTGAGGT AAGAACCAAG GGAGGGCCTC CCAGAGGTCAGGTGGAAAAA GTTTTAGGAA GGAGGAAGTA GTCAACAGGGTTACCTGTTG CAAAGTACTT AAGTAATATG AGGCCTGATAGTGGTAAACT TGACTACCGT TGGATTTCAC TAGTGGGAAAGGAAGTCTAA TTAAAATGCA CTCAAGAGAC TAACAGTCGCAGGCATGAAA TACAATACAG GTACATGGTT TTTTATTATGTGTGCATCTG CTTCAGTAAT AGGTGTGAAT TACTCATTTGGATCATTAGG AGTTTCAAAA TCTAGTTAAA TGACTAGATTTTTGTTGATG TAAATTCTGT CATTCTGAAC TGCAGGGATTGTCAGTAACT TAACTGCAAA CTAAACTGGT GATAATTATGGTAAAATTGC AAGACGAGCA ATAAATCTCA ACCAACTTGA GAGAACACTG ATAA TXKNM_003328.2 GATTTCAGTT GAAAGATGTG TTTTTGTGAG TAGAGCACCG 29CAGAAGAACT GAAGACTGTT GTGTGCTCCC CGCAGAAGGGGCTACCATGA TCCTTTCCTC CTATAACACC ATCCAGTCGGTTTTCTGTTG CTGCTGTTGC TGTTCAGTGC AGAAGCGACAAATGAGAACA CAGATAAGCC TGAGCACAGA TGAAGAGCTTCCAGAAAAAT ACACCCAGCG TCGCAGGCCG TGGCTCAGCCAATTGTCAAA TAAGAAGCAA TCCAACACGG GCCGTGTGCAGCCGTCAAAA CGAAAGCCAC TGCCTCCCCT CCCACCCTCTGAGGTTGCTG AAGAGAAGAT CCAAGTCAAG GCACTTTATGATTTTCTGCC CAGAGAACCC TGTAATTTAG CCTTAAGGAGAGCAGAAGAA TACCTGATAC TGGAGAAATA CAATCCTCACTGGTGGAAGG CAAGAGACCG TTTGGGGAAT GAAGGCTTAATCCCAAGCAA CTATGTGACT GAAAACAAAA TAACTAATTTAGAAATATAT GAGTGGTACC ATAGAAACAT TACCAGAAATCAGGCAGAAC ATCTATTGAG ACAAGAGTCT AAAGAAGGTGCATTTATTGT CAGAGATTCA AGACATTTAG GATCCTACACAATTTCCGTA TTTATGGGAG CTAGAAGAAG TACGGAGGCTGCCATAAAAC ATTATCAGAT AAAAAAGAAT GACTCAGGACAGTGGTATGT GGCTGAAAGA CACGCCTTTC AATCAATCCCTGAGTTAATC TGGTATCACC AGCACAATGC AGCCGGTCTCATGACTCGTC TCCGATATCC AGTTGGGCTG ATGGGCAGTTGTTTACCAGC CACAGCTGGG TTTAGCTACG AAAAGTGGGAGATAGATCCA TCTGAGTTGG CTTTTATAAA GGAGATTGGAAGCGGTCAGT TTGGAGTGGT CCATTTAGGT GAATGGCGGTCACATATCCA GGTAGCTATC AAGGCCATCA ATGAAGGCTCCATGTCTGAA GAGGATTTCA TTGAAGAGGC CAAAGTGATGATGAAATTAT CTCATTCAAA GCTAGTGCAA CTTTATGGAGTCTGTATACA GCGGAAGCCC CTTTACATTG TGACAGAGTTCATGGAAAAT GGCTGCCTGC TTAACTATCT CAGGGAGAATAAAGGAAAGC TTAGGAAGGA AATGCTACTG AGTGTATGCCAGGATATATG TGAAGGAATG GAATATCTGG AGAGGAATGGCTATATTCAT AGGGATTTGG CGGCAAGGAA TTGTTTGGTCAGTTCAACAT GCATAGTAAA AATTTCAGAC TTTGGAATGACAAGGTACGT TTTGGATGAT GAGTATGTCA GTTCTTTTGGAGCCAAGTTC CCAATCAAGT GGTCCCCTCC TGAAGTTTTTCTTTTCAATA AGTACAGCAG TAAATCTGAT GTCTGGTCATTTGGAGTTTT AATGTGGGAA GTTTTTACAG AAGGAAAAATGCCTTTTGAA AATAAGTCAA ATTTGCAAGT CGTGGAAGCTATTTCTGAAG GCTTCAGGCT ATATCGCCCT CACCTGGCACCAATGTCCAT ATATGAAGTC ATGTACAGCT GCTGGCATGAGAAACCTGAA GGCCGCCCTA CATTTGCCGA GCTGCTGCGGGCTGTCACAG AGATTGCGGA AACCTGGTGA CCGGAAACAGAATGCCAACC CAAAGAGTCA TCTTGCAAAA CTGTCATTTATTGTGAATAT CTTCACCATA TGGGGTCACT TATGGTGAATATCTTTCTTC AGAGTTGCTG ACTCTTGAAA ACAGTGCAAAGATCACAGTT TTTAAAAGTT TTAAAAATTT AAGAATATTCACACAATCGT TTTTCTATGT GTGAGAGGGA TTTGCACACTCTTATTTTTC TGTAAAATAT TTCACATCCC AAATGTGAAGAAGTGAAAAA GACTTCGCAG CAGTCTTCAT TGTGGTGCTCTTCATGATCA TAGCCCCAGG AACCCTTGAG GTTCTTCTTCACAAGGCTGA GAGTGCTTCC TTCTTGAAGA CGAGTGACATTCATCACTTC AGTGATCCAT GCATAGAATA TGAAAATAAATTCTTCCAAC TCATGGGATA AAGGGGACTC CCTTGAAGAATTTCATGTTT TTGGGCTGTA TAGCTCTTTA CAGAAAATGCACCTTTATAA ATCACATGAA TGTTAGTATT CTGGAAATGTCTTTTGTTAA TATAATCTTC CCATGTTATT TAACAAATTGTTTTTGCACA TATCTGATTA TATTGAAAGC AGTTTTTTGCATTCGAGTTT TAAACACTGT TATAAAATGT AGCCAAAGCTCACCTTTGAA CAGATCCCGG TGACATTCTA TTTCCAGGAAAATCCGGAAC CTGATTTTAG TTCTGTGATT TTACACTTTTTACATGTGAG ATTGGACAGT TTCAGAGGCC TTATTTTGTCATACTAAGTG TCTCCTGTAA TTTTCAGGAA GATGATTTGTTCTTTCCAGA AGAGGAGACA AAAGCAAGAT AGCCAAATGTGACATCAAGC TCCATTGTTT CGGAAATCCA GGATTTTGAATTCGAGATGA AACAACCAGC AATCACAGTT AAATCTTAACTTTGCCTGCA CTCTTTGTAG GAATGATCAG AAATTTATCTTTATCATTCT GAGTGCTTCA GGAGTACAAT AGGAAGAAAGATACTGGAGA AAGCACTAAT GTAATCACCA TGAAGTCTGACAACAGGAGC CCATTATTTG CGTACTGTCC CACCCTGTATCATGGTTCTC TGGGAACAAG CTTTATGATT CTCATTAGAGTTTATTTGTT GATTGTCAGT AGTTGCGACT TTTAAATTATATTTCCCCCA CTCAAAGAAT GGTATCTTTA TATATCAATGACATTCAATA AATGTGTATT ATTTCTAATG AGAA YY2 NM_206923.3ATTAAATAAG AGAAAAAAGC ATAAAAGGAG TAGGCTTTTT 30TGGCAGATAC TGTTATATGG GATGGACAGG AGGGGAAGACATGAAAATCA ACTAAAATGA AATACATAAA AAATCAGTAAAGAGCCTGCT TACGAAAGTG GAAAAACAAC AGCTGGGCGGGGTCGCAGGG TGGCAAACGT ACGCGGGCAC GTGCACGTGCTTTTGGGGCC GACAGACGCG CCAGTTGCCT AGGCGCATGCGTCTGGCTAT CCCAGAAGCA CCTGCGCCTT CCGGCTCGTGCTTTCCTCAG TCTCGCGCCT TTCTCTGCAG CTCGCGCCTTTCTCTGCAGC TCGCGCCTTT CTCTGCAGCT CGCGCCTTTCTCTGCAGCTC GCGCCTTTCT CTGCAGCTCG CCCCTTCCTCTGCAGCTCGC CCCTTCCTCT GCAGCTCCCA CCTCACTCCCCTCAGCGTTC TTTTTCCCAC GGTCTTCCCG TTGCCGCTAACCTAACTAAC TCTCAGCCAT GGCCTCCAAC GAAGATTTCTCCATCACACA AGACCTGGAG ATCCCGGCAG ATATTGTGGAGCTCCACGAC ATCAATGTGG AGCCCCTTCC TATGGAGGACATTCCGACGG AAAGCGTCCA GTACGAGGAT GTGGATGGCAATTGGATCTA CGGTGGCCAC AACCATCCGC CATTGATGGTGTTGCAGCCG CTCTTCACGA ACACGGGCTA TGGCGACCACGACCAGGAAA TGCTTATGTT GCAGACACAA GAGGAAGTGGTGGGCTATTG CGACTCAGAC AACCAGCTAG GCAACGACTTGGAGGACCAG TTGGCCCTCC CGGATAGCAT TGAAGACGAGCACTTCCAGA TGACCCTGGC CTCTCTGTCG GCCTCGGCGGCATCAACATC AACATCAACC CAGAGCCGCA GCAAAAAGCCCAGCAAAAAG CCCAGCGGCA AGAGTGCCAC CAGCACTGAGGCCAACCCGG CAGGCAGCAG CTCCAGCCTG GGCACGAGGAAGTGGGAGCA GAAGCAAATG CAGGTCAAAA CGCTGGAGGGTGAGTTTTCC GTGACTATGT GGTCCCCTAA CGATAACAATGACCAAGGGG CAGTGGGTGA AGGCCAGGCT GAAAACCCACCTGATTATTC CGAGTACTTG AAAGGGAAGA AACTTCCTCCTGGGGGGTTA CCAGGCATTG ATCTCTCAGA TCCTAAACAGCTGGCAGAAT TTACTAAAGT GAAGCCCAAA AGGTCCAAAGGAGAACCTCC CAAAACAGTC CCTTGCTCTT ATAGCGGCTGCGAAAAGATG TTCCGGGATT ACGCCGCCAT GAGAAAACATCTCCACATCC ACGGGCCCAG AGTCCACGTA TGTGCAGAATGTGGCAAAGC TTTTCTTGAG AGCTCAAAGC TGAGACGACACCAGCTGGTC CACACCGGCG AGAAGCCCTT TCAGTGCACATTCGAAGGCT GCGGGAAACG CTTTTCCCTT GATTTCAATTTGCGCACACA CTTGCGCATC CACACCGGCG ATAAGCCCTTCGTGTGCCCC TTCGATGTTT GCAACAGGAA GTTCGCTCAGTCAACCAACC TGAAAACCCA CATATTAACG CATGTGAAGACCAAAAACAA CCCGTGAAAA GGAGAAGACC CCTCTCAGACTTGGGAATTA TCTTCCAGGA CTGCGGTAGG GAATAAATATGCCTCTCAAA GCTTTGTATG TTGTTTCTAA GAGTTTTAAAAAAAAATGAA TCCTGCACAT TTAAGGTTCG TGTTTTGTTAGAGTAGTAAA AATAGAATTT AAACGTTTTT AAAAAGGTAAACCTTGACAT AAGATAATAG TGCTAAGATG CCATAGCTTGTTCTGTAACT ATTTTTGTAA AGTTTGGTCC CAACAGGAGAAAAATTCGTA GACTTCACAT CAAGAGACGG TTCTTACAAACTGTTTAAAA TGGGACTTTT CACATTCTTA GAAATAGGAAGTTCATTTAT TGTTTACAAT GTTTTTAAAA AACTTGTTAAAAAATTCAAA GTGTTCATGT TTATACTTTT AGGAATATGCTTAATAAGTC TATGTATGGT TTTTCTGGAG GTTGATAACTTTGGGAAAGA TTTACTTTAA AAGAGTGAAC AATTATATGCATACGTGAAG TATTTTCCTG CTTAAAAAAG TTATATAGGTGTTATTTGTT TTAATCTTGG TTGTAGTCTT GGATGTTAACACATCTTGCA TTTTAGCTGT ATTAGGTCAT GTAGTATTGATATTAGGTGA TTTAATAGTA CTAGTTTAAA CCTATTTTAGTCATTTTATT TTCCCCAAAA TACTACCAGA TGCTGTTGTTTAGTGTAATT TCTTTGCCTG TTCAGTTAAA GTAGTGCTTGCTTGTAGAAT ATATTGTGTA TATGTTGACT TTAACACTTAAGAAGTACAT CCTGTGTAAT AGAAAAAGCA AAATAAAACACCTCTTCTAA AGAAGGAAAA AAGTAGTTTG CCTATATCAGTACAGAAGTT AGAACTAAAG AAAAGGGGGA GGGTGCTACTGGCATCTGGT GAGTGGAGGG AGATCAGGAA TGCCACTAAACATCCTACAA TGCACAGACA GCCCCACGAA ACACATAATTATTTGGCTAA AATGCCAATA GTGTCAGGTG CAGGGGCTCAGGCCTGTAAT GTCAACACTT TGGGAGGCCG AGGTGGGTGGATCGTTTGAG CTCAGGAATT GAACATCAGC CTGGGCAACA TGGCATAACT CGGTCTCTAC C ALG9NM_001077690.1 GTCTTTTGTC CCTCGGCGGA CACCGTTTGC CAGCCAAAGC 31TATGTCTGCG CGCTCACCGA CTTCATAGGG TGCCGAATTCTTTTTTCCCC AGGCTTGCCA TGGCTAGTCG AGGGGCTCGGCAGCGCCTGA AGGGCAGCGG GGCCAGCAGT GGGGATACGGCCCCGGCTGC GGACAAGCTG CGGGAGCTGC TGGGCAGCCGAGAGGCGGGC GGCGCGGAGC ACCGGACCGA GTTATCTGGGAACAAAGCAG GACAAGTCTG GGCACCTGAA GGATCTACTGCTTTCAAGTG TCTGCTTTCA GCAAGGTTAT GTGCTGCTCTCCTGAGCAAC ATCTCTGACT GTGATGAAAC ATTCAACTACTGGGAGCCAA CACACTACCT CATCTATGGG GAAGGGTTTCAGACTTGGGA ATATTCCCCA GCATATGCCA TTCGCTCCTATGCTTACCTG TTGCTTCATG CCTGGCCAGC TGCATTTCATGCAAGAATTC TACAAACTAA TAAGATTCTT GTGTTTTACTTTTTGCGATG TCTTCTGGCT TTTGTGAGCT GTATTTGTGAACTTTACTTT TACAAGGCTG TGTGCAAGAA GTTTGGGTTGCACGTGAGTC GAATGATGCT AGCCTTCTTG GTTCTCAGCACTGGCATGTT TTGCTCATCA TCAGCATTCC TTCCTAGTAGCTTCTGTATG TACACTACGT TGATAGCCAT GACTGGATGGTATATGGACA AGACTTCCAT TGCTGTGCTG GGAGTAGCAGCTGGGGCTAT CTTAGGCTGG CCATTCAGTG CAGCTCTTGGTTTACCCATT GCCTTTGATT TGCTGGTCAT GAAACACAGGTGGAAGAGTT TCTTTCATTG GTCGCTGATG GCCCTCATACTATTTCTGGT GCCTGTGGTG GTCATTGACA GCTACTATTATGGGAAGTTG GTGATTGCAC CACTCAACAT TGTTTTGTATAATGTCTTTA CTCCTCATGG ACCTGATCTT TATGGTACAGAACCCTGGTA TTTCTATTTA ATTAATGGAT TTCTGAATTTCAATGTAGCC TTTGCTTTGG CTCTCCTAGT CCTACCACTGACTTCTCTTA TGGAATACCT GCTGCAGAGA TTTCATGTTCAGAATTTAGG CCACCCGTAT TGGCTTACCT TGGCTCCAATGTATATTTGG TTTATAATTT TCTTCATCCA GCCTCACAAAGAGGAGAGAT TTCTTTTCCC TGTGTATCCA CTTATATGTCTCTGTGGCGC TGTGGCTCTC TCTGCACTTC AGAAATGTTACCACTTTGTG TTTCAACGAT ATCGCCTGGA GCACTATACTGTGACATCGA ATTGGCTGGC ATTAGGAACT GTCTTCCTGTTTGGGCTCTT GTCATTTTCT CGCTCTGTGG CACTGTTCAGAGGATATCAC GGGCCCCTTG ATTTGTATCC AGAATTTTACCGAATTGCTA CAGACCCAAC CATCCACACT GTCCCAGAAGGCAGACCTGT GAATGTCTGT GTGGGAAAAG AGTGGTATCGATTTCCCAGC AGCTTCCTTC TTCCTGACAA TTGGCAGCTTCAGTTCATTC CATCAGAGTT CAGAGGTCAG TTACCAAAACCTTTTGCAGA AGGACCTCTG GCCACCCGGA TTGTTCCTACTGACATGAAT GACCAGAATC TAGAAGAGCC ATCCAGATATATTGATATCA GTAAATGCCA TTATTTAGTG GATTTGGACACCATGAGAGA AACACCCCGG GAGCCAAAAT ATTCATCCAATAAAGAAGAA TGGATCAGCT TGGCCTATAG ACCATTCCTTGATGCTTCTA GATCTTCAAA GCTGCTGCGG GCATTCTATGTCCCCTTCCT GTCAGATCAG TATACAGTGT ACGTAAACTACACCATCCTC AAACCCCGGA AAGCAAAGCA AATCAGGAAGAAAAGTGGAG GTTAGCAACA CACCTGTGGC CCCAAAGGACAACCATCTTG TTAACTATTG ATTCCAGTGA CCTGACTCCCTGCAAGTCAT CGCCTGTAAC ATTTGTAATA AAGGTCTTCTGACATGAATA CTGGAATCTG GGTGCTCTGG GCTAGTCAAAGTCTATTTCA AAGTCTAATC AAAGTCACAT TTGCTCCCTGTGTGTGTCTC TGTTCTGCAT GTAAACTTTT TGCAGCTAGGCAGAGAAAGG CCCTAAAGCA CAGATAGATA TATTGCTCCACATCTCATTG TTTTTCCTCT GTTCAATTAT TTACTAGACCGGAGAAGAGC AGAACCAACT TACAGGAAGA ATTGAAAATCCTGGTACTGG ATGGCTGTGA TAAGCTGTTC TCCACACTCTGGCCTGGCAT CTGAGAACTA GCAAGCCTCT CTTAGGCCATATGGGCTTCT CCACCAAAGC TGTTTGGCAG CTCCTAGCAGACCTTCTTAT TGAAATCCTC ATGCTGAAAA TGAACACAGCCTAGTTGCCA ACCCACATGT CCTTTTCACC TCCAGCAAGACTAAGCTTCT TTAAAGCACT TCACAGGACT AGGACCCTGTCCTGGAGCTA TCTCAGGAAA AAGGTGACCA TTTGAGGAACTGTGACCTAA TTTTATTATA ATGATGCCTC TAATTTTCATTTCCTTTACA ACCAACTGTA ACTATAAGGT TGTATTGCTTTTTTGTTCAG TTTTAGCATG CTATTTTTTG AATTCTAGACTCCTCCATGT GAAGATATCA ACAGACAAAA CTACAACTGTATAGGACATA TTTGGAGAAA ATTCTATCAA TTGATACATTTGGATGACAT CACATTTTTA AGTAATGTAA TCTGAGGCCATTGCTGAGGA AATTAAGAAT TTTCCTTTTT TTTTAACCACCCCCAGTGAA AAGGATCAGT GTATATTTAT AGCACCTATTTTTTAGTTCT GTCTGTTGTG AGGCACATCC TGCATGGGGCACTTCTAGTC AAATAGGCAA TGATAAGGAC CTAATTAAAATGTGATAAGT GTATACTATT ACTTTAAAAG CCTTTACAGTCAGTACTTCA GTTTACAAGG CACTTTCACA GCATCTCGTTTGATCCTCAC AGTCACAACA TGTGGTAGAC AAGGCAGGTGATTTTTATCC CCATTTTACA GATAAGGAAA CAGGCTGCGGGTGGGGAGTG AGGGGAGGTA AAGATAGTTA GTTGCCTAAGGTCACACAGC CAGTAAGTAA TAGAGCTGGG ACTGGAACCCAGGTTTCCTT ACTCTCATCT ATTGCTCCTC CATATTCCTCACTCAACCAT GAAAACATTA CTTGAAAGGA CTGATGAGGTTAACCAGAGA CCTAACTGAT ATTGTAACTT TCTATTTTAAGGAAGAATTG TGTCTGTATT TGAGTTCTTT GGAGCCTCCAGTCTGCCTGT GTGTTAGACC AGCACAGCAG TGCTGTGTGATGCAGCCTGA CCTGTGGCAG GAAAGTAGTG CTTCTGTTTGGAAGTCATGT TCTTTTGCAG CCACACAGGA TCCAAATATCAGTACTATTC CTGTAGTCAA TCTGGGGTCA CATTATAGGTGCCTTATTTC CCTAAGGGTA ACTGATCTGA ATATCTGCAAATAGGATGAA TCTATTTTTC AGAAGTTCCA TCTTTCATTTTTCTTTTTTT TTTTGAGACA GAGTCTCATT CTGTCGCCCATGCTGGAGTG CAGTGGCGCG ATCTCGGCTC GCTGCAACCTCTGCCTCCCA GGTTGAAGCA ATTCTCATGC CTCAGCCACCCGAGTAGCTG GGATTACAGG CATGCGCCAT CATGCCCAGCTAATTTATGT ATTTTTAGTA GAGTTGGAGT TTCACCATGTTGGCCAGGCT GGTCTTGGAC TCCTGACCTC AGGTCATCCACCCGCCTCAG CCTCCCAAAG TGCTGGTATT ACAGGCGTGAGCCACCGCAC CCAGCCCCAT CTTTCATTTT CAAAGAGAAGGGCATTCTAA TAGGAACTGG TGCCAAGAGA GAAGAAAAGAAGTGATAACA GAAGAAATGG CTAGTTACAA TATTAAAAAGCTCCTCTTTG AGATCTCCTC TGCAGGAATA TCAGAGACGGAGTTGAAGCG CTGGAGAGGT AATAGGTCTA GACAGTACAGAACAATAACT GGGGAGTGTG TGAGGATAGA CTGGGCTCCCCCTTGCTTGA AAGATCTCTG GCATTTAATT CTCAATTCTTGATTACTATT TTCCAGTGTA AAACTAGCAC ATATGATCTGACTACAGGAC AGAGAATTTT AAGTGAAACA TTTGCCTTACTTGCAGTAAT AATGTGCTGT TCTTCACAGT AGCTAAGGCCCTCTATGTTT CCCAGAGGTA AATAAGAATC CAGGAATGGAGGTCCATCTG TGATGAATGG CTTTTTTCTA ATCAAAGTAGTATAATGCTG TTTTATCTGT TTTGTCATCT TGTTTTTTTTTTTTTTTAAA AAAACAAAAC CTTAATTATA ATATAGCGCAAAGAAAGGCC AGGACTGATG CAGGGATTCC TTGGAAATATCAGTTCCTAT CACTTTTAAA ACCTGATTTT GGATCTCTCTGTTCTATGTA TGTCTTTAGT GAGAGCACAA TACATGGCAGAACGCTGTGC CAAATGTTAT AGGTAAGGAA TATAGAAATGAATGTTTTTT GTTGTGAAGG TGTTTTCATG TGATATTTTATAAACACATT TTAAAAAATC TCCATCACTT TTTAGTATAGGAAGGATAGC TTTGCCTGGG AAAAACAGTT TCAACACACCTGCTCAGAGT AGCAGTTCTC CCTCAAAAAA GCAGTGTTCAGCCTGCACTG ACTGTTCTGC TTGCCAAAAG GAGGAAGCATGCAAGATACT TATTTCTCCA TAGATTGTGG AGTATAGAGGGATGTGGGAC TACAGATTAT TATTTTTTTT CCCCGAGACAGAGTCTTGCT CTGTCGCCCA GGTTGGAACA CAATGGCACGACCTCAGCTC ACTGCAACCT CTGTCTCCCG GGTTCAAGCAATTCTCCTGC TTCAGCCTCC TGAGTAGCTG GGATTACAGGCACACACCAC CACCGCACTC AGCTAATTTT TGTATTTTTAGTAGAGGTGG GGTTTTACCA TGTTGGCCAG GCTGGTCTTAAACTCCTGAC CTTGTAATCA TCCCGCCTCG GCCTCCTAAAGTGCTAGGAT TACAGGCATG AGCCACCGCA CCCGGCCCAGATAATTTTTA ATAGCCTTTG ATCATGGGGT GAGTGAGGGAGTAGGTATAC TTGGCAAATG CATGGTTCTC TGATTTCTAGCTCTAAAGCA GCCTTATCTG AATCCCCAAA TCTTGTGATGCTGAGTACCA TTACTGAACC AGTCTGCACG GTAGGCATCTGCTACCAAAA TTTACCTCCT ACCTGGTAGG TGTCATCTGATAAGAAAGAA GACAGGTTAT TTTAATTTTT TGAGATAATCACAGAAAATT GCAGCCCATA CTCTTTATTA CCGAATTCAAGTTTGGAAAT AGACCCTTTG TTTTAAATCA TGATGGGTCTTTATCCCAAT CATTTATCTG GGTCATTTTT CCAACTTTGGAGTTCTAGGA AAGAACCTTG AAAACCTGAT ATGATTCTGCAGCATGAGGT CTACGGTGAC CATTTGGGCA AAGCTCCAGTGGCAATCATT TATTGTGTTT TGCATTTCCT GGGATTTATTGAAATAAGAA TTCACTGTGA TTATGTAGTC TTCTGGCTAGTATCAGGCAG CTCTGCTTTT AATTTGGTTA ATTTTATTTTCTCTGAAGAG GGAGAAGAGG TACAATTTAA TCTTGGCCTCCACAAGCATA TTAAAGCTCA CGTGTTAATC AGTGCATTCTTATGCTCCTA CATTAAATGC CTTGGGTAAA TGGATAAATGGACATGTGCC CAGCTTTAAT TTTTTTTGCA ACAGAAAGATCAGACTTCCG TATGGCATCG TTGGATTTCA GAGGCTTTCTGGTGTATCTG TAAATCTGAA TGTTGCCTTC TGCCAGTCTGTATAACCAGG TGATTCATGC TGCAAATGAA ATCAGGAAGCAGTAAAGTGT TAAAGCAAGA GTATTGTCCA ATTCACTTGTCTTCCTGATC CTTGTACTTT ATTTCACGTG TCGGTGTTTACATTACATAC TTATATTTCC TGTGAAAGAA AGAGTTAAAT AAATTGTAGC AGTTTGA SEPNNM_031475.2 AGCGGAGCGC CAGGCAGCGC GGAGCGGAGG CCAGGCCCAC 32AGCCGCTCCG CCTCCCGGCC CGCAGATCCC CGACGGCCGCACCGCGGGCT CCTCTGGCCC GCAAGAACAC GTGCATGGCGTCCTGGGGAA GGCGCTGAGT GCGGAGTCGC GGCGCCGCACGCGGCACCAT GGCCCTGGAG CAGGCGCTGC AGGCGGCGCGGCAGGGCGAG CTGGACGTGC TGAGGTCGCT GCACGCCGCAGGCCTCCTGG GGCCCTCGCT GCGCGACCCG CTGGACGCGCTGCCCGTGCA CCACGCGGCC CGCGCTGGGA AGCTGCACTGTCTGCGCTTC CTGGTGGAGG AAGCCGCCCT CCCCGCCGCGGCCCGCGCCC GCAACGGCGC CACACCGGCC CACGACGCCTCCGCCACCGG CCACCTCGCC TGCCTGCAGT GGCTGCTGTCGCAGGGCGGC TGCAGAGTGC AGGACAAAGA CAATTCTGGTGCCACAGTCT TGCATCTGGC TGCCCGCTTC GGCCACCCCGAGGTGGTGAA CTGGCTCTTG CATCATGGCG GTGGGGACCCCACCGCGGCC ACAGACATGG GCGCCCTGCC TATCCACTACGCTGCCGCCA AAGGAGACTT CCCCTCCCTG AGGCTTCTCGTCGAGCACTA CCCTGAGGGA GTGAATGCCC AAACCAAGAACGGTGCCACG CCCCTGTACC TGGCGTGCCA GGAGGGCCACCTGGAGGTGA CCCAGTACCT GGTGCAGGAA TGCGGCGCAGACCCGCACGC GCGCGCCCAC GACGGCATGA CCCCGCTGCACGCCGCGGCG CAGATGGGCC ACAGCCCAGT CATCGTGTGGTTGGTGAGCT GCACCGACGT GAGCCTGTCC GAGCAGGACAAAGACGGCGC CACCGCCATG CACTTCGCGG CGAGCCGCGGCCACACCAAG GTGCTCAGCT GGCTGCTGCT GCACGGCGGGGAGATCTCGG CTGACCTGTG GGGCGGGACC CCGCTGCACGACGCCGCCGA GAACGGGGAG CTAGAGTGCT GCCAGATCCTGGTAGTGAAC GGCGCGGAGC TGGACGTCCG CGACCGCGACGGGTACACGG CCGCCGACCT GTCGGACTTC AACGGCCACAGCCACTGCAC CCGCTACCTG CGCACGGTGG AGAACCTGAGCGTGGAGCAC CGCGTGCTTT CCCGGGATCC ATCCGCAGAGCTGGAGGCTA AGCAGCCGGA TTCAGGCATG TCCTCACCCAATACCACGGT GTCGGTCCAG CCGCTGAACT TTGACCTCAGCTCGCCTACC AGCACCCTCT CCAACTACGA CTCCTGCTCCTCCAGCCACT CCAGCATCAA GGGCCAGCAC CCTCCATGTGGGCTTTCCAG CGCTAGAGCT GCAGACATAC AGAGCTACATGGACATGCTG AACCCGGAGC TGGGCCTGCC TCGGGGCACGATTGGGAAGC CCACACCCCC ACCACCCCCA CCCAGCTTCCCCCCGCCACC CCCGCCCCCA GGCACCCAAC TGCCCCCACCCCCACCTGGC TACCCAGCTC CCAAGCCTCC TGTAGGACCACAGGCAGCTG ACATCTACAT GCAGACCAAG AACAAACTCCGCCACGTGGA GACAGAGGCC CTCAAGAAGG AGCTGAGCTCCTGTGACGGC CACGACGGGC TGCGGAGGCA GGACTCCAGCCGCAAGCCCC GCGCCTTCAG CAAGCAGCCC AGCACGGGGGACTACTACCG GCAGCTGGGC CGCTGCCCCG GCGAGACGCTGGCCGCACGC CCGGGCATGG CGCACAGCGA GGAGGTGCGTGCCCGCCAGC CCGCGCGCGC CGGCTGCCCG CGCCTCGGCCCTGCCGCCCG CGGCTCACTC GAAGGCCCCT CCGCTCCCCCGCAGGCGGCG CTGCTTCCTG GGAACCATGT TCCTAACGGCTGCGCCGCGG ACCCCAAGGC GTCCAGGGAG CTGCCACCGCCGCCCCCACC GCCGCCGCCG CCCCTGCCGG AGGCCGCGAGTTCGCCACCG CCGGCCCCGC CTCTGCCCCT CGAGAGCGCTGGCCCTGGCT GCGGGCAGCG CCGCTCCTCC TCGTCCACCGGCAGCACCAA GTCTTTCAAC ATGATGTCCC CGACGGGCGACAACTCGGAG CTACTGGCTG AGATTAAGGC AGGCAAGAGCCTGAAGCCGA CGCCCCAGAG CAAGGGGCTG ACCACAGTGTTCTCAGGCAT CGGGCAGCCG GCCTTCCAGC CCGATTCGCCGCTGCCTTCT GTGTCACCTG CACTGTCACC AGTCCGGAGCCCCACACCGC CAGCTGCGGG GTTTCAGCCG CTGCTCAATGGAAGCTTGGT TCCCGTGCCG CCCACTACTC CTGCGCCGGGAGTGCAGCTG GACGTGGAGG CTCTCATCCC CACGCACGATGAGCAGGGCC GGCCCATCCC CGAGTGGAAG CGCCAGGTGATGGTGCGCAA GATGCAGCTG AAGATGCAGG AGGAGGAGGAGCAGAGGCGG AAGGAGGAGG AGGAGGAGGC CCGGCTGGCCAGCATGCCCG CCTGGAGGCG GGACCTCCTG CGGAAGAAGCTGGAAGAAGA GAGGGAGCAG AAGCGGAAAG AGGAGGAGCGACAGAAGCAG GAGGAGCTGC GGCGGGAGAA GGAACAGTCAGAGAAGCTGC GGACGCTGGG CTACGATGAG AGCAAGCTGGCGCCCTGGCA GCGACAGGTC ATCCTGAAGA AGGGGGACATCGCTAAGTAC TAGAGGCCGC AGACTCCTGT CCGCAGCCTCGCAGCTCCGT GGGGCCCTCC GCCCCAGCCC CAGCCAGCCAGGCCCTGGTG GAAAGGCTGG GAGCCGCACA GCCCTCCCCTCCTGCGCTGG AAACCCTCCC TGACCCCCAC CCTGGCCCCCCGTATCCCCA GCCCTTGGCA ACACTGGAGT GCACACGCCGCCACGGTTGC CCAGAAAAAG TGCCCAAGCT GCTGACGCAAACAACAACAA ATGCTGCTTA TTTGCATGCC GACTTACATATATTTGCATG TTCGTTGACT ATCAAAGAGT GCAGAGCTCTCCCCAGCCCC GTGGGTGGTG ACTTTGTTTT CCTGCGGGGCTCAGCCCCCT CCAGGATGCA GCCCCCTCCC CCGCACCCCGGAACCGGCGT CGCTGGCGCA TCCTGGGTGG AGGCAGGCCCCGAGCTCGGG GAAGGGGTTT TCCCTTCCTC TCTGACCCAGATCTGCGCGC GGCCTAGCCC GGGCCTCATT TCTTATCCCCGCCAAGGGTT TCCTCTCAGT CATTTGTTTA CCAGAAACATGAAAACTGCC TGTCTGGCCG GGCCGCACTT GTGGCCCCCGGGACCCCACC TCTGGCCCCA CCTCCCTCAA GTCTGCGCCCCGTCCCCAGC CAGACCCACT CGCTGCCGGG ACCCTTTCACTGCCCCGGTG GAGTGAATAG AGGATGAGGG GCCCTGACCCTGTGTCTCCA ACTGCTGCAC CCCATCCCGA CCCTGTCTCCGCCACCTCGC AGCCCCATTA AAGCGCTCTC ATCTGGGCTC CGGTTCACTC A YWHAQNM_006826.3 TTGGGCGGTG GACCGCCCCT CGGCCCCGGG GTAGGCTGAC 33ACGGGAGGGT CCTCAGCTAA AGCCAAAAGC AGATCAAAGTGGTGGGACTC GCGTCGCGGC CGCGGAGACG TGAAGCTCTCGAGGCTCCTC CCGCTGCGGG TCGGCGCTCG CCCTCGCTCTCCTCGCCCTC CGCCCCGGCC CCGGCCCCGC GCCCGCCATGGAGAAGACTG AGCTGATCCA GAAGGCCAAG CTGGCCGAGCAGGCCGAGCG CTACGACGAC ATGGCCACCT GCATGAAGGCAGTGACCGAG CAGGGCGCCG AGCTGTCCAA CGAGGAGCGCAACCTGCTCT CCGTGGCCTA CAAGAACGTG GTCGGGGGCCGCAGGTCCGC CTGGAGGGTC ATCTCTAGCA TCGAGCAGAAGACCGACACC TCCGACAAGA AGTTGCAGCT GATTAAGGACTATCGGGAGA AAGTGGAGTC CGAGCTGAGA TCCATCTGCACCACGGTGCT GGAATTGTTG GATAAATATT TAATAGCCAATGCAACTAAT CCAGAGAGTA AGGTCTTCTA TCTGAAAATGAAGGGTGATT ACTTCCGGTA CCTTGCTGAA GTTGCGTGTGGTGATGATCG AAAACAAACG ATAGATAATT CCCAAGGAGCTTACCAAGAG GCATTTGATA TAAGCAAGAA AGAGATGCAACCCACACACC CAATCCGCCT GGGGCTTGCT CTTAACTTTTCTGTATTTTA CTATGAGATT CTTAATAACC CAGAGCTTGCCTGCACGCTG GCTAAAACGG CTTTTGATGA GGCCATTGCTGAACTTGATA CACTGAATGA AGACTCATAC AAAGACAGCACCCTCATCAT GCAGTTGCTT AGAGACAACC TAACACTTTGGACATCAGAC AGTGCAGGAG AAGAATGTGA TGCGGCAGAAGGGGCTGAAA ACTAAATCCA TACAGGGTGT CATCCTTCTTTCCTTCAAGA AACCTTTTTA CACATCTCCA TTCCTTATTCCACTTGGATT TCCTATAGCA AAGAAACCCA TTCATGTGTATGGAATCAAC TGTTTATAGT CTTTTCACAC TGCAGCTTTGGGAAAACTTC ATTCCTTGAT TTGTGTTTGT CTTGGCCTTCCTGGTGTGCA GTACTGCTGT AGAAAAGTAT TAATAGCTTCATTTCATATA AACATAAGTA ACTCCCAAAC ACTTATGTAGAGGACTAAAA ATGTATCTGG TATTTAAGTA ATCTGAACCAGTTCTGCAAG TGACTGTGTT TTGTATTACT GTGAAAATAAGAAAATGTAG TTAATTACAA TTTAAAGAGT ATTCCACATAACTTCTTAAT TTCTACATTC CCTCCCTTAC TCTTCGGGGGTTTCCTTTCA GTAAGCAACT TTTCCATGCT CTTAATGTATTCCTTTTTAG TAGGAATCCG GAAGTATTAG ATTGAATGGAAAAGCACTTG CCATCTCTGT CTAGGGGTCA CAAATTGAAATGGCTCCTGT ATCACATACG GAGGTCTTGT GTATCTGTGGCAACAGGGAG TTTCCTTATT CACTCTTTAT TTGCTGCTGTTTAAGTTGCC AACCTCCCCT CCCAATAAAA ATTCACTTACACCTCCTGCC TTTGTAGTTC TGGTATTCAC TTTACTATGTGATAGAAGTA GCATGTTGCT GCCAGAATAC AAGCATTGCTTTTGGCAAAT TAAAGTGCAT GTCATTTCTT AATACACTAGAAAGGGGAAA TAAATTAAAG TACACAAGTC CAAGTCTAAAACTTTAGTAC TTTTCCATGC AGATTTGTGC ACATGTGAGAGGGTGTCCAG TTTGTCTAGT GATTGTTATT TAGAGAGTTGGACCACTATT GTGTGTTGCT AATCATTGAC TGTAGTCCCAAAAAAGCCTT GTGAAAATGT TATGCCCTAT GTAACAGCAGAGTAACATAA AATAAAAGTA CATTTTATAA ACCATTTACTATGGCTTTGT AACAATTGCA TACCCATATT TTAAGGGACAGGTGAATTTA CTACTTTCTA AAGTTTATTG ATACTTCCCTTTTATGTAAA ATGTAGTAGT GATACCTATA TTTCCACATTGTGCATTGTG ACACACTTGT CTAGGGATGC CTGGAAGTGTATAAAATTGG ACTGCATTTC TTAGAGTGTT TTACTATAGATCAGTCTCAT GGGCCATCTC TTCCTCAGAT GTAAATGATATCTGGTTAAG TGTTATATGG AATAAAGTGG ACATTTTAAAACTAGCAAAG TTAAAAAAAA AAAAAAAAAA AA VPS37A NM_001145152.1GCAGAGGGGG CGGAGAGCGC CCCCGGGGGC GGGGCACGCA 34AGTGACGGCG GCGCGGGTGG TGGAGCGCTG GGCGGCCAGGCTCCCTGGCT GGCCGGTTTG GGCGTCTGGG CCGTGAAGGTGGGACCTCCT GTTCCGGGCC GCAAGTTTCC CTCTCCAGCCGCCCGCCGTT CGTAGCATGT CCCCCAGAAC TCGGGGAGCGCAGGCAGGAC AGGCTTAGAG AAGACGCGGT CCCCAGCGCTTGGGCCACGG ACGTCCCACC CCGCTCCTCT GTCGCTGGAGAACCGCCGGG CCGAGCCACT GGGAGAAGCA GGCCAGAGCCTTCCAGGGCC TCCGGCCCGT GGACCCGAGG AGGATGAGCTGGCTTTTTCC CCTGACCAAG AGCGCCTCCT CCTCCGCGGCTGGGTCCCCC GGTGGCCTCA CCAGCCTCCA GCAGCAGAAGCAGCGCCTGA TCGAGTCCCT CCGGAACTCA CACTCCAGATTGCTTCCTCC ACAGTTTCCT CAGGAAAAAC CAGTGATCAGTGTTTATCCA CCAATACGAC ATCACTTAAT GGATAAACAAGGAGTGTATG TTACCTCTCC ATTAGTAAAC AATTTTACAATGCACTCAGA TCTTGGAAAA ATTATTCAGA GTCTGTTGGATGAGTTTTGG AAGAATCCTC CAGTTTTAGC TCCTACTTCAACAGCATTTC CTTATCTATA CAGTAACCCA AGTGGGATGTCTCCTTATGC TTCTCAGGGT TTTCCATTTC TTCCTCCATATCCTCCACAA GAAGCAAACA GGAGTATCAC TTCTTTATCTGTTGCTGACA CTGTTTCTTC TTCAACAACA AGTCATACCACAGCCAAGCC TGCCGCTCCT TCATTTGGTG TCCTTTCAAATCTGCCATTA CCCATTCCCA CAGTGGATGC TTCAATACCGACAAGCCAAA ATGGTTTTGG GTACAAGATG CCAGATGTCCCTGATGCATT TCCAGAACTC TCAGAACTAA GTGTGTCACAACTCACAGAT ATGAATGAAC AAGAGGAGGT ATTACTAGAACAGTTTCTGA CTTTGCCTCA ACTAAAACAA ATTATTACCGACAAAGATGA CTTAGTAAAA AGTATTGAGG AACTAGCAAGAAAAAATCTC CTTTTGGAGC CCAGCTTGGA AGCCAAAAGACAAACTGTTT TAGATAAGTA TGAATTACTT ACACAGATGAAGTCCACTTT CGAAAAGAAG ATGCAAAGGC AGCATGAACTTAGTGAGAGC TGTAGTGCAA GTGCCCTTCA GGCAAGATTGAAAGTAGCTG CACATGAAGC TGAGGAAGAA TCTGATAATATTGCAGAAGA CTTCTTGGAG GGAAAGATGG AAATAGATGATTTTCTCAGT AGCTTCATGG AAAAGAGAAC AATTTGCCACTGTAGAAGAG CCAAGGAAGA GAAACTTCAG CAGGCGATAGCAATGCACAG CCAATTTCAT GCTCCACTAT AGATTTTCCTGGAAACATGA ACTGCCAAGA GAGGAATGGG ACACAAAACCAAACACTGTT TTATATTTAT GGTTTGCAAA CTGGCATTTCATCAGTGGCT AAATTCACAG ATATCCTATA TAGATTGTATACAGAACTGA GACTGATTTT GTACCGATTA GAATGATTGCTATGATCTTT GAGAAATTTT TCTGCACTAT TTGCACTGAAATGTTTATTT ATTGTTGATA AATTGTATCA TATTTAAGTTCCACTGCTGT TCCTCTTACC TTGATTAAAT GCCTATGCATGTACTTTTAG CTAGTTTTTA ATATTTTATA AAACTTCATTTAAATTTGTA TTTTTAACTT GAAGTTCCAT TTCTTTATCAAGGATGGTAT TTAGATTTTT TTCCTCTTAA CCTTTTTTCAAAAACTATTT TCAACTGTGA GGAAACCCTT ATTTTTCTTTCTTTGTGGAT AAAACTTTCA AAAGCAATTT AAGATATTCATAGTGTTAGG AAACACCAAA CCTGCCTATG TGCCATCTCACAAAAGAAAC TTTTAATACC TACAATAAAT CAAAAGAATAAACCAGCTGT TCTTATATAT TGTTTCATTT TTAAAACTAAAGATGCATTT AAGAAGCAAT ACAAGTAAAT ATTTTACCTAATAGGAAAAA AAAAAGTTGC CTTTCATTTA AACCATTCCAACAGAAATTC TTATGCTAAT TTAAAACATA TATATATCTGGTAGGTTTGT GGTTGGATAG GTTTTCTAAA TTCCTAATGTTAAAAACAAT CTTTATGTTA ATATACACTA AATCTATACACAAAAAAAGT CAGTGAACTT TTCTGACCTT TACTGTGAGTTACCTTTTCC TAAGAGGAAA GCTATAGTAA TAAGTAAAATTTAATTTTTA GGCAATCCTG ATTTTTAATG AATTTAATTGAGTGTTCTTG TATACTACAT TGAGCAGTTT GCTTCTATACCGTGTCACAA AATTCATGTA TTTCTTGAGA AGCCCTAAAAGCTCATAAAG GAAAATGCCG TGAACTATGT AGCTCAGGCTTGGTAAGGTG CCATCTAAAT TACAAAACAA ACTAATGCATAATTTTGCTT AAATTTCATC CCAGTATGAT TGTCTTCCCAACACCAGCAT ATAGTATAGA TTGTCTGTCT TTTTTATATTTTTTAGTTCT TCCTGTACAT GTTTTTGGCA ATAAAGTTATAGGAAGAACA AAATTATTTT GTTAGAATTA AAACATGCTTAATATTTAGT CTGTTTGTGG AGGGCAGGTA TTCACGTGGACTGAGATACA ATGTTGGATA CAGAAAATAA CTTTCATTGTCTTCCTGACA CTGTGCTAAG GACATGCTGT TAAAGCTTCAAAGTGACCAG ATGAGGAAGG AATAATTAAT TATTACTCCTGATTTGTAGA TAACTGAGGT AAGAGTGTTT CAAATTTATGATAGTCTTTT GGGTATTCAG AAACCTTTCC TTATACTGCACTGGCCACCA GAGCTTAATT TTCCCAGCAG TTACAGCAATGGGAGATAGA ACAGTCTCAA TCTTTTGCCA ACCATCAGGTTCCTAGAAAC CAGGTAGGTG TATCCCATAA CAAGGGAGGAGCATACCACA GCCCCTCATT TGATTAATTC ATTTGATCTATCTATGTTAT TAAGTACCTA CTAGGAATAA GGCATTGTGGAAATACTATA CAAAGATAAA CATTGTTTAG ATGCTTATCTACTTTCCTTT TCACCAGAAA AACAGAAAAA AAAGAAACATTTTCTTACAG AGTAAAAATG TTCTACATAA TCACATGAGTAGTTCATCTC AGTGTTTTTT ATTCTTTAAA GTTGAACTATCCCAGTTTCA TTCTATACCA TTCATTGGAT AACCTTGTTACAACCCAGTC ATGAAACAGA GCAGTGTGAT CAGTTATCTGCATTTAACAA ATAGACAAAT CAGTTTACAT AAAGGTTATGTATGTCACCC ACGATGAAAA GAATCTGCAT TTGAATATGCCCGTATGAAT GTGGGTTCTG TTTTTGCAAC AGAGATTAAGTGACCATTTT TTCTAATTTT ATGGCTATAT ATTTTCTTCATAAAAATTGG TCACATCGGA GAAGCAGTGC CACAGGAAAAATGAAATGCA TGTGAAAGTT TGTATTCTGA TTTTACAAGATGAGATAGAA ATCAGAATTA AAGAGGAATA CTTAGGAGTTACTAGGCTAA TCAGTGTACG AATTTGTCAT AGGTAGAGATTTAAAGGTTA ATATCTTAAA ATAGAAGAAA ATTCTAAATCAATCAATCAG TGAGATATAA ACTAAACAGA CCCACTTCAAAGTTGAAAGA AATTTCTAGG CATAAATTGA GACTAGGAAATTTATATCAG AATAGAGGGT GCTTGACACA TATATATGCTTAAATTGAAG GACAGCTCAG ATTCATTTTT AGGAGAAGAAAGTAAACTAA TGTGCTCTTA AAGAATAAAA ATTTATTCTATGGTTTCTGT CTCTGATCAT CACCTTCCAT TCTATAAAAAGCTCAGTTAC TGATTTGCTG GGTCATGGTC AAAATTCTTACCTATTTATT TCATATCAAC TTTAAAAAAT AAATTACTTGCATTCTATAT ATTACTAATT GGGAAGTAAT ATGCCTCAAATCAGTTTTAT ACTGGATTAT TCCCTATGCT TTAAACCACTGCTCTCAATA AAACACTTCC TGATTAATGT TTGATTATTAGATATTTTAG TCTTGTTGGG GATATTTTAG TCTTGTTGGGTTAGCCATGC TCTGAAGAAT CTGTGAAAGT ACAGTAAAGTTTTAATAAGC AATAAATGTA ACCTTTTATA TAAATCTCAGTGCTAGGTTA ACTTCTAATA AGCAGACGAA CATGTTACATAAATTATAAT GTCTGTCTTG TAAAAAAGTT GAGGGGACTAAAAGTTTATG ACTCTGATAT GGAAGTTGTC ATATTAAAAAACTACATTTT AAAACATCAA ATATTTATAC TATTTGCTTTTCAAATAAAA GCATAGTGCT GTTTGGCATA PRRC2B NM_013318.3GCAGATCGGG AGCGGTGCCG AGAAAAATTT CCTTACTAGA 35TGACATTTCA TCGCAATGTC CGATCGTTTG GGGCAAATTACCAAGGGCAA GGATGGGAAA AGCAAGTACT CGACTCTCAGCCTGTTTGAT AAGTATAAAG GAAAATCAGT AGACGCGATTAGATCCTCAG TTATTCCTAG ACATGGCTTA CAGAGTCTTGGGAAAGTTGC TGCAGCCCGG CGCATGCCAC CGCCTGCAAACCTGCCAAGC TTGAAGTCTG AAAACAAAGG AAACGACCCCAACATCGTGA TAGTACCCAA GGACGGGACG GGATGGGCAAACAAGCAGGA TCAGCAAGAC CCAAAGAGTT CCAGTGCGACGGCCTCTCAG CCGCCGGAGT CGCTGCCGCA GCCGGGTTTGCAGAAATCTG TCTCCAATTT GCAGAAACCG ACACAGTCAATCAGTCAGGA GAATACAAAT TCAGTGCCAG GTGGACCAAAGTCATGGGCA CAGCTGAATG GAAAGCCAGT AGGACACGAAGGTGGTTTAA GGGGCTCAAG CCGACTGTTA TCCTTCTCTCCCGAGGAATT TCCGACGCTG AAAGCAGCTG GAGGGCAGGACAAGGCTGGC AAAGAAAAGG GCGTCTTAGA TCTGTCGTATGGGCCAGGAC CAAGCCTCCG CCCTCAGAAT GTGACAAGCTGGAGGGAGGG CGGTGGGCGA CACATAATTT CTGCCACGTCTCTGAGCACC TCCCCAACTG AGCTGGGCAG CAGGAACTCGAGTACGGGAG ATGGAGCCCC CTCCTCGGCA TGTACCAGCGATTCTAAGGA CCCCTCTCTC CGCCCGGCTC AGCCTGTCCGAAAAGGGGCT TCACAGTTCA TGGGAAATGT ATACCACCCACCTACATACC ATGACATGCT TCCTGCTTTT ATGTGTTCGCCGAAGTCATC AGAAAACCAG GGTACAGTGG AACGAGGCTCTTTTCCCCTT CCTCAGCTCC GCCTTGAACC TCGAGTTCCTTTTAGACAGT TCCAGATGAA TGACCAAGAC GGAAAAGAAAACAGGCTGGG ATTGTCTCGC CCACTCCGCC CACTAAGGCAGCTGGTGGAG CGGGCACCAC GGCCCACCAT TATCAATGCGGAAAACCTGA AGGGCCTTGA CGATCTGGAC GCCGATGCCGATGATGGCTG GGCAGGCCTC CATGAAGAAG TGGACTATTCTGAGAAACTG AAGTTCAGTG ATGATGAAGA GGAGGAAGAAGTTGTGAAGG ACGGCAGGCC AAAGTGGAAC AGTTGGGACCCTAGGAGGCA GCGGCAGTTG TCAATGAGCT CTGCAGACAGTGCGGACGCT AAGCGGACTC GAGAGGAAGG GAAGGACTGGGCTGAAGCAG TGGGTGCGTC CCGTGTGGTC CGAAAGGCGCCAGACCCTCA GCCACCGCCC AGGAAGCTTC ATGGCTGGGCACCAGGCCCT GACTACCAGA AGTCATCAAT GGGCAGCATGTTCCGGCAAC AGTCCATCGA GGACAAGGAG GACAAGCCCCCACCAAGGCA GAAGTTCATT CAGTCAGAGA TGTCCGAGGCGGTGGAGCGA GCCCGAAAGC GCCGGGAAGA AGAGGAGCGCCGAGCCCGGG AGGAGAGGCT GGCCGCCTGT GCTGCCAAACTCAAGCAGCT GGACCAGAAG TGTAAGCAGG CACGAAAGGCAGGTGAGGCC CGGAAGCAGG CAGAGAAGGA AGTGCCCTGGTCTCCAAGTG CTGAGAAGGC ATCTCCCCAG GAAAACGGCCCTGCTGTCCA CAAAGGCTCC CCAGAATTCC CTGCCCAAGAGACCCCCACC ACATTCCCAG AAGAGGCACC CACAGTGTCCCCAGCAGTGG CACAGAGCAA CAGCAGTGAG GAAGAGGCCAGAGAGGCTGG GTCCCCTGCA CAGGAGTTCA AGTATCAGAAGTCCCTTCCT CCCCGATTCC AGCGCCAGCA GCAGCAACAACAGCAGGAGC AGCTGTACAA GATGCAGCAC TGGCAGCCGGTGTACCCCCC GCCGTCCCAC CCCCAGCGCA CCTTTTACCCACACCACCCC CAGATGTTGG GCTTCGATCC CAGGTGGATGATGATGCCTT CCTACATGGA CCCACGTATC ACGCCCACTCGGACCCCGGT GGACTTCTAC CCCTCCGCCC TGCATCCCTCAGGACTGATG AAGCCCATGA TGCCCCAGGA GTCCCTCAATGGGACAGGCT GTCGCTCTGA GGATCAGAAC TGTGTGCCCCCACTCCAAGA AAGAAAAGTG ACCCCCATCG ACTCACCCCCTGTGTGGAGC CCAGAGGGCT ACATGGCACT GCAGAGCAAGGGCTACCCGC TCCCGCACCC GAAGTCGAGT GACACCTTGGCTATGGACAT GCGTGTCAGG AATGAAAGCT CTTTCTCTGCCTCACTCGGA AGGGCAGGGG GCGTAAGTGC TCAGCGCGATCTCTTTGAGG AGAGAGGGGA GGAGTACTTG AGTGCTTTTGACAAGAAGGC CCAAGCAGAC TTTGACAGCT GTATCTCTTCTCAAAGAATA GGCCAGGAGC TTTTGTTTCC ACCCCAAGAAAATGTTCAGG ATGCAGGTGC TCCTGGGGGT CACACCCAAAACCTCAGGTG TTCCCCATTG GAGCCTGACT TTGTCCCAGATGAGAAAAAG CCAGAGTGTG GCAGTTGGGA TGTTAGCCACCAGCCAGAGA CCGCTGACAC AGCCCATGGT GTTGAGCGGGAGACACCCCG GGAGGGGACG GCCTTTAACA TCTCCTCCTGGGACAAGAAC GGGAGCCCCA ACAAACAGCC ATCCTCGGAGCCTGAATGGA CTCCCGAGCC CCGGAGCTCC AGCAGCCAGCACCCGGAGCA GACGGGCAGG ACCCGGAGGT CGGGACCCATCAAGAAACCA GTCCTGAAAG CCCTCAAGGT GGAAGACAAGGAGAAGGAGC TTGAGAAGAT TAAGCAGGAG CTAGGGGAGGAGAGTACCCG GCTGGCCAAG GAGAAGGAGC AGAGCCCCACGGCAGAAAAG GATGAGGACG AAGAGAACGA TGCCTCTCTGGCCAACTCCT CCACCACCAC TTTGGAGGAC AAAGGCCCTGGCCATGCCAC TTTTGGCCGC GAGGCCACCA AATTTGAAGAGGAGGAGAAA CCTGACAAGG CCTGGGAAGC CAGACCCCCACGAGAGTCCA GCGATGTTCC CCCCATGAAG AGAAATAACTGGATCTTTAT TGATGAGGAG CAAGCCTTTG GGGTCAGAGGACAGGCCCGG GGCCGGGGCC GTGGTTTCAG AGAGTTCACTTTTCGTGGTC GGCCTGCTGG CGGAAATGGG AGCGGCCTCTGTGGTGGGGG GGTCCTGGGG GCCCGCAGCA TCTACTGCAGCAGTCAGCGC AGCGGCCGTG GCCGGGGCCT GCGAGAGTTTGCGCGGCCAG AGGACTGCCC CAGAGCCAAG CCCCGACGGAGAGTTGCCAG TGAGACCCAT AGCGAGGGCT CAGAGTATGAAGAACTTCCC AAGCGCCGCC GGCAGAGGGG CTCCGAGAACGGGAATGAAG GCTCGCTCCT GGAGAGGGAG GAGAGCACCTTGAAGAAGGG CGACTGCAGA GATTCTTGGC GGTCCAACAAGGGGTGCTCT GAGGACCACA GCGGTCTAGA TGCCAAGAGCCGAGGCCCTC GGGCCTTTGG GCGAGCCCTC CCTCCCCGGCTGAGCAATTG CGGGTATGGA CGGAGAACCT TCGTCTCCAAAGAGTCACCC CACTGGCAGA GCAAAAGTCC AGGCAGCTCTTGGCAGGAAT ATGGCCCTTC CGACACATGC GGATCCCGGCGACCTACAGA CAGAGACTAT GTCCCAGATT CCTACAGACACCCTGACGCA TTTGGTGGCC GGGGCTTTGA GGACAGCCGCGCGGAGGACA AGAGATCCTT CTTCCAAGAT GAACACGTGGCAGATTCTGA AAATGCAGAG AACCGGCCCT TCAGGAGAAGGCGCCCCCCA CGCCAAGATA AGCCCCCTCG ATTCCGGCGCCTCCGGCAAG AGCGGGAGTC CCTGGGCCTG TGGGGACCCGAGGAGGAGCC CCACCTGCTG GCAGGTCAGT GGCCAGGCAGGCCCAAACTG TGTTCTGGGG ACAAGAGTGG CACTGTGGGCCGCAGGTCCC CTGAGCTCTC CTACCAGAAC TCCTCCGATCACGCCAATGA GGAGTGGGAG ACGGCCTCCG AAAGCAGCGACTTCAGCGAG CGGCGGGAGC GGCGGGAAGG CCCTGGGTCCGAGCCCGACT CCCAGGTGGA TGGTGGCCTG TCGGGGGCTAGTTTGGGTGA GAAGAAGGAG CTGGCCAAGA GGAGCTTCTCCAGTCAGAGA CCCGTGGTTG ACAGACAGAG CCGAAAGCTGGAGCCGGGAG GGTTTGGGGA GAAGCCCGTT AGGCCAGGTGGTGGTGACAC CTCCCCTCGC TATGAGAGCC AACAGAATGGGACGCCTTTG AAAGTGAAAA GATCCCCAGA CGAGGCCTTGCCTGGAGGTC TTAGTGGCTG CAGCAGTGGG AGTGGCCACTCCCCCTATGC CCTGGAGCGG GCAGCCCATG CCAGTGCTGACCTTCCCGAA GCCTCCAGTA AAAAGGCAGA GAAGGAGGCCAAGTTGGCTG CTCCGAGGGC AGGTGAACAG GGAGAGGCCATGAAACAGTT TGACCTGAAC TATGGAAGTG CCATCATTGAAAATTGCGGG TCCAGCCCCG GGGAGGAGAG TGAGGTGGGTTCTATGGTGG GCGAAGGCTT CATCGAAGTC CTGACCAAGAAGCAGCGCCG CCTGCTGGAG GAAGAGAGAA GAAAGAAGGAGCAGGCCGTG CAGGTGCCTG TCAAAGGTCG AGGCCTTTCCTCCCGTATTC CTCCTCGATT TGCAAAAAAG CAGAACAACTTATGTCTGGA GCAAGGTGAC GTGACCGTGC CTGGCAGCAGCCTGGGCACT GAGATCTGGG AGAGCAGCAG CCAGGCTCTCCCTGTGCAGG CCCCAGCCAA CGACTCCTGG AGGAAAGCTGTCACTGCCTT CAGCAGCACC GAGACTGGCT CTGCGGAGCAGGGTTTTAAG AGCAGCCAGG GAGATAGTGG CGTTGACTTGAGTGCCGAGT CTCGGGAGTC GTCTGCGACC TCCTCGCAGCGCAGCTCCCC ATATGGGACT CTGAAGCCAG AGGAGATGAGCGGGCCCGGC CTGGCGGAAC CCAAGGCCGA CAGCCACAAGGAGCAGGCTC CAAAGCCATC TGAGCAGAAG GATTCAGAACAAGGCTCTGG ACAGAGCAAG GAGCACAGAC CAGGACCCATCGGCAACGAG CGTTCTCTGA AAAACAGAAA GGGCTCGGAGGGGGCCGAGC GGCTGCAAGG GGCTGTCGTC CCGCCTGTTAACGGGGTGGA GATTCACGTG GACTCCGTGC TGCCTGTGCCACCCATTGAA TTTGGAGTCA GTCCAAAAGA CTCCGATTTCAGCTTGCCAC CTGGTTCTGC CTCTGGTCCT ACTGGGAGTCCAGTTGTTAA ACTTCAGGAT GCCTTGGCCA GTAATGCAGGGTTAACACAG AGTATCCCCA TCCTGCGGCG GGACCATCACATCCAGAGGG CCATCGGTCT CTCCCCAATG TCCTTCCCCACCGCCGACCT TACTCTGAAG ATGGAGTCTG CGCGCAAGGCTTGGGAAAAC TCCCCCAGTT TGCCGGAGCA GAGCTCTCCAGGCGGCGCTG GCTCAGGCAT CCAGCCTCCA TCCTCTGTGGGTGCCTCCAG CGGGGTCAAC TACAGCTCCT TCGGTGGAGTGTCCATGCCA CCCATGCCTG TGGCCTCTGT AGCACCTTCTGCTTCTATGC CAGGCAGCCA CCTCCCGCCC CTGTACCTGGATGGCCATGT GTTTGCAAGT CAGCCCCGGC TGGTTCCTCAAACGATACCT CAGCAGCAGA GTTACCAACA GGCCGCCGCTGCCCAGCAGA TCCCGATCTC CCTTCACACA TCTCTGCAGGCACAAGCTCA GCTTGGACTG AGGGGTGGGC TTCCTGTGTCCCAGTCCCAG GAGATCTTCA GCTCCTTGCA GCCCTTCAGATCTCAGGTGT ACATGCACCC CAGCCTGTCA CCGCCCAGCACCATGATCCT CTCTGGGGGC ACAGCCTTGA AGCCTCCATACTCGGCGTTC CCAGGCATGC AGCCCTTGGA GATGGTGAAGCCGCAGTCTG GCTCACCCTA CCAGCCCATG AGCGGGAACCAAGCCCTGGT CTACGAGGGC CAGCTCAGCC AGGCTGCTGGCCTGGGTGCC TCCCAGATGT TGGACTCCCA GCTCCCACAGCTGACCATGC CACTGCCTCG GTACGGCTCC GGGCAGCAGCCACTGATCCT GCCCCAGTCT ATTCAGCTGC CACCTGGGCAGAGCCTCTCC GTTGGGGCCC CCCGAAGGAT TCCTCCGCCCGGGTCCCAGC CGCCAGTCCT GAACACCAGC AGAGAGCCCTCTCAGATGGA GATGAAAGGC TTCCACTTTG CCGACAGTAAACAGAATGTC CCTTCAGGAG GCCCCGTGCC ATCGCCACAGACCTACAGGC CTAGCTCTGC TAGCCCCAGT GGGAAGCCCTCTGGATCAGC AGTTAACATG GGCTCTGTGC AGGGACACTACGTGCAACAG GCAAAACAAC GAGTGGATGA GAAACCCAGCCTGGGAGCCG TGAAGCTGCA GGAGGCCCCC TCGGCTGCCTCCCAGATGAA GCGAACCGGA GCGATCAAGC CTCGGGCTGTCAAAGTGGAG GAGAGTAAGG CCTGACAGTG CCTGGCTGCCACCTCGCCTC TCCCTACTGA GGACGGTGCC GCCATGCGGCCTCGACACAG CCGACACTCG GGAGCCTCAC CAGATCCACCGTCCAAATGC GTGGCCCAGA CTGAGAGACC TCCCTCCTCTCCACTCCCGA AAGCTCCGTT GTCAACCAGC TTGCACCCGTGGATATATGG CATTGACCCG CTTGCTTTGA TACGAAACAAAAAAGCAGAC GACTCCTTCA TCCCATCTGC TCCTACCGTGACTGTGGAGT GACGCCTCCT GTGCAGTGCA GATTTGCCCTCCCTGCCTCC TCCCTGTCCT GCCGCGCAGC CAGGGCGCCTTCTCAGCAGT GCTTCCGGCC CAGCCGCCCA TCCCTAGGCACAGTGATTTG GCAGCAGGGT CATTTTACTT TGAGGCTTTTTGTTTTAAAA TGTAGCCAAG GTTTTTACAA AGGGGAAAGGAAAAGAAAAC AAAAACGCAA GCTCCATGTG TATAGCTGAACTTTTATATG TTTCTTGCCA GCCCCTCCGC TCCCTTCCATCTCTAGCCTC TGTCCTGTTT AGTTTGATAC GTCACTGCAGTACCTTAAGA GGTGACTCTT AAGAATGCAT CCCCTCCTGATTCCTCAGCT GGTTCACCCT TGAGGTTATT TGCAAAAAGAAAAGGAGGTT CTTGAGGGCA CCGATTGCGA GCATTCTGGTGCCTGGCTCC CCGCCTGGGA AGCGATGGGG TGCTCAGAGCAGCAGGCAGG TTGGGGGAGG GGGGGGGTCA TAGTTGGGTTCCAGCTCCTG GCTTGATGAG CCCAGGGCGC TTACAGGCAGCCCATGAAGT TGATGACAGT TTTAGCATGA GAATCACACAGGGTCCCTGT CCTGGGCTCC TCTAAAGCCA GTGGATGTGCTGGGCACCAG AGACAAATCA TGGAGATGGC TGCTGGTGGCTCCCAGGTTG GCCCAGATGG GGTGAGCTGA CATACCACAGGCCCATCCCA GGCCCCGTGG GCTCTGCTTC TGGGGCTCCATACCCTGCCC TGCAGGGGTG CTGTGTTTTT CACACATTTCTTTCCCTGAA GCCTTCTGTA ACCTGTCATT TTCCTTCCTTCCTCTTCCGG AGCCTGCTGC TTTCTCTGGA CCTGTCTCCACCTCCCACAC AGCTCATCGT GAACACCACT TGGTGATGGAGGGAGTGGAC CCGTGTGTGG TCCCCAAGTG AGGCCACTGGGAGTTTGTCC TTTTCCTCCT TTGCTTCACT CCCAGCAGCAGACCCAGGTT GTCAGGACAG GAGGGCCTGA GCTAAGCAGTAGGCATCAGT CTCGTTTGTC TTCAGACGGC GGGGGCAGGTCCAGGGTGAG GCTGGGTGGA GGGCTGACCA AGGTCCAAAGGGCCTGCGCA GCCTCCGGGA GGGCAGCTTC TCCAGCCAGAGGCTTGTGTG AGCCATCGTG TGCTGGGCTT GTTTTTAAGTAAGAAACAAG GAAATCACTC CAGATTCTGT CATTCCAAGGAAAGGGAAGG GGACAGTTCA GGTTTCTCAG CTGTTCTTAGGGGTCACTGA GCGTCTACCT CCTCCTCCAG AGGAGGCTGGCTCAGAACAC CTAGAGGAGG GGGCCGGGGA TGCACCCCCCACCAGAGGCT GCCTTCAGCG TCTCACGGGT GCAGGACAGCGCTCAGGCTT GGGCTCTAAG CTCTGTGTCT AGTGTAGAACATGGGGAAGG AGCATCTTAG GAACTGCTGA AGTAACTTCTTACTGCTCTC ACAATTCTAA GGAAGCGGGA GAACGGCCTCCTACCAACAG CGCCCACCCC AGAGCTGCCT GGGAAAGGGCAGTTTTACTG AAAGGTGCTT TACTGTTCAC CTGCATCTTTCAGCAGCTCC CCTCCTGCCC TCACCTGGTC TTTTCCCTCTTTATCCCAAG CCTTTATGCT TGAGTCCCTT CCCCAGGGGCTGCCCACCCG ACAGTTCCAG GCATTCCCTA CCTGAGCTTCTTGTCTGCTT TTCCTTCTCC CACTGCAAGC GGCTGCTTGTGGGGCCTGGG ATGAGCCCTC TCTGTCCCCA CCGGCCCTCCTTGCCAAGCC ATTCCTGGGT GAGTTCAGGC CTGCGGGAGCCACACATTCA TCTCCACCTG GACACTTGAG CCGCATGGCCAGACCCCTCC CACCTGATGC GGTGGTGCGT GTGATTTGTCAAAAGAAAGC CTTCTGGATG CTGTTAAGAT GTACCCTTCAGGTGAACCTG GTATCAGACC CACAGTACTT GCTGTTTGAGAAAAAATAAA AACAAAAAGG TCACCTGTTC TCCAGCCCTTTTCTCTTACC TGGTATTTCC TTCCTTTCTC CTCCCCCACCCCAAATAAAA AAACAAAAAA CACTAGAATT TATTTATATGTATTGATGTT GTAGGTCTAG GTGAAAAAAA AAGAAGTAAATGTTTCACTG CTCTATTTAT ATATAATGTC TGAATTAATTCTGTGCAGGA AAGGCCAGGA AATTGCATGT GAAGTTCGGTGCAGTCACCA CCTGTGTGTG ACCTGAGCTG CAGTCTCTTCGCTGAGATGC AGGTTTTAAA TGAGACTTGG GGGGCTGAGGGCAGGCCTCA GGCCTCCCAG CGCCCCAACC CCTCCTTGGTCTAATGAAAT GCAGTTCTTA GTGCAGAGAT GTTTTAAGGTGCAATATATC TCTTCCTTTC CCGTGGTTTT AGAGCCAAGCTCAAGGTAGT AGGACGTAGG GTCTTATTTT GTTTTCAAACCCCCATCCTC AGAGCGCAGA TACATGCAGA GGCTTCTGCCAGGATACCAC GGGGCCTTAG TGGGAACAGG TGGAGACCAGCACTTCCCTT TCCTGCTGCT GAGGTAGGGA TTGGGGGGTCAGAACCCACT CACTTTTGCC TGTTAAAGTT GCCCTCCTGACGCTGGCAGC TCTGCCTTGG TCACTGGGGA TGCGGCTCGTTGCTCAGCCA CCAGTGGCCT TGCGGTATTG TCCACCATCCACTAGAGTGG GATGAAGTCC AGAGTGTGGG TATACATCTCAGATGCCCAT CTACCCACTG GGGACTTCAA TGCCAGCTGCATTTGGTTTG GTTTTCTTAA CTGTTGGCTT CTCCCCACAGCGTTTTTTGT TTTTTTTTAA ACATTCATAT TGTTTTCAAACTTGGAATTC ATAGACACTC TGGCTCTAGG TTCCTTAAGGGGGAAAACAA AAGATGACTT TATTTCACAT TCAAGAAAATCAGTTCAGTT CCAAAGCTGT GGTCCTTCCA GCCACTTCTAGGGACACTGG GGAACCTTGT TAAACGTTGA CATCAGTGCTCTCCAGCCGT GCTGTCACCC TCCTATCTTC TGGATCTGCCTTCGCGATGG TCAGTGACAG CTTCTGGAAG CTGAGCACACACAGGTGCAC AGCCATGCTG TGGTCTGGCC TGCTACGGCAGCATGGCAGC TCTGGTGGAG CCTTCTCCCT TGCCATTTGGTTCCCCTGTG CCAAGTAGCT GCAGGCTGCC CCTCAAATCTTCATTTGTCC CTTTTCACTT CCTGCAGAAC AAGCCTGGGTTAGAGGGTCT GCTGGAAATG GCCTTTGAAG ACCAAGGATACCAGGATGTG TGCACTCTGT CGTGTTCTGT GATGAATGGGAAACGTAGGC TTCCAGAAAG CCAGCTCTCT TCTGAAATGTGACGGACCTA AGCAGGAAGT CATCCAGGAC AGGAGTGGCTCAGTGTTGGG GATGGACGCT GTCGCCCAGC CATGCTCCACCAGGGCCACC AATGTGTAGT TGGCTGGTGG TCTTCGGGCATGTGAGACCT GCTCTTCACT GTTTCCACCC CACTTGGTGGCCTCCAGGAT GGTAGTGGCA CCCTCAGAGC CCCATCTTCAGCATGTTCTG AAGCCTCAGA GTGGAAATTC CTGCTAAGGCTCTGTGTGGA CGCCTTTCTC CCGTGATCTA AAGGGGACACTGTACTCAAG CTTTTGACCT CATGCCTTGT GTAGTAAAAAAGGATTTGGG GGTTTTGTTT GGTTCCTGAG AGGGTTGTGTTTTGTTTTTG TTTCCTTTTG TTTATGTTTT GGCCTTTCCTCTTTGTCTTT CCATGTAGAC CAGATATTTG AAAGGGCAGACGATGGCTAG AGGTGTAATG TGCAGCTTGT TTATACGGTATTTTGGGAAA CTTACCTTGG ATGGGAAATC GAATCGTGGATTCACCAGGC CGGTGCTGGC ACACTCACCC TCGCCCTTTCCCTCCGGTTC AGTACCTATT GTTTCTCCTT TCAAATATGTGATTGTACTA GCTCTTTCCA TATGAAAGAA TTCTCCTTAT TTAAATAAAA AAAGTTTAAA AADOPEY2 NM_005128.3 TCCCACAGTG CCTGGCCCAG AAGCCTTGCT AAATATTTGA 36ACAGGATTGC CCAATACTTT TCTGCTGTGA GAATGTAAGATGGATCCAGA AGAGCAGGAG CTCTTAAATG ATTACAGATACAGAAGCTAC TCTTCAGTGA TTGAAAAGGC TTTGAGAAATTTTGAGTCCT CGAGTGAATG GGCGGATCTC ATATCTTCACTTGGCAAACT CAACAAGGCT CTTCAGAGTA ACCTGAGGTACTCCTTGTTG CCAAGACGGC TCCTCATCAG CAAAAGATTAGCTCAGTGTT TGCACCCTGC CCTGCCCAGT GGTGTCCACTTAAAAGCTCT GGAAACCTAC GAGATTATCT TTAAAATCGTGGGGACCAAA TGGCTGGCCA AGGACTTGTT TCTGTACAGCTGCGGGTTAT TTCCTCTCCT GGCACACGCG GCGGTGTCGGTGAGGCCGGT GCTGCTCACC CTGTACGAGA AGTACTTCCTCCCACTGCAG AAGCTGCTCC TGCCCAGTCT GCAGGCCTTCATCGTGGGCC TGCTGCCCGG CCTTGAAGAG GGCTCCGAGATCTCCGACAG AACGGATGCT CTGCTCCTGA GACTGTCGCTGGTGGTTGGC AAAGAGGTGT TTTACACCGC CCTCTGGGGGAGCGTCCTGG CCAGCCCGTC CATCCGCCTC CCTGCCTCAGTCTTCGTGGT GGGCCACATC AACAGGGATG CCCCCGGCCGGGAGCAGAAG TACATGCTGG GGACCAATCA CCAACTCACGGTGAAGTCTT TGCGTGCCTC CCTGTTGGAC TCAAATGTTCTTGTGCAAAG AAATAATCTG GAAATCGTTC TGTTTTTCTTCCCATTTTAT ACCTGTCTGG ATTCCAATGA GAGAGCCATCCCCCTCCTCA GATCTGACAT CGTGCGCATT CTCTCAGCCGCCACCCAGAC CCTACTGAGA AGGGACATGT CCCTGAACAGAAGACTGTAT GCATGGTTAC TAGGCTCAGA CATAAAAGGAAATACCGTTG TGCCAGAATC TGAAATCTCA AATTCTTATGAAGACCAGTC GTCTTATTTT TTTGAAAAAT ACTCCAAGGATCTTTTAGTT GAGGGTTTGG CTGAGATATT GCATCAGAAGTTCATAGATG CTGACGTGGA GGAACGCCAT CATGCATACCTGAAGCCTTT TCGCGTCCTC ATCAGTCTGC TTGACAAGCCAGAAATAGGG CCTCAAGTGG TTGGGAATTT GTTTCTCGAAGTCATCAGGG CCTTTTATTC TTACTGCAGA GATGCCCTTGGCTCTGATCT TAAACTTAGC TACACCCAGA GTGGAAATTCGCTGATAAGT GCAATCAAGG AAAACAGAAA TGCCTCTGAGATTGTCAAAA CGGTAAATTT GCTGATAACT TCTCTAAGCACAGACTTTCT CTGGGATTAT ATGACAAGGT GTTTTGAGGAATGCTTTAGA CCAGTGAAGC AGCGTTACAG CGTGAGGAACAGCGTCAGCC CTCCCCCCAC GGTCTCGGAG CTCTGCGCCCTCCTGGTCTT CCTGCTGGAT GTCATTCCTT TGGAACTTTACTCTGAGGTG CAAACCCAGT ATCTCCCTCA GGTGCTCGGCTGCCTGGTGC AGCCTCTTGC TGAGGACATG GAGGCCTTAAGTTTACCTGA ACTCACGCAT GCCTTGAAGA CGTGTTTCAAGGTGCTCAGC AAAGTCCAGA TGCCTCCTTC CTACCTCGACACGGAGTCCA CCAGCGGAAC CTCGAGTCCA GTAAAAGGTGAAAACGGCAA AATAATTTTG GAAACAAAGG CAGTGATTCCCGGTGACGAA GATGCTTCGT TTCCCCCTCT GAAGTCTGAGGACAGTGGGA TCGGGCTCAG TGCCTCGTCA CCGGAGCTCTCTGAGCACTT GAGGGTTCCT CGAGTTTCTC TGGAAAGGGACGACGTTTGG AAGAAGGGCG GGAGCATGCA GAGGACGTTTCTTTGCATCC AAGAGCTAAT CGCCAACTTT GCCAGCAAGAACATTTTTGG AGTACAGCTG ACAGCGTCAG GAGAAGAAAGCAAGTCCGAG GAGCCTGCAG GGAAGAGGGA CAGGGATGGGACGCAGAGCC TGGCAGCCAA TGATTCCAGC AGGAAGAACTCTTGGGAGCC CAAGCCCATC ACTGTGCCTC AGTTCAAGCAGATGCTGTCA GACTTGTTCA CAGCACGAGG GTCTCCATTCAAGACAAAAA GTTCAGAGTC ACCATCGTCT TCGCCCAGCAGCCCTGCCAG GAAAAACGGG GGAGAATGGG ATGTTGAGAAGGTGGTCATT GACCTGGGGG GTTCCAGGGA GGAACGCAGGGAGGCCTTTG CCGCCGCCTG CCACCTGCTG CTGGATTGTGCCACTTTCCC TGTCTACCTG TCCGAGGAAG AGACCGAGCAGCTCTGTGCA ACGCTCTTCC AGCTGCCAGG AGCCGGTGATTCCAGTTTTC CATCTTGGCT GAAGTCCCTC ATGACTATTTGCTGCTGTGT GACTGACTGC TACCTCCAGA ACGTGGCCATTTCCACTCTG CTGGAAGTGA TAAACCATTC CCAGTCCCTGGCGCTTGTCA TTGAAGACAA GATGAAACGC TATAAGAGCTCTGGACACAA CCCTTTTTTT GGCAAGCTGC AGATGGTGACGGTTCCTCCC ATTGCTCCAG GGATATTGAA AGTCATTGCAGAGAAAACAG ATTTCTATCA GAGGGTGGCT CGTGTGCTTTGGAATCAGCT GAACAAAGAG ACCCGGGAGC ATCACGTCACCTGCGTAGAA TTGTTCTACC GGCTGCACTG CCTGGCCCCTACGGCCAACA TCTGCGAGGA CATCATCTGC CATGCCCTCCTGGACCCTGA CAAGGGAACA AGGCTGGAAG CTCTGTTTAGATTTTCCGTG ATCTGGCATC TGACAAGAGA GATCCAAGGCAGTCGAGTAA CATCTCACAA TCGCTCCTTT GATAGGTCCTTGTTTGTCGT GCTGGACAGC CTGGCCTGCA CGGATGGTGCCATCGGTGCG GCAGCCCAGG GCTGGCTGGT GCGTGCGCTCTCCCTCGGGG ACGTGGCTCG CATCCTCGAA CCCGTGCTCCTGCTGCTGCT GCAGCCAAAA ACCCAGAGAA CCTCCATCCACTGCCTCAAG CAGGAGAACT CGGCCGATGA CTTGCACCGTTGGTTTAACA GGAAGAAAAC CTCTTTCAGA GAGGCATGCGCAGTGCCCGA GCCTCAGGAG AGCGGCTCTG AAGAGCACCTGCCTCTGAGC CAGTTCACCA CAGTGGACCG TGAAGCCATTTGGGCCGAAG TGGAGAAGGA GCCCGAGAAG TACCCGCTGCGAGGCGAGCT GAGCGAGGAA GAGCTGCCCT ACTACGTGGAGCTTCCAGAC AGGACGGCCC ACGGCGCCCC GGACAGCAGCGAGCACACCG AGTCTGCAGA TACAAGCTCC TGCCACACGGACAGCGAGAA CACGTCCTCC TTCTCCTCCC CTTCCCACGACCTGCAGGAG CTGAGCAACG AAGAGAACTG CTGTGCACCCATCCCCATGG GGGGCAGGGC GTACCCCAAG CGCTCGGCCCTGCTGGCGGC CTTCCAGTCA GAAAGCTTCA AGGCTGGGGCCAAGTTAAGC CTGGTGCGGG TGGACTCGGA CAAGACGCAGGCTTCTGAGT CGTTCTCCAG CGACGAGGAG GCGGACTTGGAGCTCCAGGC CCTCACCACA TCCAGGCTGC TAAAGCAGCAGCGGGAAAGG CAGGAGGCCG TCGAGGCCTT GTTCAAGCACATCCTGCTCT ACCTGCAGCC CTACGACTCT CGGCGGGTCCTCTATGCCTT CTCGGTGCTG GAGGCTGTGC TCAAAACCAACCCTAAGGAA TTCATCGAGG CTGTGTCCAG GACTAGCATGGATACCAGCT CCACCGCGCA CCTCAACCTC ATCTCCAACCTCCTCGCTCG CCACCAGGAG GCCCTCATTG GCCAGAGTTTCTACGGAAAG CTCCAGACCC AGGTCCCCAA CGTGTGCCCCCACTCTCTGC TCCTGGAGCT GCTCACCTAC CTCTGCCTGAGCTTCCTGCG CTCCTACTAC CCTTGCTATT TGAAGGTCTCGCACCGAGAC ATTCTCGGCA ACCGGGACGT GCAGGTCAAAAGTGTCGAGG TTTTGATCAG GATAATGATG CAGCTGGTCTCAGTGGCCAA GTCTTCGGAA GGGAAGAACG TGGAGTTCATCCACAGCTTG CTGCAGAGGT GCAAAGTTCA GGAGTTTGTCCTGCTCTCCC TGTCGGCGTC CATGTACACG AGCCAGAAGCGCTACGGGCT GGCCACCGCC CACCACGGCA GGGCCCTGCCAGAGGACAGC CTCTTTGAGG AGAGTCTCAT TAACTTGGGTCAGGACCAGA TCTGGAGTGA GCACCCGCTG CAGATTGAGCTGCTGAAGCT GCTGCAGGTG CTGATTGTCT TGGAACACCACCTGGGTCGG GCCCATGAGG AGGCGGAAAA CCAGCCCGACCTGTCCCGGG AGTGGCAGAG AGCCCTGAAC TTCCAGCAGGCCATCAGCGC CCTGCAGTAC GTGCAGCCCC ACCCCCTCACCTCCCAGGGT CTTCTGGTCT CTGCGGTGGT GAGGGGTCTGCAGCCCGCCT ACGGTTACGG CATGCATCCG GCCTGGGTGAGCTTGGTCAC GCATTCCTTG CCCTACTTCG GAAAGTCCCTGGGCTGGACG GTGACACCCT TTGTTGTCCA GATTTGCAAAAACTTGGATG ACTTGGTCAA GCAGTATGAA AGCGAATCTGTGAAGCTCTC TGTCAGCACA ACCTCCAAGA GGGAAAACATTTCTCCAGAT TATCCACTCA CCCTTCTAGA AGGTCTAACGACCATTAGTC ATTTTTGTCT TTTGGAACAA GCCAACCAAAACAAAAAGAC CATGGCTGCA GGTGATCCTG CCAACTTGAGGAATGCCAGA AATGCCATTT TGGAAGAGCT GCCTCGAACTGTTAACACCA TGGCCCTTCT CTGGAATGTT CTCAGAAAGGAGGAGACTCA AAAGAGACCT GTCGATCTCC TAGGGGCCACGAAGGGATCC TCTTCCGTTT ACTTTAAAAC CACCAAAACCATAAGACAAA AAATTTTAGA CTTCTTAAAC CCCTTGACGGCCCATCTTGG GGTTCAGTTG ACAGCGGCTG TTGCGGCAGTGTGGAGCAGA AAGAAAGCCC AGCGTCACAG TAAGATGAAGATTATCCCAA CGGCAAGTGC ATCCCAGCTA ACCCTTGTCGACTTGGTGTG TGCACTCAGC ACCCTGCAGA CTGACACGCTGCTGCACCTG GTGAAGGAGG TGGTGAAGAG GCCACCCCAAGTCAAAGGGG GTGATGAGAA ATCGCCCCTA GTGGACATTCCTGTGTTGCA GTTTTGCTAT GCTTTTCTCC AAAGGCTCCCAGTACCAGCC TTGCAAGAGA ACTTTTCTTC ACTGTTGGGAGTATTGAAAG AGTCTGTACA GTTGAATCTA GCCCCACCTGGGTATTTTCT GCTTCTCAGC ATGCTGAATG ACTTTGTAACAAGAACTCCC AACCTGGAAA ACAAGAAGGA CCAAAAAGACCTGCAGGAAA TCACTCAGAA AATCCTAGAA GCTGTGGGGAACATTGCCGG CTCTTCCTTG GAGCAAACCA GCTGGCTAAGCAGAAACCTG GAAGTGAAGG CCCAACCTCA GGCCTCTCTAGAAGAATCTG ATGCTGAGGA GGACCTGTAT GATGCTGCTGCAGCTTCAGC AATGGTGTCT TCATCCGCCC CGTCGGTGTACAGCGTGCAA GCCCTCTCTC TCCTGGCAGA GGTACTGGCTTCCCTCCTGG ACATGGTTTA TCGAAGTGAT GAGAAGGAGAAAGCTGTGCC GTTAATCTCC CGTCTGCTTT ACTATGTTTTTCCATACTTA CGCAACCACA GTGCCTACAA TGCTCCCAGCTTCCGGGCTG GCGCTCAGCT GCTGAGCTCC CTGAGTGGCTATGCCTACAC AAAGCGAGCC TGGAGGAAGG AGGTCCTGGAGCTGTTTCTC GACCCCGCTT TCTTTCAGAT GGATACTTCCTGTGTTCATT GGAAGTCCAT TATTGACCAT CTTTTGACTCATGAGAAAAC AATGTTTAAG GATTTAATGA ACATGCAGAGCAGTTCTTTG AAACTATTCT CAAGTTTTGA ACAGAAAGCCATGCTGTTAA AGCGCCAGGC TTTTGCTGTC TTCAGTGGAGAACTTGATCA ATACCACCTT TACCTTCCAC TGATACAAGAACGCCTGACA GACAATCTCA GAGTTGGACA GACATCCATAGTTGCTGCTC AGATGTTTCT TTTTTTCAGA GTTTTGCTGCTAAGAATATC TCCTCAACAT TTGACTTCAT TGTGGCCAATAATGGTCTCT GAATTGATTC AGACATTCAC ACAGCTTGAAGAAGATCTAA AAGATGAAGA TGAGTCATTG AGAAGCACCAACAAAGTAAA CAGAACGAAA GTTTCAGTCC CGGATGCAAATGGACCCTCA GTGGGGGAGA TACCCCAGAG TGAACTCATCTTGTATTTAT CAGCTTGCAA ATTCTTGGAC ACAGCGCTTTCTTTTCCACC TGACAAGATG CCATTATTTC AAATTTATAGGTGGGCATTT ATTCCAGAAG TGGACACAGA GGGCCCTGCCTTCCTGTCGG ATGTAGAGGA GAATCACCAA GAATGCAAACCCCACACTGT CAGGATTCTA GAACTTCTAA AATTAAAGTTTGGGGAAATC AGTAGCTCTG ATGAGATCAC CATGAAGAGTGAATTCCCGC TTCTGCGCCA ACATTCTGTT TCCAGCATCAGGCAGTTGAT GCCATTCTTC ATGACTCTAA ATGGTGCATTTAAGACCCAG AGACAGCTGC CTGCTGATAG CCCAGGAACTCCATTCTTGG ACTTTCCTGT CACAGATAGC CCAAGGATCTTAAAACAACT GGAAGAATGC ATCGAATATG ATTTTCTGGAACATCCAGAA TGTTAACCAT GTGAGAGAGA ATATGTTTAATCCATGTATT GGTACTTTAC TGAAAACCAG GTTATATTCTAAAGAAGAAA GAAGGCAGGA TAGTGCTTTT GAACAAGCCTATTTCCATTT TGAAAGTAGA TTTCAGGCTA GGTGCGGTGGCTCACACCTG TAATCTCAGC ACTTTGGGAG GCCAAGGCAGGCAGATCACT TGAGGTCAGG AGTTCGAGAC CAGCCTGACCAACATGGTGA GACCCTGTCT CTACTAAAAA TACAAAAATTAGCTGGGTGT GGTGGCGGCG CCTGTAATCC CAGCTACTTGGGAGGCTAAG GCATGAGAAT TGCTTGAACC CAGGAGGTGGAGGCTGCAGT GAGCCGAGAT CACGACACTG CACTCCAGCTGTGTGACAGA ATGAGACCAT CTCCAAAAAA AAAAAAAAGTAGATTTCAGA TAATTTACTG TTCAGCAACA GGACACACCTCCCTAAATGC CTTGTAATAT ATTTGAATCT GATTCTGCATTTCTTCCTCA ATTTATGTAA TGAAAATAAA ATTAATATATCATCTAACAG TAGCACAAAA TTTGTAATAT GAAGTAAAGTATGAAGATAA TGAAGAAGTT GTTTTCTTTG TTGAAGCAGTTATATGGGTC TTTCTCAGTA TATTTCTCTT TTCTCTAAAAGTTTAAACTT ATTAAAAGAA TGTTATTTTT AACCTTTCAA AAAAAAAAA NDUFB11NM_019056.6 GCTCTGGCCG GCCCCGGCGA TTGGTCACCG CCCGCTAGGG 37GACAGCCCTG GCCTCCTCTG ATTGGCAAGC GCTGGCCACCTCCCCACACC CCTTGCGAAC GCTCCCCTAG TGGAGAAAAGGAGTAGCTAT TAGCCAATTC GGCAGGGCCC GCTTTTTAGAAGCTTGATTT CCTTTGAAGA TGAAAGACTA GCGGAAGCTCTGCCTCTTTC CCCAGTGGGC GAGGGAACTC GGGGCGATTGGCTGGGAACT GTATCCACCC AAATGTCACC GATTTCTTCCTATGCAGGAA ATGAGCAGAC CCATCAATAA GAAATTTCTCAGCCTGGCCG AAAATGGTTG GCCCCACGAA GCCACGACAACTGGAGGCAA AGAGGGTTGC TCAACGCCCC GCCTCATTGGAAAACCAAAT CAGATCTGGG ACCTATATAG CGTGGCGGAGGCGGGGCGAT GATTGTCGCG CTCGCACCCA CTGCAGCTGCGCACAGTCGC ATTTCTTTCC CCGCCCCTGA GACCCTGCAGCACCATCTGT CATGGCGGCT GGGCTGTTTG GTTTGAGCGCTCGCCGTCTT TTGGCGGCAG CGGCGACGCG AGGGCTCCCGGCCGCCCGCG TCCGCTGGGA ATCTAGCTTC TCCAGGACTGTGGTCGCCCC GTCCGCTGTG GCGGGAAAGC GGCCCCCAGAACCGACCACA CCGTGGCAAG AGGACCCAGA ACCCGAGGACGAAAACTTGT ATGAGAAGAA CCCAGACTCC CATGGTTATGACAAGGACCC CGTTTTGGAC GTCTGGAACA TGCGACTTGTCTTCTTCTTT GGCGTCTCCA TCATCCTGGT CCTTGGCAGCACCTTTGTGG CCTATCTGCC TGACTACAGG TGCACAGGGTGTCCAAGAGC GTGGGATGGG ATGAAAGAGT GGTCCCGCCGCGAAGCTGAG AGGCTTGTGA AATACCGAGA GGCCAATGGCCTTCCCATCA TGGAATCCAA CTGCTTCGAC CCCAGCAAGATCCAGCTGCC AGAGGATGAG TGACCAGTTG CTAAGTGGGGCTCAAGAAGC ACCGCCTTCC CCACCCCCTG CCTGCCATTCTGACCTCTTC TCAGAGCACC TAATTAAAGG GGCTGAAAGT CTGAAAAAAA AAAAAAAA ND4NC_012920.1 ATGCTAAAACTAATCGTCCCAACAATTATATTACTACCACTGAC 38ATGACTTTCCAAAAAACACATAATTTGAATCAACACAACCACCCACAGCCTAATTATTAGCATCATCCCTCTACTATTTTTTAACCAAATCAACAACAACCTATTTAGCTGTTCCCCAACCTTTTCCTCCGACCCCCTAACAACCCCCCTCCTAATACTAACTACCTGACTCCTACCCCTCACAATCATGGCAAGCCAACGCCACTTATCCAGTGAACCACTATCACGAAAAAAACTCTACCTCTCTATACTAATCTCCCTACAAATCTCCTTAATTATAACATTCACAGCCACAGAACTAATCATATTTTATATCTTCTTCGAAACCACACTTATCCCCACCTTGGCTATCATCACCCGATGAGGCAACCAGCCAGAACGCCTGAACGCAGGCACATACTTCCTATTCTACACCCTAGTAGGCTCCCTTCCCCTACTCATCGCACTAATTTACACTCACAACACCCTAGGCTCACTAAACATTCTACTACTCACTCTCACTGCCCAAGAACTATCAAACTCCTGAGCCAACAACTTAATATGACTAGCTTACACAATAGCTTTTATAGTAAAGATACCTCTTTACGGACTCCACTTATGACTCCCTAAAGCCCATGTCGAAGCCCCCATCGCTGGGTCAATAGTACTTGCCGCAGTACTCTTAAAACTAGGCGGCTATGGTATAATACGCCTCACACTCATTCTCAACCCCCTGACAAAACACATAGCCTACCCCTTCCTTGTACTATCCCTATGAGGCATAATTATAACAAGCTCCATCTGCCTACGACAAACAGACCTAAAATCGCTCATTGCATACTCTTCAATCAGCCACATAGCCCTCGTAGTAACAGCCATTCTCATCCAAACCCCCTGAAGCTTCACCGGCGCAGTCATTCTCATAATCGCCCACGGGCTTACATCCTCATTACTATTCTGCCTAGCAAACTCAAACTACGAACGCACTCACAGTCGCATCATAATCCTCTCTCAAGGACTTCAAACTTACTCCCACTAATAGCTTTTTGATGACTTCTAGCAAGCCTCGCTAACCTCGCCTTACCCCCCACTATTAACCTACTGGGAGAACTCTCTGTGCTAGTAACCACGTTCTCCTGATCAAATATCACTCTCCTACTTACAGGACTCAACATACTAGTCACAGCCCTATACTCCCTCTACATATTTACCACAACACAATGGGGCTCACTCACCCACCACATTAACAACATAAAACCCTCATTCACACGAGAAAACACCCTCATGTTCATACACCTATCCCCCATTCTCCTCCTATCCCTCAACCCCGACATCATTACCGGG TTTTCCTCTT MORF4L1NM_001265603.1 CGGCGTGCCC TGGGGCGGCG CGGGCGCAGG GGCGCGTGCG 39CGGCGGGCTG TCGTTGGCTG GAGCAGCGGC TGCGCGGGTCGCGGTGCTGT GAGGTCTGCG GGCGCTGGCA AATCCGGCCCAGGATGTAGA GCTGGCAGTG CCTGACGGCG CGTCTGACGCGGAGTTGGGT GGGGTAGAGA GTAGGGGGCG GTAGTCGGGGGTGGTGGGAG AAGGAGGAGG CGGCGAATCA CTTATAAATGGCGCCGAAGC AGGACCCGAA GCCTAAATTC CAGGAGGTTGGGATGAATGG GTTCCGGAGA GCAGAGTACT CAAATACGTGGACACCAATT TGCAGAAACA GCGAGAACTT CAAAAAGCCAATCAGGAGCA GTATGCAGAG GGGAAGATGA GAGGGGCTGCCCCAGGAAAG AAGACATCTG GTCTGCAACA GAAAAATGTTGAAGTGAAAA CGAAAAAGAA CAAACAGAAA ACACCTGGAAATGGAGATGG TGGCAGTACC AGTGAGACCC CTCAGCCTCCTCGGAAGAAA AGGGCCCGGG TAGATCCTAC TGTTGAAAATGAGGAAACAT TCATGAACAG AGTTGAAGTT AAAGTAAAGATTCCTGAAGA GCTAAAACCG TGGCTTGTTG ATGACTGGGACTTAATTACC AGGCAAAAAC AGCTCTTTTA TCTTCCTGCCAAGAAGAATG TGGATTCCAT TCTTGAGGAT TATGCAAATTACAAGAAATC TCGTGGAAAC ACAGATAATA AGGAGTATGCGGTTAATGAA GTTGTGGCAG GGATAAAAGA ATACTTCAACGTAATGTTGG GTACCCAGCT ACTCTATAAA TTTGAGAGACCACAGTATGC TGAAATTCTT GCAGATCATC CCGATGCACCCATGTCCCAG GTGTATGGAG CGCCACATCT CCTGAGATTATTTGTACGAA TTGGAGCAAT GTTGGCTTAT ACACCTCTGGATGAGAAGAG CCTTGCTTTA TTACTCAATT ATCTTCACGATTTCCTAAAG TACCTGGCAA AGAATTCTGC AACTTTGTTCAGTGCCAGCG ATTATGAAGT GGCTCCTCCT GAGTACCATCGGAAAGCTGT GTGAGAGGCA CTCTCACTCA CTTATGTTTGGATCTCCGTA AACACATTTT TGTTCTTAGT CTATCTCTTGTACAAACGAT GTGCTTTGAA GATGTTAGTG TATAACAATTGATGTTTGTT TTCTGTTTGA TTTTAAACAG AGAAAAAATAAAAGGGGGTA ATAGCTCCTT TTTTCTTCTT TCTTTTTTTTTTTCATTTCA AAATTGCTGC CAGTGTTTTC AATGATGGACAACAGAGGGA TATGCTGTAG AGTGTTTTAT TGCCTAGTTGACAAAGCTGC TTTTGAATGC TGGTGGTTCT ATTCCTTTGACACTACGCAC TTTTATAATA CATGTTAATG CTATATGACAAAATGCTCTG ATTCCTAGTG CCAAAGGTTC AATTCAGTGTATATAACTGA ACACACTCAT CCATTTGTGC TTTTGTTTTTTTTTATGGTG CTTAAAGTAA AGAGCCCATC CTTTGCAAGTCATCCATGTT GTTACTTAGG CATTTTATCT TGGCTCAAATTGTTGAAGAA TGGTGGCTTG TTTCATGGTT TTTGTATTTGTGTCTAATGC ACGTTTTAAC ATGATAGACG CAATGCATTGTGTAGCTAGT TTTCTGGAAA AGTCAATCTT TTAGGAATTGTTTTTCAGAT CTTCAATAAA TTTTTTCTTT AAATTTCAAA GAACAAAAAA AAAAAAAAA MRPL19NM_014763.3 GTAGTCTTGA CGTGAGCTAG CTGGCATGGC GGCCTGCATT 40GCAGCGGGGC ACTGGGCTGC AATGGGCCTA GGCCGGAGTTTCCAAGCCGC CAGGACTCTG CTCCCCCCGC CGGCCTCTATCGCCTGCAGG GTCCACGCGG GGCCTGTCCG GCAGCAGAGCACTGGGCCTT CCGAGCCCGG TGCGTTCCAA CCGCCGCCGAAACCGGTCAT CGTGGACAAG CACCGCCCCG TGGAACCGGAACGCAGGTTC TTGAGTCCTG AATTCATTCC TCGAAGGGGAAGAACAGATC CTCTGAAATT TCAAATAGAA AGAAAAGATATGTTAGAAAG GAGAAAAGTA CTCCACATTC CAGAGTTCTATGTTGGAAGT ATTCTTCGTG TTACTACAGC TGACCCATATGCCAGTGGAA AAATCAGCCA GTTTCTGGGG ATTTGCATTCAGAGATCAGG AAGAGGACTT GGAGCTACTT TCATCCTTAGGAATGTTATC GAAGGACAAG GTGTCGAGAT TTGCTTTGAACTTTATAATC CTCGGGTCCA GGAGATTCAG GTGGTCAAATTAGAGAAACG GCTGGATGAT AGCTTGCTAT ACTTACGAGATGCCCTTCCT GAATATAGCA CTTTTGATGT GAATATGAAGCCAGTAGTAC AAGAGCCTAA CCAAAAAGTT CCTGTTAATGAGCTGAAAGT AAAAATGAAG CCTAAGCCCT GGTCTAAACGCTGGGAACGT CCAAATTTTA ATATTAAAGG AATCAGATTTGATCTTTGTT TAACTGAACA GCAAATGAAA GAAGCTCAGAAGTGGAATCA GCCATGGCTT GAATTTGATA TGATGAGGGAATATGATACT TCAAAAATTG AAGCTGCAAT ATGGAAGGAAATTGAAGCGT CGAAAAGGTC TTGATTCTGA GAATGAATTTGGTTAGTTGC AGAAGATACA TTGGCTCTAA GAGGATATATTTTGAGACCA ATTTAATTTC ATTTATAAGA ACATAGTAATTAAGTGAACT AAGCATTCAT TGTTTTATTA ATACTTTTTTTCTAAAATAA AACTTGTACA CCAGTTTATT ACTCTAAAAAGAGAATTACA CATGCCAAAT GGACCAATGT CCATTTGCTTATTGGAGGCA AAGCTACAAT AGAAGTCAGA GCATCACCAGAATGGTCTTT AATGAGCATG GAACCTGAGC AAAGGGAATAGGTGGGATGA ATTTTTTTTT TAATTGTGAA ACAATTCATAAGCACAATAT GATTTACAGA ATAATAAACA TTCATGTACCCACTATCAGG TTAAGAAATA GAACATTTAT TAATATGTAGGAATGTTAAG AAATAAAACA TTTAATAAGA TCTCAGAAGACTCCAGTAAA TCTGCAATTG TATCTCTCTC CTTTTTAAATGTAAATATCA TCTTGACTTG TTAATTATTC CCTTGCATTTCTTTTAGTTT ACTGCCAACA CATATATTCT TCAACAATATATTTAATTTT GAAAAACCTG AAAAAAAAAA CCTGTTAGCAAGTATAAAGG GGCAGTATTA CTATTATTGC ATGAAGGCTTCAAGGGAAAC GTTACAGTCT TTGGGTCATA GTCTGGCTTCAGCTTCCTCT GAGAGTTTAC AGAGGCCAAT TTTGAGCAAATTCATGGCTA AGGTTATGAG TGAGTTCTGC TAAACAGAAGGCTCACCACA AGGTATCTGG CAGGATTATA CTGGGTAGCTGGATGTTGCA GAAATGTGGT TAGAGGAAGT AAACTGTTTTTTGATGCTCA CAGCATGATG AATCAAACTC TGTATCTTAGGATTAGGTTA AAACAATACC TTTGGTATGA TATGAGTGTTGTTGCTGATC CATGCAGCAT GGATTGGAAA GCTGGGGTATAAGCACACAT GCTAAAGAAA AACATGTAAT TTGGTCCATACTCACCTGGA TATACTGTTC CTCAGGTTAA AAAATACAGTACTATCCTAA ATCTTGAAGG CAACTCTCAG CCTATCCATTGAGTTACCTT CAGATCTGCC CTCTGGTTCC TAGCTGTCTTGGGACTAACT TCTTTCCTGC GCTCAGCTGT TTTCTGGATTCCATGTTTTC CATTTTATTG AGTACTAACT TGTTTTGCTGCAGCACATCC TTTGGTAGCT TCTAGAGGAA GTTTGTGTGGAGGTAAAATT TTTGAGACCT TGCATGTCTC ATGTTTGATTGATACTTTAT ACGTTTAGGT AGGAGGTAAT TTTCCTTCAGGACTTTAAAA ATATTGTTGC TCCATTTTCT TTGTTTCTATTGTTGTATTG AGAAATCCAA TGCCATTTTG ATTTCCCCATCATAAATTTC ATGATGATGT GTCTTGGTGT GGGTCTATATTTATCCATTG TATTGGGTTT TAGGTGAACC CTTCCAGATAGTAACTCATT TCTGTCAGTT CTGGGAAACA CTTAGCATTGGTTGATGATT TATTCTCTGC TGCTTTGTTC TCCCAACTATTATTTGGATG TTGGATATCC AGCACTGGGT ATCTATTTTCTTACCTCCCT CCCTTGACCC CAGTCTCTGT TTTTTAGCTCTTTAGCTCAA TCTTCCAACT CTTTGCTATT GTATTTTAAAATCTTAAGAC CCCTTCTTGA TTTGTAGAAG TTCCTTTTCTTACAACCAAA AAGCCTTTAT CTATGGATTT GTTCACAGATAAGGGGTATT CAATATAGTG TATTTTTTTT TCATTTAAAATTGTTTGCGC ATCTATTTCC TCCAAATTTC TTTCTGTATTTATTTTTTGT TGTCTATATT TCAGACTTTT CCAGGATATCTGATAATCTT TGGCTGTCTT CTTATGGTTG AAAGAGGGACTAAAAAGCTT GGAAAGCCTT TGGGTTGTGG GAAGGGGCTGTCTTTAGGAT TATCTGAATG GGCTTTTTTG GGAGTCCCCTCCTCCACATG AATATTTTGG TTTTGTCAGA TTCCCTAGAATAGAGGCTTC CAATCTCCTT CCTGGAGGGG TCTGTCCAGGAAGGAGATTG TCTAGGGGTC TGTCAGACAG CAGCTTTCAGCTACTTCCTT GATCTTTTTC ACTAATGATT ATATAGTCATCTAACTACTG TCAACAAGTA ATAGATATCC TATCCTTCACTTGTTTAGAT TATTTGCTGA GATAACCTCT CAAAAGAACCTCTCAAAATA AAAGGTTAAC AAGAGCCTAT ATCTTATATTTTTCTTCTCT TTATCTTGTT AGAAGATAGC TATTAAAACCTGTTCTTTTT CTGTCTTGAT AAACACACTT CAATCTTGGTAGAATGGTAG ATGGGACAGT ATATTTTAGG ACCTAAAGCTCTGCAAATGT ATGATCAGCT TGTAAGTACA GGTGCTCAAAAACATGTAAA CAATCATGCT TTTTACTCTG TAGGAATATCTTTAAAATTC TTGTGAATTT TTCCCCAGAA GTAAAGCAAATCTTCCCCCA GAAATAAAAT TAAATGTGCA TAATCTAAAGCTTTTTTTTT TTATTGTGGT AGGATATATA TATAAAACATAATTTGCCAT TGTAAACATT TTAAATTTAC AAGTCAGAGGCATTAATTAC ATCACAATGT TGTGAAATTA TTACTACTATTTCCAAAATT TTCTCATCAC CCCAAACTGA AACTCTGTAACTGTTGAGCA ATAACCTCAT TCCTGTATCT CTCCCAACCCCAGGTAACCT CAAATCTTTC TTTTTATCTT TGAGACAAGGTCTCATTCTA TCACTCAGGT AGGAGTGCAG TGGTGTGATCATAGCTCATT GCAGCCTCAA AATCCTGGGC TCAAGCAATCCTCCTTGAGT AGCTAAGACT ATAGGCACAC ATTAACTGCGCCTGGCTGAT TTTGTTTTTT GTAGAGATGT GGTCTTGCTATGTTTCCCAT GCTGGTCTTG AGTTCCTGGC CTCAAGCAGTCCTTAAGATT CATCCATGTT GTGGCATGTG TCAGAATTTCATTTGTTTTT ATGACTAAAT AATATTCCAT TGTATGTATATACATTTTGT TCATCCATCT TCTGATGAAC ACTGGGATATGTCTACCTTT TGGCTATTGT GAATAATGCT GCAGTAAACATTGACATAAC AAGTATGTAT TTGATTGCCT GTTTCTAAGTTCTTTTGGGT ATACATCTTG AGTAGAATTG CTAGATAATGTCATGTTTTA TTTCTCTTGT GATTTCTTCT TCGATCCCCTGGTTGAGTGT GTTAATTTCT ACATGTTTAT GAATTTCCCACTGTTTTTTT GTTATTGATT TCCAAGTTCA TTCCATTGTGATTAGAGAAG ATACTTAGTA TGATTTTAAT GTTTTTGAGAATTGGTGTGT GGCCTGATAG ATGGTCTGTC CTGGAGAATGTTCCTCATAC ACTTGAGCAA AATATTTATC ATGCTATTGTTGACTGTAGT TTTCTATATG TCTCTTAGGT CAAGGTGGTTTACAATGTGT TAAGGTTCTC TTTTTTTAAA AAAATTTTTGCACAGAGTAT CTTTTTCTAT GTGTTCCATG TATTTGTGTCTTTGGAGCTA TAGTCTCTTG TAGACAGCAT ATCACTATCTTGTTTTGTTT TGTTTTTTCT GTCCATTCTG CCAATTTCTGCCTTTTGATT GGAAAATTTA ATCCATTTGC ATTTAAAGTAATTAAGGAAG GACTTTCTTC TACCATTTAA CACTTCTTCTATATGTCATA TACTTTTTTG GCCCCTCATT TCCTCTTTATGGCCTTCTTT TCTGTTTTTT TGTAGTGAAC TAGTCTGATTCTCTTTCCAC TCCCCTTTGT GTATATTTGT TAGATGTTTTATTTGTGGTT GCTATGGGGA TTATAGTTAA CATCCTACACTTAAAACAAT CTAATTTAAA CTGATACCAA TTTACCTTCAATAGCATACA AAATCTCTAC TCCTGTAAAG CTCTGCCCCTGCCCCCCTTA TGTTATTGAT GGCACAAATT GCCTAATAAATAATTTATAG TTATTTGTAT GAGTTTGTCT TTTAAATCATTTAGGAAATA AAAAGTGGAG TTAGAAAACA GTATGATAGTAATACTGACT TTTATATTTG TCAATATATT TATCTTATTTTGGATCCTTA TTTCATTATA TAGATTTGAG TTACTGTCTAGTGCCCTTCC ATTTCGGCCC AAAGGATTCC CTTATGCATTTCTTGCAGGG CAAGTCTAAT TGTAATAAAC TCCCTCAGCTTTTGTTTTAT CTGAGAATGT CTTGATTTCT CCCTTATTTTTGATGGATAA TTTTGCCAGA TACATGAATT TTTGGTAACAGTATTTTTCT TTCAGCACTT TAAATATGTC ATCCCACTACCTTCTGACTT CATGGTTTCT CATGAGATAT TAGATGTTATAAAATTTGAG GATTCCTCAT TCTTGATGAG TCAGTTCTGTCTTATTGCTT TTCGGATTTG CTCAGCTTTT GTCTTTTGACAGTTTGATTA TAACGCGGCT CAGTGTGGGT CTCTGAGTTTATCCCACTTA GAGTTTGTTG AGTTTCTTGG AGTCATAGATTTATGTCTTT TATCAAATTT TGGACATATT TGGCTATTATTTCTTCAATT TTTTTCACTG CTTCTTTCTT TTCCTTCTGAAATATTCTTA ATGTATATGT TGGTCTGTTT GATGCTGTCTCACCAGTTTC TTAGGCTGTG TTCTCTTTTG TTCCTCAGACTTGATTATTG CAGTTGCCCT TCTTTTTATT TTTTTCAAGTTTGTTGATTC TTCTCCCTGT TCAGATCAAC TGTTGAACTCCTCTAGTGAA TTTATTTCAG TTACTGTACT TTTCAGCTCCAAGATTTATC TTTGGTTCCT TTTTATAACG TCTGTGTCTTTATTGATATT CTCATTTTGT TCATATGTCT CTTTCTTCCTTTAGTTCTTT GTCCATGTTT TCCTTTAGCT CTTTGGGCTTATTTAAGACA ATTGTTTAAA GTCTTTGCAT AGTAAGTCCAATGTCTGTGT TTCTTCAGGG ATGGTTTTCA TTATTTTGTTTTCAATGAGC CATACTTTCC TGTGTCTTTG TATGCTGTCTTTTTGTTGTT GAAAACTGTA TGTTTGAACA TCATAACGTGGTGGCCCTGA AAATCAGATA TTCCCCCCTT CCTGAGAGTTAGTTTTATTT TTATTATTGA AGATTGTAGC AGTCTATTGCTACATGTGCA GTCATTTCCA AACTATTTTT GCAAAGACTGTATTCCTTCT GTGTGTCATC ACTGAAGTCT CTGTTCCTTAGTTTGTGTTT AATAGTTTGA CATAGATTTC CTTGAAAGGAGTTAAAACTA GCAGAAAAAT CTCTCTCCCA GTCTTTCCAGTCTTTGTAGA TTGGTTCTGT GCTGGGCTTT TCCATTAATACTTAGCCAGG CTTGTACTGA GCCTAACAAT CAGGCCCAAAAGCGTAGGGT CTTTGCAGAT CTTGTCTGAG CATGCTTCTTGCTGTGTATG CACGTAGTTT TCTAAATCTC CCTGTATGTGCTGTTGAATA TTCTAATTTC CCAAAGAAAC TCCTTTGCAGCTTTTTCTCA CAGAACATAG ATGGTTTTTT GGATATCTTGACCATAGTCT TTCGACCCAG GTGTTTGCGG TTGTTAGTTCACCTTACACT TTTTTCAAGC ATTGCCTACT GCTTACGATGAGTGCTCTGT CAATCCTTTA AGTAGCCCCA GACAGGCTACCAGAGACTTA AACAAGAATT TGTAAGTTCT GCTCAGCTTCCTCTAGAAAT GGGGATCAGG GTCCAAGACA GAATGCAGTTGCTGATTTCA AGACTGCTGC AACACCAGGG AGCTTGTGGGGGAAGGGCAA GCAGAAATGT CACAAAGCTT TCTTGCCATTTTAAAGTTGC CTGTTCTTGA CTCAGCATTT GCTTCATTGCTATAAACTTT TTACTGTTTT TCAGAGTTCT GATAAAATTGGCTATGCCTG TTCCTGCTTT AAAAAATATA TATATATTTTTTAGGGATTG GGGTCTCACT ATACTGACCA GGCTGGTCTTGAACTTCTGG CCTCAAGCCA TCCTCTCATT TCAGCTTCCCAAAGTGCTGC AATTACACGC GTGAACCACC ACACCCAGCCCCTGCTTGTT TTTCAATGTG CCTACTCCAC CATGTTGCTCAAGTATGTAT ATTTTCTAAA CTACCTTGTA GTGTTGTGATGGGAAATAAA TCCCTGAGCC TTTTGAATAA CTCAGAGAGATCAAAAACTT AGTTTATCCT ATTCGAAGGA TTAGAAAAATGATATATCTT TCACTTTTTC AGGGATAGGC TCCTCATTAGAAGGCTCCTA TGTGCCGATG CTGTACAAGA CATTTCATTTCTCTTAATGT TTACAACAAG CTTGTTGCCA AGGCTGATCTTGAACTCCTG GCCTCAAACG ATCCTCCCAG CTCAGTCTCACAAAGTGTTG GGATGTCTGG CCAACTAATG ACTATCTTAACTCTTGTGTT TCAATGTTTA TGCCTTCTTT TATCTTGACTGATTGTATGA CTATGTCTTC TAGAACAATG TTGAACAGAAATGGTGAGAG CAGACATCCT TGCTTTAATA TTTCACCATTATATATGATG TTAGGTATAG ATTTTTCTCA CAGATGCCTTTTATCAGATT GAGGAATTTA TATTCCTACT TTGCCGAAAGGTTTTTGTAG TATGAGGGGG TGCTGAATTT TGTCAAACACTTTTTCGGTA ATAATTGAGA TGATTGGTTC TGCAGTCATCGAGATGTGGA TTTTCTCCTT TATTCTGTTC GTGAGTGATTACACTGGTTG ACTAATGTTA AAACAACCTT ACTTTCCAGGAATAAACCCT ATTATCTTTT TTATACA PSMC4 NM_153001.2TGCGGGTACG GACAGCGCAT GAGCTTATGT TGAGGGCGGA 41GCCCAGACCA GCCCTTCGTC CTATCCTGCC CTTCCAGCACCTCTCAGCCG TAACTTAAAC TACACTTCCC AGAAGCCTCCTCAGCCAGGG ACTTCCGTTG TCGTCAGCGG AAGCGGTGACAGATCATCCC AGGCCACACA GAGGCCGGCT TGGTCACTATGGAGGAGATA GGCATCTTGG TGGAGAAGGC TCAGGATGAGATCCCAGCAC TGTCCGTGTC CCGGCCCCAG ACCGGCCTGTCCTTCCTGGG CCCTGAGCCT GAGGACCTGG AGGACCTGTACAGCCGCTAC AAGGAGGAGG TGAAGCGAAT CCAAAGCATCCCGCTGGTCA TCGGACAATT TCTGGAGGCT GTGGATCAGAATACAGCCAT CGTGGGCTCT ACCACAGGCT CCAACTATTATGTGCGCATC CTGAGCACCA TCGATCGGGA GCTGCTCAAGCCCAACGCCT CAGTGGCCCT CCACAAGCAC AGCAATGCACTGGTGGACGT GCTGCCCCCC GAAGCCGACA GCAGCATCATGATGCTCACC TCAGACCAGA AGCCAGATGT GATGTACGCGGACATCGGAG GCATGGACAT CCAGAAGCAG GAGGTGCGGGAGGCCGTGGA GCTCCCGCTC ACGCATTTCG AGCTCTACAAGCAGATCGGC ATCGATCCCC CCCGAGGCGT CCTCATGTATGGCCCACCTG GCTGTGGGAA GACCATGTTG GCAAAGGCGGTGGCACATCA CACAACAGCT GCATTCATCC GGGTCGTGGGCTCGGAGTTT GTACAGAAGT ATCTGGGTGA GGGCCCCCGCATGGTCCGGG ATGTGTTCCG CCTGGCCAAG GAGAATGCACCTGCCATCAT CTTCATAGAC GAGATTGATG CCATCGCCACCAAGAGATTC GATGCTCAGA CAGGGGCCGA CAGGGAGGTTCAGAGGATCC TGCTGGAGCT GCTGAATCAG ATGGATGGATTTGATCAGAA TGTCAATGTC AAGGTAATCA TGGCCACAAACAGAGCAGAC ACCCTGGATC CGGCCCTGCT ACGGCCAGGACGGCTGGACC GTAAAATTGA ATTTCCACTT CCTGACCGCCGCCAGAAGAG ATTGATTTTC TCCACTATCA CTAGCAAGATGAACCTCTCT GAGGAGGTTG ACTTGGAAGA CTATGTGGCCCGGCCAGATA AGATTTCAGG AGCTGATATT AACTCCATCTGTCAGGAGAG TGGAATGTTG GCTGTCCGTG AAAACCGCTACATTGTCCTG GCCAAGGACT TCGAGAAAGC ATACAAGACTGTCATCAAGA AGGACGAGCA GGAGCATGAG TTTTACAAGTGACCCTTCCC TTCCCTCCAC CACACCACTC AGGGGCTGGGGCTTCTCTCG CACCCCCAGC ACCTCTGTCC CAAAACCTCATTCCCTTTTT TCTTTACCCA GGATTGGTTT CTTCAATAAATAGATAAGAT CGAATCCATT TAATTTCTTC TTAGAAGTTTAACTCCTTTG GAGAATGTGG GCCTTGAATA GGATCCTCTGGGTCCCTCTT AATCTGACAG ATGAGCAGAC GAGGTGCATGGCCTGGGTTG CAGCTTGAGA GAACCAAAAT ATTCAAACCAGATGACTTCC AAAATGTGGG GAAAGGGATG GAAAATGAACCTGAGATGGA GTCCTTAATC ACGGGATAAA GCCCTGTGCATCTCCCTCAT TTCCTACAGG TAAAAGACAG TAAAGAAATTCAGGTCACAG GCCTTGGGAG TTCATAGGAA GGAGATGTCC AGTGCTGTCC AGTAGAACTT TSF3A1 NM_005877.5 GGTCCCGGAA GTGCGCCAGT CGTACCTTCG CGGCCGCAAC 42TCGCTCGGCC GCCGCCATCT TGCGAGCTCG TCGTACTGACCGAGCGGGGA GGCTGTCTTG AGGCGGCACC GCTCACCGACACCGAGGCGG ACTGGCAGCC CTGAGCGTCG CAGTCATGCCGGCCGGACCC GTGCAGGCGG TGCCCCCGCC GCCGCCCGTGCCCACGGAGC CCAAACAGCC CACAGAAGAA GAAGCATCTTCAAAGGAGGA TTCTGCACCT TCTAAGCCAG TTGTGGGGATTATTTACCCT CCTCCAGAGG TCAGAAATAT TGTTGACAAGACTGCCAGCT TTGTGGCCAG AAACGGGCCT GAATTTGAAGCTAGGATCCG ACAGAACGAG ATCAACAACC CCAAGTTCAACTTTCTGAAC CCCAATGACC CTTACCATGC CTACTACCGCCACAAGGTCA GCGAGTTCAA GGAAGGGAAG GCTCAGGAGCCGTCCGCCGC CATCCCCAAG GTCATGCAGC AGCAGCAGCAGACCACCCAG CAGCAGCTGC CCCAGAAGGT CCAAGCCCAAGTAATCCAAG AGACCATCGT GCCCAAAGAG CCTCCTCCTGAGTTTGAGTT CATTGCTGAT CCTCCCTCTA TCTCAGCCTTCGACTTGGAT GTGGTGAAGC TGACGGCTCA GTTTGTGGCCAGGAATGGGC GCCAGTTTCT GACCCAGCTG ATGCAGAAAGAGCAGCGCAA CTACCAGTTT GACTTTCTCC GCCCACAGCACAGCCTCTTC AACTACTTCA CGAAGCTAGT GGAACAGTACACCAAGATCT TGATTCCACC CAAAGGTTTA TTTTCAAAGCTCAAGAAAGA GGCTGAAAAC CCCCGAGAAG TTTTGGATCAGGTGTGTTAC CGAGTGGAAT GGGCCAAATT CCAGGAACGTGAGAGGAAGA AGGAAGAAGA GGAGAAGGAG AAGGAGCGGGTGGCCTATGC TCAGATCGAC TGGCATGATT TTGTGGTGGTGGAAACAGTG GACTTCCAAC CCAATGAGCA AGGGAACTTCCCTCCCCCCA CCACGCCAGA GGAGCTGGGG GCCCGAATCCTCATTCAGGA GCGCTATGAA AAGTTTGGGG AGAGTGAGGAAGTTGAGATG GAGGTCGAGT CTGATGAGGA GGATGACAAACAGGAGAAGG CGGAGGAGCC TCCTTCCCAG CTGGACCAGGACACCCAAGT ACAAGATATG GATGAGGGTT CAGATGATGAAGAAGAAGGG CAGAAAGTGC CCCCACCCCC AGAGACACCCATGCCTCCAC CTCTGCCCCC AACTCCAGAC CAAGTCATTGTCCGCAAGGA TTATGATCCC AAAGCCTCCA AGCCCTTGCCTCCAGCCCCT GCTCCAGATG AGTATCTTGT GTCCCCCATTACTGGGGAGA AGATCCCCGC CAGCAAAATG CAGGAACACATGCGCATTGG ACTTCTTGAC CCTCGCTGGC TGGAGCAGCGGGATCGCTCC ATCCGTGAGA AGCAGAGCGA TGATGAGGTGTACGCACCAG GTCTGGATAT TGAGAGCAGC TTGAAGCAGTTGGCTGAGCG GCGTACTGAC ATCTTCGGTG TAGAGGAAACAGCCATTGGT AAGAAGATCG GTGAGGAGGA GATCCAGAAGCCAGAGGAAA AGGTGACCTG GGATGGCCAC TCAGGCAGCATGGCCCGGAC CCAGCAGGCT GCCCAGGCCA ACATCACCCTCCAGGAGCAG ATTGAGGCCA TTCACAAGGC CAAAGGCCTGGTGCCAGAGG ATGACACTAA AGAGAAGATT GGCCCCAGCAAGCCCAATGA AATCCCTCAA CAGCCACCGC CACCATCTTCAGCCACCAAC ATCCCCAGCT CGGCTCCACC CATCACTTCAGTGCCCCGAC CACCCACAAT GCCACCTCCA GTTCGTACTACAGTTGTCTC CGCAGTACCC GTCATGCCCC GGCCCCCAATGGCATCTGTG GTCCGGCTGC CCCCAGGCTC AGTGATCGCCCCCATGCCGC CCATCATCCA CGCGCCCAGA ATCAACGTGGTGCCCATGCC TCCCTCGGCC CCTCCTATTA TGGCCCCCCGCCCACCCCCC ATGATTGTGC CAACAGCCTT TGTGCCTGCTCCACCTGTGG CACCTGTCCC AGCTCCAGCC CCAATGCCCCCTGTGCATCC CCCACCTCCC ATGGAAGATG AGCCCACCTCCAAAAAACTG AAGACAGAGG ACAGCCTCAT GCCAGAGGAGGAGTTCCTGC GCAGAAACAA GGGTCCAGTG TCCATCAAAGTCCAGGTGCC CAACATGCAG GATAAGACGG AATGGAAACTGAATGGGCAG GTGCTGGTCT TCACCCTCCC ACTCACGGACCAGGTCTCTG TCATTAAGGT GAAGATTCAT GAAGCCACAGGCATGCCTGC AGGGAAACAG AAGCTACAGT ATGAGGGTATCTTCATCAAA GATTCCAACT CACTGGCTTA CTACAACATGGCCAATGGCG CAGTCATCCA CCTGGCCCTC AAGGAGAGAGGCGGGAGGAA GAAGTAGACA AGAGGAACCT GCTGTCAAGTCCCTGCCATT TTGCCTCTCC TGTCTCCCAC CCCCTGCCCCAGACCCAGGA GCCCCCCTGA GGCTTTGCCT TGCCTGCATATTTGTTTCGC TCTTACTCAG TTTGGGAATT CAAATTGTCCTGCAGAGGTT CATTCCCCTG ACCCTTTCCC CACATTGGTAAGAGTAGCTG GGTTTTCTAA GCCACTCTCT GGAATCTCTTTGTGTTAGGG TCTCGATTTG AGGACATTCA TTTCTTCAGCAGCCCATTAG CAACTGAGAG CCCAGGGATG TCCTACAGGATAGTTTCATA GTGACAGGTG GCACTTGGCT AATAGAATATGGCTGATATT GTCATTAATC ATTTTGTACC TTGACATGGGTTGTCTAATA AAACTCGGAC CCTTCTTGTG AAATCAGTTAAATAAGACTT GTCTCGGTCA CCTGTGCCCT GTCCAGACTCGAGGCAGTGG TAACACTGCA CAGTGCTATG TGGCTTCTCTTTGAGGATTT TTGGGTTTTG TAACTAAATT CTTGCTGCCCTCATACTTTT TATGTATTAG AATCATATTC GTATTGCCCTTTTAAAACAT TGGGATCCTC CAAAGGCCTG CCCCATGTATTTAACAGTAA TACAGGAAGC ATGGCAGGCA CCATGCAAACCAAGGATGGA TGGTGCAGTC CCTGTGTCAG TGGGCGGTGGTTTCCTGCTG GCCTGGAATC ACTCATCACC TGATTGATTGGCTCTGTGGT CCTGGGCAGG TGCCTCATAG GTGTGTGGATATGATGACGT TTCTTTAAAA TGTATGTATT TAACAAATACTTAATTGTAT TAAGGTCATG TACCAAGGAT TTGATAAAGTTTAAATAATT TACTCTCTAC TTTTATCCAT TTTATCCATTTTAACTCATG TAATCCTCAT GTGAGTATTC CTGTTTAACACTTGAGTAAA CTGAGGCACA GAGAACATAA GTTGCATGCCATAGTCACAC ACTGTGAAAG TGAAAAGAGA ATGTGTGCAAAACACGTCAC AGTCCTGGTT TCTGAGTAAA GGCAGGCTGTTATCTTTAGA ATCAAGCTAT CACAGGGAGA TAGGCAATGCTGTGGGTGTT GGAGGAAGGT GAGAGCCTGT TGCTAACAATTTCCTGGTTT TAAAGCTAAG GCTGATTTTA TTGGGAAGATCTCACATGTG TGTGGCCCCT GAGAGTTCCC AGTGCCTTTTATTTGCAGTC CTTCCATTTG GACCTCCTAG CTGCCCCATCAGGTCATCTC CAGGGCTCAG AGGGGTGAGA CCATTTCCCAAGGTCACAGA ACCAGCTCTC TAGTCACCAC CCTGCCTCTCCCTCTCACCC AGAGTCAGTA CCAGTTTTAT GGCTTTATTACAAACTGCTG GGTCCCTCCC ATTTTCAACT TGATTGATGGGATGTCATCC CTTATCCTGT CTGACATTTG CCTCTGGCCTGGTTGCTAGA AGTTTGCCCC AGGGGCAAGA GTTGAAATTTGGCTTCCTGA GGTGGGCTTT GTGGTTTGCG TCCCTAAAGTGAGCCCACTA CTGGTTGCTT GTCCATGGCC AACACCAGAAATCCCCTGAG CACTACCTGG GTCTCATTCC AAGAAGGAAGAGGGTCAGGA GACCTGGGGA GTCTCATATT CCAAGTTCTTCTTTCTTTCT GGGAGCAGTG GGCAGTTCAT GGTGTTAGGGCACTCACCCC CACAGACTGG CAAACCCTGC AGGACTTCCGTGGCTGAGGC TGTGACCGGA GGCCAGGAAT GCCGTTGGGTGGATTGTGAG TGAATGGGCC CTTTGAGCTG CCCTCTAGAGAGCAAATCCA GTTTCCTGGA GCTCCTGAAT GAATATCTGTACTGGCTCGC TCAGATGCAG AAGCTCCATT GACCATGAGGCCTTGTGAAC ATCAGTGGCC ACAGGCCCAG TGTGCTGCTTGGCACTGCAC TAGTTTAGGA CCTGCAGCAT GTAGGTAGCGTCCTAGTGTT TATAATACAA AGCTGCTCTG CACAGCTTTTCTGATTCTTC TTGCAATCTC CTGAGGATTA TCTGCCCCATTTTTAAAACG AGGTGGAATA CCCAAGGTCA TGTAGCCAGTGAGTGCTCTG GAAAGCCAAA GCAGCTCATC CCTTCCTGGGGACCACACTG CTCTGCTCCA CCAGACCACA CTATGAAATAGGAATAAGTG CTCCTGTTGC AGGACTGCTG GGAAAACAGGTGGTGTGGGA CTTAAGTCAC CATAATTTTG AAGACTTGCATGCAGAGGGC TCCAGGAATT GTAGACATTA AGGAATTTCACTTTCAGTTC TACCCACTAC TTAAGTACTT GTCATGTACTCTTAGAGGAG GCCAGTAATG ATCAGAACCA TTTTACTTTAAAATTAATAA TATTGTATTA GAGAATATAT TAAATGGTTATATTGGGTTA TGTTAGGATA TATACTTGAA TGGAAATACATGTACTATTA GCAATCATAT TTCATTTATC CCTGTAATTAGACAAGAAAG CATAATATAG CTCTACTCAT GGGTACACATACCAGTGTAT AAGATTTTTA GAAGTTTACT TTTTAAAAATAAAAGCAAAA TGTAAGATCT TAAAAAAAAA AAAAAAAAA PUM1 NM_001020658.1AGTGGGCCGC CATGTTGTCG GAGTGAAAGG TAAGGGGGAG 43CGAGAGCGCC AGAGAGAGAA GATCGGGGGG CTGAAATCCATCTTCATCCT ACCGCTCCGC CCGTGTTGGT GGAATGAGCGTTGCATGTGT CTTGAAGAGA AAAGCAGTGC TTTGGCAGGACTCTTTCAGC CCCCACCTGA AACATCACCC TCAAGAACCAGCTAATCCCA ACATGCCTGT TGTTTTGACA TCTGGAACAGGGTCGCAAGC GCAGCCACAA CCAGCTGCAA ATCAGGCTCTTGCAGCTGGG ACTCACTCCA GCCCTGTCCC AGGATCTATAGGAGTTGCAG GCCGTTCCCA GGACGACGCT ATGGTGGACTACTTCTTTCA GAGGCAGCAT GGTGAGCAGC TTGGGGGAGGAGGAAGTGGA GGAGGCGGCT ATAATAATAG CAAACATCGATGGCCTACTG GGGATAACAT TCATGCAGAA CATCAGGTGCGTTCCATGGA TGAACTGAAT CATGATTTTC AAGCACTTGCTCTGGAGGGA AGAGCGATGG GAGAGCAGCT CTTGCCAGGTAAAAAGTTTT GGGAAACAGA TGAATCCAGC AAAGATGGACCAAAAGGAAT ATTCCTGGGT GATCAATGGC GAGACAGTGCCTGGGGAACA TCAGATCATT CAGTTTCCCA GCCAATCATGGTGCAGAGAA GACCTGGTCA GAGTTTCCAT GTGAACAGTGAGGTCAATTC TGTACTGTCC CCACGATCGG AGAGTGGGGGACTAGGCGTT AGCATGGTGG AGTATGTGTT GAGCTCATCCCCGGGCGATT CCTGTCTAAG AAAAGGAGGA TTTGGCCCAAGGGATGCAGA CAGTGATGAA AACGACAAAG GTGAAAAGAAGAACAAGGGT ACGTTTGATG GAGATAAGCT AGGAGATTTGAAGGAGGAGG GTGATGTGAT GGACAAGACC AATGGTTTACCAGTGCAGAA TGGGATTGAT GCAGACGTCA AAGATTTTAGCCGTACCCCT GGTAATTGCC AGAACTCTGC TAATGAAGTGGATCTTCTGG GTCCAAACCA GAATGGTTCT GAGGGCTTAGCCCAGCTGAC CAGCACCAAT GGTGCCAAGC CTGTGGAGGATTTCTCCAAC ATGGAGTCCC AGAGTGTCCC CTTGGACCCCATGGAACATG TGGGCATGGA GCCTCTTCAG TTTGATTATTCAGGCACGCA GGTACCTGTG GACTCAGCAG CAGCAACTGTGGGACTTTTT GACTACAATT CTCAACAACA GCTGTTCCAAAGACCTAATG CGCTTGCTGT CCAGCAGTTG ACAGCTGCTCAGCAGCAGCA GTATGCACTG GCAGCTGCTC ATCAGCCGCACATCGGTTTA GCTCCCGCTG CGTTTGTCCC CAATCCATACATCATCAGCG CTGCTCCCCC AGGGACGGAC CCCTACACAGCTGGATTGGC TGCAGCAGCG ACACTAGGCC CAGCTGTGGTCCCTCACCAG TATTATGGAG TTACTCCCTG GGGAGTCTACCCTGCCAGTC TTTTCCAGCA GCAAGCTGCC GCTGCCGCTGCAGCAACTAA TTCAGCTAAT CAACAGACCA CCCCACAGGCTCAGCAAGGA CAGCAGCAGG TTCTCCGTGG AGGAGCCAGCCAACGTCCTT TGACCCCAAA CCAGAACCAG CAGGGACAGCAAACGGATCC CCTTGTGGCA GCTGCAGCAG TGAATTCTGCCCTTGCATTT GGACAAGGTC TGGCAGCAGG CATGCCAGGTTATCCGGTGT TGGCTCCTGC TGCTTACTAT GACCAAACTGGTGCCCTTGT AGTGAATGCA GGCGCGAGAA ATGGTCTTGGAGCTCCTGTT CGACTTGTAG CTCCTGCCCC AGTCATCATTAGTTCCTCAG CTGCACAAGC AGCTGTTGCA GCAGCCGCAGCTTCAGCAAA TGGAGCAGCT GGTGGTCTTG CTGGAACAACAAATGGACCA TTTCGCCCTT TAGGAACACA GCAGCCTCAGCCCCAGCCCC AGCAGCAGCC CAATAACAAC CTGGCATCCAGTTCTTTCTA CGGCAACAAC TCTCTGAACA GCAATTCACAGAGCAGCTCC CTCTTCTCCC AGGGCTCTGC CCAGCCTGCCAACACATCCT TGGGATTCGG AAGTAGCAGT TCTCTCGGCGCCACCCTGGG ATCCGCCCTT GGAGGGTTTG GAACAGCAGTTGCAAACTCC AACACTGGCA GTGGCTCCCG CCGTGACTCCCTGACTGGCA GCAGTGACCT TTATAAGAGG ACATCGAGCAGCTTGACCCC CATTGGACAC AGTTTTTATA ACGGCCTTAGCTTTTCCTCC TCTCCTGGAC CCGTGGGCAT GCCTCTCCCTAGTCAGGGAC CAGGACATTC ACAGACACCA CCTCCTTCCCTCTCTTCACA TGGATCCTCT TCAAGCTTAA ACCTGGGAGGACTCACGAAT GGCAGTGGAA GATACATCTC TGCTGCTCCAGGCGCTGAAG CCAAGTACCG CAGTGCAAGC AGCGCCTCCAGCCTCTTCAG CCCGAGCAGC ACTCTTTTCT CTTCCTCTCGTTTGCGATAT GGAATGTCTG ATGTCATGCC TTCTGGCAGGAGCAGGCTTT TGGAAGATTT TCGAAACAAC CGGTACCCCAATTTACAACT GCGGGAGATT GCTGGACATA TAATGGAATTTTCCCAAGAC CAGCATGGGT CCAGATTCAT TCAGCTGAAACTGGAGCGTG CCACACCAGC TGAGCGCCAG CTTGTCTTCAATGAAATCCT CCAGGCTGCC TACCAACTCA TGGTGGATGTGTTTGGTAAT TACGTCATTC AGAAGTTCTT TGAATTTGGCAGTCTTGAAC AGAAGCTGGC TTTGGCAGAA CGGATTCGAGGCCACGTCCT GTCATTGGCA CTACAGATGT ATGGCTGCCGTGTTATCCAG AAAGCTCTTG AGTTTATTCC TTCAGACCAGCAGGTAATTA ATGAGATGGT TCGGGAACTA GATGGCCATGTCTTGAAGTG TGTGAAAGAT CAGAATGGCA ATCACGTGGTTCAGAAATGC ATTGAATGTG TACAGCCCCA GTCTTTGCAATTTATCATCG ATGCGTTTAA GGGACAGGTA TTTGCCTTATCCACACATCC TTATGGCTGC CGAGTGATTC AGAGAATCCTGGAGCACTGT CTCCCTGACC AGACACTCCC TATTTTAGAGGAGCTTCACC AGCACACAGA GCAGCTTGTA CAGGATCAATATGGAAATTA TGTAATCCAA CATGTACTGG AGCACGGTCGTCCTGAGGAT AAAAGCAAAA TTGTAGCAGA AATCCGAGGCAATGTACTTG TATTGAGTCA GCACAAATTT GCAAGCAATGTTGTGGAGAA GTGTGTTACT CACGCCTCAC GTACGGAGCGCGCTGTGCTC ATCGATGAGG TGTGCACCAT GAACGACGGTCCCCACAGTG CCTTATACAC CATGATGAAG GACCAGTATGCCAACTACGT GGTCCAGAAG ATGATTGACG TGGCGGAGCCAGGCCAGCGG AAGATCGTCA TGCATAAGAT CCGGCCCCACATCGCAACTC TTCGTAAGTA CACCTATGGC AAGCACATTCTGGCCAAGCT GGAGAAGTAC TACATGAAGA ACGGTGTTGACTTAGGGCCC ATCTGTGGCC CCCCTAATGG TATCATCTGAGGCAGTGTCA CCCGCTGTTC CCTCATTCCC GCTGACCTCACTGGCCCACT GGCAAATCCA ACCAGCAACC AGAAATGTTCTAGTGTAGAG TCTGAGACGG GCAAGTGGTT GCTCCAGGATTACTCCCTCC TCCAAAAAAG GAATCAAATC CACGAGTGGAAAAGCCTTTG TAAATTTAAT TTTATTACAC ATAACATGTACTATTTTTTT TAATTGACTA ATTGCCCTGC TGTTTTACTGGTGTATAGGA TACTTGTACA TAGGTAACCA ATGTACATGGGAGGCCACAT ATTTTGTTCA CTGTTGTATC TATATTTCACATGTGGAAAC TTTCAGGGTG GTTGGTTTAA CAAAAAAAAAAAGCTTTAAA AAAAAAAGAA AAAAAGGAAA AGGTTTTTAGCTCATTTGCC TGGCCGGCAA GTTTTGCAAA TAGCTCTTCCCCACCTCCTC ATTTTAGTAA AAAACAAACA AAAACAAAAAAACCTGAGAA GTTTGAATTG TAGTTAAATG ACCCCAAACTGGCATTTAAC ACTGTTTATA AAAAATATAT ATATATATATATATATATAT AATGAAAAAG GTTTCAGAGT TGCTAAAGCTTCAGTTTGTG ACATTAAGTT TATGAAATTC TAAAAAATGCCTTTTTTGGA GACTATATTA TGCTGAAGAA GGCTGTTCGTGAGGAGGAGA TGCGAGCACC CAGAACGTCT TTTGAGGCTGGGCGGGTGTG ATTGTTTACT GCCTACTGGA TTTTTTTCTATTAACATTGA AAGGTAAAAT CTGATTATTT AGCATGAGAAAAAAAAATCC AACTCTGCTT TTGGTCTTGC TTCTATAAATATATAGTGTA TACTTGGTGT AGACTTTGCA TATATACAAATTTGTAGTAT TTTCTTGTTT TGATGTCTAA TCTGTATCTATAATGTACCC TAGTAGTCGA ACATACTTTT GATTGTACAATTGTACATTT GTATACCTGT AATGTAAATG TGGAGAAGTTTGAATCAACA TAAACACGTT TTTTGGTAAG AAAAGAGAATTAGCCAGCCC TGTGCATTCA GTGTATATTC TCACCTTTTATGGTCGTAGC ATATAGTGTT GTATATTGTA AATTGTAATTTCAACCAGAA GTAAATTTTT TTCTTTTGAA GGAATAAATGTTCTTTATAC AGCCTAGTTA ATGTTTAAAA AGAAAAAAATAGCTTGGTTT TATTTGTCAT CTAGTCTCAA GTATAGCGAGATTCTTTCTA AATGTTATTC AAGATTGAGT TCTCACTAGTGTTTTTTTAA TCCTAAAAAA GTAATGTTTT GATTTTGTGACAGTCAAAAG GACGTGCAAA AGTCTAGCCT TGCCCGAGCTTTCCTTACAA TCAGAGCCCC TCTCACCTTG TAAAGTGTGAATCGCCCTTC CCTTTTGTAC AGAAGATGAA CTGTATTTTGCATTTTGTCT ACTTGTAAGT GAATGTAACA TACTGTCAATTTTCCTTGTT TGAATATAGA ATTGTAACAC TACACGGTGTACATTTCCAG AGCCTTGTGT ATATTTCCAA TGAACTTTTTTGCAAGCACA CTTGTAACCA TATGTGTATA ATTAACAAACCTGTGTATGC TTATGCCTGG GCAACTATTT TTTGTAACTCTTGTGTAGAT TGTCTCTAAA CAATGTGTGA TCTTTATTTTGAAAAATACA GAACTTTGGA ATCTGAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAA ACTBNM_001101.4 GAGTGAGCGG CGCGGGGCCA ATCAGCGTGC GCCGTTCCGA 44AAGTTGCCTT TTATGGCTCG AGCGGCCGCG GCGGCGCCCTATAAAACCCA GCGGCGCGAC GCGCCACCAC CGCCGAGACCGCGTCCGCCC CGCGAGCACA GAGCCTCGCC TTTGCCGATCCGCCGCCCGT CCACACCCGC CGCCAGCTCA CCATGGATGATGATATCGCC GCGCTCGTCG TCGACAACGG CTCCGGCATGTGCAAGGCCG GCTTCGCGGG CGACGATGCC CCCCGGGCCGTCTTCCCCTC CATCGTGGGG CGCCCCAGGC ACCAGGGCGTGATGGTGGGC ATGGGTCAGA AGGATTCCTA TGTGGGCGACGAGGCCCAGA GCAAGAGAGG CATCCTCACC CTGAAGTACCCCATCGAGCA CGGCATCGTC ACCAACTGGG ACGACATGGAGAAAATCTGG CACCACACCT TCTACAATGA GCTGCGTGTGGCTCCCGAGG AGCACCCCGT GCTGCTGACC GAGGCCCCCCTGAACCCCAA GGCCAACCGC GAGAAGATGA CCCAGATCATGTTTGAGACC TTCAACACCC CAGCCATGTA CGTTGCTATCCAGGCTGTGC TATCCCTGTA CGCCTCTGGC CGTACCACTGGCATCGTGAT GGACTCCGGT GACGGGGTCA CCCACACTGTGCCCATCTAC GAGGGGTATG CCCTCCCCCA TGCCATCCTGCGTCTGGACC TGGCTGGCCG GGACCTGACT GACTACCTCATGAAGATCCT CACCGAGCGC GGCTACAGCT TCACCACCACGGCCGAGCGG GAAATCGTGC GTGACATTAA GGAGAAGCTGTGCTACGTCG CCCTGGACTT CGAGCAAGAG ATGGCCACGGCTGCTTCCAG CTCCTCCCTG GAGAAGAGCT ACGAGCTGCCTGACGGCCAG GTCATCACCA TTGGCAATGA GCGGTTCCGCTGCCCTGAGG CACTCTTCCA GCCTTCCTTC CTGGGCATGGAGTCCTGTGG CATCCACGAA ACTACCTTCA ACTCCATCATGAAGTGTGAC GTGGACATCC GCAAAGACCT GTACGCCAACACAGTGCTGT CTGGCGGCAC CACCATGTAC CCTGGCATTGCCGACAGGAT GCAGAAGGAG ATCACTGCCC TGGCACCCAGCACAATGAAG ATCAAGATCA TTGCTCCTCC TGAGCGCAAGTACTCCGTGT GGATCGGCGG CTCCATCCTG GCCTCGCTGTCCACCTTCCA GCAGATGTGG ATCAGCAAGC AGGAGTATGACGAGTCCGGC CCCTCCATCG TCCACCGCAA ATGCTTCTAGGCGGACTATG ACTTAGTTGC GTTACACCCT TTCTTGACAAAACCTAACTT GCGCAGAAAA CAAGATGAGA TTGGCATGGCTTTATTTGTT TTTTTTGTTT TGTTTTGGTT TTTTTTTTTTTTTTGGCTTG ACTCAGGATT TAAAAACTGG AACGGTGAAGGTGACAGCAG TCGGTTGGAG CGAGCATCCC CCAAAGTTCACAATGTGGCC GAGGACTTTG ATTGCACATT GTTGTTTTTTTAATAGTCAT TCCAAATATG AGATGCGTTG TTACAGGAAGTCCCTTGCCA TCCTAAAAGC CACCCCACTT CTCTCTAAGGAGAATGGCCC AGTCCTCTCC CAAGTCCACA CAGGGGAGGTGATAGCATTG CTTTCGTGTA AATTATGTAA TGCAAAATTTTTTTAATCTT CGCCTTAATA CTTTTTTATT TTGTTTTATTTTGAATGATG AGCCTTCGTG CCCCCCCTTC CCCCTTTTTTGTCCCCCAAC TTGAGATGTA TGAAGGCTTT TGGTCTCCCTGGGAGTGGGT GGAGGCAGCC AGGGCTTACC TGTACACTGACTTGAGACCA GTTGAATAAA AGTGCACACC TTAAAAATGA GGAAAAAAAA AAAAAAAAAA GAPDNM_002046.6 GCTCTCTGCT CCTCCTGTTC GACAGTCAGC CGCATCTTCT 45TTTGCGTCGC CAGCCGAGCC ACATCGCTCA GACACCATGGGGAAGGTGAA GGTCGGAGTC AACGGATTTG GTCGTATTGGGCGCCTGGTC ACCAGGGCTG CTTTTAACTC TGGTAAAGTGGATATTGTTG CCATCAATGA CCCCTTCATT GACCTCAACTACATGGTTTA CATGTTCCAA TATGATTCCA CCCATGGCAAATTCCATGGC ACCGTCAAGG CTGAGAACGG GAAGCTTGTCATCAATGGAA ATCCCATCAC CATCTTCCAG GAGCGAGATCCCTCCAAAAT CAAGTGGGGC GATGCTGGCG CTGAGTACGTCGTGGAGTCC ACTGGCGTCT TCACCACCAT GGAGAAGGCTGGGGCTCATT TGCAGGGGGG AGCCAAAAGG GTCATCATCTCTGCCCCCTC TGCTGATGCC CCCATGTTCG TCATGGGTGTGAACCATGAG AAGTATGACA ACAGCCTCAA GATCATCAGCAATGCCTCCT GCACCACCAA CTGCTTAGCA CCCCTGGCCAAGGTCATCCA TGACAACTTT GGTATCGTGG AAGGACTCATGACCACAGTC CATGCCATCA CTGCCACCCA GAAGACTGTGGATGGCCCCT CCGGGAAACT GTGGCGTGAT GGCCGCGGGGCTCTCCAGAA CATCATCCCT GCCTCTACTG GCGCTGCCAAGGCTGTGGGC AAGGTCATCC CTGAGCTGAA CGGGAAGCTCACTGGCATGG CCTTCCGTGT CCCCACTGCC AACGTGTCAGTGGTGGACCT GACCTGCCGT CTAGAAAAAC CTGCCAAATATGATGACATC AAGAAGGTGG TGAAGCAGGC GTCGGAGGGCCCCCTCAAGG GCATCCTGGG CTACACTGAG CACCAGGTGGTCTCCTCTGA CTTCAACAGC GACACCCACT CCTCCACCTTTGACGCTGGG GCTGGCATTG CCCTCAACGA CCACTTTGTCAAGCTCATTT CCTGGTATGA CAACGAATTT GGCTACAGCAACAGGGTGGT GGACCTCATG GCCCACATGG CCTCCAAGGAGTAAGACCCC TGGACCACCA GCCCCAGCAA GAGCACAAGAGGAAGAGAGA GACCCTCACT GCTGGGGAGT CCCTGCCACACTCAGTCCCC CACCACACTG AATCTCCCCT CCTCACAGTTGCCATGTAGA CCCCTTGAAG AGGGGAGGGG CCTAGGGAGCCGCACCTTGT CATGTACCAT CAATAAAGTA CCCTGTGCTCAACCAGTTAA AAAAAAAAAA AAAAAAAAA GUSB NM_000181.3GTCCTCAACC AAGATGGCGC GGATGGCTTC AGGCGCATCA 46CGACACCGGC GCGTCACGCG ACCCGCCCTA CGGGCACCTCCCGCGCTTTT CTTAGCGCCG CAGACGGTGG CCGAGCGGGGGACCGGGAAG CATGGCCCGG GGGTCGGCGG TTGCCTGGGCGGCGCTCGGG CCGTTGTTGT GGGGCTGCGC GCTGGGGCTGCAGGGCGGGA TGCTGTACCC CCAGGAGAGC CCGTCGCGGGAGTGCAAGGA GCTGGACGGC CTCTGGAGCT TCCGCGCCGACTTCTCTGAC AACCGACGCC GGGGCTTCGA GGAGCAGTGGTACCGGCGGC CGCTGTGGGA GTCAGGCCCC ACCGTGGACATGCCAGTTCC CTCCAGCTTC AATGACATCA GCCAGGACTGGCGTCTGCGG CATTTTGTCG GCTGGGTGTG GTACGAACGGGAGGTGATCC TGCCGGAGCG ATGGACCCAG GACCTGCGCACAAGAGTGGT GCTGAGGATT GGCAGTGCCC ATTCCTATGCCATCGTGTGG GTGAATGGGG TCGACACGCT AGAGCATGAGGGGGGCTACC TCCCCTTCGA GGCCGACATC AGCAACCTGGTCCAGGTGGG GCCCCTGCCC TCCCGGCTCC GAATCACTATCGCCATCAAC AACACACTCA CCCCCACCAC CCTGCCACCAGGGACCATCC AATACCTGAC TGACACCTCC AAGTATCCCAAGGGTTACTT TGTCCAGAAC ACATATTTTG ACTTTTTCAACTACGCTGGA CTGCAGCGGT CTGTACTTCT GTACACGACACCCACCACCT ACATCGATGA CATCACCGTC ACCACCAGCGTGGAGCAAGA CAGTGGGCTG GTGAATTACC AGATCTCTGTCAAGGGCAGT AACCTGTTCA AGTTGGAAGT GCGTCTTTTGGATGCAGAAA ACAAAGTCGT GGCGAATGGG ACTGGGACCCAGGGCCAACT TAAGGTGCCA GGTGTCAGCC TCTGGTGGCCGTACCTGATG CACGAACGCC CTGCCTATCT GTATTCATTGGAGGTGCAGC TGACTGCACA GACGTCACTG GGGCCTGTGTCTGACTTCTA CACACTCCCT GTGGGGATCC GCACTGTGGCTGTCACCAAG AGCCAGTTCC TCATCAATGG GAAACCTTTCTATTTCCACG GTGTCAACAA GCATGAGGAT GCGGACATCCGAGGGAAGGG CTTCGACTGG CCGCTGCTGG TGAAGGACTTCAACCTGCTT CGCTGGCTTG GTGCCAACGC TTTCCGTACCAGCCACTACC CCTATGCAGA GGAAGTGATG CAGATGTGTGACCGCTATGG GATTGTGGTC ATCGATGAGT GTCCCGGCGTGGGCCTGGCG CTGCCGCAGT TCTTCAACAA CGTTTCTCTGCATCACCACA TGCAGGTGAT GGAAGAAGTG GTGCGTAGGGACAAGAACCA CCCCGCGGTC GTGATGTGGT CTGTGGCCAACGAGCCTGCG TCCCACCTAG AATCTGCTGG CTACTACTTGAAGATGGTGA TCGCTCACAC CAAATCCTTG GACCCCTCCCGGCCTGTGAC CTTTGTGAGC AACTCTAACT ATGCAGCAGACAAGGGGGCT CCGTATGTGG ATGTGATCTG TTTGAACAGCTACTACTCTT GGTATCACGA CTACGGGCAC CTGGAGTTGATTCAGCTGCA GCTGGCCACC CAGTTTGAGA ACTGGTATAAGAAGTATCAG AAGCCCATTA TTCAGAGCGA GTATGGAGCAGAAACGATTG CAGGGTTTCA CCAGGATCCA CCTCTGATGTTCACTGAAGA GTACCAGAAA AGTCTGCTAG AGCAGTACCATCTGGGTCTG GATCAAAAAC GCAGAAAATA CGTGGTTGGAGAGCTCATTT GGAATTTTGC CGATTTCATG ACTGAACAGTCACCGACGAG AGTGCTGGGG AATAAAAAGG GGATCTTCACTCGGCAGAGA CAACCAAAAA GTGCAGCGTT CCTTTTGCGAGAGAGATACT GGAAGATTGC CAATGAAACC AGGTATCCCCACTCAGTAGC CAAGTCACAA TGTTTGGAAA ACAGCCTGTTTACTTGAGCA AGACTGATAC CACCTGCGTG TCCCTTCCTCCCCGAGTCAG GGCGACTTCC ACAGCAGCAG AACAAGTGCCTCCTGGACTG TTCACGGCAG ACCAGAACGT TTCTGGCCTGGGTTTTGTGG TCATCTATTC TAGCAGGGAA CACTAAAGGTGGAAATAAAA GATTTTCTAT TATGGAAATA AAGAGTTGGCATGAAAGTGG CTACTGAAAA AAAAAAAAAA AAAAAAAAAA A RPLP0 NM_001002.3GTCTGACGGG CGATGGCGCA GCCAATAGAC AGGAGCGCTA 47TCCGCGGTTT CTGATTGGCT ACTTTGTTCG CATTATAAAAGGCACGCGCG GGCGCGAGGC CCTTCTCTCG CCAGGCGTCCTCGTGGAAGT GACATCGTCT TTAAACCCTG CGTGGCAATCCCTGACGCAC CGCCGTGATG CCCAGGGAAG ACAGGGCGACCTGGAAGTCC AACTACTTCC TTAAGATCAT CCAACTATTGGATGATTATC CGAAATGTTT CATTGTGGGA GCAGACAATGTGGGCTCCAA GCAGATGCAG CAGATCCGCA TGTCCCTTCGCGGGAAGGCT GTGGTGCTGA TGGGCAAGAA CACCATGATGCGCAAGGCCA TCCGAGGGCA CCTGGAAAAC AACCCAGCTCTGGAGAAACT GCTGCCTCAT ATCCGGGGGA ATGTGGGCTTTGTGTTCACC AAGGAGGACC TCACTGAGAT CAGGGACATGTTGCTGGCCA ATAAGGTGCC AGCTGCTGCC CGTGCTGGTGCCATTGCCCC ATGTGAAGTC ACTGTGCCAG CCCAGAACACTGGTCTCGGG CCCGAGAAGA CCTCCTTTTT CCAGGCTTTAGGTATCACCA CTAAAATCTC CAGGGGCACC ATTGAAATCCTGAGTGATGT GCAGCTGATC AAGACTGGAG ACAAAGTGGGAGCCAGCGAA GCCACGCTGC TGAACATGCT CAACATCTCCCCCTTCTCCT TTGGGCTGGT CATCCAGCAG GTGTTCGACAATGGCAGCAT CTACAACCCT GAAGTGCTTG ATATCACAGAGGAAACTCTG CATTCTCGCT TCCTGGAGGG TGTCCGCAATGTTGCCAGTG TCTGTCTGCA GATTGGCTAC CCAACTGTTGCATCAGTACC CCATTCTATC ATCAACGGGT ACAAACGAGTCCTGGCCTTG TCTGTGGAGA CGGATTACAC CTTCCCACTTGCTGAAAAGG TCAAGGCCTT CTTGGCTGAT CCATCTGCCTTTGTGGCTGC TGCCCCTGTG GCTGCTGCCA CCACAGCTGCTCCTGCTGCT GCTGCAGCCC CAGCTAAGGT TGAAGCCAAGGAAGAGTCGG AGGAGTCGGA CGAGGATATG GGATTTGGTCTCTTTGACTA ATCACCAAAA AGCAACCAAC TTAGCCAGTTTTATTTGCAA AACAAGGAAA TAAAGGCTTA CTTCTTTAAAAAGTAAAAAA AAAAAAAAAA AAAAAAAAA TFRC NM_003234.3AGAGCGTCGG GATATCGGGT GGCGGCTCGG GACGGAGGAC 48GCGCTAGTGT GAGTGCGGGC TTCTAGAACT ACACCGACCCTCGTGTCCTC CCTTCATCCT GCGGGGCTGG CTGGAGCGGCCGCTCCGGTG CTGTCCAGCA GCCATAGGGA GCCGCACGGGGAGCGGGAAA GCGGTCGCGG CCCCAGGCGG GGCGGCCGGGATGGAGCGGG GCCGCGAGCC TGTGGGGAAG GGGCTGTGGCGGCGCCTCGA GCGGCTGCAG GTTCTTCTGT GTGGCAGTTCAGAATGATGG ATCAAGCTAG ATCAGCATTC TCTAACTTGTTTGGTGGAGA ACCATTGTCA TATACCCGGT TCAGCCTGGCTCGGCAAGTA GATGGCGATA ACAGTCATGT GGAGATGAAACTTGCTGTAG ATGAAGAAGA AAATGCTGAC AATAACACAAAGGCCAATGT CACAAAACCA AAAAGGTGTA GTGGAAGTATCTGCTATGGG ACTATTGCTG TGATCGTCTT TTTCTTGATTGGATTTATGA TTGGCTACTT GGGCTATTGT AAAGGGGTAGAACCAAAAAC TGAGTGTGAG AGACTGGCAG GAACCGAGTCTCCAGTGAGG GAGGAGCCAG GAGAGGACTT CCCTGCAGCACGTCGCTTAT ATTGGGATGA CCTGAAGAGA AAGTTGTCGGAGAAACTGGA CAGCACAGAC TTCACCGGCA CCATCAAGCTGCTGAATGAA AATTCATATG TCCCTCGTGA GGCTGGATCTCAAAAAGATG AAAATCTTGC GTTGTATGTT GAAAATCAATTTCGTGAATT TAAACTCAGC AAAGTCTGGC GTGATCAACATTTTGTTAAG ATTCAGGTCA AAGACAGCGC TCAAAACTCGGTGATCATAG TTGATAAGAA CGGTAGACTT GTTTACCTGGTGGAGAATCC TGGGGGTTAT GTGGCGTATA GTAAGGCTGCAACAGTTACT GGTAAACTGG TCCATGCTAA TTTTGGTACTAAAAAAGATT TTGAGGATTT ATACACTCCT GTGAATGGATCTATAGTGAT TGTCAGAGCA GGGAAAATCA CCTTTGCAGAAAAGGTTGCA AATGCTGAAA GCTTAAATGC AATTGGTGTGTTGATATACA TGGACCAGAC TAAATTTCCC ATTGTTAACGCAGAACTTTC ATTCTTTGGA CATGCTCATC TGGGGACAGGTGACCCTTAC ACACCTGGAT TCCCTTCCTT CAATCACACTCAGTTTCCAC CATCTCGGTC ATCAGGATTG CCTAATATACCTGTCCAGAC AATCTCCAGA GCTGCTGCAG AAAAGCTGTTTGGGAATATG GAAGGAGACT GTCCCTCTGA CTGGAAAACAGACTCTACAT GTAGGATGGT AACCTCAGAA AGCAAGAATGTGAAGCTCAC TGTGAGCAAT GTGCTGAAAG AGATAAAAATTCTTAACATC TTTGGAGTTA TTAAAGGCTT TGTAGAACCAGATCACTATG TTGTAGTTGG GGCCCAGAGA GATGCATGGGGCCCTGGAGC TGCAAAATCC GGTGTAGGCA CAGCTCTCCTATTGAAACTT GCCCAGATGT TCTCAGATAT GGTCTTAAAAGATGGGTTTC AGCCCAGCAG AAGCATTATC TTTGCCAGTTGGAGTGCTGG AGACTTTGGA TCGGTTGGTG CCACTGAATGGCTAGAGGGA TACCTTTCGT CCCTGCATTT AAAGGCTTTCACTTATATTA ATCTGGATAA AGCGGTTCTT GGTACCAGCAACTTCAAGGT TTCTGCCAGC CCACTGTTGT ATACGCTTATTGAGAAAACA ATGCAAAATG TGAAGCATCC GGTTACTGGGCAATTTCTAT ATCAGGACAG CAACTGGGCC AGCAAAGTTGAGAAACTCAC TTTAGACAAT GCTGCTTTCC CTTTCCTTGCATATTCTGGA ATCCCAGCAG TTTCTTTCTG TTTTTGCGAGGACACAGATT ATCCTTATTT GGGTACCACC ATGGACACCTATAAGGAACT GATTGAGAGG ATTCCTGAGT TGAACAAAGTGGCACGAGCA GCTGCAGAGG TCGCTGGTCA GTTCGTGATTAAACTAACCC ATGATGTTGA ATTGAACCTG GACTATGAGAGGTACAACAG CCAACTGCTT TCATTTGTGA GGGATCTGAACCAATACAGA GCAGACATAA AGGAAATGGG CCTGAGTTTACAGTGGCTGT ATTCTGCTCG TGGAGACTTC TTCCGTGCTACTTCCAGACT AACAACAGAT TTCGGGAATG CTGAGAAAACAGACAGATTT GTCATGAAGA AACTCAATGA TCGTGTCATGAGAGTGGAGT ATCACTTCCT CTCTCCCTAC GTATCTCCAAAAGAGTCTCC TTTCCGACAT GTCTTCTGGG GCTCCGGCTCTCACACGCTG CCAGCTTTAC TGGAGAACTT GAAACTGCGTAAACAAAATA ACGGTGCTTT TAATGAAACG CTGTTCAGAAACCAGTTGGC TCTAGCTACT TGGACTATTC AGGGAGCTGCAAATGCCCTC TCTGGTGACG TTTGGGACAT TGACAATGAGTTTTAAATGT GATACCCATA GCTTCCATGA GAACAGCAGGGTAGTCTGGT TTCTAGACTT GTGCTGATCG TGCTAAATTTTCAGTAGGGC TACAAAACCT GATGTTAAAA TTCCATCCCATCATCTTGGT ACTACTAGAT GTCTTTAGGC AGCAGCTTTTAATACAGGGT AGATAACCTG TACTTCAAGT TAAAGTGAATAACCACTTAA AAAATGTCCA TGATGGAATA TTCCCCTATCTCTAGAATTT TAAGTGCTTT GTAATGGGAA CTGCCTCTTTCCTGTTGTTG TTAATGAAAA TGTCAGAAAC CAGTTATGTGAATGATCTCT CTGAATCCTA AGGGCTGGTC TCTGCTGAAGGTTGTAAGTG GTCGCTTACT TTGAGTGATC CTCCAACTTCATTTGATGCT AAATAGGAGA TACCAGGTTG AAAGACCTTCTCCAAATGAG ATCTAAGCCT TTCCATAAGG AATGTAGCTGGTTTCCTCAT TCCTGAAAGA AACAGTTAAC TTTCAGAAGAGATGGGCTTG TTTTCTTGCC AATGAGGTCT GAAATGGAGGTCCTTCTGCT GGATAAAATG AGGTTCAACT GTTGATTGCAGGAATAAGGC CTTAATATGT TAACCTCAGT GTCATTTATGAAAAGAGGGG ACCAGAAGCC AAAGACTTAG TATATTTTCTTTTCCTCTGT CCCTTCCCCC ATAAGCCTCC ATTTAGTTCTTTGTTATTTT TGTTTCTTCC AAAGCACATT GAAAGAGAACCAGTTTCAGG TGTTTAGTTG CAGACTCAGT TTGTCAGACTTTAAAGAATA ATATGCTGCC AAATTTTGGC CAAAGTGTTAATCTTAGGGG AGAGCTTTCT GTCCTTTTGG CACTGAGATATTTATTGTTT ATTTATCAGT GACAGAGTTC ACTATAAATGGTGTTTTTTT AATAGAATAT AATTATCGGA AGCAGTGCCTTCCATAATTA TGACAGTTAT ACTGTCGGTT TTTTTTAAATAAAAGCAGCA TCTGCTAATA AAACCCAACA GATACTGGAAGTTTTGCATT TATGGTCAAC ACTTAAGGGT TTTAGAAAACAGCCGTCAGC CAAATGTAAT TGAATAAAGT TGAAGCTAAGATTTAGAGAT GAATTAAATT TAATTAGGGG TTGCTAAGAAGCGAGCACTG ACCAGATAAG AATGCTGGTT TTCCTAAATGCAGTGAATTG TGACCAAGTT ATAAATCAAT GTCACTTAAAGGCTGTGGTA GTACTCCTGC AAAATTTTAT AGCTCAGTTTATCCAAGGTG TAACTCTAAT TCCCATTTTG CAAAATTTCCAGTACCTTTG TCACAATCCT AACACATTAT CGGGAGCAGTGTCTTCCATA ATGTATAAAG AACAAGGTAG TTTTTACCTACCACAGTGTC TGTATCGGAG ACAGTGATCT CCATATGTTACACTAAGGGT GTAAGTAATT ATCGGGAACA GTGTTTCCCATAATTTTCTT CATGCAATGA CATCTTCAAA GCTTGAAGATCGTTAGTATC TAACATGTAT CCCAACTCCT ATAATTCCCTATCTTTTAGT TTTAGTTGCA GAAACATTTT GTGGTCATTAAGCATTGGGT GGGTAAATTC AACCACTGTA AAATGAAATTACTACAAAAT TTGAAATTTA GCTTGGGTTT TTGTTACCTTTATGGTTTCT CCAGGTCCTC TACTTAATGA GATAGTAGCATACATTTATA ATGTTTGCTA TTGACAAGTC ATTTTAACTTTATCACATTA TTTGCATGTT ACCTCCTATA AACTTAGTGCGGACAAGTTT TAATCCAGAA TTGACCTTTT GACTTAAAGCAGAGGGACTT TGTATAGAAG GTTTGGGGGC TGTGGGGAAGGAGAGTCCCC TGAAGGTCTG ACACGTCTGC CTACCCATTCGTGGTGATCA ATTAAATGTA GGTATGAATA AGTTCGAAGCTCCGTGAGTG AACCATCATT ATAAACGTGA TGATCAGCTGTTTGTCATAG GGCAGTTGGA AACGGCCTCC TAGGGAAAAGTTCATAGGGT CTCTTCAGGT TCTTAGTGTC ACTTACCTAGATTTACAGCC TCACTTGAAT GTGTCACTAC TCACAGTCTCTTTAATCTTC AGTTTTATCT TTAATCTCCT CTTTTATCTTGGACTGACAT TTAGCGTAGC TAAGTGAAAA GGTCATAGCTGAGATTCCTG GTTCGGGTGT TACGCACACG TACTTAAATGAAAGCATGTG GCATGTTCAT CGTATAACAC AATATGAATACAGGGCATGC ATTTTGCAGC AGTGAGTCTC TTCAGAAAACCCTTTTCTAC AGTTAGGGTT GAGTTACTTC CTATCAAGCCAGTACGTGCT AACAGGCTCA ATATTCCTGA ATGAAATATCAGACTAGTGA CAAGCTCCTG GTCTTGAGAT GTCTTCTCGTTAAGGAGATG GGCCTTTTGG AGGTAAAGGA TAAAATGAATGAGTTCTGTC ATGATTCACT ATTCTAGAAC TTGCATGACCTTTACTGTGT TAGCTCTTTG AATGTTCTTG AAATTTTAGACTTTCTTTGT AAACAAATGA TATGTCCTTA TCATTGTATAAAAGCTGTTA TGTGCAACAG TGTGGAGATT CCTTGTCTGATTTAATAAAA TACTTAAACA CTGAAAAAAA AAAA 18S X03205.1TACCTGGTTG ATCCTGCCAG TAGCATATGC TTGTCTCAAA 49GATTAAGCCA TGCATGTCTA AGTACGCACG GCCGGTACAGTGAAACTGCG AATGGCTCAT TAAATCAGTT ATGGTTCCTTTGGTCGCTCG CTCCTCTCCC ACTTGGATAA CTGTGGTAATTCTAGAGCTA ATACATGCCG ACGGGCGCTG ACCCCCTTCGCGGGGGGGAT GCGTGCATTT ATCAGATCAA AACCAACCCGGTCAGCCCCT CTCCGGCCCC GGCCGGGGGG CGGGCGCCGGCGGCTTTGGT GACTCTAGAT AACCTCGGGC CGATCGCACGCCCCCCGTGG CGGCGACGAC CCATTCGAAC GTCTGCCCTATCAACTTTCG ATGGTAGTCG CCGTGCCTAC CATGGTGACCACGGGTGACG GGGAATCAGG GTTCGATTCC GGAGAGGGAGCCTGAGAAAC GGCTACCACA TCCAAGGAAG GCAGCAGGCGCGCAAATTAC CCACTCCCGA CCCGGGGAGG TAGTGACGAAAAATAACAAT ACAGGACTCT TTCGAGGCCC TGTAATTGGAATGAGTCCAC TTTAAATCCT TTAACGAGGA TCCATTGGAGGGCAAGTCTG GTGCCAGCAG CCGCGGTAAT TCCAGCTCCAATAGCGTATA TTAAAGTTGC TGCAGTTAAA AAGCTCGTAGTTGGATCTTG GGAGCGGGCG GGCGGTCCGC CGCGAGGCGAGCCACCGCCC GTCCCCGCCC CTTGCCTCTC GGCGCCCCCTCGATGCTCTT AGCTGAGTGT CCCGCGGGGC CCGAAGCGTTTACTTTGAAA AAATTAGAGT GTTCAAAGCA GGCCCGAGCCGCCTGGATAC CGCAGCTAGG AATAATGGAA TAGGACCGCGGTTCTATTTT GTTGGTTTTC GGAACTGAGG CCATGATTAAGAGGGACGGC CGGGGGCATT CGTATTGCGC CGCTAGAGGTGAAATTCTTG GACCGGCGCA AGACGGACCA GAGCGAAAGCATTTGCCAAG AATGTTTTCA TTAATCAAGA ACGAAAGTCGGAGGTTCGAA GACGATCAGA TACCGTCGTA GTTCCGACCATAAACGATGC CGACCGGCGA TGCGGCGGCG TTATTCCCATGACCCGCCGG GCAGCTTCCG GGAAACCAAA GTCTTTGGGTTCCGGGGGGA GTATGGTTGC AAAGCTGAAA CTTAAAGGAATTGACGGAAG GGCACCACCA GGAGTGGAGC CTGCGGCTTAATTTGACTCA ACACGGGAAA CCTCACCCGG CCCGGACACGGACAGGATTG ACAGATTGAT AGCTCTTTCT CGATTCCGTGGGTGGTGGTG CATGGCCGTT CTTAGTTGGT GGAGCGATTTGTCTGGTTAA TTCCGATAAC GAACGAGACT CTGGCATGCTAACTAGTTAC GCGACCCCCG AGCGGTCGGC GTCCCCCAACTTCTTAGAGG GACAAGTGGC GTTCAGCCAC CCGAGATTGAGCAATAACAG GTCTGTGATG CCCTTAGATG TCCGGGGCTGCACGCGCGCT ACACTGACTG GCTCAGCGTG TGCCTACCCTACGCCGGCAG GCGCGGGTAA CCCGTTGAAC CCCATTCGTGATGGGGATCG GGGATTGCAA TTATTCCCCA TGAACGAGGAATTCCCAGTA AGTGCGGGTC ATAAGCTTGC GTTGATTAAGTCCCTGCCCT TTGTACACAC CGCCCGTCGC TACTACCGATTGGATGGTTT AGTGAGGCCC TCGGATCGGC CCCGCCGGGGTCGGCCCACG GCCCTGGCGG AGCGCTGAGA AGACGGTCGAACTTGACTAT CTAGAGGAAG TAAAAGTCGT AACAAGGTTTCCGTAGGTGA ACCTGCGGAA GGATCATTA PPIA NM_021130.4GGGGCCGAAC GTGGTATAAA AGGGGCGGGA GGCCAGGCTC 50GTGCCGTTTT GCAGACGCCA CCGCCGAGGA AAACCGTGTACTATTAGCCA TGGTCAACCC CACCGTGTTC TTCGACATTGCCGTCGACGG CGAGCCCTTG GGCCGCGTCT CCTTTGAGCTGTTTGCAGAC AAGGTCCCAA AGACAGCAGA AAATTTTCGTGCTCTGAGCA CTGGAGAGAA AGGATTTGGT TATAAGGGTTCCTGCTTTCA CAGAATTATT CCAGGGTTTA TGTGTCAGGGTGGTGACTTC ACACGCCATA ATGGCACTGG TGGCAAGTCCATCTATGGGG AGAAATTTGA AGATGAGAAC TTCATCCTAAAGCATACGGG TCCTGGCATC TTGTCCATGG CAAATGCTGGACCCAACACA AATGGTTCCC AGTTTTTCAT CTGCACTGCCAAGACTGAGT GGTTGGATGG CAAGCATGTG GTGTTTGGCAAAGTGAAAGA AGGCATGAAT ATTGTGGAGG CCATGGAGCGCTTTGGGTCC AGGAATGGCA AGACCAGCAA GAAGATCACCATTGCTGACT GTGGACAACT CGAATAAGTT TGACTTGTGTTTTATCTTAA CCACCAGATC ATTCCTTCTG TAGCTCAGGAGAGCACCCCT CCACCCCATT TGCTCGCAGT ATCCTAGAATCTTTGTGCTC TCGCTGCAGT TCCCTTTGGG TTCCATGTTTTCCTTGTTCC CTCCCATGCC TAGCTGGATT GCAGAGTTAAGTTTATGATT ATGAAATAAA AACTAAATAA CAATTGTCCTCGTTTGAGTT AAGAGTGTTG ATGTAGGCTT TATTTTAAGCAGTAATGGGT TACTTCTGAA ACATCACTTG TTTGCTTAATTCTACACAGT ACTTAGATTT TTTTTACTTT CCAGTCCCAGGAAGTGTCAA TGTTTGTTGA GTGGAATATT GAAAATGTAGGCAGCAACTG GGCATGGTGG CTCACTGTCT GTAATGTATTACCTGAGGCA GAAGACCACC TGAGGGTAGG AGTCAAGATCAGCCTGGGCA ACATAGTGAG ACGCTGTCTC TACAAAAAATAATTAGCCTG GCCTGGTGGT GCATGCCTAG TCCTAGCTGATCTGGAGGCT GACGTGGGAG GATTGCTTGA GCCTAGAGTGAGCTATTATC ATGCCACTGT ACAGCCTGGG TGTTCACAGATCTTGTGTCT CAAAGGTAGG CAGAGGCAGG AAAAGCAAGGAGCCAGAATT AAGAGGTTGG GTCAGTCTGC AGTGAGTTCATGCATTTAGA GGTGTTCTTC AAGATGACTA ATGTCAAAAATTGAGACATC TGTTGCGGTT TTTTTTTTTT TTTTTTCCCCTGGAATGCAG TGGCGTGATC TCAGCTCACT GCAGCCTCCGCCTCCTGGGT TCAAGTGATT CTAGTGCCTC AGCCTCCTGAGTAGCTGGGA TAATGGGCGT GTGCCACCAT GCCCAGCTAATTTTTGTATT TTTAGTATAG ATGGGGTTTC ATCATTTTGACCAGGCTGGT CTCAAACTCT TGACCTCAGC TGATGCGCCTGCCTTGGCCT CCCAAACTGC TGAGATTACA GATGTGAGCCACCGCACCCT ACCTCATTTT CTGTAACAAA GCTAAGCTTGAACACTGTTG ATGTTCTTGA GGGAAGCATA TTGGGCTTTAGGCTGTAGGT CAAGTTTATA CATCTTAATT ATGGTGGAATTCCTATGTAG AGTCTAAAAA GCCAGGTACT TGGTGCTACAGTCAGTCTCC CTGCAGAGGG TTAAGGCGCA GACTACCTGCAGTGAGGAGG TACTGCTTGT AGCATATAGA GCCTCTCCCTAGCTTTGGTT ATGGAGGCTT TGAGGTTTTG CAAACCTGACCAATTTAAGC CATAAGATCT GGTCAAAGGG ATACCCTTCCCACTAAGGAC TTGGTTTCTC AGGAAATTAT ATGTACAGTGCTTGCTGGCA GTTAGATGTC AGGACAATCT AAGCTGAGAAAACCCCTTCT CTGCCCACCT TAACAGACCT CTAGGGTTCTTAACCCAGCA ATCAAGTTTG CCTATCCTAG AGGTGGCGGATTTGATCATT TGGTGTGTTG GGCAATTTTT GTTTTACTGTCTGGTTCCTT CTGCGTGAAT TACCACCACC ACCACTTGTGCATCTCAGTC TTGTGTGTTG TCTGGTTACG TATTCCCTGGGTGATACCAT TCAATGTCTT AATGTACTTG TGGCTCAGACCTGAGTGCAA GGTGGAAATA AACATCAAAC ATCTTTTCAT TATCCCTA PGK1 NM_000291.3GAGAGCAGCG GCCGGGAAGG GGCGGTGCGG GAGGCGGGGT 51GTGGGGCGGT AGTGTGGGCC CTGTTCCTGC CCGCGCGGTGTTCCGCATTC TGCAAGCCTC CGGAGCGCAC GTCGGCAGTCGGCTCCCTCG TTGACCGAAT CACCGACCTC TCTCCCCAGCTGTATTTCCA AAATGTCGCT TTCTAACAAG CTGACGCTGGACAAGCTGGA CGTTAAAGGG AAGCGGGTCG TTATGAGAGTCGACTTCAAT GTTCCTATGA AGAACAACCA GATAACAAACAACCAGAGGA TTAAGGCTGC TGTCCCAAGC ATCAAATTCTGCTTGGACAA TGGAGCCAAG TCGGTAGTCC TTATGAGCCACCTAGGCCGG CCTGATGGTG TGCCCATGCC TGACAAGTACTCCTTAGAGC CAGTTGCTGT AGAACTCAAA TCTCTGCTGGGCAAGGATGT TCTGTTCTTG AAGGACTGTG TAGGCCCAGAAGTGGAGAAA GCCTGTGCCA ACCCAGCTGC TGGGTCTGTCATCCTGCTGG AGAACCTCCG CTTTCATGTG GAGGAAGAAGGGAAGGGAAA AGATGCTTCT GGGAACAAGG TTAAAGCCGAGCCAGCCAAA ATAGAAGCTT TCCGAGCTTC ACTTTCCAAGCTAGGGGATG TCTATGTCAA TGATGCTTTT GGCACTGCTCACAGAGCCCA CAGCTCCATG GTAGGAGTCA ATCTGCCACAGAAGGCTGGT GGGTTTTTGA TGAAGAAGGA GCTGAACTACTTTGCAAAGG CCTTGGAGAG CCCAGAGCGA CCCTTCCTGGCCATCCTGGG CGGAGCTAAA GTTGCAGACA AGATCCAGCTCATCAATAAT ATGCTGGACA AAGTCAATGA GATGATTATTGGTGGTGGAA TGGCTTTTAC CTTCCTTAAG GTGCTCAACAACATGGAGAT TGGCACTTCT CTGTTTGATG AAGAGGGAGCCAAGATTGTC AAAGACCTAA TGTCCAAAGC TGAGAAGAATGGTGTGAAGA TTACCTTGCC TGTTGACTTT GTCACTGCTGACAAGTTTGA TGAGAATGCC AAGACTGGCC AAGCCACTGTGGCTTCTGGC ATACCTGCTG GCTGGATGGG CTTGGACTGTGGTCCTGAAA GCAGCAAGAA GTATGCTGAG GCTGTCACTCGGGCTAAGCA GATTGTGTGG AATGGTCCTG TGGGGGTATTTGAATGGGAA GCTTTTGCCC GGGGAACCAA AGCTCTCATGGATGAGGTGG TGAAAGCCAC TTCTAGGGGC TGCATCACCATCATAGGTGG TGGAGACACT GCCACTTGCT GTGCCAAATGGAACACGGAG GATAAAGTCA GCCATGTGAG CACTGGGGGTGGTGCCAGTT TGGAGCTCCT GGAAGGTAAA GTCCTTCCTGGGGTGGATGC TCTCAGCAAT ATTTAGTACT TTCCTGCCTTTTAGTTCCTG TGCACAGCCC CTAAGTCAAC TTAGCATTTTCTGCATCTCC ACTTGGCATT AGCTAAAACC TTCCATGTCAAGATTCAGCT AGTGGCCAAG AGATGCAGTG CCAGGAACCCTTAAACAGTT GCACAGCATC TCAGCTCATC TTCACTGCACCCTGGATTTG CATACATTCT TCAAGATCCC ATTTGAATTTTTTAGTGACT AAACCATTGT GCATTCTAGA GTGCATATATTTATATTTTG CCTGTTAAAA AGAAAGTGAG CAGTGTTAGCTTAGTTCTCT TTTGATGTAG GTTATTATGA TTAGCTTTGTCACTGTTTCA CTACTCAGCA TGGAAACAAG ATGAAATTCCATTTGTAGGT AGTGAGACAA AATTGATGAT CCATTAAGTAAACAATAAAA GTGTCCATTG AAACCGTGAT TTTTTTTTTTTTCCTGTCAT ACTTTGTTAG GAAGGGTGAG AATAGAATCTTGAGGAACGG ATCAGATGTC TATATTGCTG AATGCAAGAAGTGGGGCAGC AGCAGTGGAG AGATGGGACA ATTAGATAAATGTCCATTCT TTATCAAGGG CCTACTTTAT GGCAGACATTGTGCTAGTGC TTTTATTCTA ACTTTTATTT TTATCAGTTACACATGATCA TAATTTAAAA AGTCAAGGCT TATAACAAAAAAGCCCCAGC CCATTCCTCC CATTCAAGAT TCCCACTCCCCAGAGGTGAC CACTTTCAAC TCTTGAGTTT TTCAGGTATATACCTCCATG TTTCTAAGTA ATATGCTTAT ATTGTTCACTTCTTTTTTTT TTATTTTTTA AAGAAATCTA TTTCATACCATGGAGGAAGG CTCTGTTCCA CATATATTTC CACTTCTTCATTCTCTCGGT ATAGTTTTGT CACAATTATA GATTAGATCAAAAGTCTACA TAACTAATAC AGCTGAGCTA TGTAGTATGCTATGATTAAA TTTACTTATG TAAAAAAAAA AAAAAAAAA RPL13A NM_012423.3CACTTCTGCC GCCCCTGTTT CAAGGGATAA GAAACCCTGC 52GACAAAACCT CCTCCTTTTC CAAGCGGCTG CCGAAGATGGCGGAGGTGCA GGTCCTGGTG CTTGATGGTC GAGGCCATCTCCTGGGCCGC CTGGCGGCCA TCGTGGCTAA ACAGGTACTGCTGGGCCGGA AGGTGGTGGT CGTACGCTGT GAAGGCATCAACATTTCTGG CAATTTCTAC AGAAACAAGT TGAAGTACCTGGCTTTCCTC CGCAAGCGGA TGAACACCAA CCCTTCCCGAGGCCCCTACC ACTTCCGGGC CCCCAGCCGC ATCTTCTGGCGGACCGTGCG AGGTATGCTG CCCCACAAAA CCAAGCGAGGCCAGGCCGCT CTGGACCGTC TCAAGGTGTT TGACGGCATCCCACCGCCCT ACGACAAGAA AAAGCGGATG GTGGTTCCTGCTGCCCTCAA GGTCGTGCGT CTGAAGCCTA CAAGAAAGTTTGCCTATCTG GGGCGCCTGG CTCACGAGGT TGGCTGGAAGTACCAGGCAG TGACAGCCAC CCTGGAGGAG AAGAGGAAAGAGAAAGCCAA GATCCACTAC CGGAAGAAGA AACAGCTCATGAGGCTACGG AAACAGGCCG AGAAGAACGT GGAGAAGAAAATTGACAAAT ACACAGAGGT CCTCAAGACC CACGGACTCCTGGTCTGAGC CCAATAAAGA CTGTTAATTC CTCATGCGTTGCCTGCCCTT CCTCCATTGT TGCCCTGGAA TGTACGGGACCCAGGGGCAG CAGCAGTCCA GGTGCCACAG GCAGCCCTGGGACATAGGAA GCTGGGAGCA AGGAAAGGGT CTTAGTCACTGCCTCCCGAA GTTGCTTGAA AGCACTCGGA GAATTGTGCAGGTGTCATTT ATCTATGACC AATAGGAAGA GCAACCAGTTACTATGAGTG AAAGGGAGCC AGAAGACTGA TTGGAGGGCCCTATCTTGTG AGTGGGGCAT CTGTTGGACT TTCCACCTGGTCATATACTC TGCAGCTGTT AGAATGTGCA AGCACTTGGGGACAGCATGA GCTTGCTGTT GTACACAGGG TATTTCTAGAAGCAGAAATA GACTGGGAAG ATGCACAACC AAGGGGTTACAGGCATCGCC CATGCTCCTC ACCTGTATTT TGTAATCAGAAATAAATTGC TTTTAAAGAA AAAAAAAAAA AAAAAA B2M NM_004048.2AATATAAGTG GAGGCGTCGC GCTGGCGGGC ATTCCTGAAG 53CTGACAGCAT TCGGGCCGAG ATGTCTCGCT CCGTGGCCTTAGCTGTGCTC GCGCTACTCT CTCTTTCTGG CCTGGAGGCTATCCAGCGTA CTCCAAAGAT TCAGGTTTAC TCACGTCATCCAGCAGAGAA TGGAAAGTCA AATTTCCTGA ATTGCTATGTGTCTGGGTTT CATCCATCCG ACATTGAAGT TGACTTACTGAAGAATGGAG AGAGAATTGA AAAAGTGGAG CATTCAGACTTGTCTTTCAG CAAGGACTGG TCTTTCTATC TCTTGTACTACACTGAATTC ACCCCCACTG AAAAAGATGA GTATGCCTGCCGTGTGAACC ATGTGACTTT GTCACAGCCC AAGATAGTTAAGTGGGATCG AGACATGTAA GCAGCATCAT GGAGGTTTGAAGATGCCGCA TTTGGATTGG ATGAATTCCA AATTCTGCTTGCTTGCTTTT TAATATTGAT ATGCTTATAC ACTTACACTTTATGCACAAA ATGTAGGGTT ATAATAATGT TAACATGGACATGATCTTCT TTATAATTCT ACTTTGAGTG CTGTCTCCATGTTTGATGTA TCTGAGCAGG TTGCTCCACA GGTAGCTCTAGGAGGGCTGG CAACTTAGAG GTGGGGAGCA GAGAATTCTCTTATCCAACA TCAACATCTT GGTCAGATTT GAACTCTTCAATCTCTTGCA CTCAAAGCTT GTTAAGATAG TTAAGCGTGCATAAGTTAAC TTCCAATTTA CATACTCTGC TTAGAATTTGGGGGAAAATT TAGAAATATA ATTGACAGGA TTATTGGAAATTTGTTATAA TGAATGAAAC ATTTTGTCAT ATAAGATTCATATTTACTTC TTATACATTT GATAAAGTAA GGCATGGTTGTGGTTAATCT GGTTTATTTT TGTTCCACAA GTTAAATAAATCATAAAACT TGATGTGTTA TCTCTTA YWHAZ NM_003406.3CTTTCTCCTT CCCCTTCTTC CGGGCTCCCG TCCCGGCTCA 54TCACCCGGCC TGTGGCCCAC TCCCACCGCC AGCTGGAACCCTGGGGACTA CGACGTCCCT CAAACCTTGC TTCTAGGAGATAAAAAGAAC ATCCAGTCAT GGATAAAAAT GAGCTGGTTCAGAAGGCCAA ACTGGCCGAG CAGGCTGAGC GATATGATGACATGGCAGCC TGCATGAAGT CTGTAACTGA GCAAGGAGCTGAATTATCCA ATGAGGAGAG GAATCTTCTC TCAGTTGCTTATAAAAATGT TGTAGGAGCC CGTAGGTCAT CTTGGAGGGTCGTCTCAAGT ATTGAACAAA AGACGGAAGG TGCTGAGAAAAAACAGCAGA TGGCTCGAGA ATACAGAGAG AAAATTGAGACGGAGCTAAG AGATATCTGC AATGATGTAC TGTCTCTTTTGGAAAAGTTC TTGATCCCCA ATGCTTCACA AGCAGAGAGCAAAGTCTTCT ATTTGAAAAT GAAAGGAGAT TACTACCGTTACTTGGCTGA GGTTGCCGCT GGTGATGACA AGAAAGGGATTGTCGATCAG TCACAACAAG CATACCAAGA AGCTTTTGAAATCAGCAAAA AGGAAATGCA ACCAACACAT CCTATCAGACTGGGTCTGGC CCTTAACTTC TCTGTGTTCT ATTATGAGATTCTGAACTCC CCAGAGAAAG CCTGCTCTCT TGCAAAGACAGCTTTTGATG AAGCCATTGC TGAACTTGAT ACATTAAGTGAAGAGTCATA CAAAGACAGC ACGCTAATAA TGCAATTACTGAGAGACAAC TTGACATTGT GGACATCGGA TACCCAAGGAGACGAAGCTG AAGCAGGAGA AGGAGGGGAA AATTAACCGGCCTTCCAACT TTTGTCTGCC TCATTCTAAA ATTTACACAGTAGACCATTT GTCATCCATG CTGTCCCACA AATAGTTTTTTGTTTACGAT TTATGACAGG TTTATGTTAC TTCTATTTGAATTTCTATAT TTCCCATGTG GTTTTTATGT TTAATATTAGGGGAGTAGAG CCAGTTAACA TTTAGGGAGT TATCTGTTTTCATCTTGAGG TGGCCAATAT GGGGATGTGG AATTTTTATACAAGTTATAA GTGTTTGGCA TAGTACTTTT GGTACATTGTGGCTTCAAAA GGGCCAGTGT AAAACTGCTT CCATGTCTAAGCAAAGAAAA CTGCCTACAT ACTGGTTTGT CCTGGCGGGGAATAAAAGGG ATCATTGGTT CCAGTCACAG GTGTAGTAATTGTGGGTACT TTAAGGTTTG GAGCACTTAC AAGGCTGTGGTAGAATCATA CCCCATGGAT ACCACATATT AAACCATGTATATCTGTGGA ATACTCAATG TGTACACCTT TGACTACAGCTGCAGAAGTG TTCCTTTAGA CAAAGTTGTG ACCCATTTTACTCTGGATAA GGGCAGAAAC GGTTCACATT CCATTATTTGTAAAGTTACC TGCTGTTAGC TTTCATTATT TTTGCTACACTCATTTTATT TGTATTTAAA TGTTTTAGGC AACCTAAGAACAAATGTAAA AGTAAAGATG CAGGAAAAAT GAATTGCTTGGTATTCATTA CTTCATGTAT ATCAAGCACA GCAGTAAAACAAAAACCCAT GTATTTAACT TTTTTTTAGG ATTTTTGCTTTTGTGATTTT TTTTTTTTTG ATACTTGCCT AACATGCATGTGCTGTAAAA ATAGTTAACA GGGAAATAAC TTGAGATGATGGCTAGCTTT GTTTAATGTC TTATGAAATT TTCATGAACAATCCAAGCAT AATTGTTAAG AACACGTGTA TTAAATTCATGTAAGTGGAA TAAAAGTTTT ATGAATGGAC TTTTCAACTACTTTCTCTAC AGCTTTTCAT GTAAATTAGT CTTGGTTCTGAAACTTCTCT AAAGGAAATT GTACATTTTT TGAAATTTATTCCTTATTCC CTCTTGGCAG CTAATGGGCT CTTACCAAGTTTAAACACAA AATTTATCAT AACAAAAATA CTACTAATATAACTACTGTT TCCATGTCCC ATGATCCCCT CTCTTCCTCCCCACCCTGAA AAAAATGAGT TCCTATTTTT TCTGGGAGAGGGGGGGATTG ATTAGAAAAA AATGTAGTGT GTTCCATTTAAAATTTTGGC ATATGGCATT TTCTAACTTA GGAAGCCACAATGTTCTTGG CCCATCATGA CATTGGGTAG CATTAACTGTAAGTTTTGTG CTTCCAAATC ACTTTTTGGT TTTTAAGAATTTCTTGATAC TCTTATAGCC TGCCTTCAAT TTTGATCCTTTATTCTTTCT ATTTGTCAGG TGCACAAGAT TACCTTCCTGTTTTAGCCTT CTGTCTTGTC ACCAACCATT CTTACTTGGTGGCCATGTAC TTGGAAAAAG GCCGCATGAT CTTTCTGGCTCCACTCAGTG TCTAAGGCAC CCTGCTTCCT TTGCTTGCATCCCACAGACT ATTTCCCTCA TCCTATTTAC TGCAGCAAATCTCTCCTTAG TTGATGAGAC TGTGTTTATC TCCCTTTAAAACCCTACCTA TCCTGAATGG TCTGTCATTG TCTGCCTTTAAAATCCTTCC TCTTTCTTCC TCCTCTATTC TCTAAATAATGATGGGGCTA AGTTATACCC AAAGCTCACT TTACAAAATATTTCCTCAGT ACTTTGCAGA AAACACCAAA CAAAAATGCCATTTTAAAAA AGGTGTATTT TTTCTTTTAG AATGTAAGCTCCTCAAGAGC AGGGACAATG TTTTCTGTAT GTTCTATTGTGCCTAGTACA CTGTAAATGC TCAATAAATA TTGATGATGGGAGGCAGTGA GTCTTGATGA TAAGGGTGAG AAACTGAAATCCCAAACACT GTTTTGTTGC TTGTTTTATT ATGACCTCAGATTAAATTGG GAAATATTGG CCCTTTTGAA TAATTGTCCCAAATATTACA TTCAAATAAA AGTGCAATGG AGAAAAAAAA AAA SDHA NM_004168.3ACTGCAGCCC CGCTCGACTC CGGCGTGGTG CGCAGGCGCG 55GTATCCCCCC TCCCCCGCCA GCTCGACCCC GGTGTGGTGCGCAGGCGCAG TCTGCGCAGG GACTGGCGGG ACTGCGCGGCGGCAACAGCA GACATGTCGG GGGTCCGGGG CCTGTCGCGGCTGCTGAGCG CTCGGCGCCT GGCGCTGGCC AAGGCGTGGCCAACAGTGTT GCAAACAGGA ACCCGAGGTT TTCACTTCACTGTTGATGGG AACAAGAGGG CATCTGCTAA AGTTTCAGATTCCATTTCTG CTCAGTATCC AGTAGTGGAT CATGAATTTGATGCAGTGGT GGTAGGCGCT GGAGGGGCAG GCTTGCGAGCTGCATTTGGC CTTTCTGAGG CAGGGTTTAA TACAGCATGTGTTACCAAGC TGTTTCCTAC CAGGTCACAC ACTGTTGCAGCACAGGGAGG AATCAATGCT GCTCTGGGGA ACATGGAGGAGGACAACTGG AGGTGGCATT TCTACGACAC CGTGAAGGGCTCCGACTGGC TGGGGGACCA GGATGCCATC CACTACATGACGGAGCAGGC CCCCGCCGCC GTGGTCGAGC TAGAAAATTATGGCATGCCG TTTAGCAGAA CTGAAGATGG GAAGATTTATCAGCGTGCAT TTGGTGGACA GAGCCTCAAG TTTGGAAAGGGCGGGCAGGC CCATCGGTGC TGCTGTGTGG CTGATCGGACTGGCCACTCG CTATTGCACA CCTTATATGG AAGGTCTCTGCGATATGATA CCAGCTATTT TGTGGAGTAT TTTGCCTTGGATCTCCTGAT GGAGAATGGG GAGTGCCGTG GTGTCATCGCACTGTGCATA GAGGACGGGT CCATCCATCG CATAAGAGCAAAGAACACTG TTGTTGCCAC AGGAGGCTAC GGGCGCACCTACTTCAGCTG CACGTCTGCC CACACCAGCA CTGGCGACGGCACGGCCATG ATCACCAGGG CAGGCCTTCC TTGCCAGGACCTAGAGTTTG TTCAGTTCCA CCCTACAGGC ATATATGGTGCTGGTTGTCT CATTACGGAA GGATGTCGTG GAGAGGGAGGCATTCTCATT AACAGTCAAG GCGAAAGGTT TATGGAGCGATACGCCCCTG TCGCGAAGGA CCTGGCGTCT AGAGATGTGGTGTCTCGGTC CATGACTCTG GAGATCCGAG AAGGAAGAGGCTGTGGCCCT GAGAAAGATC ACGTCTACCT GCAGCTGCACCACCTACCTC CAGAGCAGCT GGCCACGCGC CTGCCTGGCATTTCAGAGAC AGCCATGATC TTCGCTGGCG TGGACGTCACGAAGGAGCCG ATCCCTGTCC TCCCCACCGT GCATTATAACATGGGCGGCA TTCCCACCAA CTACAAGGGG CAGGTCCTGAGGCACGTGAA TGGCCAGGAT CAGATTGTGC CCGGCCTGTACGCCTGTGGG GAGGCCGCCT GTGCCTCGGT ACATGGTGCCAACCGCCTCG GGGCAAACTC GCTCTTGGAC CTGGTTGTCTTTGGTCGGGC ATGTGCCCTG AGCATCGAAG AGTCATGCAGGCCTGGAGAT AAAGTCCCTC CAATTAAACC AAACGCTGGGGAAGAATCTG TCATGAATCT TGACAAATTG AGATTTGCTGATGGAAGCAT AAGAACATCG GAACTGCGAC TCAGCATGCAGAAGTCAATG CAAAATCATG CTGCCGTGTT CCGTGTGGGAAGCGTGTTGC AAGAAGGTTG TGGGAAAATC AGCAAGCTCTATGGAGACCT AAAGCACCTG AAGACGTTCG ACCGGGGAATGGTCTGGAAC ACGGACCTGG TGGAGACCCT GGAGCTGCAGAACCTGATGC TGTGTGCGCT GCAGACCATC TACGGAGCAGAGGCACGGAA GGAGTCACGG GGCGCGCATG CCAGGGAAGACTACAAGGTG CGGATTGATG AGTACGATTA CTCCAAGCCCATCCAGGGGC AACAGAAGAA GCCCTTTGAG GAGCACTGGAGGAAGCACAC CCTGTCCTAT GTGGACGTTG GCACTGGGAAGGTCACTCTG GAATATAGAC CCGTGATCGA CAAAACTTTGAACGAGGCTG ACTGTGCCAC CGTCCCGCCA GCCATTCGCTCCTACTGATG AGACAAGATG TGGTGATGAC AGAATCAGCTTTTGTAATTA TGTATAATAG CTCATGCATG TGTCCATGTCATAACTGTCT TCATACGCTT CTGCACTCTG GGGAAGAAGGAGTACATTGA AGGGAGATTG GCACCTAGTG GCTGGGAGCTTGCCAGGAAC CCAGTGGCCA GGGAGCGTGG CACTTACCTTTGTCCCTTGC TTCATTCTTG TGAGATGATA AAACTGGGCACAGCTCTTAA ATAAAATATA AATGAACAAA CTTTCTTTTATTTCCAAATC CATTTGAAAT ATTTTACTGT TGTGACTTTAGTCATATTTG TTGACCTAAA AATCAAATGT AATCTTTGTATTGTGTTACA TCAAAATCCA GATATTTTGT ATAGTTTCTTTTTTCTTTTT CTTTTCTTTT TTTTTTTTGA GACAGGATCGGTGCAGTAGT ACAATCACAG CTCACTGCAG CCTCAAACTCCTGGGCAGCT CAGGTGATCT TCCTGACTCA GCCTTCTGAGTAGTTGGGGC TACAGGTGTG CACCACCATG CCCAGCTCATTTATTTTGTA ATTGTAGGGA CAGGGTCTCA CTGTGTTGCCTAGGCTGGTC TCAAGTGATC CTCCCTCCTT GGCCTCCCAAGGTGCTGGAA TTATAGGTGT GAACAAACCA AAAAAAAAAA AAA HPRT1 NM_000194.2GGCGGGGCCT GCTTCTCCTC AGCTTCAGGC GGCTGCGACG 56AGCCCTCAGG CGAACCTCTC GGCTTTCCCG CGCGGCGCCGCCTCTTGCTG CGCCTCCGCC TCCTCCTCTG CTCCGCCACCGGCTTCCTCC TCCTGAGCAG TCAGCCCGCG CGCCGGCCGGCTCCGTTATG GCGACCCGCA GCCCTGGCGT CGTGATTAGTGATGATGAAC CAGGTTATGA CCTTGATTTA TTTTGCATACCTAATCATTA TGCTGAGGAT TTGGAAAGGG TGTTTATTCCTCATGGACTA ATTATGGACA GGACTGAACG TCTTGCTCGAGATGTGATGA AGGAGATGGG AGGCCATCAC ATTGTAGCCCTCTGTGTGCT CAAGGGGGGC TATAAATTCT TTGCTGACCTGCTGGATTAC ATCAAAGCAC TGAATAGAAA TAGTGATAGATCCATTCCTA TGACTGTAGA TTTTATCAGA CTGAAGAGCTATTGTAATGA CCAGTCAACA GGGGACATAA AAGTAATTGGTGGAGATGAT CTCTCAACTT TAACTGGAAA GAATGTCTTGATTGTGGAAG ATATAATTGA CACTGGCAAA ACAATGCAGACTTTGCTTTC CTTGGTCAGG CAGTATAATC CAAAGATGGTCAAGGTCGCA AGCTTGCTGG TGAAAAGGAC CCCACGAAGTGTTGGATATA AGCCAGACTT TGTTGGATTT GAAATTCCAGACAAGTTTGT TGTAGGATAT GCCCTTGACT ATAATGAATACTTCAGGGAT TTGAATCATG TTTGTGTCAT TAGTGAAACTGGAAAAGCAA AATACAAAGC CTAAGATGAG AGTTCAAGTTGAGTTTGGAA ACATCTGGAG TCCTATTGAC ATCGCCAGTAAAATTATCAA TGTTCTAGTT CTGTGGCCAT CTGCTTAGTAGAGCTTTTTG CATGTATCTT CTAAGAATTT TATCTGTTTTGTACTTTAGA AATGTCAGTT GCTGCATTCC TAAACTGTTTATTTGCACTA TGAGCCTATA GACTATCAGT TCCCTTTGGGCGGATTGTTG TTTAACTTGT AAATGAAAAA ATTCTCTTAAACCACAGCAC TATTGAGTGA AACATTGAAC TCATATCTGTAAGAAATAAA GAGAAGATAT ATTAGTTTTT TAATTGGTATTTTAATTTTT ATATATGCAG GAAAGAATAG AAGTGATTGAATATTGTTAA TTATACCACC GTGTGTTAGA AAAGTAAGAAGCAGTCAATT TTCACATCAA AGACAGCATC TAAGAAGTTTTGTTCTGTCC TGGAATTATT TTAGTAGTGT TTCAGTAATGTTGACTGTAT TTTCCAACTT GTTCAAATTA TTACCAGTGAATCTTTGTCA GCAGTTCCCT TTTAAATGCA AATCAATAAATTCCCAAAAA TTTAAAAAAA AAAAAAAAAA AAAAA

Definitions

The articles “a” and “an” are used in this disclosure to refer to one ormore than one (i.e., to at least one) of the grammatical object of thearticle. By way of example, “an element” means one element or more thanone element.

The term “and/or” is used in this disclosure to mean either “and” or“or” unless indicated otherwise.

As used herein, the terms “polynucleotide” and “nucleic acid molecule”are used interchangeably to mean a polymeric form of nucleotides of atleast 10 bases or base pairs in length, either ribonucleotides ordeoxynucleotides or a modified form of either type of nucleotide, and ismeant to include single and double stranded forms of DNA. As usedherein, a nucleic acid molecule or nucleic acid sequence that serves asa probe in a microarray analysis preferably comprises a chain ofnucleotides, more preferably DNA and/or RNA. In other embodiments, anucleic acid molecule or nucleic acid sequence comprises other kinds ofnucleic acid structures such a for instance a DNA/RNA helix, peptidenucleic acid (PNA), locked nucleic acid (LNA) and/or a ribozyme. Hence,as used herein the term “nucleic acid molecule” also encompasses a chaincomprising non-natural nucleotides, modified nucleotides and/ornon-nucleotide building blocks which exhibit the same function asnatural nucleotides.

As used herein, the terms “hybridize,” “hybridizing”, “hybridizes,” andthe like, used in the context of polynucleotides, are meant to refer toconventional hybridization conditions, such as hybridization in 50%formamide/6×SSC/0.1% SDS/100 μg/ml ssDNA, in which temperatures forhybridization are above 37 degrees and temperatures for washing in0.1×SSC/0.1% SDS are above 55 degrees C., and preferably to stringenthybridization conditions.

As used herein, the term “normalization” or “normalizer” refers to theexpression of a differential value in terms of a standard value toadjust for effects which arise from technical variation due to samplehandling, sample preparation, and measurement methods rather thanbiological variation of biomarker concentration in a sample. Forexample, when measuring the expression of a differentially expressedprotein, the absolute value for the expression of the protein can beexpressed in terms of an absolute value for the expression of a standardprotein that is substantially constant in expression.

The terms “diagnosis” and “diagnostics” also encompass the terms“prognosis” and “prognostics”, respectively, as well as the applicationsof such procedures over two or more time points to monitor the diagnosisand/or prognosis over time, and statistical modeling based thereupon.Furthermore, the term diagnosis includes: a. prediction (determining ifa patient will likely develop aggressive disease(hyperproliferative/invasive)), b. prognosis (predicting whether apatient will likely have a better or worse outcome at a pre-selectedtime in the future), c. therapy selection, d. therapeutic drugmonitoring, and e. relapse monitoring.

The term “providing” as used herein with regard to a biological samplerefers to directly or indirectly obtaining the biological sample from asubject. For example, “providing” may refer to the act of directlyobtaining the biological sample from a subject (e.g., by a blood draw,tissue biopsy, lavage and the like). Likewise, “providing” may refer tothe act of indirectly obtaining the biological sample. For example,providing may refer to the act of a laboratory receiving the sample fromthe party that directly obtained the sample, or to the act of obtainingthe sample from an archive.

“Accuracy” refers to the degree of conformity of a measured orcalculated quantity (a test reported value) to its actual (or true)value. Clinical accuracy relates to the proportion of true outcomes(true positives (TP) or true negatives (TN) versus misclassifiedoutcomes (false positives (FP) or false negatives (FN)), and may bestated as a sensitivity, specificity, positive predictive values (PPV)or negative predictive values (NPV), or as a likelihood, odds ratio,among other measures.

The term “biological sample” as used herein refers to any sample ofbiological origin potentially containing one or more biomarkers.Examples of biological samples include tissue, organs, or bodily fluidssuch as whole blood, plasma, serum, tissue, lavage or any other specimenused for detection of disease.

The term “subject” as used herein refers to a mammal, preferably ahuman.

“Treating” or “treatment” as used herein with regard to a condition mayrefer to preventing the condition, slowing the onset or rate ofdevelopment of the condition, reducing the risk of developing thecondition, preventing or delaying the development of symptoms associatedwith the condition, reducing or ending symptoms associated with thecondition, generating a complete or partial regression of the condition,or some combination thereof.

Biomarker levels may change due to treatment of the disease. The changesin biomarker levels may be measured by the present disclosure. Changesin biomarker levels may be used to monitor the progression of disease ortherapy.

“Altered”, “changed” or “significantly different” refer to a detectablechange or difference from a reasonably comparable state, profile,measurement, or the like. Such changes may be all or none. They may beincremental and need not be linear. They may be by orders of magnitude.A change may be an increase or decrease by 1%, 5%, 10%, 20%, 30%, 40%,50%, 60%, 70%, 80%, 90%, 95%, 99%, 100%, or more, or any value inbetween 0% and 100%. Alternatively, the change may be 1-fold, 1.5-fold,2-fold, 3-fold, 4-fold, 5-fold or more, or any values in between 1-foldand five-fold. The change may be statistically significant with a pvalue of 0.1, 0.05, 0.001, or 0.0001.

The term “stable disease” refers to a diagnosis for the presence of amelanoma, however the melanoma has been treated and remains in a stablecondition, i.e. one that that is not progressive, as determined byimaging data and/or best clinical judgment.

The term “progressive disease” refers to a diagnosis for the presence ofa highly active state of a melanoma, i.e. one has not been treated andis not stable or has been treated and has not responded to therapy, orhas been treated and active disease remains, as determined by imagingdata and/or best clinical judgment.

EXAMPLES

The disclosure is further illustrated by the following examples, whichare not to be construed as limiting this disclosure in scope or spiritto the specific procedures herein described. It is to be understood thatthe examples are provided to illustrate certain embodiments and that nolimitation to the scope of the disclosure is intended thereby. It is tobe further understood that resort may be had to various otherembodiments, modifications, and equivalents thereof which may suggestthemselves to those skilled in the art without departing from the spiritof the present disclosure and/or scope of the appended claims.

Example 1

Derivation of a 28-Marker Gene Panel

Raw probe intensities (n=6,892,960 features) from n=49 whole bloodsamples were used to identify genes that best discriminated betweendifferent types of melanoma samples e.g., treated versus untreated,simultaneously. A total of 28 transcripts were identified in an unbiasedmanner as potential markers of melanoma behavior (Table 2).

An artificial intelligence model of melanoma disease dynamics was builtusing normalized gene expression of these 28 markers in whole blood fromControls (n=90), Responders/Stable (n=68), and Progressive (n=66)samples. The dataset was randomly split into training (n=169) andtesting (n=55) partitions for model creation and validationrespectively. Five algorithms (XGB, RF, TreeBag, SVM, NNET) wereidentified that best predicted the training data. In the test set, eachalgorithm produced probability scores that predicted the sample. Eachprobability score reflects the “certainty” of an algorithm that anunknown sample belongs to Control, Responder/Stable or Progressiveclass. For example, an unknown sample 51 can have the followingprobability vector {Control=20, Responder=50, Progressive=30}. Thissample would be considered a responder, given a score of 50, but theremay be potential of progression (probability of 30) (FIG. 1 ).

TABLE 2 Amplicon produced Chromosome using forward and Assay ExonMelanoma Biomarker or Housekeeping Gene location UniGene reverse primersLoca- Bound- Symbol Name [Cytogenetic band] ID RefSeq Length (bp) tionary ATL1 atlastin GTPase 1 Chr.14: Hs.584905 NM_001127713.1 65 154412-13 50533082-50633068 [14q22.1] ATP6V0D ATPase H+ transporting V0Chr.16: Hs.106876 NM_004691.4 72 224 1-2 subunit d1 67438014-67481186[16q22.1] C1ORF21 chromosome 1 open Chr.1: Hs.497159 NM_030806.3 84 8055-6 reading frame 21 184387016-184629021 [1q25.3] CFLAR CASP8 and FADDlike Chr.2: Hs.390736 NM_001127183.2 59 874 3-4 apoptosis regulator201116015-201172688 [2q33.1] CFLAR-AS1 CFLAR antisense RNA 1 Chr.2:Hs.664613 NR_040030.1 103 883 6-7 201140289-201157792 [2q33.1] CHP1calcineurin like EF-hand Chr.15: Hs.406234 NM_007236.4 120 212 1-2protein 1 41231149-41281887 [15q15.1 ] DDX55 DEAD-box helicase 55Chr.12: Hs.286173 NM_020936.2 74 183 1-2 123602077-123620943 [12q24.31]DMD dystrophin Chr.X: Hs.495912 NM_000109.3 76 9607 63-6431119219-33339609 [Xp21.1] DNAJC9 DnaJ heat shock protein Chr.10:Hs.408577 NM_015190.4 102 198 1-1 family (Hsp40) member C973241954-73247331 [10q22.2] ENOSF1 enolase superfamily Chr.18: Hs.658550NM_001126123.3 110 X 13-14 member 1 670012-712664 [18p11.32] FANCLFanconi anemia Chr.2: Hs.631890 NM_001114636.1 138 540 6-7complementation group L 58159243-58241380 [2p16.1] HJURP Hollidayjunction Chr.2: Hs.532968 NM_018410.4 52 399 4-5 recognition protein233836701-233854566 [2q37.1] HLA-DOA major histocompatibility Chr.6:Hs.631991 NM_002119.3 124 160 1-2 complex, class II, DO alpha33004182-33009612 [6p21.32] HLA-DRA major histocompatibility Chr.6:Hs.520048 NM_019111.4 129 884 4-5 complex, class II, DR alpha32439842-32445046 [6p21.32] HNRNPA3P1 heterogeneous nuclear Chr.10:Hs.632956 NR_002726.2 99 2455 1-1 ribonucleoprotein A3 43787412-43790417pseudogene 1 [10q11.21] IL23A interleukin 23 subunit alpha Chr.12:Hs.382212 NM_016584.2 107 323 1-2 56334159-56340410 [12q13.3] IQGAP1 IQmotif containing Chr.15: Hs.430551 NM_003870.3 69 4562 34-35 GTPase90388241-90502243 activating protein 1 [15q26.1] LOC494127 NFYCpseudogene Chr.9: Hs.626316 NR_036691.1 86 150 1-1 87083886-87085225[9q21.33] LOC646471 uncharacterized Chr.1: Hs.727271 NR_024498.1 80 28581-1 LOC646471 25819954-25823606 [1p36.11] LOH12CR loss ofheterozygosity, 12, Chr.12: Hs.67553 NR_024061.1 69 140 1-2 chromosomalregion 2 12355408-12357067 (non-protein coding) [12p13.2] MTRNR2L2_MTO1CUSTOM PRIMER PBXIP1 PBX homeobox interacting Chr.1: Hs.505806NM_020524.3 60 189 2-3 protein 1 154944080-154956163 [1q21.3] RNF5 ringfinger protein 5 Chr.6: Hs.731774 NM_006913.3 67 273 1-232178385-32180793 [6p21.32] SERTAD2 SERTA domain containing Chr.2:Hs.591569 NM_014755.2 91 288 1-2 2 64631621-64751091 [2p14] SLC35G5solute carrier family 35 Chr.8: Hs.458397 NM_054028.1 144 541 1-1 memberG5 11330986-11332186 [8p23.1] SPATS2L spermatogenesis associated Chr.2:Hs.120323 NM_001100422.1 89 1364 10-11 serine rich 2 like200305881-200482263 [2q33.1] TDRD7 tudor domain containing Chr.9:Hs.193842 NM_001302884.1 59 3084 15-16 7 97412020-97496125 [9q22.33]TOX4 TOX high mobility group Chr.14: Hs.555910 NM_001303523.1 145 4473-3 (housekeeping box family member 4 21477176-21499177 gene) [14q11.2]TPT1 tumor protein, Chr.13: Hs.374596 NM_001286272.1 131 377 3-3(housekeeping translationally-controlled 1 45333471-45341284 gene)[13q14.13] TXK TXK tyrosine kinase Chr.4: Hs.479669 NM_003328.2 113 126511-12 48066393-48135322 [4p12 ] YY2 YY2 transcription factor Chr.X:Hs.673601 NM_206923.3 110 552 1-1 21855987-21858727 [Xp22.12]

Diagnosis: Identification of Samples as Melanoma

In the test set 1, the data for the utility of the test to differentiatemelanoma from controls are included in Table 3. The metrics are includedin FIG. 2 . These are: sensitivity >90%, specificity 100%, PPV 100%, NPV87%. The overall accuracy is 94%. The tool can therefore differentiatebetween controls and aggressive and stable melanoma disease.

TABLE 3 Confusion matrix showing classification accuracy of the 5-modelalgorithm that determines whether a sample is a melanoma or a control inblood samples Predicted/Reference Melanoma Control Control 3 20 Melanoma30 0 Sensitivity 91% Specificity 100%  Positive Predictive Value 100% Negative Predictive Value 87% Accuracy 94%

The test was evaluated in a second test set (test set 2) that included74 controls and 92 melanoma patients. The mean Melanomx score in themelanoma group was 73±31 versus 10±8 in the control group (FIG. 3A). Thereceiver operator curve analysis demonstrated the score exhibited anarea under the curve (AUC) of 0.96 (FIG. 3B) and the metrics were88-100% (FIG. 3C).

Correlation with Surgical Removal of Melanoma.

In the surgical series (n=46), removal of melanoma decreased the scorefrom 74±16 to 20±12 (FIG. 4A). Evaluation of the post-surgical groupidentified the score was significantly different between patients withno evidence of disease 13±6 (not different to the control group) andthose with residual disease (33±9) (FIG. 4B). The Melanomx score cantherefore define the extent of surgery and identify those who aresurgical cures.

Evaluation of Immune-Therapy and Targeted (BRAF Inhibitor) Therapy.

In the therapy series (n=30), treatment with ipilimumab (immune therapytargeting CTLA-4), nivolumab (immune therapy targeting PD-1) or a BRAFinhibitor (vemurafenib) for 5 months significantly decreased theMelanomx scores from 88±12 to 15±5 (p<0.0001), 35±14 (p<0.001) and 38±21(p<0.0001), respectively (FIG. 5 ). All patients in the treated groupswere stable. This indicates that the Melanomx score can therefore beused to measure the efficacy of both immune and targeted-therapy inmelanoma and that a decrease in score correlated with response totherapeutic intervention.

Confirmation that Gene Expression is Melanoma Derived.

We confirmed that melanoma was the source for the blood-based geneexpression assay by evaluating expression in different melanoma celllines, in tumor tissue and by comparing expression in blood with tumortissue collected at the same time-point during surgery.

All 28 genes were highly expressed in all 3 melanoma cell lines. Scoresranged from 94±6 (Hs294T) to 82±5 (CHL) to 42±9 (A375) (FIG. 6A).

Spike-in experiments using these 3 cell lines and normal whole blooddemonstrated that gene expression scores were detected when as few as 1cell was spiked into 1 ml of blood. One single melanoma cell wasdetectable. Scores ranged from 21±4 (A375) to 30±5 (CHL) to 34±2 (H2294)(FIG. 6B). Scores were significantly elevated compared to control blood(no spike-in; p<0.0001).

We then evaluated gene expression in tumor tissue. All 28 genes werehighly expressed in melanoma compared to matched normal tissue andscores were significantly elevated 70±20 versus 4±3 (p<0.0001) (FIG.7A).

We also compared gene expression in tumor tissue and blood collected atthe same time point. Gene expression was highly concordant (Pearson r:0.74-0.83, median: 0.819) identifying gene expression in tumor tissueand blood was concordant (FIG. 7B).

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EQUIVALENTS

While the present invention has been described in conjunction with thespecific embodiments set forth above, many alternatives, modificationsand other variations thereof will be apparent to those of ordinary skillin the art. All such alternatives, modifications and variations areintended to fall within the spirit and scope of the present invention.

What is claimed is:
 1. A kit comprising at least one of:

or any combination thereof, and at least one species of probe thathybridizes to at least one of ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1,CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA,HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5,SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, YY2.
 2. The kit of claim 1,wherein the kit comprises:


3. The kit of claim 1, wherein the kit comprises:


4. The kit of claim 1, wherein the kit comprises:


5. The kit of claim 1, wherein the kit comprises:


6. The kit of claim 1, wherein the kit comprises:


7. The kit of claim 1, wherein the kit comprises:


8. The kit of claim 1, wherein the at least one probe further comprisesat least one detectable label.
 9. The kit of claim 1, wherein the kitcomprises at least 28 species of probe, wherein the at least 28 speciesof probe bind to each of ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1,DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1,IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2,SLC35G5, SPATS2L, TDRD7, TXK, YY2.
 10. The kit of claim 1, wherein thekit further comprises at least one species of probe that binds to TOX4.11. The kit of claim 1, wherein the kit further comprises at least onespecies of probe that binds to TPT1.
 12. A method of treating a cancerin a subject in need thereof, the method comprising administering to thesubject at least one therapeutically effective amount of at least oneof:

or any combination thereof.
 13. The method of claim 12, wherein themethod comprises administering at least one therapeutically effectiveamount of:


14. The method of claim 12, wherein the method comprises administeringat least one therapeutically effective amount of:


15. The method of claim 12, wherein the method comprises administeringat least one therapeutically effective amount of:


16. The method of claim 12, wherein the method comprises administeringat least one therapeutically effective amount of: